207 completed, 41 unknown, 35 terminated, 18 withdrawn. 95 Phase 2, 82 Phase 1, 69 Phase 4, 59 Phase 3, 20 Not applicable.
Follow Valproic Acid: new trials by email Literature Review of Valproic Acid trials Research Report on Valproic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Valproic AcId for Traumatic BRAin INjury Trial Valproic Acid (VPA), Standard of care treatment + normal saline - Moderate Traumatic Brain Injury (TBI), Severe Traumatic Brain Injury | Phase 2 / Phase 3 | Not yet recruiting | Northwestern University | 432 | 2027-05-01 | 2026-08-13 |
| VISTA: Valproic Acid, Irinotecan, and Simvastatin for Recurrent Glioma Valproic Acid (VPA), Irinotecan, Simvastatin - Glioblastoma, Astrocytoma, IDH-Mutant, Grade 4 | Phase 2 | Recruiting | Inova Health Care Services | 52 | 2026-09-04 | 2026-09-21 |
| Valproate for the Treatment of Residual Amblyopia Valproate, Placebo, Patch - Amblyopia, Amblyopia Unilateral | Phase 1 / Phase 2 | Recruiting | Boston Children's Hospital | 28 | 2026-07-01 | 2026-07-30 |
| A Study to Assess the Long-term Safety of KarXT for the Treatment of Manic Episodes in Bipolar-I Disorder (BALSAM-3) KarXT, Lithium, Valproate - Bipolar Disorder Type I With Mania | Phase 3 | Recruiting | Bristol-Myers Squibb | 450 | 2025-07-18 | 2026-09-14 |
| Τhe Combination of Pharmacotherapy With RECOVERYTRSGR and RECOVERYTRSBDGR. Group A: (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol,anxiolytics: clonazepam, stedon, tavor antidepressants: seropram),, Group B (Pharmacotherapy and TAU) (Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, antidepressants,, Group C (Pharmacotherapy and Psychotherapy) Clozapine, quietiapine, olanzapine, aripiprazole, zyprasidone, risperidone, asenapine, paliperidone, clopixol, clonazepam, stedon, tavor, lithium, depakine - Treatment Resistant Schizophrenia, Treatment Resistant Bipolar Disorder | Phase 4 | Active not recruiting | Dr. Stavroula Rakitzi | 84 | 2025-06-04 | 2026-05-01 |
| A Study of the Effectiveness of Risk Minimization Measures Related to Depakine® (Sodium Valproate) in Saudi Arabia Sodium valporate - Epilepsy, Seizures | Completed | Sanofi | 455 | 2025-04-29 | 2026-04-28 | |
| ValproIc Acid to Potentiate Anti-EGFR Treatment Efficacy and Prevent/Revert Resistance in Colorectal Cancer irinotecan, panitumumab, Valproic Acid (VPA) - Colorectal Cancer Metastatic | Phase 2 | Recruiting | National Cancer Institute, Naples | 130 | 2025-03-12 | 2025-12-17 |
| A Study to Evaluate the Effects of Lithium, Valproic Acid, and Lamotrigine on the Pharmacokinetics of KarXT and Effects of KarXT on the Pharmacokinetics of Lithium, Valproic Acid, and Lamotrigine in Healthy Participants Xanomeline/Trospium Chloride, Lithium, Valproic Acid - Healthy Volunteers | Phase 1 | Completed | Karuna Therapeutics, Inc., a Bristol Myers Squibb company | 133 | 2024-12-26 | 2026-02-24 |
| Efficacy Comparison Between Levetiracetam and Valproic Acid in Pediatric Patients With Status Epilepticus Levetiracetam, Valproic acid - Status Epilepticus | Not applicable | Completed | RESnTEC, Institute of Research | 138 | 2024-11-01 | 2025-07-04 |
| Evaluation of Intravenous Sodium Valproate on Interleukin-6 Levels in Patients With TMJ Disc Displacement sodium valproate, TMJ Arthrocentesis - Temporomandibular Joint Internal Derangement (ADWR) | Phase 2 | Active not recruiting | Tanta University | 10 | 2024-09-29 | 2026-03-23 |
| Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study Sodium Valproate 500 Mg Prolonged-Release Oral Tablet, Lamotrigine, E.E.G - Epilepsy, Lamotrigine | Phase 4 | Unknown | Assiut University | 50 | 2024-07-29 | 2024-07-30 |
| A Study to Investigate Treatment of HU and VPA, or 6-MP and VPA in Unfit AML/HR-MDS Patients Hydroxyurea, Hydroxycarbamide, Valproic acid, 6-Mercaptopurine (6-MP) - Acute Myeloid Leukemia, Adult, Myelodysplastic Syndromes, Adult | Phase 1 / Phase 2 | Recruiting | Haukeland University Hospital | 48 | 2024-05-23 | 2025-06-29 |
| Efficacy of Hydroxyzine for Patients With Panic Disorder Hydroxyzine, Escitalopram Oxalate - Panic Disorder | Phase 4 | Not yet recruiting | Sultan Qaboos University | 80 | 2023-12-30 | 2023-02-21 |
| SCN2A Polymorphisms Are Associated With Response to Valproic Acid in Paediatric Population(Pakistan) Valproic Acid - Epilepsy | Completed | Riphah International University | 200 | 2023-12-01 | 2024-11-05 | |
| Antiseizure Medication in Seizure Networks at Early Acute Brain Injury Phenobarbital Sodium Injection, Levetiracetam, Lacosamide Injectable Product - Brain Injuries, Acute, Brain Injuries, Traumatic | Phase 4 | Terminated | University of North Carolina, Chapel Hill | 5 | 2023-11-20 | 2025-11-14 |
| Bioavailability of Orfiril Long 500 mg Prolonged-Release Minitablets and Ergenyl Chrono 500 mg Prolonged-Release Tablets Sodium valproate 500 MG, Valproic Acid 500 MG - Multiple Drug Use | Phase 1 | Completed | Desitin Arzneimittel GmbH | 22 | 2023-09-22 | 2024-01-23 |
| Bioavailability and Food Effect of Sodium Valproate Minitablets in Healthy Subjects. Sodium valproate - Food-drug Interaction | Phase 1 | Completed | Desitin Arzneimittel GmbH | 28 | 2023-09-11 | 2024-01-22 |
| Sodium Valproate in Patients With Acute Ischemic Stroke Sodium valproate, Normal saline - Acute Ischemic Stroke | Phase 2 | Unknown | RenJi Hospital | 40 | 2023-09-01 | 2024-02-21 |
| Bioequivalence Study of Sodium Valproate and Valproic Acid Tablets Sodium valproate and valproic acid extended release tablet - Epilepsy | Phase 4 | Unknown | Kathmandu University | 16 | 2023-08-06 | 2023-10-11 |
| Valproic Acid/Simvastatin Plus Gemcitabine/Nab-paclitaxel Based Regimens in Untreated Metastatic Pancreatic Adenocarcinoma Patients Valproic acid, Simvastatin 20mg, Gemcitabine 1000 mg - Adenocarcinoma of the Pancreas | Phase 2 | Recruiting | National Cancer Institute, Naples | 240 | 2023-06-12 | 2026-04-14 |
Showing 20 of 321. Sign in to see all of them.
Bipolar Disorder (56) · Epilepsy (34) · Seizures (11) · Leukemia, Myeloid, Acute (10) · Mania (10) · Migraine Disorders (10) · Myelodysplastic Syndromes (9) · Status Epilepticus (9) · Brain Neoplasms (8) · Schizophrenia (8) · Glioblastoma (7) · Alcoholism (6) · Leukemia, Lymphocytic, Chronic, B-Cell (6) · Neoplasm Metastasis (6) · Alzheimer Disease (5)
M.D. Anderson Cancer Center (12) · Abbott (10) · Dr. Reddy's Laboratories Limited (7) · AstraZeneca (5) · National Cancer Institute (NCI) (5) · National Cancer Institute, Naples (5) · University Hospitals Cleveland Medical Center (5) · University of Utah (5) · Mylan Pharmaceuticals Inc (4) · National Institute of Cancerología (4) · Sanofi (4) · Teva Pharmaceuticals USA (4) · Assistance Publique - Hôpitaux de Paris (3) · Assiut University (3) · Children's Hospital Medical Center, Cincinnati (3)
United States (163) · France (18) · Canada (13) · China (12) · India (12) · Italy (12) · Egypt (9) · Germany (9) · Norway (9) · South Korea (9) · Spain (9) · United Kingdom (9) · Belgium (7) · Czechia (6) · Netherlands (6)
Hasan Alam, MD (3) · James D Carlson, Pharm. D. (3) · Keming Gao, MD, PhD (3) · S Sai Krishna, MBBS (3) · Adam Cohen, MD (2) · Andrew Poklepovic, MD (2) · Cristina Rabadan-Diehl, PharmD, PhD (2) · Daniel Freeland, D.O. (2) · Dr. Gunjan Shah, MBBS (2) · Guillermo Garcia-Manero, MD (2)
PMID 11914403, PMID 12807523, PMID 18588360, PMID 23761037, PMID 24290461, PMID 25978742, PMID 26745211, PMID 28877686, PMID 33917201, PMID 34171339, PMID 8984084, PMID 10334539, PMID 11765093, PMID 15005752, PMID 15072107, PMID 15110730, PMID 15199078, PMID 15330403, PMID 15349007, PMID 15465989, PMID 15541061, PMID 15569893, PMID 15630071, PMID 15677618, PMID 15723025, PMID 15767218, PMID 15898966, PMID 15950022, PMID 15960566, PMID 16023735, PMID 16168792, PMID 16176440, PMID 16197928, PMID 16338761, PMID 16339615, PMID 16339616, PMID 16426088, PMID 16448626, PMID 16449473, PMID 16449474, PMID 16552982, PMID 16566627, PMID 16595351, PMID 16635643, PMID 16675760, PMID 16677228, PMID 16816280, PMID 16816301, PMID 16882711, PMID 16928441
2017 (3), U01CA076576 (3), 2018 (2), R01AI064074 (2), 1RC2AG036535 (1), 2014 (1), K08MH001516 (1), K23MH064975 (1), K23MH067795 (1), K23NS058669 (1), M01RR010710 (1), P01CA128115 (1), P20MH068662 (1), P30AI050410 (1), P30CA016059 (1)