70 completed, 17 recruiting, 12 terminated, 12 unknown. 130 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Early Phase 1 | 130 | Completed 70, Recruiting 17, Terminated 12, Unknown 12, Not yet recruiting 7, Active not recruiting 6, Withdrawn 4, Enrolling by invitation 1, Suspended 1 |
Follow Neurocognitive Disorders: new trials by email Literature Review of Neurocognitive Disorders trials Research Report on Neurocognitive Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cholinergic Enhancement of Theta COBENFY KarXT (50/20 mg), Control - Epilepsy, Seizures | Early Phase 1 | Not yet recruiting | University of Texas Southwestern Medical Center | 50 | 2026-12-01 | 2026-09-29 |
| Reducing Days DELirious With DEXmedetomidine as Part of an Intensive Care Unit Sleep Promotion Bundle Dexmedetomidine, Control (placebo) group - Sleep, Delirium | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-12-01 | 2026-10-13 |
| reALIGNing Circadian Rhythm and Promoting Sleep in the Intensive Care Unit Sleep chronobundle, Control - Sleep, Circadian Dysregulation | Early Phase 1 | Not yet recruiting | University of Alberta | 50 | 2026-11-30 | 2026-10-21 |
| Guanfacine and Cromolyn Sodium for POTS: The DBPOTS Trial Guanfacine (GFC), Cromolyn Sodium, Placebo - Postural Orthostatic Tachycardia Syndrome (POTS), Dysautonomia | Early Phase 1 | Not yet recruiting | Johns Hopkins University | 25 | 2026-11-15 | 2026-10-09 |
| Mild Cognitive Impairment Community Screening and Early Intervention Via Stem Cell Therapy and Wearable Brain Computer Interface Device. Structured wellness care, Wearable brain-computer interface devices, Stem Cell Therapy - Experimental - Mild Cognitive Impairment (MCI), Early Stages of Cognitive Decline | Early Phase 1 | Not yet recruiting | Noah Tech, Corp. | 600 | 2026-09-01 | 2026-03-10 |
| LpD3.5 Intervention Study in Older Adults- LISA-I Trial LpD3.5, Placebo - Mild Cognitive Impairment (MCI), Cognition | Early Phase 1 | Recruiting | University of South Florida | 15 | 2026-03-03 | 2026-08-31 |
| iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009 Radioligand [11C]CHDI-00491009 - Huntington Disease, HD | Early Phase 1 | Recruiting | CHDI Foundation, Inc. | 27 | 2026-02-24 | 2026-03-13 |
| First-in-Human Study for the Safety and Evaluation of Two 4R Tau Ligands as Potential PET Radioligands for Imaging Tau Protein in the Brain [18F]ABBV-964i, [18F]ABBV-965i, Lead Candidate - Progressive Supranuclear Palsy (PSP), Healthy Participants | Early Phase 1 | Completed | Invicro | 11 | 2025-11-17 | 2026-07-10 |
| REstoring CONsciousness With NEurostimulation of the Central Thalamus: The RECONNECT Study Deep brain stimulation (DBS) electrode implantation - Disorders of Consciousness | Early Phase 1 | Recruiting | Samuel Snider, MD | 2 | 2025-11-01 | 2026-06-23 |
| An Exploratory Study of Near-infrared Light Therapy for Mild to Moderate Alzheimer's Disease Near infrared light therapy - Alzheimer Disease | Early Phase 1 | Not yet recruiting | Xuanwu Hospital, Beijing | 40 | 2025-10-30 | 2025-09-15 |
| Investigator Initiated Trial of Galcanezumab Treatment in Alzheimer's Disease Galcanezumab - Alzheimer Disease | Early Phase 1 | Recruiting | Xuanwu Hospital, Beijing | 10 | 2025-08-01 | 2026-01-07 |
| Intravenous Infusion of Umbilical Cord Blood as an Adjunctive Treatment for Alzheimer's Disease Intravenous infusion of mononuclear cells from umbilical cord blood, Conventional medical treatment：donepezil, rivastigmine or galantamine - Alzheimer Disease (AD) | Early Phase 1 | Recruiting | Anhui Provincial Hospital | 30 | 2025-07-31 | 2025-10-06 |
| Near-Infrared Light Therapy Combined With Lecanemab for Mild Alzheimer's Disease NirsCure with Lecanemab, sham NirsCure with Lecanemab - Alzheimer Disease | Early Phase 1 | Recruiting | Xuanwu Hospital, Beijing | 20 | 2025-05-28 | 2025-09-09 |
| Study of Biodistribution, Metabolism, Excretion and Brain Uptake 18F-JSS20-183A 18F-JSS20-183A PET, Brain MRI, Amyloid PET - Tauopathies | Early Phase 1 | Recruiting | University of Pennsylvania | 90 | 2025-05-09 | 2025-12-23 |
| [18F]ACI-15916 PET in α-synucleinopathies [18F]ACI-15916 - Parkinson's Disease (PD), Multiple System Atrophy (MSA) | Early Phase 1 | Recruiting | AC Immune SA | 46 | 2025-03-20 | 2026-10-28 |
| High Confusion: Cannabis & Driving Delta-9-THC, Delta-8-THC, Placebo - Impairment, Cognitive, Impairment of Attention | Early Phase 1 | Completed | University of Wisconsin, Madison | 5 | 2025-01-25 | 2025-10-10 |
| [18F]ACI-19626 PET in TDP-43 Proteinopathies [18F]ACI-19626 - Frontotemporal Dementia (FTD), Amyotrophic Lateral Sclerosis (ALS) | Early Phase 1 | Recruiting | AC Immune SA | 45 | 2025-01-21 | 2026-08-26 |
| Long-term Potentiation Disruption Underlying Cognitive Impairment in ECT Electroconvulsive Therapy - Major Depressive Disorder, Bipolar Disorder II | Early Phase 1 | Withdrawn | University of New Mexico | 2025-01-21 | 2026-01-21 | |
| Propranolol in Primary Progressive Aphasia Propranolol, Magnetic Resonance Imaging (MRI), Placebo - Aphasia, Primary Progressive | Early Phase 1 | Recruiting | University of Missouri-Columbia | 30 | 2025-01-13 | 2026-07-17 |
| Nitrous Oxide Neuroimaging Nitrous oxide, Peripheral Nerve Stimulation - Anesthesia, Pain | Early Phase 1 | Completed | Keith M Vogt | 34 | 2025-01-13 | 2026-08-19 |
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Alzheimer Disease (63) · Cognitive Dysfunction (34) · Emergence Delirium (9) · Cognition Disorders (8) · Delirium (8) · Dementia (8) · Parkinson Disease (8) · Supranuclear Palsy, Progressive (7) · Huntington Disease (6) · Consciousness Disorders (4) · Depression (4) · Frontotemporal Dementia (4) · Pain (4) · Anxiety Disorders (3) · Lewy Body Disease (3)
Mental Disorders (130) · Nervous System Diseases (109) · Brain Diseases (88) · Central Nervous System Diseases (88) · Neurodegenerative Diseases (74) · Dementia (72) · Tauopathies (61) · Pathological Conditions, Signs and Symptoms (45) · Cognition Disorders (41) · Signs and Symptoms (39) · Neurologic Manifestations (37) · Neurobehavioral Manifestations (29) · Basal Ganglia Diseases (20) · Movement Disorders (20)
Dexmedetomidine (8) · florbetapir (5) · Ketamine (3) · Magnetic Resonance Spectroscopy (3) · Midazolam (3) · Propofol (3) · 2-(2-(3-(4-(2-fluoroethoxy)phenyl)-7-methyl-4-oxo-3,4-dihydroquinazolin-2-yl)ethyl)-4-isopropoxyisoindoline-1,3-dione (2) · 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole (2) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (2) · Acetaminophen (2) · Acetylcysteine (2) · Alanine (2) · Glycine (2) · Idazoxan (2) · Nicotine (2)
Avid Radiopharmaceuticals (4) · CHDI Foundation, Inc. (4) · Institute for Neurodegenerative Disorders (3) · Invicro (3) · Janssen Research & Development, LLC (3) · Massachusetts General Hospital (3) · Molecular NeuroImaging (3) · University of Pennsylvania (3) · Xuanwu Hospital, Beijing (3) · AC Immune SA (2) · Baylor College of Medicine (2) · Boston University (2) · ExoRNA Bioscience (2) · Gregory Jicha, 323-5550 (2) · Imperial College London (2)
United States (75) · China (13) · Netherlands (5) · Sweden (5) · Belgium (4) · Canada (3) · Denmark (3) · France (3) · Norway (3) · Spain (3) · Taiwan (3) · United Kingdom (3) · Egypt (2) · South Korea (2) · Argentina (1)
Danna Jennings, MD (4) · Bradley C Lega, MD (2) · Cristina Sampaio, MD, PhD (2) · David J Nutt, MD (2) · Adam Mecca, M.D., Ph.D. (1) · Akiva Mintz, MD (1) · Alan Anticevic, PhD (1) · Albert Garcia-Romeu, PhD (1) · Alberto M. Borobia Perez, MD, Ass.Prof (1) · Ali Rezai, MD, FAANS (1) · Amala Soumyanath, PhD (1) · Amanda J Lloyd, PhD, BSc (1)
PMID 20097391, PMID 20501908, PMID 22459048, PMID 23763450, PMID 25948052, PMID 26158265, PMID 26203461, PMID 27206648, PMID 27763627, PMID 27814297, PMID 28709450, PMID 29282327, PMID 29286983, PMID 29682542, PMID 29882765, PMID 31112605, PMID 31814084, PMID 31888732, PMID 32129462, PMID 32302292, PMID 32854196, PMID 34254356, PMID 34272774, PMID 34344873, PMID 34500036, PMID 34722563, PMID 34784941, PMID 35204098, PMID 35253919, PMID 35535879, PMID 35573092, PMID 35914911, PMID 36281668, PMID 36399169, PMID 36894900, PMID 37213047, PMID 37224131, PMID 37889573, PMID 38353689, PMID 38563872, PMID 39882299, PMID 40394335, PMID 40527969, PMID 40797182, PMID 41224653, PMID 41438154, PMID 41679918, PMID 41715219, PMID 42028138, PMID 42063312
R35GM146822 (2), 2018 (1), K23AG057794 (1), P20GM109089 (1), P30AG072958 (1), R01AG033581 (1), R01AG054130 (1), R01AG059424 (1), R01AG066670 (1), R01AG068001 (1), R01NS125250 (1), R21AG068657 (1), R43DA051270 (1), R44AG076299 (1), R61AT009628 (1)