22 completed, 4 terminated, 1 unknown. 14 Phase 1, 7 Phase 2, 5 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 14 | Completed 10, Terminated 4 |
| Phase 2 | 7 | Completed 6, Unknown 1 |
| Early Phase 1 | 5 | Completed 5 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Assessment of the Biodistribution and Safety of [18F]MNI-968 in Healthy Subjects [18F]MNI-968 - Healthy Volunteers | Phase 1 | Completed | Molecular NeuroImaging | 6 | 2017-05-01 | 2018-03-06 |
| Phase 0 Study of [18F]MNI-968 as a Marker for D1 Receptor in Healthy Subjects [18F]MNI-968 - Healthy Volunteers | Early Phase 1 | Completed | Molecular NeuroImaging | 6 | 2017-03-03 | 2018-03-06 |
| Phase 0 Evaluation of [18F]MNI-958 as a Potential PET Radioligand for Imaging Tau Protein in the Brain [18F]MNI-958, [18F]Florbetapir, DaTscan - Alzheimer Disease, Healthy Volunteers | Early Phase 1 | Completed | Molecular NeuroImaging | 12 | 2016-11-29 | 2019-03-25 |
| Evaluation of [18F]MNI-952 as a Potential PET Radioligand for Imaging Tau Protein in the Brain [18F]MNI-952, [18F]Florbetapir - Progressive Supranuclear Palsy, Alzheimer Disease | Early Phase 1 | Completed | Molecular NeuroImaging | 6 | 2016-08-01 | 2017-10-06 |
| Evaluation of Microglial Activation in ALS With [18F]PBR06 (Peripheral Benzodiazepine Receptor-06) PET [18F]PBR06 - Healthy Volunteers, Amyotrophic Lateral Sclerosis | Phase 1 | Completed | Molecular NeuroImaging | 23 | 2016-06-28 | 2019-03-26 |
| Evaluation of [18F]MNI-815 as a Potential PET Radioligand for Imaging Tau Protein in the Brain of Patients With Tauopathies [18F]MNI-815 (MNI-815) - Alzheimer's Disease (AD), Progressive Supranuclear Palsy (PSP) | Early Phase 1 | Completed | Molecular NeuroImaging | 7 | 2015-05-01 | 2016-12-16 |
| Quantitative Evaluation of [18F]T807 as a Potential PET Radioligand for Imaging Tau in Patients With Alzheimer's Disease [18F]T807 - Alzheimer's Disease (AD) | Phase 1 | Completed | Molecular NeuroImaging | 16 | 2015-01-01 | 2017-03-08 |
| Evaluation of [18F]MNI-777 PET as a Marker of Tau Pathology in Subjects With Tauopathies Compared to Healthy Subjects [18F]T807 ([18F]MNI-777) - Alzheimer's Disease (AD), Parkinson's Disease (PD) | Phase 1 | Completed | Molecular NeuroImaging | 16 | 2014-02-01 | 2016-12-16 |
| Efficacy and Safety of MNI-672 SPECT for Detection/Exclusion of Cerebral B-amyloid in AD Subjects Compared to HVs. [123I]MNI-672 SPECT - Alzheimer's Disease | Phase 1 | Completed | Molecular NeuroImaging | 6 | 2013-04-01 | 2016-12-16 |
| Safety and Efficacy of Positron Emission Tomography (PET) Imaging With MNI-558 [18F] MNI-558 - Alzheimer Disease | Early Phase 1 | Completed | Institute for Neurodegenerative Disorders | 10 | 2010-09-01 | 2011-07-25 |
| Evaluation of [123I] MNI-330 and SPECT as a Marker of Beta-amyloid Protein Deposition MNI-330 as a brain SPECT tracer of Beta-Amyloid - Alzheimer Disease | Phase 1 | Terminated | Institute for Neurodegenerative Disorders | 3 | 2008-03-01 | 2019-04-03 |
| Evaluation of [123I] MNI-308 and SPECT as a Marker of Beta-amyloid Protein Deposition in AD Subjects Compared to HC [123I] MNI-308 - Alzheimer Disease | Phase 1 | Terminated | Molecular NeuroImaging | 2 | 2007-10-01 | 2009-08-21 |
| Assessment of the Effect of Sertaline on the Specific Binding of 123-I MZINT in Healthy Subjects 123-I MZINT injection and SPECT imaging - Depression | Phase 1 | Terminated | Institute for Neurodegenerative Disorders | 30 | 2007-05-01 | 2019-04-03 |
| Evaluation of [123I] MNI-187 and SPECT in Patients With Alzheimers Disease in Comparison to Healthy Subjects 123-I MNI-187 Injection and Imaging Procedures - Alzheimers Disease | Phase 1 | Completed | Institute for Neurodegenerative Disorders | 30 | 2007-04-01 | 2019-03-14 |
| Evaluation of [123I] AV83 and SPECT in Patients With Alzheimer Disease in Comparison to Healthy Controls [123-I] AV-83 Injection and Imaging Procedures - Alzheimers Disease | Phase 1 | Completed | Molecular NeuroImaging | 30 | 2007-03-01 | 2008-05-13 |
| Use of [123I] AV39 and SPECT Imaging as a Marker of Protein Disposition in Subjects With Alzheimer Disease Compared to Healthy Subjects [123I] AV 39 - Alzheimers Disease | Phase 1 | Completed | Molecular NeuroImaging | 30 | 2007-02-01 | 2008-04-24 |
| Assessment of the Biodistribution and Safety of 123-I MZINT in Healthy Subjects and Parkinson Disease Patients [123I] mZINT injection and serial dynamic SPECT imaging - Parkinson Disease | Phase 1 | Terminated | Institute for Neurodegenerative Disorders | 28 | 2007-01-01 | 2010-10-06 |
| A Study Evaluating Potential Screening Tools for Detecting Parkinson Disease [123I]β-CIT and SPECT imaging, [123I]β-CIT - Parkinson Disease | Phase 2 | Unknown | Institute for Neurodegenerative Disorders | 3000 | 2006-11-01 | 2022-03-29 |
| ALTROPANE® SPECT Imaging in Patients With Parkinson Disease ALTROPANE® - Parkinson Disease | Phase 2 | Completed | Molecular NeuroImaging | 27 | 2006-11-01 | 2016-12-16 |
| Biodistribution and Safety of a Radiopharmaceutical in Healthy Subjects 123-I INER - Neurodegenerative Diseases | Phase 1 | Completed | Institute for Neurodegenerative Disorders | 35 | 2006-04-01 | 2014-04-10 |
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Alzheimer Disease (13) · Parkinson Disease (9) · Parkinsonian Disorders (5) · Disease (4) · Neurologic Manifestations (4) · Supranuclear Palsy, Progressive (4) · Amyotrophic Lateral Sclerosis (1) · Chronic Traumatic Encephalopathy (1) · Depression (1) · Neurodegenerative Diseases (1) · Pick Disease of the Brain (1) · Tauopathies (1)
Iodine-123 (5) · florbetapir (4) · 7-(6-fluoropyridin-3-yl)-5H-pyrido(4,3-b)indole (2) · X-Rays (2) · 2,3-dihydro-1H-imidazo(1,2-b)pyrazole (1) · 4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene (1) · N-fluoroacetyl-N-(2,5-dimethoxybenzyl)-2-phenoxyaniline (1) · N-iodoallyl-2-carbomethoxy-3-(4-fluorophenyl)tropane (1) · Stalevo (1) · ioflupane (1)
United States (25)
Danna Jennings, MD (11) · Danna L Jennings, MD (3) · Jennifer Madonia, PA-C (3) · John P Seibyl, MD (2) · Danna L. Jennings, MD (1) · David Russell, M.D., Ph. D (1) · David Russell, MD, PhD (1) · John Seibyl, MD (1) · Kenneth L Marek, MD (1) · Kenneth L. Marek, MD (1) · Kenneth Marek, MD (1) · Laura Leary (1)