323 completed, 114 unknown, 54 not yet recruiting, 45 recruiting. 494 Not applicable, 38 Phase 2, 24 Phase 1, 16 Phase 3, 6 Early Phase 1.
Follow Low-Level Light Therapy: new trials by email Literature Review of Low-Level Light Therapy trials Research Report on Low-Level Light Therapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Nano Silver Fluoride and Photobiomodulation Therapy for Hypersensitivity and Pain in MIH-Affected Molars Nano Silver Fluoride, Photobiomodulation Therapy, Pre-appointment analgesics - Molar-Incisor Hypomineralization (MIH) | Not applicable | Not yet recruiting | Ain Shams University | 45 | 2027-05-01 | 2026-09-17 |
| Can Acute Photobiomodulation Improve Balance and Cognition in Individuals With Ataxia: a Pilot Feasibility Placebo Randomized Controlled Trial. Photobiomodulation, Sham photobiomodulation - Ataxia | Not applicable | Not yet recruiting | University of Central Lancashire | 20 | 2027-01-01 | 2026-09-22 |
| Photobiomodulation in Coronary Artery Bypass Grafting With No-Touch vs Conventional Saphenous Vein Harvesting. Photobiomodulation Therapy, Sham Laser irradiation, Conventional Saphenous Vein Harvesting - Coronary Artery Disease, Coronary Artery Bypass Graft (CABG) | Not applicable | Not yet recruiting | Federal University of São Paulo | 292 | 2027-01-01 | 2026-10-07 |
| Frequency-Dependent Effects of Transcranial Photobiomodulation With Same Peak Irradiance on Cortical Excitability and Fine Motor Performance Transcranial Photobiomodulation - Healthy Volunteers (HV), Transcranial Photobiomodulation | Phase 1 | Not yet recruiting | Hospital de Clinicas de Porto Alegre | 20 | 2027-01-01 | 2026-08-07 |
| A Clinical Trial of the Administration of Light Therapy to Prevent Mouth Sores in Children With Cancer Photobiomodulation for prevention arm, Photobiomodulation for exploratory arm - Mucositis Oral | Not applicable | Not yet recruiting | Medical College of Wisconsin | 50 | 2026-11-01 | 2026-10-06 |
| Machine Learning for Evaluating and Diagnosing Temporomandibular Disorders Low-Level Laser Acupuncture, Proprioceptive Training, Stabilization Splint Treatment - Temporomandibular Disorders (TMD), TMJ Disorder | Not applicable | Recruiting | En Chu Kong Hospital | 180 | 2026-10-09 | 2026-10-13 |
| Photobiomodulation Laser for Reticular Pseudodrusen in Age-Related Macular Degeneration Photobiomodulation Therapy, Sham Photobiomodulation - AMD - Age-Related Macular Degeneration | Not applicable | Not yet recruiting | Fondazione G.B. Bietti, IRCCS | 67 | 2026-10-01 | 2026-09-04 |
| Efficacy and Safety of Photobiomodulation for Postoperative Pain After Cesarean Section Photobiomodulation Therapy (MitoQUAD® Belt System), Sham Photobiomodulation Device - Postoperative Pain After Cesarean Section | Not applicable | Recruiting | Universidad Nacional Autonoma de Honduras | 210 | 2026-10-01 | 2026-10-07 |
| Effects of Low-Level Laser Therapy and Hyaluronic Acid After Free Gingival Graft Topical Hyaluronic Acid Gel, Low-Level Laser Therapy, Free Gingival Graft Surgery - Gingival Recession, Mucogingival Surgery | Not applicable | Recruiting | Altinbas University | 30 | 2026-09-06 | 2026-10-07 |
| Effects of Photobiomodulation on Inflammation and Chronic Pain in Knee Osteoarthritis (EPIC-KO) Photobiomodulation therapy (PBM) device, Sham PBM device - Chronic Knee Pain | Not applicable | Not yet recruiting | University of Florida | 30 | 2026-09-01 | 2026-08-20 |
| Low-Level Laser Therapy Versus Isometric Handgrip Exercise On Arteriovenous Fistula Maturation in Hemodialysis Patients Low-level laser therapy, Isometric handgrip exercises, Standard postoperative care - Hemodialysis | Not applicable | Not yet recruiting | Cairo University | 75 | 2026-09-01 | 2026-08-26 |
| Ischemic Compression and Low-Level Laser Therapy for Myofascial Low Back Pain Ischemic Compression, Low-Level Laser Therapy, Exercise Program - Low Back Pain, Myofascial Pain Syndromes | Not applicable | Not yet recruiting | Nova Southeastern University | 45 | 2026-09-01 | 2026-09-22 |
| The Use of Photobiomodulation for Pain and Healing in Cesarean Section Photobiomodulation (PBM), Placebo PBM, Standard Hospital Treatment - Post Partum, Cesarean Birth | Phase 2 | Not yet recruiting | University of Nove de Julho | 30 | 2026-09-01 | 2026-09-08 |
| Low-Level Laser Therapy for Carpal Tunnel Syndrome Low-Level Laser Therapy (LLLT), Paraffin Bath Therapy, Sham Low-Level Laser Therapy - Carpal Tunnel Syndrome (CTS) | Not applicable | Not yet recruiting | Bursa Yuksek Ihtisas Training and Research Hospital | 105 | 2026-09-01 | 2026-08-26 |
| Acceleration of Tooth Movement Using PRP and Photobiomodulation With Clear Aligners Platelet Rich Plasma (PRP) injection, photobiomodulation (PBM) Therapy, clear aligner(12-hour wear protocol) - Orthodontic Tooth Movement | Phase 1 / Phase 2 | Not yet recruiting | Sana'a University | 42 | 2026-09-01 | 2026-08-31 |
| Randomized Clinical Investigation of Photobiomodulation (PBM) for the Management of Early Peripheral Neuropathy Related to Medical Oncologic Therapy Photobiomodulation - Chemotherapy Induced Peripheral Neuropathy | Not applicable | Not yet recruiting | Jules Bordet Institute | 98 | 2026-09-01 | 2026-07-02 |
| Acupoint Catgut Embedding With Laser Acupuncture for Weight Loss in Adults With Obesity Acupoint catgut embedding, Active laser acupuncture, Sham laser acupuncture - Obesity, Obesity, Abdominal | Not applicable | Not yet recruiting | Taipei City Hospital | 120 | 2026-09-01 | 2026-08-18 |
| Transcranial Photobiomodulation (tPBM) in Alzheimer's Disease Study Photobiomodulation - Alzheimer's Disease | Not applicable | Recruiting | Cedars-Sinai Medical Center | 45 | 2026-09-01 | 2026-10-13 |
| Efficacy of Low-Dose Laser Acupuncture for Low Back Pain Low-Dose Laser Acupuncture, Sham Laser Acupuncture - Chronic Low Back Pain | Not applicable | Not yet recruiting | Mun Fei Yam | 80 | 2026-09-01 | 2026-08-11 |
| The Use of Photobiomodulation in the Treatment of Spasticity After Stroke. Photobiomodulation Therapy, Placebo PBM, Standard Multidisciplinary Rehabilitation Program for Spasticity - Stroke, Spasticity | Phase 1 / Phase 2 | Recruiting | University of Nove de Julho | 42 | 2026-08-28 | 2026-09-01 |
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Pain (23) · Stomatitis (22) · Temporomandibular Joint Disorders (19) · Breast Neoplasms (15) · Head and Neck Neoplasms (15) · Osteoarthritis, Knee (14) · Dentin Sensitivity (13) · Fatigue (11) · Inflammation (11) · Xerostomia (10) · Neck Pain (9) · Neoplasms (9) · Osteoarthritis (9) · Pain, Postoperative (9) · Radiodermatitis (9)
University of Nove de Julho (67) · Cairo University (45) · Damascus University (11) · Riphah International University (10) · University of Sao Paulo (10) · Ain Shams University (7) · Federal University of Rio Grande do Sul (6) · Hasselt University (6) · University of Lahore (6) · Al-Azhar University (5) · Alexandria University (5) · Faculty of Dental Medicine for Girls (5) · Universidade Federal de Sao Carlos (5) · University of Florida (5) · University of Sao Paulo General Hospital (5)
Brazil (116) · Egypt (91) · United States (75) · Turkey (Türkiye) (40) · Pakistan (24) · Taiwan (18) · China (15) · Syria (11) · Canada (10) · Belgium (9) · France (9) · Italy (7) · Poland (6) · Saudi Arabia (6) · United Kingdom (6)
Mohammad Y Hajeer, DDS MSc PhD (4) · Binash Afzal, PHD* (3) · Jeroen Mebis, MD, PhD (3) · Nivaldo A Parizotto, PhD (3) · Rodrigo DM Plentz, PhD (3) · Aliaa Hamouda, MSc (2) · Amani Khalil, PhD (2) · Dawn Bowers, Ph.D. (2) · Doa'a Tahseen Alfailany, DDS (2) · Ebtesam Nabil, doctoral (2) · Ehab Hassanien, PhD (2) · Ernesto Cesar P Leal-Junior, PhD, PT (2) · Farzaneh Ahrari, DDS, MS (2) · Gene Alexander, Ph.D. (2)
PMID 20602109, PMID 20932157, PMID 24942380, PMID 25491701, PMID 26873501, PMID 26964798, PMID 28364861, PMID 30001202, PMID 31118057, PMID 33534428, PMID 35236871, PMID 37891549, PMID 39706483, PMID 8694033, PMID 10423050, PMID 10630935, PMID 11049150, PMID 11072777, PMID 11168198, PMID 11276514, PMID 11553080, PMID 12498538, PMID 12513916, PMID 12544040, PMID 12601569, PMID 12931761, PMID 12956475, PMID 1430181, PMID 1443317, PMID 14485018, PMID 14709224, PMID 15015736, PMID 15109507, PMID 15214219, PMID 15222710, PMID 15225944, PMID 15315733, PMID 15332186, PMID 15464564, PMID 15617967, PMID 15626317, PMID 15882225, PMID 15966876, PMID 16144476, PMID 16195010, PMID 16280237, PMID 16480503, PMID 16565685, PMID 16568210, PMID 16862549
2008 (1), 2015 (1), 2019 (1), F31AG071264 (1), K01DA047433 (1), P30CA022453 (1), R01AG064587 (1)