69 completed, 12 unknown, 11 terminated, 4 recruiting. 30 Phase 2, 27 Phase 4, 23 Phase 3, 17 Phase 1, 9 Not applicable.
Follow Lithium Carbonate: new trials by email Literature Review of Lithium Carbonate trials Research Report on Lithium Carbonate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Examining Lithium's Mechanism in Bipolar Disorder Lithium carbonate (Priadel), Controlled light exposure - Healthy, Bipolar | Not applicable | Not yet recruiting | Northumbria University | 45 | 2026-08-01 | 2026-08-06 |
| A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Subjects With Bipolar I Disorder AL001, Lithium carbonate - Bipolar I Disorder | Phase 1 / Phase 2 | Recruiting | Alzamend Neuro, Inc. | 20 | 2026-05-11 | 2026-07-28 |
| A Study to Investigate Lithium Brain/Plasma Pharmacokinetics and Safety of an AL001 Oral Capsule Compared to a Marketed Immediate-release Lithium Carbonate Capsule in Healthy Adult Subjects AL001, Lithium Carbonate Capsule - Pharmacokinetics, Neurology | Phase 1 | Completed | Alzamend Neuro, Inc. | 15 | 2025-05-09 | 2026-07-29 |
| A Study of Lithium and Enlicitide in Healthy Adult Participants (MK-0616-034) lithium carbonate, enlicitide - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 16 | 2025-01-02 | 2025-02-17 |
| Bioequivalence Study of Lithium Carbonate 300 mg Tablets. Actilitio® in Healthy Subjects Theralite®, Actilitio® - Healthy, Healthy Donors | Phase 4 | Active not recruiting | Centro de Atencion e Investigacion Medica | 24 | 2024-06-01 | 2025-03-06 |
| Lithium Versus Lamotrigine in Bipolar Disorder, Type II Lithium Carbonate, Lamotrigine - Bipolar II Disorder | Phase 4 | Recruiting | University Hospital Bispebjerg and Frederiksberg | 200 | 2024-05-08 | 2026-03-20 |
| Cornelia De Lange Syndrome: Assessing Positive Effects of Lithium Treatment Lithium Carbonate Capsule - Cornelia De Lange Syndrome | Phase 2 / Phase 3 | Recruiting | University of Milan | 34 | 2024-05-01 | 2025-01-28 |
| Effects of Lithium on Suicide Prevention in Adolescents and Young Adults With Bipolar Disorder in China Lithium Carbonate, Non-lithium medication - Bipolar Disorder, Suicidal Ideation | Unknown | Peking University | 600 | 2024-04-18 | 2024-05-22 | |
| Effect of Lithium Carbonate on Postoperative Sleep and Cognitive Function in Patients Undergoing Heart Valve Surgery With Cardiopulmonary Bypass Lithium Carbonate 250 MG Oral Tablet, Calcium Carbonate 500 MG Oral Tablet - Heart Valve Surgery | Phase 4 | Unknown | China Medical University, China | 62 | 2023-07-01 | 2023-07-18 |
| Sequenced Treatment Alternatives to Relieve Adolescent Depression (STAR-AD) Fluoxetine, Sertraline, Vortioxetine - Depression, Sequestra | Phase 1 / Phase 2 | Recruiting | First Affiliated Hospital of Chongqing Medical University | 520 | 2023-02-20 | 2026-01-27 |
| The CHAMP-study: The CHemopreventive Effect of Lithium in Familial AdenoMatous Polyposis Lithium Carbonate - Familial Adenomatous Polyposis | Phase 2 | Completed | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 12 | 2022-06-02 | 2024-10-04 |
| Effect of Lithium in Patients With Autism Spectrum Disorder and Phelan-McDermid Syndrome (SHANK3 Haploinsufficiency) Lithium Carbonate, Placebo - Autism Spectrum Disorder | Phase 3 | Completed | Assistance Publique - Hôpitaux de Paris | 22 | 2022-02-21 | 2025-10-02 |
| A Lithium-Based Medication to Improve Neurological Outcomes After Surgical Carotid Reconstruction Lithium Carbonate, Placebo - Carotid Artery Diseases, Carotid Artery Stenosis | Phase 3 | Terminated | Negovsky Reanimatology Research Institute | 107 | 2021-11-20 | 2025-09-25 |
| Platform Trial to Assess the Efficacy of Multiple Drugs in Amyotrophic Lateral Sclerosis (ALS) Lithium Carbonate 400 MG - Amyotrophic Lateral Sclerosis | Phase 3 | Terminated | Stichting TRICALS Foundation | 88 | 2021-08-09 | 2026-05-13 |
| Efficacy and Safety of Peropirone Hydrochloride Tablets in the Treatment of Adolescent Bipolar Disorder Depression Perospirone hydrochloride tablets, Lithium carbonate + perospirone hydrochloride, Lithium Carbonate Pill - Depressive Disorder | Phase 4 | Unknown | Shanghai Mental Health Center | 189 | 2020-11-25 | 2021-04-01 |
| Effect of Lithium Carbonate on Postoperative Sleep in Patients Undergoing Videoassisted Thoracic Surgery Lithium Carbonate 250 MG, Calcium Carbonate 500 MG - Sleep Deprivation | Phase 4 | Completed | China Medical University, China | 51 | 2020-11-06 | 2022-02-04 |
| Efficacy of Lithium Against Chemotherapy Induced Neutropenia in Breast Cancer Patients Lithium Carbonate - Neutropenia | Phase 3 | Completed | Al-Azhar University | 50 | 2020-08-01 | 2022-10-21 |
| Effect of Regulated Add -on Sodium Chloride Intake on Stabilization of Serum Lithium Concentration in Bipolar Disorder Lithium Carbonate, Sodium chloride - Bipolar Affective Disorder | Phase 4 | Completed | All India Institute of Medical Sciences, Bhubaneswar | 60 | 2020-01-16 | 2022-01-25 |
| RCT of Brain Longitudinal Biomarker Study (OPT-Neuro RCT) Aripiprazole Augmentation, Bupropion Augmentation, Switch to bupropion - Depression, Dementia | Phase 4 | Completed | Centre for Addiction and Mental Health | 87 | 2019-08-01 | 2024-11-25 |
| Lithium As a Treatment to Prevent Impairment of Cognition in Elders Lithium Carbonate, Placebo oral capsule - Mild Cognitive Impairment | Phase 4 | Completed | Ariel Gildengers, MD | 83 | 2018-02-02 | 2025-09-11 |
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Bipolar Disorder (37) · Depression (15) · Depressive Disorder, Major (10) · Mania (6) · Spinal Cord Injuries (5) · Alzheimer Disease (4) · Cognitive Dysfunction (4) · Depressive Disorder, Treatment-Resistant (4) · Amyotrophic Lateral Sclerosis (3) · Depressive Disorder (3) · Psychotic Disorders (3) · Spinocerebellar Ataxias (3) · Brain Neoplasms (2) · Congenital Abnormalities (2) · Dementia (2)
China Spinal Cord Injury Network (4) · University Hospitals Cleveland Medical Center (4) · Nova Scotia Health Authority (3) · Washington University School of Medicine (3) · Alzamend Neuro, Inc. (2) · AstraZeneca (2) · China Medical University, China (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Federal University of Rio Grande do Sul (2) · Federico II University (2) · Massachusetts General Hospital (2) · New York State Psychiatric Institute (2) · Peking University (2) · Sunnybrook Health Sciences Centre (2) · University of Pennsylvania (2)
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Keming Gao, MD, PhD (3) · Alessandro Filla, MD (2) · Herbert Chen, MD (2) · Hui Zhu, MD (2) · James W Murrough, MD (2) · Marcelo Fleck, PhD (2) · Robert J. DeRubeis, PhD (2) · Adam R Winstock, MBBS BSc MSc MRCP(UK) MRCP (1) · Aglaia Vignoli, Professor, MD (1) · Amit Anand, MD (1) · Andree Daigneault, Dr. (1) · Andrew A Nierenberg, MD (1) · Ariel Gildengers, MD (1) · Arifulla Khan, MD (1)
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