148 completed, 88 unknown, 87 recruiting, 32 active not recruiting. 211 Not applicable, 18 Phase 4, 17 Phase 2, 16 Phase 1, 9 Phase 3.
Follow Mitral Valve Insufficiency: new trials by email Literature Review of Mitral Valve Insufficiency trials Research Report on Mitral Valve Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Understanding the Metabolic and Functional Derangement of Primary Mitral Regurgitation: a Feasibility Study Using Carbon 11(C-11) Acetate Cardiac Positron Emission Tomography Magnetic Resonance Imaging (PET-MRI) [11C] acetate - Mitral Valve Regurgitation | Early Phase 1 | Withdrawn | University of Alabama at Birmingham | 2027-06-01 | 2025-01-24 | |
| A Clinical Study of X-Clip Mitral Valve Clip System and Steerable Guide System for Transcatheter Mitral Valve Repair of Degenerative Mitral Regurgitation X-Clip Treatment for Degenerative Mitral Regurgitation - Transcatheter Mitral Valve Repair of Degenerative Mitral Regurgitation | Not applicable | Not yet recruiting | Shenzhen Lifevalve Medical Scientific Co., Ltd. | 15 | 2027-03-01 | 2026-06-22 |
| Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation Aortic Stenosis, Mitral Regurgitation | Not yet recruiting | Josep Rodes-Cabau | 300 | 2027-01-05 | 2026-11-04 | |
| ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral SAPIEN X4 THV - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Edwards Lifesciences | 125 | 2027-01-01 | 2025-12-22 |
| Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE) Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.) - Valvular Heart Disease Patients, Aortic Stenosis | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 1088 | 2026-12-15 | 2026-11-03 |
| A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (AU) Transcatheter mitral valve repair - Mitral Valve (MV) Regurgitation | Not applicable | Not yet recruiting | Polares Medical SA | 15 | 2026-11-01 | 2026-08-11 |
| A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (FR) Transcatheter mitral valve repair (MRace Implant and Delivery System) - Mitral Valve (MV) Regurgitation | Not applicable | Not yet recruiting | Polares Medical SA | 20 | 2026-11-01 | 2026-08-11 |
| A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (DE) Transcatheter mitral valve repair (MRace Implant and Delivery System) - Mitral Valve (MV) Regurgitation | Not applicable | Not yet recruiting | Polares Medical SA | 20 | 2026-11-01 | 2026-08-11 |
| The PALMETTO Study ReValve System - Mitral Regurgitation | Not applicable | Not yet recruiting | ReValve Solutions Inc. | 10 | 2026-11-01 | 2026-10-28 |
| Multi-center Study of Three-Dimensional Transesophageal Echocardiography in Patients With Secondary Mitral Regurgitation Transthoracic and Three-Dimensional Transesophageal Echocardiography - Mitral Valve Insufficiency | Not yet recruiting | First Hospital of China Medical University | 2400 | 2026-11-01 | 2026-11-05 | |
| Early Feasibility Study of the Capstan Medical TMVR System Capstan Compass Robotic System for Transcatheter Mitral Valve Replacement - Mitral Regurgitation (MR) | Not applicable | Recruiting | Capstan Medical | 15 | 2026-11-01 | 2026-11-09 |
| PRECISE-AFMR I: Transcatheter Mitral Valve Edge-to-Edge Repair for Atrial Functional Mitral Regurgitation in Patients at High Surgical Risk Transcatheter Edge-to-Edge Repair - Atrial Functional, Mitral Regurgitation (MR) | Not applicable | Recruiting | China National Center for Cardiovascular Diseases | 182 | 2026-10-25 | 2026-10-26 |
| Achieving Optimal Medical Therapy Through Percutaneous Treatment of Secondary Mitral Regurgitation to Improve Outcome in Patients With HFrEF M-TEER, Standardized GDMT Up-Titration - Mitral Regurgitation Functional, Heart Failure With Reduced Ejection Fraction (HFrEF) | Not applicable | Recruiting | University Medical Center Mainz | 520 | 2026-10-15 | 2026-11-02 |
| Echocardiographic Perspectives on Transient Mitral Regurgitation After Septal Myectomy Hypertrophic Cardiomyopathy | Not yet recruiting | University Health Network, Toronto | 150 | 2026-10-01 | 2026-10-14 | |
| Anchord Mitral Chordal Repair System - FIH Anchord device implantation - Mitral Regurgitation | Not applicable | Not yet recruiting | Lifecord Otd | 5 | 2026-10-01 | 2026-09-04 |
| EFS of Posterior Leaflet Replacement to Reduce Mitral Regurgitation (United States) MR-ace Implant and Delivery System - Mitral Regurgitation | Not applicable | Recruiting | Polares Medical SA | 15 | 2026-09-01 | 2026-09-01 |
| Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair Usual Care, Pulmonary Vein Isolation - Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation | Not applicable | Not yet recruiting | Atrial Fibrillation Network | 956 | 2026-09-01 | 2026-09-10 |
| The REValve Clinical Trial an Evaluation Of the ReValve Palmetto Valve for the Replacement of the Native Mitral VaLVE ReValve System - Mitral Regurgitation | Phase 1 | Recruiting | ReValve Solutions Inc. | 20 | 2026-09-01 | 2026-09-29 |
| Reduction or Elimination of Mitral Regurgitation With the SATURN TMVR System (CASSINI-US) Mitral Valve Replacement - Mitral Regurgitation, Heart Disease | Not applicable | Recruiting | InnovHeart | 15 | 2026-08-05 | 2026-08-10 |
| Effects of VALsartan On atRIAl Mitral Regurgitation (VALORIA) - Pilot Valsartan, Placebo - Atrial Functional Mitral Regurgitation | Phase 2 / Phase 3 | Recruiting | Jonathan Beaudoin | 50 | 2026-07-13 | 2026-08-20 |
Showing 20 of 431. Sign in to see all of them.
Heart Failure (58) · Heart Valve Diseases (43) · Aortic Valve Stenosis (38) · Aortic Valve Insufficiency (31) · Mitral Valve Stenosis (30) · Tricuspid Valve Insufficiency (29) · Coronary Artery Disease (24) · Mitral Valve Prolapse (24) · Cardiovascular Diseases (20) · Heart Diseases (17) · Gastroesophageal Reflux (14) · Atrial Fibrillation (13) · Myocardial Infarction (8) · Ventricular Dysfunction, Left (8)
Heart Diseases (414) · Cardiovascular Diseases (411) · Heart Valve Diseases (388) · Aortic Valve Disease (51) · Pathological Conditions, Signs and Symptoms (42) · Vascular Diseases (40) · Ventricular Outflow Obstruction (38) · Pathologic Processes (35) · Myocardial Ischemia (30) · Arterial Occlusive Diseases (24) · Arteriosclerosis (24) · Coronary Disease (24) · Heart Valve Prolapse (24) · Arrhythmias, Cardiac (14) · Deglutition Disorders (14)
Mitral Valve Annuloplasty (22) · Drug Delivery Systems (4) · Metoprolol (4) · Propofol (4) · Echocardiography (3) · Exercise Test (3) · Hydroxyethyl Starch Derivatives (3) · Isoflurane (3) · Mutagenesis, Insertional (3) · Sevoflurane (3) · Adrenergic beta-Antagonists (2) · Blood Specimen Collection (2) · Bupivacaine (2) · Captopril (2) · Cardiac Catheterization (2)
Edwards Lifesciences (32) · Abbott Medical Devices (27) · Michele De Bonis (7) · China National Center for Cardiovascular Diseases (6) · Polares Medical SA (6) · HighLife SAS (5) · NeoChord (5) · Ottawa Heart Institute Research Corporation (5) · Viacor (5) · Ancora Heart, Inc. (4) · Asan Medical Center (4) · Atlantic Health System (4) · Beijing Anzhen Hospital (4) · Cardiovalve Ltd. (4) · Hospices Civils de Lyon (4)
United States (112) · Germany (79) · Italy (60) · China (46) · Canada (44) · France (38) · Switzerland (30) · United Kingdom (30) · Netherlands (27) · Poland (24) · Spain (18) · Austria (15) · Belgium (14) · Greece (14) · Australia (13)
Mayra Guerrero, MD (4) · Patrick O'Gara, MD (4) · Vinod Thourani, MD (4) · Alibek Kh Mustafin, Professor (3) · Michael Mack, MD (3) · Shoujun Li, MD (3) · Ted Feldman, M.D. (3) · Timothy Gardner, MD (3) · Annalisa Pasquini, MD, PhD (2) · Annetine C. Gelijns, Ph.D. (2) · Barathi Sethuraman (2) · Boguslaw Kapelak, MD, PhD (2) · Francesco Maisano, Prof. (2) · Gorav Ailawadi, MD (2) · JoAnn Lindenfeld, MD (2)
PMID 25593120, PMID 30586701, PMID 40392571, PMID 41251714, PMID 21422390, PMID 21492763, PMID 23633132, PMID 25011722, PMID 25500293, PMID 27777294, PMID 30145927, PMID 30280640, PMID 33038223, PMID 33573741, PMID 37194288, PMID 41616808, PMID 12831818, PMID 15942584, PMID 16305903, PMID 16325053, PMID 17080467, PMID 17543250, PMID 17570634, PMID 18036963, PMID 18544392, PMID 19329766, PMID 19679246, PMID 20185021, PMID 20598968, PMID 21126639, PMID 21168015, PMID 21463154, PMID 21570860, PMID 21741608, PMID 21983306, PMID 22222076, PMID 22322574, PMID 22422577, PMID 22423604, PMID 22464260, PMID 22818065, PMID 23136163, PMID 23428660, PMID 23580745, PMID 23608290, PMID 23665364, PMID 23720379, PMID 23747789, PMID 23882872, PMID 24014834
U01HL088942 (5), 2018 (2), 2019 (1), 2025 (1), 595 (1), K23HL177311 (1), R01AG073633 (1), U01HL084904 (1)