290 completed, 75 recruiting, 48 unknown, 29 not yet recruiting. 277 Not applicable, 70 Phase 3, 50 Phase 2, 40 Phase 4, 20 Phase 1.
Follow Generalized Anxiety Disorder: new trials by email Literature Review of Generalized Anxiety Disorder trials Research Report on Generalized Anxiety Disorder
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Qualitative Study of Student Financial Insecurity and Psychiatry Semi-structured interviews - Depressive Disorder, Generalized Anxiety Disorder | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 30 | 2027-01-01 | 2026-08-05 | |
| CannaRiver CBD Calm for Anxiety, Sleep, and Well-Being in Adults With Generalized Anxiety Disorder Cannabidiol (CBD) With Cannabinol (CBN) and Cannabigerol (CBG) Oral Tincture (CannaRiver CBD Calm) - Generalized Anxiety Disorder | Not applicable | Not yet recruiting | Associação Pan-Americana Multidisciplinar de Endocanabinologia | 60 | 2026-11-01 | 2026-09-18 |
| A Trial of the Safety and Tolerability of SEP-363856 in Adults With Generalized Anxiety Disorder SEP-363856 - Generalized Anxiety Disorder | Phase 3 | Recruiting | Otsuka Pharmaceutical Development & Commercialization, Inc. | 1120 | 2026-10-08 | 2026-10-20 |
| LIFU for Chronic Pain and Generalized Anxiety Disorder Low Intensity Focused Ultrasound - Chronic Pain, Generalized Anxiety Disorder | Not applicable | Not yet recruiting | Virginia Polytechnic Institute and State University | 10 | 2026-10-01 | 2026-09-11 |
| A Study of JNJ-99245354 (ITI-1284) as an Adjunctive Treatment in Participants With Generalized Anxiety Disorder (GAD) Who Have an Inadequate Response to GAD Treatment JNJ-99245354, Placebo - Generalized Anxiety Disorder | Phase 3 | Not yet recruiting | Intra-Cellular Therapies, Inc. | 705 | 2026-09-30 | 2026-10-02 |
| Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty Versus Applied Relaxation Group Transdiagnostic Cognitive Behavioural Therapy for Intolerance of Uncertainty (CBT-IU), Group Transdiagnostic Applied Relaxation (AR) - Mental Disorders, Mood Disorders | Not applicable | Not yet recruiting | Medical Research Council Cognition and Brain Sciences Unit | 135 | 2026-09-21 | 2026-10-08 |
| Miles for Mental Health Exercise - Generalized Anxiety Disorder (GAD), Depressive and Anxiety Disorders | Not applicable | Not yet recruiting | Emporia State University | 20 | 2026-09-10 | 2026-09-11 |
| Device for Treating Generalized Anxiety EXOMIND (BTL-699-2) Active treatment, EXOMIND (BTL-699-2) Sham treatment - Generalized Anxiety Disorder (GAD) | Not applicable | Recruiting | BTL Industries Ltd. | 40 | 2026-09-09 | 2026-09-18 |
| Continuous Theta Burst Stimulation for Generalized Anxiety Disorder Continuous Theta Burst Stimulation of the Right Posterior Parietal Cortex, Continuous Theta Burst Stimulation of the Right Dorsolateral Prefrontal Cortex - Generalized Anxiety Disorder | Not applicable | Recruiting | Military Hospital 175 | 40 | 2026-09-09 | 2026-09-10 |
| A Study to Asses Safety and Tolerability of ITI-1284 Given Alone or as an Additional Treatment in Participants With Generalized Anxiety Disorder (GAD) ITI-1284 - Generalized Anxiety Disorder | Phase 3 | Recruiting | Intra-Cellular Therapies, Inc. | 900 | 2026-09-03 | 2026-09-29 |
| Student Precarity and Psychiatry Questionnaires - Depressive Disorder, Major, Generalized Anxiety Disorder | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 45000 | 2026-09-01 | 2026-06-15 | |
| Acupuncture for Generalized Anxiety Disorder sham electro-acupuncture, 2Hz electro-acupuncture, 100Hz electro-acupuncture - Generalized Anxiety Disorder (GAD) | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 120 | 2026-09-01 | 2026-09-02 |
| Non-Coding RNAs Gene Expression in Psychiatric Disorders Reverse Transcription Quantitative Polymerase Chain Reaction - Schizophrenia Disorders, Major Depression | Not yet recruiting | Carmen Concerto | 384 | 2026-09-01 | 2026-06-23 | |
| A Trial of the Efficacy and Safety of a Fixed Dose of SEP-363856 in Adults With Generalized Anxiety Disorder SEP-363856, Placebo - Generalized Anxiety Disorder | Phase 3 | Recruiting | Otsuka Pharmaceutical Development & Commercialization, Inc. | 384 | 2026-08-06 | 2026-10-20 |
| Multimodal Cohort Study of Generalized Anxiety Disorder Generalized Anxiety Disorder (GAD) | Not yet recruiting | Shanghai Mental Health Center | 400 | 2026-08-01 | 2026-08-13 | |
| A Trial of the Efficacy and Safety of Fixed Doses of SEP-363856 in Adults With Generalized Anxiety Disorder SEP-363856, Placebo - Generalized Anxiety Disorder | Phase 3 | Recruiting | Otsuka Pharmaceutical Development & Commercialization, Inc. | 576 | 2026-07-28 | 2026-09-22 |
| Serotonin Variants & Gut Microbiota in Mental Health SNP Genotyping and Gut Metagenomics - Major Depressive Disorder (MDD, Anxiety Disorder, Generalized | Not yet recruiting | Neurobiologix | 30 | 2026-07-01 | 2026-06-10 | |
| Efficacy of Expectancy Focused Exposure Therapy for Anxiety Disorders Expectancy Focused Exposure, Anxiety Focused Exposure - Anxiety Disorders, Panic Disorder | Not applicable | Recruiting | University of Chile | 203 | 2026-07-01 | 2026-08-07 |
| Evaluate the Beneficial Effects of an Oral Nutritional Supplement Based on Leonurus Cardiaca for the Improvement of Mood and Anxiety Leonurus cardiaca extract 250 mg, Placebo, Leonurus cardiaca extract 500 mg - General Anxiety Disorder | Not applicable | Not yet recruiting | Azienda di Servizi alla Persona di Pavia | 60 | 2026-06-15 | 2025-11-25 |
| Transcranial Alternating Current Stimulation to Enhance Mindfulness Therapy in Generalized Anxiety Disorder Synchronous Individualized Alpha-Frequency tACS, Desynchronous Individualized Alpha-Frequency tACS, Sham tACS - Generalized Anxiety Disorder (GAD) | Not applicable | Not yet recruiting | Central South University | 99 | 2026-06-01 | 2026-06-16 |
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Anxiety Disorders (228) · Phobia, Social (119) · Panic Disorder (106) · Depression (68) · Depressive Disorder, Major (66) · Obsessive-Compulsive Disorder (53) · Anxiety, Separation (48) · Stress Disorders, Post-Traumatic (41) · Agoraphobia (30) · Phobia, Specific (28) · Bipolar Disorder (21) · Psychological Well-Being (17) · Mood Disorders (13) · Mental Disorders (12)
Mental Disorders (497) · Anxiety Disorders (281) · Phobic Disorders (110) · Behavior (94) · Mood Disorders (87) · Behavioral Symptoms (74) · Depressive Disorder (67) · Neurodevelopmental Disorders (61) · Trauma and Stressor Related Disorders (42) · Stress Disorders, Traumatic (40) · Pathological Conditions, Signs and Symptoms (31) · Nervous System Diseases (27) · Signs and Symptoms (25) · Bipolar and Related Disorders (20) · Neurologic Manifestations (17)
Cognitive Behavioral Therapy (44) · Therapeutics (16) · imagabalin (10) · Escitalopram (9) · Paroxetine (9) · Quetiapine Fumarate (8) · Duloxetine Hydrochloride (7) · Transcranial Magnetic Stimulation (7) · Exercise (6) · Sertraline (6) · Waiting Lists (6) · Vortioxetine (5) · Alprazolam (4) · Cannabidiol (4) · Lorazepam (4)
Pfizer (12) · Baylor College of Medicine (11) · Karolinska Institutet (11) · Massachusetts General Hospital (11) · AstraZeneca (9) · University of South Florida (9) · University of Pennsylvania (7) · NYU Langone Health (6) · Otsuka Pharmaceutical Development & Commercialization, Inc. (6) · University of California, Los Angeles (6) · AbbVie (5) · Georgetown University (5) · Laureate Institute for Brain Research, Inc. (5) · University of Pittsburgh (5) · Babes-Bolyai University (4)
United States (263) · Canada (50) · Sweden (23) · China (22) · United Kingdom (15) · France (11) · Germany (11) · Romania (10) · Russia (10) · Turkey (Türkiye) (10) · Mexico (9) · Norway (8) · Poland (8) · Spain (8) · Finland (7)
Eric A Storch, Ph.D. (4) · Alexander Bystritsky, MD (3) · Arun Ravindran, MD, PhD (3) · Giovanna Forero, MA (3) · Gretchen J Diefenbach, Ph.D. (3) · Michael Van Ameringen, MD, FRCPC (3) · Michel J. Dugas, Ph.D. (3) · Michelle G. Newman, PhD (3) · Anca Dobrean, Ph.D. (2) · Asle Hoffart, PhD (2)
PMID 22143997, PMID 24394383, PMID 27486544, PMID 18974308, PMID 24565357, PMID 25721183, PMID 29081307, PMID 34197151, PMID 34693989, PMID 41730563, PMID 42574109, PMID 10193207, PMID 11952187, PMID 12567277, PMID 1409977, PMID 15337269, PMID 15902586, PMID 16142633, PMID 16320215, PMID 16330721, PMID 16360929, PMID 16441069, PMID 16540816, PMID 16876832, PMID 16930894, PMID 17316822, PMID 17562493, PMID 18176908, PMID 18348596, PMID 18373143, PMID 18458207, PMID 18572984, PMID 19042026, PMID 19155456, PMID 19204653, PMID 19212970, PMID 19317960, PMID 19351943, PMID 19592748, PMID 19593179, PMID 19691907, PMID 19745648, PMID 19829198, PMID 19881891, PMID 19915521, PMID 20051130, PMID 20146834, PMID 20206470, PMID 20455246, PMID 20483968
2008 (2), 2025 (2), P50MH080215 (2), R01MH053932 (2), R34MH100468 (2), R61AT009988 (2), 1IK2RX003395 (1), 2005 (1), 5SC1MH090599 (1), F32MH129076 (1), K01MH072952 (1), K08MH094441 (1), K22MH074945 (1), K23AT004432 (1), K23MH108707 (1)