177 completed, 28 unknown, 26 recruiting, 13 not yet recruiting. 82 Not applicable, 47 Phase 2, 46 Phase 3, 27 Phase 1, 20 Phase 4.
Follow Plaque, Amyloid: new trials by email Literature Review of Plaque, Amyloid trials Research Report on Plaque, Amyloid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| AV-1959R Vaccine in Individuals With Preclinical Alzheimer's Disease AV-1959R, Placebo - Preclinical Alzheimer's Disease, Alzheimer Disease | Phase 2 | Not yet recruiting | Institute for Molecular Medicine | 160 | 2027-10-01 | 2026-10-21 |
| Evaluation of Safety and Efficacy of IRX4204 in Mild to Moderate Plaque Psoriasis IRX4204, Placebo - Psoriasis, Plaque Type Psorisis | Phase 2 | Suspended | Io Therapeutics | 20 | 2027-03-01 | 2026-11-12 |
| A 28-Day Study of GAL-101 in Participants With Mild to Moderate Alzheimer's Disease GAL-101 Salt, Placebo - Mild to Moderate Alzheimer's Disease | Phase 2 | Not yet recruiting | Galimedix Therapeutics Inc | 100 | 2027-02-28 | 2026-08-27 |
| Postsurgical Pain and Opioid Use in Older Adults: Effects of Mild Cognitive Impairment Mild Cognitive Impairment (MCI), Opioid Use | Not yet recruiting | Miklos Kertai | 552 | 2027-01-01 | 2026-10-21 | |
| Efficacy of Two Brushing Regimens in the Reduction of Established Dental Plaque and Gingivitis 0.412% stannous fluoride toothpaste and flat trimmed toothbrush, 0.76% Na MFP and flat trimmed toothbrush - Plaque, Gingivitis | Phase 3 | Completed | Colgate Palmolive | 84 | 2026-10-09 | 2026-11-10 |
| Ceramol PSOR Cream as an Adjuvant Treatment in Patients With Mild-to-Moderate Psoriasis Treated With Narrowband UVB Phototherapy (CERAMOL PSOR CREMA) Narrowband UVB Phototherapy, Ceramol PSOR Cream, Comparator Emollient Cream - Psoriasis, Psoriasis; Plaque | Not applicable | Not yet recruiting | Unifarco SpA | 128 | 2026-10-01 | 2026-09-30 |
| A Study of LY4560736 in Healthy Participants and Participants With Alzheimer's Disease (AD) LY4560736, Placebo, Florbetapir F18 - Healthy Volunteers, Alzheimer Disease | Phase 1 | Not yet recruiting | Eli Lilly and Company | 111 | 2026-10-01 | 2026-10-08 |
| Clinical Study Examining the Control of Plaque and Gingivitis Silica Free Meridol, Meridol, Colgate Dental Product - Gingivitis | Phase 3 | Not yet recruiting | Colgate Palmolive | 135 | 2026-10-01 | 2026-09-25 |
| Phase 1 Study to Evaluate the Safety and Tolerability of 8M2D in Healthy People and Alzheimer's Patients 8M2D, Placebo - Alzheimer's Disease (AD) | Phase 1 | Not yet recruiting | Cenna Biosciences Inc. | 54 | 2026-09-15 | 2026-05-05 |
| Effect of Mazdutide on Coronary Plaque in Patients With Coronary Atherosclerosis and Overweight or Obesity Mazdutide, Placebo - Obesity & Overweight, Coronary Heart Disease | Phase 4 | Recruiting | China National Center for Cardiovascular Diseases | 116 | 2026-09-14 | 2026-10-13 |
| A Master Protocol Studying Multiple Amyloid-Targeting Therapies in Healthy Participants and Participants With Alzheimer's Disease LY4405094, Placebo, Florbetapir F18 - Alzheimer Disease, Amyloid | Phase 1 | Recruiting | Eli Lilly and Company | 179 | 2026-09-09 | 2026-11-05 |
| Multimodality Optical and Ultrasound Intravascular Imaging for Stent Optimization and Atheroma Assessment Conavi Medical Novasight Hybrid System intervention - Coronary Artery Disease, Coronary Stenosis | Not applicable | Withdrawn | Barts & The London NHS Trust | 2026-09-01 | 2025-09-17 | |
| Amyloid Lowering for Alzheimer's in Down's With Donanemab Investigation Donanemab, Placebo - Down Syndrome (DS), Down Syndrome (Trisomy 21) | Phase 4 | Not yet recruiting | Michael Rafii, MD, PhD | 60 | 2026-08-01 | 2026-05-15 |
| Clinical Evaluation of a Toothpaste for Dental Plaque Reduction and Prevention of Gum Problems 0.45% SnF HW with NaF (1450 F), 67% Bicarbonate with NaF (1400 F), Colgate Cavity Protection Toothpaste - Plaque, Dental Plaque | Phase 3 | Recruiting | Colgate Palmolive | 120 | 2026-07-20 | 2026-09-25 |
| Oil Pulling Reduction GuruNanda natural Oil Pulling oral rinse, TheraBreath Plaque Control Oral Rinse, GuruNanda water-based non-whitening mouthwash - Good Health, Gingival Inflammation and Bleeding | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 120 | 2026-07-08 | 2026-08-24 |
| Restoring Cervical Lymphatic Drainage in Alzheimer's Disease Cervical lymphovenous anastomosis (LVA) - Alzheimer, Alzheimer Dementia (AD) | Not applicable | Recruiting | University of Siena | 5 | 2026-07-01 | 2026-10-02 |
| Assessing the Influence of Habitual Beef Intake on Key Molecular Markers of Brain Health Lean Beef, Non-Beef Control - Healthy Aging, Brain Health | Not applicable | Recruiting | South Dakota State University | 20 | 2026-06-03 | 2026-06-03 |
| A Study of Donanemab (LY3002813) in Participants Who Completed Study AACM (TRAILBLAZER-ALZ 3-EXT). Donanemab, Placebo - Alzheimer Disease, Dementia | Phase 3 | Recruiting | Eli Lilly and Company | 550 | 2026-05-22 | 2026-10-28 |
| Study to Investigate Toothpaste on Antibacterial Effects in the Different Regions of the Mouth stannous fluoride toothpaste, 0.76% Sodium Monofluorophosphate (Na MFP) toothpaste - Plaque, Gingivitis | Phase 3 | Completed | Colgate Palmolive | 95 | 2026-05-18 | 2026-09-24 |
| DIV-AD BARCELONA: Alzheimer's Blood-Based Biomakers for a Diverse Community Alzheimer Disease, Cognitive Dysfunction, Cognitive Disorder | Not yet recruiting | Barcelonabeta Brain Research Center, Pasqual Maragall Foundation | 250 | 2026-04-27 | 2026-04-13 |
Showing 20 of 272. Sign in to see all of them.
Alzheimer Disease (72) · Gingivitis (56) · Dementia (29) · Psoriasis (27) · Cognitive Dysfunction (25) · Dental Plaque (16) · Atherosclerosis (14) · Coronary Artery Disease (14) · Pick Disease of the Brain (14) · Gingival Hemorrhage (11) · Pruritus (10) · Dental Caries (9) · Periodontitis (9) · Skin Diseases (9)
Pathological Conditions, Anatomical (272) · Pathological Conditions, Signs and Symptoms (272) · Nervous System Diseases (93) · Central Nervous System Diseases (88) · Brain Diseases (87) · Stomatognathic Diseases (86) · Neurocognitive Disorders (77) · Mental Disorders (76) · Mouth Diseases (70) · Neurodegenerative Diseases (70) · Tauopathies (68) · Periodontal Diseases (64) · Gingival Diseases (59) · Infections (59) · Dementia (47)
secukinumab (15) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (10) · florbetapir (7) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (5) · Atorvastatin (4) · Sugars (4) · donanemab (4) · Chlorhexidine (3) · Magnetic Resonance Spectroscopy (3) · Supersmile (3) · hydrated silica gel-based toothpaste (3) · Dentifrices (2) · Endarterectomy, Carotid (2) · Fluorides (2) · Fluorodeoxyglucose F18 (2)
Novartis Pharmaceuticals (16) · Colgate Palmolive (15) · Eli Lilly and Company (9) · Koite Health Oy (6) · University of Southern California (6) · Home Skinovations Ltd. (4) · I.R.A. Istituto Ricerche Applicate S.p.A. (4) · Lantheus Biosciences Ltd. (4) · Pfizer (4) · Procter and Gamble (4) · University of California, Los Angeles (4) · Al-Mustansiriyah University (3) · Chang Gung Memorial Hospital (3) · Johnson & Johnson Consumer Inc. (J&JCI) (3) · University of Florida (3)
United States (114) · Canada (28) · Germany (24) · Japan (18) · France (17) · Spain (17) · United Kingdom (17) · Italy (16) · China (12) · Netherlands (12) · Taiwan (11) · Czechia (10) · Australia (9) · Israel (9) · Belgium (8)
Mihaela Fratila (4) · Paul Aisen, MD (4) · Timo Sorsa, Professor (4) · Brendan Lucey, MD (3) · Chhaju Ram Goyal, DDS (2) · Marcelle Nascimento, DDS, MS, PhD (2) · Michael W. Weiner, MD (2) · Ming-Jang Chiu, M.D. (2)
PMID 33773598, PMID 35305260, PMID 37341961, PMID 39324520, PMID 23640952, PMID 27573260, PMID 27576559, PMID 32791950, PMID 33748660, PMID 34110605, PMID 34187867, PMID 38853879, PMID 39219209, PMID 42862762, PMID 14326695, PMID 16564083, PMID 17183151, PMID 20598972, PMID 21471671, PMID 21481640, PMID 22149222, PMID 22455413, PMID 22473769, PMID 22789936, PMID 23214115, PMID 23357149, PMID 23534323, PMID 23686372, PMID 23873319, PMID 24152824, PMID 24970906, PMID 25007392, PMID 25242558, PMID 25243910, PMID 25354738, PMID 25563640, PMID 25669746, PMID 25693783, PMID 25790876, PMID 25824567, PMID 25936321, PMID 26051365, PMID 26185328, PMID 26267726, PMID 26516010, PMID 26662044, PMID 26823561, PMID 27213629, PMID 27271195, PMID 27421618
2014 (2), 2015 (2), 2016 (2), 2017 (2), K23DE023579 (2), U01AG024904 (2), 1RC2AG036535-01 (1), 1RF1AG047866-01A1 (1), 1UG3DE030401-01 (1), 2009 (1), 2025 (1), 8UL1TR000114-02 (1), K01AG047279 (1), P01AG025831 (1), P50AG005134 (1)