16 completed, 2 not yet recruiting, 1 terminated. 6 Not applicable, 5 Phase 2, 2 Phase 1, 1 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 6 | Completed 4, Not yet recruiting 1, Terminated 1 |
| Phase 2 | 5 | Completed 5 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
| Phase 4 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Keratinized Tissue Augmentation Using Augmented Gingival Matrix Compared to Free Gingival Graft Around Implants Augmented Gingival Matrix graft, Free Gingival Graft - Keratinized Tissue Augmentation Around Dental Implants | Not applicable | Not yet recruiting | The Forsyth Institute | 50 | 2026-11-01 | 2026-10-07 |
| The Effect of Nitrate Supplementation on Tongue Microbiome Nitrate-Supplemented Beet Juice, Nitrate-Depleted Beet Juice - Healthy Individuals With no Periodontal Disease | Not applicable | Completed | The Forsyth Institute | 24 | 2025-09-13 | 2026-10-08 |
| Optical Coherence Tomography (OCT) Based Intraoral Scanner The Focus of the Study is to Evaluate the Efficacy of OCT in Scanning and Reconstructing General Tooth and Gum Anatomy, Tooth Anatomy | Not yet recruiting | Perceptive Technologies, Inc | 70 | 2025-08-07 | 2025-07-30 | |
| Phase 2 Study of KH001 in Long-term Relief From Dentin Hypersensitivity KH001, Placebo - Dentin Hypersensitivity | Phase 2 | Completed | HysensBio Co., Ltd | 120 | 2024-10-08 | 2026-10-29 |
| Menopause and Oral Microbiome Intraoral examination, saliva, dental plaque and serum collection. - Menopause | Completed | Ege University | 220 | 2022-02-15 | 2024-01-02 | |
| Commensal Oral Microbiota in Head and Neck Cancer Standard of Care Oral Hygiene, Oral mucosal deterging and dental prophylaxis - Head and Neck Cancer, Oral Mucositis | Not applicable | Terminated | University of Pennsylvania | 60 | 2019-09-23 | 2025-09-26 |
| Reproducibility of HbA1c Measurement on the Aina HbA1c Monitoring System Aina HbA1c Monitoring System - Diabetes | Completed | Jana Care | 6 | 2017-06-14 | 2017-07-28 | |
| The Effect of Silver Diamine Fluoride (SDF) on Bacteria Involved in Root or Cervical Carious Lesions Silver Diamine Fluoride (SDF) - Caries | Phase 4 | Completed | Heba Mitwalli | 21 | 2016-11-01 | 2018-09-28 |
| Salivary Bacterial Profiles in Relation to Periodontal Treatment Conventional periodontal treatment - Periodontitis | Not applicable | Completed | University of Copenhagen | 30 | 2016-10-01 | 2017-02-03 |
| Salivary Bacterial Associations to Short Term Discontinuation of Self-performed Oral Hygiene Oral hygiene discontinuation group - Mouth Diseases | Not applicable | Completed | University of Copenhagen | 30 | 2016-09-01 | 2017-02-03 |
| Randomized Trial of a Gum Health Formulation Gingival health formulation in an accelerating device, Gingival health formulation on a toothbrush, OTC fluoride toothpaste - Periodontal Diseases, Gingivitis | Not applicable | Completed | Glo Science, Inc. | 39 | 2015-05-01 | 2017-06-23 |
| Safety and Preliminary Efficacy of Lipoxin Analog BLXA4-ME Oral Rinse for the Treatment of Gingivitis BLXA4, Placebo oral rinse - Gingival Inflammation | Phase 1 / Phase 2 | Completed | The Forsyth Institute | 127 | 2015-04-01 | 2023-12-20 |
| LGG/BB12-pastille Study Probiotics in an pastille, Control pastille - Probiotics | Phase 1 | Completed | University of Turku | 60 | 2012-08-01 | 2013-01-04 |
| AGING EFFECTS ON DENTAL GUM TISSUE biopsy - Aging | Completed | The Forsyth Institute | 100 | 2012-04-01 | 2026-09-10 | |
| Biomarkers of Periodontal Disease Progression Periodontal therapy - Periodontal Disease | Completed | The Forsyth Institute | 157 | 2012-01-01 | 2018-02-07 | |
| Effect of Three Periodontal Therapies in Current Smokers and Non-Smokers Scaling and root planing, Metronidazole, Amoxicillin - Periodontitis, Periodontal Diseases | Phase 2 | Completed | The Forsyth Institute | 146 | 2003-07-01 | 2013-04-22 |
| Microbial Associations in Periodontal Health and Disease metronidazole - Periodontitis, Periodontal Diseases | Phase 2 | Completed | The Forsyth Institute | 154 | 2002-12-01 | 2010-11-09 |
| Study Comparing Two Different Methods of Treating Periodontal Disease Periodontal Treatment - Periodontal Diseases | Phase 2 | Completed | The Forsyth Institute | 400 | 2000-06-01 | 2010-12-02 |
| Control of Periodontal Infections scaling and root planing, local tetracycline, systemic metronidazole and amoxicillin - Periodontitis | Phase 3 | Completed | The Forsyth Institute | 187 | 1999-09-01 | 2010-04-02 |
Periodontal Diseases (5) · Periodontitis (5) · Gingivitis (2) · Chronic Periodontitis (1) · Dentin Sensitivity (1) · Diabetes Mellitus (1) · Halitosis (1) · Head and Neck Neoplasms (1) · Inflammation (1) · Mouth Diseases (1) · Stomatitis (1)
Amoxicillin (2) · Metronidazole (2) · Root Planing (2) · Tooth Exfoliation (2) · Biopsy (1) · Dental Prophylaxis (1) · Doxycycline (1) · Periodontal Index (1) · Probiotics (1) · Surgical Procedures, Operative (1)
United States (14) · Denmark (1) · Finland (1) · Turkey (Türkiye) (1)
Alex Lin, MD (1) · Ann Haffajee (1) · Anne D Haffajee, BDS (1) · Anne Haffajee, DDS (1) · Hatice Hasturk (1) · Hatice Hasturk, DDS, PhD (1) · Hatice Hasturk, DDS., Ph.D. (1) · Hatice Hasturk, PhD (1) · Heba Mitwalli, DDS (1) · J Max Goodson, DDS, PhD (1) · Joel Neutel, MD (1) · Margherita Fontana, DDS, PhD (1) · Michael McCartney, MD (1)
PMID 25918553, PMID 29662960, PMID 31893018, PMID 32681659, PMID 33197289, PMID 34589083, PMID 39003582
R01DE012108 (1), R01DE013850 (1), R01DE014242 (1), R01DE022586 (1), R44DE033316 (1), U01DE021127 (1), U01DE026934 (1), U01DE027637 (1)