436 completed. 436 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 436 | Completed 436 |
Follow Mood Disorders: new trials by email Literature Review of Mood Disorders trials Research Report on Mood Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Esketamine Nasal Spray in Korean Participants With Treatment-resistant Depression Esketamine 56 mg, Esketamine 84 mg - Depressive Disorder, Treatment-Resistant | Phase 4 | Completed | Janssen Korea, Ltd., Korea | 47 | 2025-06-09 | 2026-08-03 |
| Tachyphylaxis, Tolerance, & Withdrawal Post Treatment With Igalmi for Agitation in Schizophrenia or Bipolar Disorder Sublingual film containing Igalmi - Bipolar Disorder, Schizophrenia | Phase 4 | Completed | BioXcel Therapeutics Inc | 29 | 2023-10-02 | 2026-08-11 |
| Study of the Effectiveness of Valbenazine on Patient- and Clinician-Reported Outcomes in Participants With Tardive Dyskinesia Valbenazine - Schizophrenia, Schizoaffective Disorder | Phase 4 | Completed | Neurocrine Biosciences | 59 | 2023-05-09 | 2026-01-16 |
| Oral Aspirin + Ketamine as Adjunct to Oral Antidepressant Therapy for Depression VTS-K - Treatment Resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Theresa Jacob, PhD, MPH | 15 | 2022-12-06 | 2026-04-21 |
| SMART Trial to Predict Anhedonia Response to Antidepressant Treatment Sertraline, Bupropion - Major Depressive Disorder | Phase 4 | Completed | Mclean Hospital | 57 | 2022-09-30 | 2026-10-30 |
| The BIomarker Guided (BIG) Study for Depression Guanfacine Tablets - Major Depressive Disorder | Phase 4 | Completed | Stanford University | 28 | 2022-09-14 | 2025-03-20 |
| Low-dose Ketamine Infusion Among Adolescents With Treatment-resistant Depression Midazolam (active placebo), Ketamine and Midazolam (active placebo), Ketamine - Treatment-resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Taipei Veterans General Hospital, Taiwan | 12 | 2022-03-15 | 2025-09-05 |
| Vortioxetine Adjunctive Treatment in Bipolar Depression Vortioxetine, valprote - Bipolar Depression | Phase 4 | Completed | First Affiliated Hospital of Zhejiang University | 131 | 2022-03-01 | 2023-09-14 |
| Repurposing of Dextromethorphan as an Adjunct Therapy in Patients With Major Depressive Disorder Selective Serotonin Reuptake Inhibitors, Dextromethorphan, Placebo - Major Depressive Disorder | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 60 | 2022-02-10 | 2023-12-22 |
| Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial Nitrous Oxide 99 %, Oxygen + Midazolam - Treatment Resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Unity Health Toronto | 40 | 2021-11-03 | 2024-05-08 |
| A Study To Assess The Safe-Use Conditions For Administration of ZULRESSO® in a Home Setting ZULRESSO® - Postpartum Depression | Phase 4 | Completed | Supernus Pharmaceuticals, Inc. | 52 | 2021-10-08 | 2025-09-15 |
| Stellate Ganglion Block for Major Depressive Disorder. Bupivacaine Hydrochloride, Normal Saline - Treatment Resistant Depression, Major Depressive Disorder | Phase 4 | Completed | Unity Health Toronto | 10 | 2021-09-23 | 2024-02-09 |
| Integrating a Stepped Care Model of Screening and Treatment for Depression Into Malawi's National HIV Care Delivery Platform Problem Management Plus, Antidepressant Therapy - Depressive Disorder | Phase 4 | Completed | RAND | 487 | 2021-09-01 | 2026-06-09 |
| Evaluation of Efficacy and Safety of add-on Sarcosine in Patients With Major Depressive Disorder Sarcosine and SSRI, Placebo and SSRI - Major Depressive Disorder | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 60 | 2021-08-26 | 2023-07-25 |
| Clonidine to Prevent Delirium After Electroconvulsive Therapy. Clonidine, Placebo - Major Depressive Disorder, Catatonia | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 130 | 2021-04-27 | 2026-05-19 |
| A Long-Term Extension Study for Participants With Treatment-resistant Major Depressive Disorder Who Are Continuing Esketamine Nasal Spray Treatment Esketamine, SSRI/SNRI - Depressive Disorder, Major | Phase 4 | Completed | Janssen-Cilag Ltd. | 183 | 2021-04-26 | 2025-09-18 |
| Brexpiprazole as Adjunctive Therapy in Adults With Major Depressive Disorder Brexpiprazole - Major Depressive Disorder | Phase 4 | Completed | Otsuka Pharmaceutical Development & Commercialization, Inc. | 122 | 2021-04-01 | 2024-02-02 |
| A Study of Esketamine Nasal Spray, Administered as Monotherapy, in Adult Participants With Treatment-resistant Depression Esketamine 56 mg, Esketamine 84 mg, Placebo - Depressive Disorder, Treatment-Resistant | Phase 4 | Completed | Janssen Research & Development, LLC | 477 | 2020-11-04 | 2025-04-25 |
| Ketamine for Older Adults Pilot Ketamine - Treatment Resistant Depression, Refractory Depression | Phase 4 | Completed | Washington University School of Medicine | 25 | 2020-10-22 | 2023-02-14 |
| Rapid Antidepressant Improvement Secondary to Excitatory Brain Responses Buprenorphine, Naltrexone, Oral Placebo - Major Depressive Disorder, Depression | Phase 4 | Completed | Marta Peciña, MD PhD | 120 | 2020-10-19 | 2026-07-31 |
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Depressive Disorder, Major (222) · Bipolar Disorder (164) · Depression (140) · Depressive Disorder (43) · Mania (24) · Schizophrenia (23) · Anxiety Disorders (19) · Psychotic Disorders (19) · Depressive Disorder, Treatment-Resistant (18) · Dysthymic Disorder (16) · Alcoholism (13) · Cognitive Dysfunction (8) · Depression, Postpartum (7) · Generalized Anxiety Disorder (6)
Mental Disorders (431) · Depressive Disorder (237) · Bipolar and Related Disorders (164) · Behavior (153) · Behavioral Symptoms (144) · Pathological Conditions, Signs and Symptoms (58) · Nervous System Diseases (54) · Signs and Symptoms (47) · Neurologic Manifestations (42) · Neurobehavioral Manifestations (32) · Chemically-Induced Disorders (26) · Schizophrenia Spectrum and Other Psychotic Disorders (25) · Substance-Related Disorders (20) · Alcohol-Related Disorders (13)
Escitalopram (55) · Duloxetine Hydrochloride (30) · Lithium (23) · Quetiapine Fumarate (23) · Olanzapine (22) · Aripiprazole (20) · Bupropion (20) · Venlafaxine Hydrochloride (20) · Ketamine (19) · Sertraline (19) · Fluoxetine (18) · Valproic Acid (17) · Lamotrigine (15) · Lithium Carbonate (15) · Risperidone (13)
New York State Psychiatric Institute (29) · Eli Lilly and Company (24) · Massachusetts General Hospital (23) · University of California, Los Angeles (14) · University of Texas Southwestern Medical Center (13) · University of Pittsburgh (11) · Stanford University (10) · Emory University (7) · Indiana University (7) · National Institute of Mental Health (NIMH) (7) · The University of Texas Health Science Center at San Antonio (7) · University of Pennsylvania (7) · Forest Laboratories (6) · Cambridge Health Alliance (5) · H. Lundbeck A/S (5)
United States (289) · Canada (30) · South Korea (17) · China (14) · Russia (11) · France (10) · Germany (10) · Italy (9) · Spain (9) · Taiwan (9) · Australia (8) · Puerto Rico (8) · India (6) · Mexico (6) · Netherlands (6)
Amit Anand, MD (7) · Janet Wozniak, MD (5) · Joseph Biederman, MD (5) · David J. Hellerstein, MD (4) · Ian A Cook, MD (4) · Bret Rutherford, MD (3) · Charles Bowden, MD (3) · Helen Lavretsky, M.D. (3) · Jonathan W. Stewart, M.D. (3) · Katherine Burdick, PhD (3)
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R01MH060353 (2), 1RC1MH088438 (1), 2004 (1), 2005 (1), 2008 (1), 2016 (1), 2018 (1), 2019 (1), K12DA000357 (1), K12HD001441 (1), K23AA016340 (1), K23AA017666 (1), K23MH064196 (1), K23MH067060 (1), K23MH067894 (1)