13 completed, 5 terminated, 4 unknown, 3 active not recruiting. 10 Phase 2, 9 Not applicable, 7 Phase 3, 4 Early Phase 1, 3 Phase 1.
Follow Glycine: new trials by email Literature Review of Glycine trials Research Report on Glycine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mexidol® Safety and Efficacy in Treatment of Hyperacute and Acute Ischemic Stroke Mexidol, Glycine - Ischemic Stroke | Phase 4 | Recruiting | Pharmasoft | 120 | 2025-11-04 | 2026-05-13 |
| Dietary Glycine Supplementation in Metabolic Dysfunction-associated Steatotic Liver Disease Glycine, Placebo - Metabolic Dysfunction Associated Fatty Liver Disease | Not applicable | Recruiting | Singapore General Hospital | 90 | 2025-11-01 | 2026-10-27 |
| Glycine and Magnesium+Thiamine for the Treatment of Primary Ciliary Dyskinesia Glycine, Magnesium+thiamine, Placebo - Primary Ciliary Dyskinesia | Not applicable | Recruiting | Instituto Nacional de Enfermedades Respiratorias | 60 | 2025-10-02 | 2025-11-25 |
| Glycine Supplementation Improves Cognitive Performance in Mexican Older Adults Glycine - Older Adults With Cognitive Decline, Insulin Resistance Syndrome | Not applicable | Completed | Brenda Sarahí Beristain Lujano | 59 | 2024-12-01 | 2026-06-15 |
| A Nasal Treatment for COVID-19 Optate, Placebo - COVID-19, Healthy | Phase 2 | Active not recruiting | Indiana University | 24 | 2023-06-27 | 2026-05-28 |
| Glutathione, Brain Metabolism and Inflammation in Alzheimer's Disease Glycine, N-acetylcysteine, Alanine - Alzheimer Disease | Early Phase 1 | Active not recruiting | Baylor College of Medicine | 52 | 2022-02-15 | 2026-09-09 |
| Glycine "Deficiency" and the Kinetics of Acylglycine in Morbid Obesity Glycine - Morbid Obesity, Glycine; Metabolic Disorder | Not applicable | Unknown | Singapore General Hospital | 20 | 2021-01-20 | 2021-03-17 |
| Glutathione, Oxidative Stress and Mitochondrial Function in COVID-19 Glycine, N-acetylcysteine, Alanine - Covid19 | Early Phase 1 | Terminated | Baylor College of Medicine | 4 | 2021-01-11 | 2024-06-26 |
| Glycine Supplement for Severe COVID-19 Glycine - COVID-19, SARS-CoV Infection | Not applicable | Terminated | Instituto Nacional de Enfermedades Respiratorias | 59 | 2020-06-15 | 2022-08-04 |
| The Effects of Glycine on Atherosclerosis and Metabolic Syndrome-related Parameters. Glycine - Metabolic Syndrome, Dyslipidemias | Phase 2 / Phase 3 | Unknown | Prof. Tony hayek MD | 50 | 2019-03-01 | 2019-02-21 |
| Glutathione in Mild Cognitive Impairment Glycine, N-acetylcysteine (NAC), Alanine - Mild Cognitive Impairment | Early Phase 1 | Active not recruiting | Baylor College of Medicine | 60 | 2018-04-19 | 2026-09-04 |
| Effects of Dietary Amino Acids on Serum and Macrophage Atherogenicity Cellulose (control), Glycine, Alanine - Atherosclerosis, Diet Modification | Not applicable | Unknown | Rambam Health Care Campus | 110 | 2017-07-01 | 2017-06-08 |
| Energetics and Function in Older Humans Cysteine (as n-acetylcysteine) and Glycine - Aging, Erythrocyte Glutathione Deficiency | Phase 1 | Completed | Baylor College of Medicine | 16 | 2014-11-01 | 2022-02-11 |
| Glutathione and Fuel Oxidation in Aging Glycine, cysteine (as n-acetylcysteine), alanine - Aging | Early Phase 1 | Completed | Rajagopal V Sekhar | 36 | 2013-04-23 | 2023-02-15 |
| Neurobiology of a Mutation in Glycine Metabolism in Psychotic Disorders Glycine, placebo - Schizo-affective Disorder, Bipolar Disorder | Phase 2 | Completed | Mclean Hospital | 2 | 2012-12-10 | 2017-09-19 |
| Protein Nutrition for Muscle Hypertrophy in Older Adults isolated whey protein, micellar whey protein, glycine - Healthy Elderly Muscle, Anabolically Resistant Elderly Muscle | Not applicable | Completed | Société des Produits Nestlé (SPN) | 30 | 2012-09-01 | 2014-12-18 |
| Effect of Glycine in Cystic Fibrosis Glycine, Placebo - Cystic Fibrosis | Phase 2 | Terminated | Instituto Nacional de Enfermedades Respiratorias | 13 | 2012-03-01 | 2014-11-05 |
| Role of HIV on Glutathione Synthesis and Oxidative Stress Cysteine (as n-acetylcysteine) and glycine, Cysteine/glycine - HIV Infection, Erythrocyte Glutathione Deficiency | Phase 1 | Completed | Baylor College of Medicine | 10 | 2010-08-01 | 2013-02-07 |
| Acute Glycine Pharmacodynamic Study Glycine administration - Schizophrenia, Psychotic Disorders | Not applicable | Completed | Mclean Hospital | 21 | 2010-07-01 | 2015-10-27 |
| A Randomized Double-Blind Control-Comparison Crossover Trial of Oral Glutamine to Suppress Frequently Recurrent Herpes Labialis Glutamine, Glycine - Herpes Labialis, Herpes Simplex Virus | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 11 | 2009-06-01 | 2012-06-11 |
Showing 20 of 31. Sign in to see all of them.
Schizophrenia (7) · Psychotic Disorders (5) · COVID-19 (3) · Cognitive Dysfunction (3) · Atherosclerosis (2) · Diarrhea (2) · Hyperglycinemia, Nonketotic (2) · Malnutrition (2) · Metabolic Syndrome (2) · Alcoholism (1) · Alzheimer Disease (1) · Bipolar Disorder (1) · Cerebral Infarction (1) · Child Nutrition Disorders (1) · Ciliary Motility Disorders (1)
Baylor College of Medicine (5) · Instituto Nacional de Enfermedades Respiratorias (3) · University of Virginia (3) · Yale University (3) · Mclean Hospital (2) · Singapore General Hospital (2) · Brenda Sarahí Beristain Lujano (1) · Indiana University (1) · Massachusetts General Hospital (1) · Nathan Kline Institute for Psychiatric Research (1) · National Institute of Allergy and Infectious Diseases (NIAID) (1) · National Institute of Mental Health (NIMH) (1) · North Suffolk Mental Health Association (1) · Pharmasoft (1) · Prof. Tony hayek MD (1)
United States (17) · Mexico (4) · Singapore (2) · Brazil (1) · Israel (1) · Russia (1)
R V Sekhar, MD (2) · Richard L Guerrant, MD (2) · Scott W Woods, MD (2) · A. Eden Evins, M.D., M.P.H. (1) · Andrew Prescot, Ph.D. (1) · Deborah L Levy, PhD (1) · Donald Goff, MD (1) · Ismene Petrakis, M.D. (1) · Marc J. Kaufman, Ph.D. (1) · Mario H Vargas, MD, MSc (1) · Mario H Vargas, MSc (1) · Mario H. Vargas, MSc (1) · R V Sekhar, M.D. (1) · Rajagopal V Sekhar, M.D. (1)
PMID 23089076, PMID 12449285, PMID 17364057, PMID 17898352, PMID 19046587, PMID 20038852, PMID 22249475, PMID 23644855, PMID 24401239, PMID 24714829, PMID 29246256, PMID 31279534, PMID 35975308, PMID 38773199, PMID 38837034, PMID 40234280, PMID 41107432
R01AG041782 (1), R01MH059807 (1), R21MH097470 (1)