10 completed, 7 unknown, 2 active not recruiting, 2 terminated. 15 Not applicable, 4 Early Phase 1, 2 Phase 2, 1 Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigating the Acute Effects of Increasing Alanine Exposure in Healthy Participants alanine - Glucose Metabolism, Glucagon | Not applicable | Not yet recruiting | Nicolai Jacob Wewer Albrechtsen | 15 | 2026-01-20 | 2026-01-20 |
| The Separate and Combined Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Subjects With and Without Type 1 Diabetes Glucose-dependent Insulinotropic Polypeptide (GIP), alanine, Saline (NaCl 0,9 %) (placebo) - Type 1 Diabetes | Not applicable | Completed | Asger Lund, MD | 10 | 2025-01-01 | 2026-04-29 |
| Targeted Nutritional Supplement After Lumbar Spine Surgery: A Randomized, Placebo-Controlled, Double-Blind Trial Essential amino acids, Alanine - Lumbar Spinal Stenosis | Not applicable | Withdrawn | University of California, Irvine | 2025-01-01 | 2025-05-29 | |
| The Glucagonotropic Effects of Glucose-dependent Insulinotropic Polypeptide and Alanine in Healthy Individuals Placebo (saline), GIP, Alanine - Effect of iv Administration of GIP and Alanine | Phase 1 | Unknown | University Hospital, Gentofte, Copenhagen | 10 | 2024-01-01 | 2024-05-17 |
| Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease Glycine, N-acetylcysteine, Alanine - Alzheimer Disease | Early Phase 1 | Active not recruiting | Baylor College of Medicine | 52 | 2022-02-15 | 2026-09-09 |
| Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19 Glycine, N-acetylcysteine, Alanine - Covid19 | Early Phase 1 | Terminated | Baylor College of Medicine | 4 | 2021-01-11 | 2024-06-26 |
| Study of Arginine and Nitric Oxide in Patients With Diabetes Citrulline, Alanine - Ketosis Prone Diabetes | Not applicable | Completed | Baylor College of Medicine | 10 | 2018-07-01 | 2022-07-29 |
| Glutathione in Mild Cognitive Impairment Glycine, N-acetylcysteine (NAC), Alanine - Mild Cognitive Impairment | Early Phase 1 | Active not recruiting | Baylor College of Medicine | 60 | 2018-04-19 | 2026-09-04 |
| Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity Cellulose (control), Glycine, Alanine - Atherosclerosis, Diet Modification | Not applicable | Unknown | Rambam Health Care Campus | 110 | 2017-07-01 | 2017-06-08 |
| Mechanistic Approach to Preventing Atrophy and Restoring Function in Older Adults Essential Amino Acids (EAA), Placebo (Alanine) - Muscle Atrophy, Quality of Life | Phase 2 | Completed | University of Oregon | 80 | 2014-12-01 | 2024-07-23 |
| Investigation of Supplemental L-alanine in the Management of Dietary Fructose Intolerance Placedo, Alanine - Fructose Intolerance | Not applicable | Unknown | Augusta University | 65 | 2014-01-07 | 2020-04-15 |
| Theramine® in the Prevention of Migraine Headache Theramine (medical food/old drug), Placebo (l-alanine) - Migraine Headaches | Phase 4 | Terminated | Vincent Martin, MD | 31 | 2013-11-01 | 2016-05-05 |
| Resistance Exercise Training and Amino Acid Leucine Supplementation in Frail Elderly Women Leucine, Alanine - Frail Elderly | Not applicable | Completed | McGill University Health Centre/Research Institute of the McGill University Health Centre | 19 | 2013-11-01 | 2019-03-08 |
| Glutathione and Fuel Oxidation in Aging Glycine, cysteine (as n-acetylcysteine), alanine - Aging | Early Phase 1 | Completed | Rajagopal V Sekhar | 36 | 2013-04-23 | 2023-02-15 |
| Enteral Glutamine in Reducing Bloodstream Infections in Short Bowel Syndrome Infants Glutamine, L-alanine - Bloodstream Infections, Short Bowel Syndrome | Not applicable | Completed | Children's Hospital Medical Center, Cincinnati | 10 | 2012-04-01 | 2020-06-11 |
| Effects of Chronic Leucine Supplemetion on Glucose Homeostasis, Body Compositin, Muscle Mass and Strength of Healthy and Young Subjects Leucine, Alanine - Effect of Chronic Leucine Supplementation on Glucose Homeostasis, Lipid Profile, Body Composition, and Muscle Mass and Strenght | Not applicable | Suspended | University of Sao Paulo | 24 | 2012-01-01 | 2013-02-25 |
| L-citrulline Supplementation During Sepsis L-citrulline supplementation, L-alanine - Sepsis, Multiple Organ Failure | Phase 3 | Unknown | Maastricht University Medical Center | 48 | 2011-01-01 | 2010-09-03 |
| Effects of Citrulline on Gut Functioning During Excercise Citrulline, alanine - Gastrointestinal, Hypoperfusion | Not applicable | Unknown | Maastricht University Medical Center | 30 | 2010-12-01 | 2011-11-08 |
| Glutamine Supplementation in Cystic Fibrosis Glutamine, L-alanine - Cystic Fibrosis, Immune Function | Phase 2 | Completed | Emory University | 17 | 2010-02-01 | 2015-01-14 |
| Muscle Mass During Space Exploration Leucine, Alanine - Muscle Loss | Not applicable | Completed | The University of Texas Medical Branch, Galveston | 40 | 2009-08-01 | 2019-05-31 |
Showing 20 of 24. Sign in to see all of them.
Diabetes Mellitus, Type 1 (2) · Fructose Intolerance (2) · Muscular Atrophy (2) · Sepsis (2) · Alzheimer Disease (1) · Atherosclerosis (1) · COVID-19 (1) · Cognitive Dysfunction (1) · Cystic Fibrosis (1) · Disease (1) · Endocrine System Diseases (1) · Frailty (1) · Hyperglycemia (1) · Hyperphagia (1) · Infant, Newborn, Diseases (1)
Baylor College of Medicine (4) · Augusta University (2) · Maastricht University Medical Center (2) · University of Oregon (2) · Asger Lund, MD (1) · Children's Hospital Medical Center, Cincinnati (1) · Emory University (1) · Keith D Lindor, M.D. (1) · McGill University Health Centre/Research Institute of the McGill University Health Centre (1) · National Center for Research Resources (NCRR) (1) · Nicolai Jacob Wewer Albrechtsen (1) · Rajagopal V Sekhar (1) · Rambam Health Care Campus (1) · The University of Texas Medical Branch, Galveston (1) · University Hospital, Gentofte, Copenhagen (1)
United States (16) · Denmark (3) · Netherlands (2) · Brazil (1) · Canada (1)
Agneta L. Sunehag (1) · Conrad R Cole, MD (1) · Douglas Paddon-Jones, PhD (1) · Filip K Knop, MD, PhD (1) · Hans C Dreyer, PT, PhD (1) · Keith D Lindor, MD (1) · Kerolyn de Souza Valente (1) · Martijn Poeze, MD, PhD (1) · Nicolai Jacob Wewer Albrechtsen, MD PhD (1) · R V Sekhar, MD (1) · Rajagopal V Sekhar, M.D. (1) · Satish Rao, Md, PhD (1) · Tony Hayek, Prof (1) · Vincent Martin, MD (1)
PMID 12449285, PMID 17364057, PMID 22204954, PMID 24135139, PMID 24401239, PMID 26718415, PMID 26733251, PMID 26829246, PMID 30280129, PMID 31149709, PMID 31343947, PMID 33006765, PMID 33553232, PMID 35975308, PMID 42595807, PMID 42712058
K01HD057332 (1), R01AG041782 (1), R01AG046401 (1), R21DK088027 (1)