436 completed, 74 unknown, 55 terminated, 32 recruiting. 648 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 648 | Completed 436, Unknown 74, Terminated 55, Recruiting 32, Withdrawn 30, Not yet recruiting 15, Active not recruiting 4, Enrolling by invitation 1, Suspended 1 |
Follow Mood Disorders: new trials by email Literature Review of Mood Disorders trials Research Report on Mood Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Bupropion Hydrobromide in Adolescents and Children With Major Depressive Disorder bupropion hydrobromide, Placebo - Major Depressive Disorder | Phase 4 | Not yet recruiting | Bausch Health Americas, Inc. | 246 | 2027-07-01 | 2026-09-29 |
| Stony Brook Medicine Anti-Inflammatory Trial Celecoxib, Minocycline - Major Depressive Disorder | Phase 4 | Not yet recruiting | Stony Brook University | 42 | 2027-06-01 | 2026-04-23 |
| Broadband Near Infrared Spectroscopy to Understand the Role of Brain Cytochrome C Oxidase in Bipolar Disorder Lurasidone (Latuda) - Bipolar Disorder Depression | Phase 4 | Not yet recruiting | Martin Lan | 60 | 2026-11-01 | 2026-09-08 |
| Understanding the Role of the Kappa Opioid Receptor in Ketamine's Attenuation of Suicidal Thoughts Ketamine hydrochloride infusion - Major Depressive Disorder (MDD) | Phase 4 | Not yet recruiting | New York State Psychiatric Institute | 12 | 2026-10-01 | 2026-08-03 |
| The Effects of Lumateperone on Obesity and Physiologic Aging and Their Association With Antidepressant Response in Bipolar Depression Lumateperone 42 mg - Bipolar Depression Depressed Phase, Obesity & Overweight | Phase 4 | Recruiting | Massachusetts General Hospital | 25 | 2026-09-09 | 2026-09-11 |
| Biomarker-Guided Antidepressant Selection TMS, Ketamine - Depression - Major Depressive Disorder, Treatment-resistant Depression (TRD) | Phase 4 | Recruiting | Weill Medical College of Cornell University | 27 | 2026-08-10 | 2026-09-23 |
| Neuromodulation of Mood Switch Circuitry in Bipolar Disorder MagVenture MagPro TMS system, Sham Stimulation - Bipolar Disorder (BD), Bipolar 1 Depression | Phase 4 | Recruiting | Weill Medical College of Cornell University | 62 | 2026-08-03 | 2026-09-23 |
| Light and Sleep Fragmentation Light therapy - Sleep, Mild Cognitive Impairment | Phase 4 | Not yet recruiting | Stanford University | 120 | 2026-06-01 | 2023-08-25 |
| Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression Esketamine-dexmedetomidine combination, Placebo - Parturients, Depressive Symptoms | Phase 4 | Not yet recruiting | Peking University First Hospital | 164 | 2026-06-01 | 2026-06-15 |
| Efficacy and Safety of Daridorexant in Patients With Major Depressive Disorder and Insomnia Daridorexant 50 mg, Placebo - Insomnia, Major Depressive Disorder | Phase 4 | Not yet recruiting | Institut d'Investigació Biomèdica de Bellvitge | 134 | 2026-04-01 | 2026-04-29 |
| RNA Editing as a Biomarker of Antidepressant Response in Unipolar and Bipolar Depression (EDIT-ANDRE) Vortioxetine, Cariprazine (Augmentation Phase) - Unipolar Depression, Bipolar Depression | Phase 4 | Recruiting | Mayo Clinic | 120 | 2026-02-17 | 2026-06-22 |
| Esketamine With or Without Integration Therapy for Treatment-Resistant Depression Esketamine hydrochloride (intranasal), Integration Therapy - Treatment-resistant Depression (TRD) | Phase 4 | Recruiting | University of Puerto Rico | 20 | 2026-02-01 | 2026-01-27 |
| Individualized Pharmacological Approach to Obesity in Patients With Bipolar Disorder Group Therapy Program, semaglutide, Phentermine-Topiramate - Bipolar I Disorder, Bipolar II Disorder | Phase 4 | Recruiting | Mayo Clinic | 100 | 2026-01-19 | 2026-03-11 |
| Dopamine D3 Receptor Occupancy in Bipolar Depression Cariprazine - Bipolar Depression | Phase 4 | Withdrawn | New York State Psychiatric Institute | 2026-01-06 | 2026-04-14 | |
| Right-sided 1-Hz Repetitive Transcranial Magnetic Stimulation (rTMS) Versus Left-sided Intermittent Theta Burst Stimulation (iTBS) in Patients With Depression repetitive transcranial magnetic stimulation, intermittent theta burst stimulation - Depression - Major Depressive Disorder, Depression Bipolar | Phase 4 | Recruiting | Region Örebro County | 350 | 2025-12-15 | 2025-12-16 |
| Treatment of Anaemia After Caesarean With Intravenous Versus Oral Iron and Postpartum Depression Ferric carboxymaltose IV, TIMOFÉROL® - Postpartum Depression (PPD) | Phase 4 | Recruiting | Assistance Publique - Hôpitaux de Paris | 2860 | 2025-10-22 | 2026-09-21 |
| Does Semaglutide Improve Depressive Symptoms in Patients With Major Depressive Disorder and Overweight or Obesity Semaglutide Injectable Product, Placebo - Major Depressive Disorder | Phase 4 | Recruiting | Nordsjaellands Hospital | 116 | 2025-09-11 | 2026-02-06 |
| A Study to Evaluate the Effectiveness of Valbenazine in Adult Participants With Tardive Dyskinesia (TD) Who Remain Symptomatic While Receiving or After Stopping a Vesicular Monoamine Transporter 2 (VMAT2) Inhibitor Valbenazine - Schizophrenia, Schizoaffective Disorder | Phase 4 | Recruiting | Neurocrine Biosciences | 100 | 2025-08-29 | 2026-09-18 |
| Disposition Kinetics of Dolutegravir Among People Living With HIV With Major Depression in Nigeria Fluoxetine, Cognitive-behavioral therapy - Depression, HIV | Phase 4 | Not yet recruiting | University of Ibadan | 168 | 2025-08-14 | 2025-08-08 |
| Algorithm Guided Treatment Versus Treatment as Usual (TAU) for Patients With Treatment Resistant Depression Algorithm guided treatment (AGT), Treatment as usual (TAU) - Treatment Resistant Depression (TRD) | Phase 4 | Recruiting | Aalborg University Hospital | 80 | 2025-08-13 | 2026-04-27 |
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Depressive Disorder, Major (333) · Bipolar Disorder (232) · Depression (194) · Depressive Disorder (64) · Depressive Disorder, Treatment-Resistant (34) · Schizophrenia (30) · Psychotic Disorders (28) · Mania (27) · Anxiety Disorders (24) · Dysthymic Disorder (20) · Alcoholism (15) · Depression, Postpartum (14) · Cognitive Dysfunction (13) · Sleep Initiation and Maintenance Disorders (9)
Mental Disorders (641) · Depressive Disorder (369) · Bipolar and Related Disorders (232) · Behavior (213) · Behavioral Symptoms (200) · Pathological Conditions, Signs and Symptoms (79) · Nervous System Diseases (74) · Signs and Symptoms (60) · Neurologic Manifestations (52) · Neurobehavioral Manifestations (38) · Schizophrenia Spectrum and Other Psychotic Disorders (35) · Chemically-Induced Disorders (29) · Substance-Related Disorders (22) · Nutritional and Metabolic Diseases (21)
Escitalopram (83) · Ketamine (37) · Duloxetine Hydrochloride (36) · Quetiapine Fumarate (35) · Sertraline (35) · Bupropion (34) · Lithium (34) · Fluoxetine (29) · Olanzapine (29) · Venlafaxine Hydrochloride (29) · Aripiprazole (27) · Valproic Acid (23) · Paroxetine (21) · Lithium Carbonate (20) · Citalopram (18)
New York State Psychiatric Institute (43) · Massachusetts General Hospital (39) · Eli Lilly and Company (25) · University of California, Los Angeles (16) · University of Texas Southwestern Medical Center (14) · University of Pittsburgh (12) · Stanford University (11) · Shanghai Mental Health Center (10) · Emory University (8) · Weill Medical College of Cornell University (8) · Icahn School of Medicine at Mount Sinai (7) · Indiana University (7) · National Institute of Mental Health (NIMH) (7) · The University of Texas Health Science Center at San Antonio (7) · University of Pennsylvania (7)
United States (381) · Canada (42) · China (31) · South Korea (23) · France (15) · Taiwan (15) · Italy (14) · Germany (13) · Spain (13) · Australia (12) · Denmark (11) · Israel (11) · Russia (11) · Brazil (9) · Puerto Rico (9)
Amit Anand, MD (7) · Janet Wozniak, MD (7) · Joseph Biederman, MD (6) · Bret Rutherford, MD (5) · Ian A Cook, MD (5) · David J. Hellerstein, MD (4) · Warren D Taylor, MD, MHSc (4) · Bret R Rutherford, MD (3) · Charles Bowden, MD (3) · Helen Lavretsky, M.D. (3)
PMID 28832750, PMID 17074942, PMID 21095016, PMID 23380715, PMID 25758058, PMID 25980552, PMID 26709542, PMID 26803397, PMID 27733282, PMID 29608461, PMID 34183490, PMID 35592490, PMID 36999619, PMID 39428602, PMID 42214294, PMID 10082232, PMID 10511011, PMID 10588403, PMID 10686270, PMID 10913502, PMID 11072948, PMID 11806859, PMID 12032971, PMID 12813115, PMID 1308374, PMID 1438661, PMID 14627997, PMID 14639062, PMID 15685125, PMID 15729083, PMID 15800181, PMID 15939837, PMID 16086624, PMID 16390886, PMID 16426099, PMID 16457894, PMID 16540613, PMID 16551710, PMID 16554525, PMID 16554526, PMID 16566612, PMID 16566901, PMID 16636629, PMID 16642436, PMID 16690084, PMID 16754414, PMID 16816220, PMID 16824617, PMID 16946176, PMID 16946177
2016 (2), 2018 (2), 2019 (2), 2023 (2), K23MH076049 (2), R01MH060353 (2), 1RC1MH088438 (1), 2004 (1), 2005 (1), 2008 (1), 2025 (1), K12DA000357 (1), K12HD001441 (1), K23AA016340 (1), K23AA017666 (1)