161 completed, 39 unknown, 38 recruiting, 24 terminated. 76 Phase 2, 63 Not applicable, 57 Phase 1, 29 Phase 3, 6 Early Phase 1.
Follow Huntington Disease: new trials by email Literature Review of Huntington Disease trials Research Report on Huntington Disease
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Multi-Modal Digital Monitoring of Disease Symptoms Huntington's Disease Huntington Disease | Not yet recruiting | BioSensics | 75 | 2027-01-31 | 2026-10-13 | |
| Creatine and Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation Plus Home-Based Exercise for Sarcopenia in Huntington's Disease Creatine monohydrate, Beta-hydroxy-beta-methylbutyrate (HMB), Placebo (microcrystalline cellulose) - Huntington Disease, Sarcopenia | Not applicable | Not yet recruiting | Universidad de Burgos | 88 | 2026-11-01 | 2026-10-28 |
| Pridopidine Phase 3 Study in Huntington's Disease Pridopidine, Placebo - Huntington Disease | Phase 3 | Recruiting | Prilenia | 400 | 2026-07-01 | 2026-10-28 |
| A First-in-human Study of the Effects of SRP-1005 in Participants With Huntington's Disease SRP-1005, Placebo - Huntington's Disease | Phase 1 | Recruiting | Sarepta Therapeutics, Inc. | 32 | 2026-05-12 | 2026-10-19 |
| Mass Balance Study of [14C] LPM3770164 in Healthy Participants [14C] LPM3770164 - Huntington Disease | Phase 1 | Not yet recruiting | Luye Pharma Group Ltd. | 8 | 2026-04-30 | 2026-04-08 |
| Optimizing Parameters of Low-Intensity Focused Ultrasound for Pallidal Modulation in Huntington's Disease Low-Intensity Focused Ultrasound Stimulation（LIFU） - Huntington Disease | Not applicable | Recruiting | First Affiliated Hospital of Fujian Medical University | 24 | 2026-04-20 | 2026-04-29 |
| An Extension of SKY-0515 in Participants With Huntington's Disease SKY-0515 - Huntington's Disease (HD) | Phase 2 / Phase 3 | Enrolling by invitation | Skyhawk Therapeutics, Inc. | 500 | 2026-04-10 | 2026-07-24 |
| Safety and Tolerability Study of Human Neural Stem Cells for Huntington's Disease hNSC-01 - Huntington Disease | Phase 1 / Phase 2 | Recruiting | Leslie Thompson | 21 | 2026-04-06 | 2026-04-13 |
| Autobiographical Memory, Future Thought, and Eye Movements in Huntington's Disease neuropsychological tests, Eye tracker use - Huntington Disease, Autobiographical Memory | Not applicable | Not yet recruiting | University Hospital, Angers | 80 | 2026-04-01 | 2026-04-06 |
| A Study to Investigate the Efficacy, Safety and Tolerability of Votoplam in Participants With Huntington's Disease Votoplam (blinded), Placebo - Huntington Disease | Phase 3 | Recruiting | Novartis Pharmaceuticals | 770 | 2026-03-24 | 2026-09-22 |
| iMagemHTT-009- FIH Evaluation of Novel Mutant Huntingtin PET Radioligand [11C]CHDI-00491009 Radioligand [11C]CHDI-00491009 - Huntington Disease, HD | Early Phase 1 | Recruiting | CHDI Foundation, Inc. | 27 | 2026-02-24 | 2026-03-13 |
| Study to Evaluate the Pharmacodynamics, Safety and Efficacy of SKY-0515 in Participants With Huntington's Disease SKY-0515, SKY-0515 Placebo - Huntington Disease | Phase 2 / Phase 3 | Recruiting | Skyhawk Therapeutics, Inc. | 400 | 2026-01-06 | 2026-10-29 |
| Evaluation of Three Tests to Assess Social Cognition in Huntington Disease Huntington Disease | Recruiting | Region Skane | 40 | 2025-12-01 | 2026-03-11 | |
| Modification of Threat Interpretation Bias to Reduce Anxiety in Neurodegenerative Movement Disorders (Aim 3) MindTrails-Movement, Waitlist Control - Huntington Disease, Parkinson Disease | Not applicable | Active not recruiting | University of Virginia | 136 | 2025-11-20 | 2026-07-20 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RG6496 in Huntington's Disease RG6496, Placebo - Huntington's Disease | Phase 1 | Active not recruiting | Hoffmann-La Roche | 3 | 2025-11-19 | 2026-09-02 |
| Home-based TDCS (Transcranial Direct Current Stimulation) for Cognitive and Behavioral Symptoms in Huntington's Disease Transcranial direct current stimulation (tDCS), Sham tDCS - Huntington Disease | Not applicable | Recruiting | The University of Texas Health Science Center at San Antonio | 16 | 2025-09-02 | 2026-02-11 |
| Hinting Task for Huntington's Disease Neuropsychological assessment - Huntington Disease | Recruiting | University Medical Center Groningen | 52 | 2025-09-01 | 2026-01-29 | |
| Transcranial Static Magnetic Stimulation (tSMS) in Huntington's Disease (HD) Portable ergonomic helmet for real tSMS, portable ergonomic helmet for placebo tSMS - Huntington Disease | Not applicable | Not yet recruiting | Neuromed IRCCS | 30 | 2025-09-01 | 2025-05-16 |
| Cognitive Assessment Tools for Huntington's Disease. Assessments - Huntington Disease | Recruiting | Ohio State University | 76 | 2025-06-20 | 2026-03-02 | |
| Digital Measures for Clinical Trial Endpoints in Huntington's Disease ActiGraph LEAP, Axivity AX6 - Huntington Disease, Healthy | Recruiting | University of Rochester | 100 | 2025-06-20 | 2026-08-17 |
Showing 20 of 292. Sign in to see all of them.
Parkinson Disease (30) · Alzheimer Disease (25) · Chorea (23) · Neurodegenerative Diseases (11) · Lewy Body Disease (9) · Movement Disorders (9) · Amyotrophic Lateral Sclerosis (8) · Cognitive Dysfunction (7) · Dementia (7) · Rare Diseases (7) · Mental Disorders (6) · Multiple Sclerosis (6) · Supranuclear Palsy, Progressive (6) · Dyskinesias (5)
Congenital, Hereditary, and Neonatal Diseases and Abnormalities (292) · Neurocognitive Disorders (291) · Heredodegenerative Disorders, Nervous System (290) · Basal Ganglia Diseases (289) · Central Nervous System Diseases (289) · Cognition Disorders (289) · Genetic Diseases, Inborn (289) · Nervous System Diseases (289) · Brain Diseases (288) · Dyskinesias (287) · Mental Disorders (286) · Dementia (285) · Movement Disorders (283) · Neurodegenerative Diseases (281) · Chorea (269)
latrepirdine (11) · pridopidine (8) · Creatine (7) · deutetrabenazine (6) · 6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (4) · Blood Specimen Collection (4) · Neuropsychological Tests (4) · Cell- and Tissue-Based Therapy (3) · Deep Brain Stimulation (3) · Exercise (3) · Tetrabenazine (3) · Transcranial Direct Current Stimulation (3) · tominersen (3) · valbenazine (3) · 2-((4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)phenoxy)methyl)quinoline (2)
Assistance Publique - Hôpitaux de Paris (12) · Pfizer (12) · CHDI Foundation, Inc. (11) · Massachusetts General Hospital (8) · Hoffmann-La Roche (7) · Institut National de la Santé Et de la Recherche Médicale, France (7) · University Hospital, Angers (7) · Prilenia (6) · Centre Hospitalier Universitaire, Amiens (5) · Huntington Study Group (5) · Novartis Pharmaceuticals (5) · Universitaire Ziekenhuizen KU Leuven (5) · University of Rochester (5) · Wave Life Sciences USA, Inc. (5) · Azidus Brasil (4)
United States (138) · France (62) · Canada (52) · United Kingdom (51) · Germany (44) · Spain (29) · Australia (28) · Netherlands (20) · Italy (19) · Poland (19) · Denmark (15) · Belgium (12) · China (12) · Austria (11) · New Zealand (11)
Diana Rosas, MD, MS (4) · Fanny Mochel, MD, PhD (3) · Steven M Hersch, MD, PhD (3) · Amber Southwell, PhD (2) · Bernhard G Landwehrmeyer, MD, PhD (2) · Cristina Sampaio, MD, PhD (2) · David Russell, MD (2)
PMID 36463457, PMID 38489195, PMID 29480210, PMID 32250312, PMID 31381524, PMID 36811812, PMID 25568297, PMID 26714284, PMID 28265459, PMID 30103342, PMID 30776019, PMID 35747889, PMID 35766355, PMID 35794169, PMID 36084356, PMID 38557959, PMID 38795650, PMID 39825184, PMID 10378380, PMID 11130527, PMID 1341966, PMID 13679594, PMID 16178020, PMID 18334537, PMID 1838577, PMID 18627059, PMID 19064745, PMID 19776381, PMID 20021666, PMID 20037137, PMID 20142523, PMID 20392980, PMID 20890398, PMID 21097549, PMID 21304753, PMID 21432905, PMID 21736564, PMID 21811303, PMID 21989477, PMID 22071279, PMID 22231310, PMID 22323755, PMID 22359536, PMID 22517114, PMID 23108692, PMID 23527646, PMID 23930667, PMID 24126537, PMID 24375941, PMID 24878825
2014 (5), 2015 (3), 2009 (2), 2018 (2), 2023 (2), 2025 (2), U01NS055903 (2), 2016 (1), K23NR020210 (1), K23NS055733 (1), KL2TR003016 (1), P01NS058793 (1), R01AG078169 (1), R01HG008045 (1), R01NS040068 (1)