126 completed, 31 unknown, 20 recruiting, 17 not yet recruiting. 211 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 211 | Completed 126, Unknown 31, Recruiting 20, Not yet recruiting 17, Active not recruiting 14, Enrolling by invitation 1, Suspended 1, Terminated 1 |
Follow Periapical Diseases: new trials by email Literature Review of Periapical Diseases trials Research Report on Periapical Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy of Different Disinfection Technologies in Molar Non-Surgical Retreatment GentleWave System, Conventional rotary instrumentation with passive ultrasonic irrigation - Apical Periodontitis | Not applicable | Not yet recruiting | University of Alabama at Birmingham | 60 | 2027-07-01 | 2026-04-08 |
| Clinical and Radiographic Success of Calcium Hydroxide-Iodoform Paste Versus Modified Triple Antibiotic Paste for Necrotic Primary Molars in Children Calcium Hydroxide, Iodoform, paste, modified triple antibiotic paste - Dental Pulp Necrosis, Periapical Diseases | Not applicable | Not yet recruiting | Cairo University | 50 | 2027-01-01 | 2026-08-19 |
| PRP-Assisted Regenerative Endodontics Versus Conventional Root Canal Treatment in Mature Necrotic Teeth PRP-Assisted Regenerative Endodontic Treatment, Conventional Root Canal Treatment - Pulp Necrosis, Apical Periodontitis | Not applicable | Not yet recruiting | TC Erciyes University | 10 | 2027-01-01 | 2026-11-05 |
| Laser-Activated Versus Passive Ultrasonic Irrigation in Endodontic Retreatment Photon-Induced Photoacoustic Streaming, Shock Wave Enhanced Emission Photoacoustic Streaming, Passive Ultrasonic Irrigation - Apical Periodontitis | Not applicable | Not yet recruiting | Inonu University | 90 | 2026-11-01 | 2026-10-29 |
| Post-operative Pain and Clinical Outcome After Single-cone Obturation With a Calcium Silicate-based Versus Epoxy Resin Sealer A calcium silicate-based sealer, An epoxy resin- based sealer - Post Operative Pain, Acute, Irreversible Pulpitis (Toothache) | Not applicable | Not yet recruiting | University Ghent | 138 | 2026-11-01 | 2026-11-06 |
| Conventional and Nano-Metronidazole Irrigation With/Without Activation in Necrotic Teeth With Apical Periodontitis Metronidazole 0.5%, Nano-formulated Metronidazole 0.5%, Sodium Hypochlorite 2.5% - Pulp Necrosis, Apical Periodontitis | Not applicable | Recruiting | October 6 University | 60 | 2026-10-01 | 2026-10-27 |
| Post-operative Pain and Apical Healing After Root Canal (re)Treatment With Laser-activated Irrigation Versus Sonic or no Activation sonically activated irrigation, laser activated irrigation, conventional needle irrigation - Apical Periodontitis, Post Operative Pain, Acute | Not applicable | Not yet recruiting | University Ghent | 183 | 2026-10-01 | 2026-10-29 |
| Effects of Different Activation Techniques on Antimicrobial Photodynamic Therapy in Apical Periodontitis Control - aPDT Without Additional Activation, Passive Ultrasonic Irrigation (PUI), Standard Needle Irrigation (SNI) - Apical Periodontitis, Endodontic Retreatment | Not applicable | Recruiting | Karadeniz Technical University | 60 | 2026-10-01 | 2026-11-06 |
| Comparing Amla (Emblica Officinalis) and 3% Sodium Hypochlorite Against Enterococcus Faecalis in Root Canal Treatment. Sodium Hypochlorite 3% Solution, Emblica officinalis Solution - Pulp Necrosis, Apical Periodontitis | Not applicable | Not yet recruiting | Postgraduate Medical Institute, Lahore | 66 | 2026-09-17 | 2026-09-22 |
| Silver Nanoparticle-Reinforced Double Antibiotic Paste in Symptomatic Apical Periodontitis: A Randomized Controlled Trial silver nanoparticles reinforced double antibiotic paste, Double Antibiotic Paste - Apical Periodontitis, Post Endodontic Pain | Not applicable | Not yet recruiting | All India Institute of Medical Sciences | 50 | 2026-08-30 | 2026-08-13 |
| Biomarkers in Apical Periodontitis laser activation, PUI, CSI - Apical Periodontitis, Retreatment | Not applicable | Completed | Kırıkkale University | 66 | 2026-08-30 | 2026-10-21 |
| Effect of Different Apical Motion Algorithms on Postoperative Pain After Root Canal Treatment Root Canal Treatment, Rotary Instrumentation, Reciprocating Instrumentation - Apical Periodontitis, Postoperative Pain After Endodontic Treatment | Not applicable | Recruiting | Alanya Alaaddin Keykubat University | 120 | 2026-08-20 | 2026-10-27 |
| Evaluation of Post Operative Pain After Using Intracranial Cryotherapy During Single Visit RCT Saline 0.9% (1.5-2.5°C) - Periapical Diseases | Not applicable | Not yet recruiting | Islamabad Medical and Dental College | 60 | 2026-07-10 | 2026-05-20 |
| Accuracy and Healing Outcomes of Endodontic Surgery Using a Static Surgical Guide. 3D-Printed Static Surgical Guide and Trephine Bur, Ultrasonic Retrograde Preparation and Bioceramic Retrograde Obturation - Periapical Periodontitis, Periradicular Lesion | Not applicable | Recruiting | University of Medicine and Pharmacy at Ho Chi Minh City | 11 | 2026-07-01 | 2026-07-29 |
| Comparing Two Medicines for Healing Jaw Bone Infections After Root Canal Treatment Triple Antibiotic Paste, Calcium Hydroxide (Ca(OH)2) - Periapical Lesion, Periapical Periodontitis | Not applicable | Not yet recruiting | Faiz ur rahman | 62 | 2026-06-15 | 2026-03-18 |
| Early Healing of Apical Periodontitis After Root Canal Treatment With Bioceramic and Calcium Hydroxide Medicaments: Evaluation Using PAI and ImageJ Bioceramic Intracanal Medicament, Calcium Hydroxide Intracanal Medication - Apical Periodontitis, Root Canal Treatment | Not applicable | Active not recruiting | Hasanuddin University | 24 | 2026-06-12 | 2026-11-03 |
| Effect of Intracanal Cryotherapy on Postoperative Endodontic Pain root canal treatment and cryotherapy - Periapical Periodontitis, Asymptomatic Irreversible Pulpitis | Not applicable | Completed | Recep Tayyip Erdogan University | 132 | 2026-05-11 | 2026-07-17 |
| Postoperative Pain After OCT or EDTA Irrigation in Regenerative Endodontic Treatment Regenerative Endodontic Treatment Using Different Irrigation Solutions - Apical Periodontitis, Endodontic Disease | Not applicable | Completed | TC Erciyes University | 40 | 2026-04-10 | 2026-10-23 |
| Comparison of Root Canal Desinfection Protocols Desinfection device, Analytical microbiological methods - Periapical Periodontitis | Not applicable | Recruiting | State University of New York at Buffalo | 50 | 2026-04-01 | 2026-06-23 |
| Mineral Trioxide Aggregate (MTA) vs Gutta-Percha for Non-Surgical Endodontic Retreatment in Teeth With Apical Lesions Mineral trioxide aggregate (MTA) group, Gutta-percha group - Periapical Diseases, Root Canal Therapy | Not applicable | Not yet recruiting | University of Santiago de Compostela | 58 | 2026-03-01 | 2026-03-23 |
Showing 20 of 211. Sign in to see all of them.
Periapical Periodontitis (180) · Pain, Postoperative (44) · Dental Pulp Necrosis (30) · Radicular Cyst (8) · Periapical Abscess (7) · Dental Pulp Diseases (6) · Pain (6) · Pulpitis (6) · Tooth, Nonvital (6) · Dental Caries (4) · Inflammation (4) · Diabetes Mellitus, Type 2 (3) · Periapical Granuloma (3) · Chronic Periodontitis (2)
Jaw Diseases (211) · Mouth Diseases (210) · Periodontal Diseases (210) · Stomatognathic Diseases (210) · Periodontitis (185) · Pathological Conditions, Signs and Symptoms (77) · Pathologic Processes (73) · Neurologic Manifestations (49) · Signs and Symptoms (49) · Tooth Diseases (48) · Pain (42) · Postoperative Complications (42) · Dental Pulp Diseases (39) · Necrosis (30)
Calcium Hydroxide (10) · Sodium Hypochlorite (6) · Control Groups (5) · Endodontics (5) · Lasers, Semiconductor (5) · Edetic Acid (4) · Low-Level Light Therapy (4) · Therapeutic Irrigation (4) · Apicoectomy (3) · Chlorhexidine (3) · Methods (3) · Prolactin-Releasing Hormone (3) · Sodium Chloride (3) · Aloe vera gel (2) · Amoxicillin (2)
Postgraduate Institute of Dental Sciences Rohtak (26) · Ain Shams University (11) · Cairo University (11) · Istanbul Medipol University Hospital (8) · Medipol University (6) · Recep Tayyip Erdogan University (5) · Seyda Ersahan, DDS, PhD (5) · TC Erciyes University (5) · Biruni University (3) · Isparta Military Hospital (3) · Kahramanmaras Sutcu Imam University (3) · National and Kapodistrian University of Athens (3) · Saglik Bilimleri Universitesi (3) · Al-Azhar University (2) · College of Physicians and Surgeons Pakistan (2)
Turkey (Türkiye) (71) · Egypt (29) · India (21) · United States (11) · Pakistan (10) · Belgium (4) · Brazil (4) · Greece (4) · China (3) · Spain (3) · Vietnam (3) · Chile (2) · Indonesia (2) · Italy (2) · Jordan (2)
Seyda Ersahan, Assoc.Prof. (4) · Aliye Kamalak (3) · Ehab Hassanien, PhD (3) · Maram F Obeid, Professor (3) · Maram Obeid, PhD (3) · Seyda Ersahan, PhD (2) · Abdulkadir Tiftik, DDS, DDS (1) · Abdurrahman Aksoy, PhD (1) · Abier Fahad Alhekeir (1) · Ahmed Gomaa, Postgraduate (1) · Ahmed M Ghobashy, Prof. Dr. (1) · Aladdin Al Qudah, BDS, MSc, PhD (1)
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