276 recruiting. 276 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 276 | Recruiting 276 |
Follow Nervous System Diseases: new trials by email Literature Review of Nervous System Diseases trials Research Report on Nervous System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Safety and Effectiveness of ELEVIDYS in Participants With Duchenne Muscular Dystrophy Treated in a Post-Marketing Setting ELEVIDYS, Sirolimus, Glucocorticoids - Duchenne Muscular Dystrophy | Phase 4 | Recruiting | Sarepta Therapeutics, Inc. | 20 | 2026-10-30 | 2026-10-06 |
| Low-Volume Pericapsular Nerve Group (PENG) Block With Dexamethasone vs Standard-Volume PENG Block After Total Hip Arthroplasty Pericapsular nerve group (PENG) block, Bupivacaine, Dexamethasone - Pain, Postoperative, Muscle Weakness | Phase 4 | Recruiting | Ain Shams University | 60 | 2026-10-15 | 2026-10-16 |
| Central Apnea in Heart Failure: Physiological Mechanisms to Inform Treatment Trazodone + positive airway pressure (PAP) therapy, Oxygen + positive airway pressure (PAP) therapy - Sleep Disordered Breathing, Able Bodied | Phase 4 | Recruiting | VA Office of Research and Development | 200 | 2026-09-16 | 2026-10-13 |
| NeuroAiD Patient-Reported Outcomes in Patients With Mild to Moderate Ischemic Stroke MLC901, Standard treatment for acute ischemic stroke - Stroke, Stroke, Acute Ischemic | Phase 4 | Recruiting | EVD Pharmacy and Medical Company Limited | 80 | 2026-09-10 | 2026-10-20 |
| A Comparative Effectiveness Study of Positive Airway Pressure (PAP) Therapy, Dental Device, and Atomoxetine-Oxybutynin for Treatment of Obstructive Sleep Apnea in Adults Positive airway pressure (PAP) therapy, Sleep dental device, Atomoxetine-oxybutynin - Obstructive Sleep Apnea (OSA) | Phase 4 | Recruiting | Sairam Parthasarathy | 2400 | 2026-09-04 | 2026-10-19 |
| A Study of Ocrelizumab Administered Subcutaneously in Participants With Multiple Sclerosis Who Switch From an Approved Anti-CD20 Therapy OCR SC - Multiple Sclerosis | Phase 4 | Recruiting | Genentech, Inc. | 100 | 2026-09-02 | 2026-10-30 |
| Lemborexant for Sleep and Delirium Prevention in Elderly ICU Patients Lemborexant, Placebo - Sleep Disturbance, Delirium | Phase 4 | Recruiting | Mahidol University | 100 | 2026-09-01 | 2026-10-08 |
| Comparing the Efficacy of Propofol and Dexmedetomidine in Prevention of Emergence Agitation After Sevoflurane Anesthesia in Children propofol 1mg/kg, Dexmedetomidine - Emergence Delirium, Anesthesia | Phase 4 | Recruiting | Pakistan Institute of Medical Sciences | 114 | 2026-08-28 | 2026-09-02 |
| ASsessing The REAl-world Safety & Effectiveness of Spinal Muscular Atrophy Participants Treated With Intrathecal Onasemnogene Abeparvovec-brve (OAV101B) (ITVISMA®): A U.S. Pragmatic Multicenter Study (STREAM) Onasemnogene Abeparvovec-brve - Spinal Muscular Atrophy | Phase 4 | Recruiting | Novartis Pharmaceuticals | 36 | 2026-08-27 | 2026-10-29 |
| Tirzepatide in Idiopathic Intracranial Hypertension Trial Tirzepatide, Tirzepatide Placebo - Idiopathic Intracranial Hypertension (IIH) | Phase 4 | Recruiting | Duke University | 60 | 2026-08-25 | 2026-09-15 |
| Outcomes After Planned Discontinuation of AntiSeizure Medication Discontinue antiseizure medications - Epilepsy | Phase 4 | Recruiting | University of Michigan | 40 | 2026-08-01 | 2026-08-06 |
| Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine for Intermediate Cervical Plexus Block Dexmedetomidine Hydrochloride, Dexamethasone Phosphate - Analgesia | Phase 4 | Recruiting | Damanhour Teaching Hospital | 60 | 2026-08-01 | 2026-09-21 |
| Autonomic and Renal Contributions to Hypertension With ADT Gonadotropin Releasing Hormone Agonists (GNRH), Androgen receptor (AR) inhibitor, Placebo - Androgen Deprivation Therapy, Prostate Cancer | Phase 4 | Recruiting | Virginia Commonwealth University | 60 | 2026-08-01 | 2026-11-02 |
| Success Rates and Safety of Steroid Injections in Managing Spinal and Sacro-Iliac Pain (CORTisone Injection Spine Study) triamcinolone acetonide (Kenalog), Celestone Soluspan 6Mg/Ml Suspension for Injection, Depo-Medrol 40Mg/Ml Suspension for Injection - Back Pain Lower Back, Neck Pain | Phase 4 | Recruiting | Igor Wilderman. MD | 500 | 2026-07-30 | 2026-08-13 |
| A Study to Find Out if the Medicine Called Rimegepant is Safe for Adults in India Rimegepant 75 mg ODT - Acute Treatment of Migraine | Phase 4 | Recruiting | Pfizer | 60 | 2026-07-24 | 2026-10-15 |
| BEACON-AA: Apixaban With or Without Clopidogrel in Stroke Patients With Atrial Fibrillation and Cerebral Atherosclerosis Apixaban, Clopidogrel - Stroke, Ischemic | Phase 4 | Recruiting | Yonsei University | 586 | 2026-07-14 | 2026-10-16 |
| Evaluation System for Lecanemab Efficacy Using Gold Electrode ECL to Monitor Alzheimer's Biomarkers Lecanemab - Alzheimer Disease | Phase 4 | Recruiting | The Fourth Affiliated Hospital of Zhejiang University School of Medicine | 100 | 2026-07-10 | 2026-07-07 |
| Cardiac Magnetic Resonance and Echocardiography Study With Acoramidis Acoramidis (AG10) oral tablet - Transthyretin Amyloidosis Cardiomyopathy (ATTR-CM), Amyloidosis | Phase 4 | Recruiting | Eidos Therapeutics, a BridgeBio company | 150 | 2026-07-01 | 2026-07-29 |
| The Effects of Orexin Antagonism on Fear Extinction in PTSD Suvorexant, Placebo - Insomnia, PTSD | Phase 4 | Recruiting | VA Office of Research and Development | 40120 | 2026-07-01 | 2026-11-05 |
| Propofol-Only Versus Dexmedetomidine-Propofol in Children Undergoing Magnetic Resonance Imaging Dexmedetomidine (IV) 0.5 mcg/kg, Propofol (IV) 2-4 mg/kg, Dexmedetomidine (IV) 1 mcg/kg - MRI Sedation, Pediatric Sedation | Phase 4 | Recruiting | Boston Children's Hospital | 105 | 2026-06-30 | 2026-09-21 |
Showing 20 of 276. Sign in to see all of them.
Stroke (27) · Agnosia (25) · Ischemic Stroke (22) · Emergence Delirium (12) · Pain, Postoperative (12) · Sleep Initiation and Maintenance Disorders (12) · Atrial Fibrillation (11) · Migraine Disorders (11) · Alzheimer Disease (10) · Parkinson Disease (9) · Sleep Apnea Syndromes (8) · Brain Injuries, Traumatic (7) · Multiple Sclerosis (7) · Pain (7) · Sleep Apnea, Obstructive (7)
Central Nervous System Diseases (146) · Brain Diseases (136) · Pathological Conditions, Signs and Symptoms (136) · Signs and Symptoms (98) · Neurologic Manifestations (95) · Cardiovascular Diseases (71) · Vascular Diseases (69) · Pathologic Processes (63) · Cerebrovascular Disorders (61) · Mental Disorders (61) · Neurobehavioral Manifestations (53) · Sleep Wake Disorders (34) · Neurocognitive Disorders (33) · Dyssomnias (31)
Saline Solution (11) · Dexmedetomidine (10) · Sodium Chloride (7) · Bupivacaine (6) · Dexamethasone (6) · Lidocaine (6) · Propofol (6) · Rivaroxaban (6) · Tablets (6) · apixaban (6) · Aspirin (5) · Ketamine (5) · Acetaminophen (4) · Methylphenidate (4) · Methylprednisolone (4)
VA Office of Research and Development (8) · Mayo Clinic (6) · Brigham and Women's Hospital (4) · Duke University (4) · Vanderbilt University Medical Center (4) · Insel Gruppe AG, University Hospital Bern (3) · Montefiore Medical Center (3) · Weill Medical College of Cornell University (3) · Xuanwu Hospital, Beijing (3) · Yonsei University (3) · Ain Shams University (2) · Assistance Publique - Hôpitaux de Paris (2) · Beijing Tiantan Hospital (2) · Centre Hospitalier Universitaire de Nice (2) · Chinese Academy of Medical Sciences, Fuwai Hospital (2)
United States (118) · China (50) · Canada (12) · Egypt (11) · South Korea (9) · Denmark (8) · France (8) · India (8) · Russia (6) · Spain (6) · Brazil (5) · Italy (5) · Switzerland (5) · Belgium (4) · Germany (4)
Andrew D Krystal, MD, MS (2) · Jana Ivanidze, MD/PhD (2) · M Safwan Badr, MD (2) · Xiangbin Pan, MD,PhD (2) · Aaron M Cook, PharmD (1) · Abeer Salamah, Lecturer (1) · Ahmed Elhaddad, Ass.prof. (1) · Ahmed M Shaat, MD (1) · Alexa N Bramall, MD (1) · Alister Bates, PhD (1) · Amy Paller, MD (1) · Andrew Little, MD (1)
PMID 21869730, PMID 22230384, PMID 22880024, PMID 22897803, PMID 25771069, PMID 27834686, PMID 29030456, PMID 41616808, PMID 10634801, PMID 10770777, PMID 11018337, PMID 11498461, PMID 11587154, PMID 11737181, PMID 11914403, PMID 12221155, PMID 12748199, PMID 12807523, PMID 14690106, PMID 16436742, PMID 16731270, PMID 17496462, PMID 17548554, PMID 17548555, PMID 17920917, PMID 18292756, PMID 18467932, PMID 18499604, PMID 19020142, PMID 19054820, PMID 19151617, PMID 19171788, PMID 19225527, PMID 19573663, PMID 19724732, PMID 20581790, PMID 20740215, PMID 20854139, PMID 21079049, PMID 21179973, PMID 21623982, PMID 21734685, PMID 21739090, PMID 21899409, PMID 22232986, PMID 22472556, PMID 23039824, PMID 23045170, PMID 24036842, PMID 24462073
2025 (5), 2023 (4), 2018 (3), 2019 (1), I01CX001944 (1), I01CX002734 (1), I01RD001576 (1), K01HL164978 (1), K23AG081463 (1), K23DA057387 (1), P30CA033572 (1), P50NS123103 (1), R01AG051588 (1), R01AG093767 (1), R01DC012519 (1)