65 completed, 23 unknown, 7 not yet recruiting, 6 active not recruiting. 108 Phase 1, 53 Phase 2.
Follow Periodontal Diseases: new trials by email Literature Review of Periodontal Diseases trials Research Report on Periodontal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting Maxillary sinus floor elevation grafting with synthetic bone substitute. - Bone Loss, Osteoclastic, Bone Loss, Alveolar | Phase 1 | Not yet recruiting | Pontificia Universidade Católica do Rio Grande do Sul | 20 | 2027-12-15 | 2026-09-21 |
| Taste Acceptance and Effectiveness of Hyaluronic Acid and Chlorhexidine Mouthwashes in Children With Gingivitis Hyaluronic Acid mouthwash, Chlorohexidine 0.12% mouthwash - Plaque Induced Gingival Disease | Phase 1 | Not yet recruiting | Cairo University | 24 | 2027-01-01 | 2026-10-13 |
| A Novel Proline-rich Peptide Hydrogel for Periodontal Regeneration in Adult Periodontitis Patients Hydrogel - Periodontal Disease, Intrabony Periodontal Defects | Phase 1 / Phase 2 | Not yet recruiting | Siddharth Shanbhag | 40 | 2026-11-01 | 2026-05-14 |
| The Effect of Dexamethasone on Short Term Patient Response: IV vs Oral Administration Dexamethasone IV injection, Dexamethasone Capsule, Placebo IV administration - Post Operative Pain, Acute, Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | The University of Texas Health Science Center at San Antonio | 40 | 2026-10-01 | 2026-09-21 |
| Minimally Invasive Non-Surgical Periodontal Therapy Alone vs. Minimally Invasive Non-Surgical Periodontal Therapy With I-PRF With or Without Chlorhexidine on Stage III Periodontitis Patients Minimally Invasive Nonsurgical Therapy, Injectable Platelet-Rich Fibrin, Chlorhexidine 2% - Bony Defects, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Cairo University | 63 | 2026-09-30 | 2026-08-27 |
| Evaluation of NIPSA Using Alloplastic Bone Graft and Cross-Linked Hyaluronic Acid in theTreatment of Intrabony Defects allopastic bone graft, cross-linked hyaluronic acid, Non-Incised Papillae Surgical Approach - Intrabony Periodontal Defect, Periodontal Disease | Phase 1 / Phase 2 | Not yet recruiting | Mansoura University | 60 | 2026-08-01 | 2026-08-04 |
| Microbiological Modulation Of The Oral-Gut Axis After Treatment With Or Without Systemic Use Of Probiotics In Patients With Periodontitis: A Randomized Controlled Clinical Study. Probiotics Bifidobacterium animalis subsp. lactis HN019 - Periodontitis Stage IV, Periodontitis | Phase 1 | Completed | University of Sao Paulo | 40 | 2026-06-25 | 2026-08-28 |
| Biological, Radiographic and Clinical Evaluation of Various Inter-Visit Root Canal Dressings in Retreatment Cases Calcium Silicate Intracanal Medication, Calcium Hydroxide Slurry mixed with Sodium Hypochlorite Intracanal Medication, Calcium Hydroxide (Ca(OH)2) Intracanal Medication - Intervention Studies, ASA Physical Status I | Phase 1 | Recruiting | Ain Shams University | 60 | 2026-06-01 | 2026-06-12 |
| Injectable Platelet-Rich Fibrin (i-PRF) and Oxygen-Releasing Gel in the Treatment of Stage II Periodontitis. Injectable Platelet-Rich Fibrin (i-PRF, Peroxoborate Oxygen-Releasing Oral Gel, Sterile 0.9% Saline Solution - Stage III Periodontitis | Phase 1 / Phase 2 | Completed | Assiut University | 24 | 2026-01-20 | 2026-10-28 |
| Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing MSC-Derived Exosomes, Platelet-rich fibrin (PRF) - Alveolar Bone Loss, Tooth Extraction | Phase 1 / Phase 2 | Recruiting | Al Salam University | 40 | 2026-01-15 | 2026-04-02 |
| Clinical and Laboratory Evaluation of Resveratrol Loaded Nanoparticles in the Treatment of Periodontitis: A Randomized Controlled Clinical Trial Resveratrol loaded gel - Periodontitis Stage III | Phase 1 | Active not recruiting | Hagar Ahmed Ali Mohammed Elzain | 48 | 2025-08-09 | 2026-02-09 |
| Effect of Nano-Hyaluronic Acid in Intrabony Defects Treated With Minimally Invasive Non-Surgical Technique Minimally invasive non-surgical technique (MINST), nano-hyaluronic acid - Periodontal Disease, Periodontitis | Phase 1 / Phase 2 | Active not recruiting | Cairo University | 28 | 2025-07-15 | 2026-05-19 |
| Evaluation of Locally Applied Ferulic Acid as Adjunct to Mechanical Debridement in Treatment of Periodontitis Ferulic Acid, Placebo, mechanical debridement only - Periodontitis | Phase 1 / Phase 2 | Active not recruiting | Salah Awad Alanazi | 80 | 2025-05-16 | 2026-02-13 |
| Evaluating Gingivitis and Systemic Biomarkers 0.76% Sodium Monofluorophosphate Dentifrice, 0.454% Stannous Fluoride Dentifrice - Gingivitis | Phase 1 | Active not recruiting | Procter and Gamble | 135 | 2025-04-30 | 2025-06-03 |
| Propolis Lozenges Extract and Their Effect on Salivary Biomarkers and on Oral Health Condition in (19_24) Years Old lozenges containing propolis - Plaque Induced Gingivitis, Mouth Diseases | Phase 1 | Completed | Al-Mustansiriyah University | 100 | 2025-03-23 | 2025-09-24 |
| PRF vs. Graftless Sinus Lift With Implant Placement Graftless Transcrestal Sinus Floor Elevation with Immediate Implant Placement, Platelet-Rich Fibrin (PRF)-Assisted Transcrestal Sinus Floor Elevation with Immediate Implant Placement - Maxillary Sinus Floor Augmentation, Alveolar Bone Loss | Phase 1 | Enrolling by invitation | Dar Al Uloom University | 8 | 2025-02-01 | 2025-07-29 |
| The Effect of Human Umbilical Cord Mesenchymal Stem Cells and Exosomes on the Healing of Postoperative Pain and Periapical Lesions in the Treatment of Apical Periodontitis: Randomized Controlled Clinical Study Stem Cell Product, Bleeding and clots - Apical Periodontitis | Phase 1 / Phase 2 | Not yet recruiting | TC Erciyes University | 45 | 2025-01-01 | 2025-01-08 |
| Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession Hyaluronic acid, Steril saline solution - Gingival Recession | Phase 1 / Phase 2 | Completed | Ordu University | 20 | 2024-09-01 | 2026-02-27 |
| Clinical Assessment of Chitosan Nanoparticles on Periodontal Problems Post Steroidal Inhalation in Asthmatic Patients: Phase I Trial Chitosan - Periodontal Diseases | Phase 1 | Completed | Deraya University | 20 | 2024-08-01 | 2025-06-26 |
| Evaluation of 2%Bromelain Gel With 0.2%CHX Gel as Subgingival LDD Following SRP in Stage II/III and Grade B Periodontitis -A RCT Bromelain gel, chlorhexidine gel, SRP - Periodontal Pocket | Phase 1 | Recruiting | Krishnadevaraya College of Dental Sciences & Hospital | 36 | 2024-07-01 | 2025-01-13 |
Showing 20 of 108. Sign in to see all of them.
Periodontitis (34) · Gingivitis (21) · Alveolar Bone Loss (14) · Chronic Periodontitis (14) · Periodontal Pocket (7) · Gingival Recession (5) · Plaque, Amyloid (5) · Dental Plaque (4) · Inflammation (4) · Periapical Periodontitis (4) · Aggressive Periodontitis (3) · Diabetes Mellitus (3) · Atrophy (2) · Bone Resorption (2)
Stomatognathic Diseases (107) · Mouth Diseases (106) · Pathological Conditions, Signs and Symptoms (29) · Gingival Diseases (27) · Periodontitis (23) · Infections (22) · Pathologic Processes (21) · Periodontal Atrophy (20) · Bone Diseases (15) · Musculoskeletal Diseases (15) · Chronic Disease (14) · Disease Attributes (14) · Bone Resorption (12) · Pathological Conditions, Anatomical (8)
Tooth Exfoliation (11) · Root Planing (6) · Saline Solution (3) · AMY-101 (2) · Chlorhexidine (2) · Control Groups (2) · Dental Implants (2) · Hyaluronic Acid (2) · Achillea millefolium flower (1) · Amoxicillin (1) · Ashwagandha (1) · Atorvastatin (1) · Benzocaine (1) · Calcium (1) · Calcium Hydroxide (1)
Cairo University (6) · Krishnadevaraya College of Dental Sciences & Hospital (5) · Assiut University (3) · Tanta University (3) · Tatyasaheb Kore Dental College (3) · University of Michigan (3) · Ain Shams University (2) · Air Force Military Medical University, China (2) · Amyndas Pharmaceuticals S.A. (2) · Deraya University (2) · Federal University of Paraíba (2) · Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus (2) · Misr University for Science and Technology (2) · Ordu University (2) · Shahid Beheshti University of Medical Sciences (2)
United States (19) · Egypt (18) · India (9) · China (6) · Brazil (5) · Turkey (Türkiye) (4) · Iran (3) · Iraq (3) · Saudi Arabia (3) · Belarus (2) · Israel (2) · Sweden (2) · Canada (1) · Chile (1) · Czechia (1)
Arash Khojasteh, DMD, OMFS (2) · Dilip Khambete, MDS (2) · Michael McGuire, DDS (2) · Sergey Rubnikovich, Prof (2) · William V Giannobile, DDS, DMedSc (2) · Ahmed Mortada Fikry, professor (1) · Ahmed Y Gamal, PhD (1) · Alabuni Emad (1) · Anderson Ferreira, Professor (1) · Angela Paliaologou-Gallis, DDS (1) · Ann Progulske-Fox, PhD (1) · Ann Wenzel, professor (1) · Antonis Konstantinidis, Professor (1) · Baoyong Yan, Doctor (1) · Benjamin Shayo, MD (1)
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D43TW012274 (1), U01DE026934 (1)