427 completed, 187 unknown, 180 recruiting, 71 active not recruiting. 455 Not applicable, 54 Phase 4, 37 Phase 3, 31 Phase 2, 6 Phase 1.
Follow Ventricular Outflow Obstruction: new trials by email Literature Review of Ventricular Outflow Obstruction trials Research Report on Ventricular Outflow Obstruction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation Aortic Stenosis, Mitral Regurgitation | Not yet recruiting | Josep Rodes-Cabau | 300 | 2027-01-05 | 2026-11-04 | |
| High Flow Nasal Oxygenation in Transcatheter Aortic Valve Replacement Procedures. TAVR-Highflow II Oxygen therapy during sedation provided via high nasal cannulae (60L/min at 60% FiO2), Oxygen therapy during sedation delivered via nasal cannulae at 5L/min - Aortic Stenosis Treated With TAVI, Sedation; Aged; Hemodynamics | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 452 | 2027-01-01 | 2026-09-18 |
| Importance of Point-of-Care Ultrasound for Early Detection of Valvular and Cardiac Diseases (IMPROVE) Kosmos Torso-One AI-guided Point-of-Care Ultrasound (EchoNous, Inc.) - Valvular Heart Disease Patients, Aortic Stenosis | Not applicable | Not yet recruiting | University of Texas Southwestern Medical Center | 1088 | 2026-12-15 | 2026-11-03 |
| A Prospective, Multi-centre, Single Arm, Pivotal Clinical Study to Determine the Safety and Effectiveness of Crea Aortic Valve for Use as a Replacement Aortic Heart Valve Investigational Transcatheter Aortic Valve Replacement System - Aortic Valve Stenosis, Severe Aortic Stenosis | Not applicable | Not yet recruiting | Onecrea Medical Inc. | 30 | 2026-12-04 | 2026-07-29 |
| Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic Stenosis Dapagliflozin (DAPA), Spironolactone (drug), Spironolactone + Dapagliflozin - Aortic Stenosis | Phase 2 | Not yet recruiting | University College, London | 445 | 2026-12-01 | 2026-09-11 |
| Effect of Double-Tap Optimization on Valve Expansion and Hemodynamics in Balloon-expandable Transcatheter Aortic Valve Implantation: A Randomized Clinical Trial (DO-OPT TAVI Trial) Double-Tap Balloon Post-dilatation, Conventional Single-Inflation TAVI - Severe Aortic Stenosis | Not applicable | Not yet recruiting | Yonsei University | 250 | 2026-12-01 | 2026-11-03 |
| Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study) Transcatheter Aortic Valve Replacement (TAVR) with surgical oversight, Transcatheter Aortic Valve Replacement (TAVR) without surgical oversight - Aortic Stenosis, Severe Aortic Stenosis | Phase 4 | Not yet recruiting | University of Alberta | 600 | 2026-12-01 | 2026-10-27 |
| Sparrow App Guided Evaluation (SAGE) Vanguard Trial for Aortic Stenosis in Adults Aged Seventy and Older Stethophone - Moderate or Severe Aortic Stenosis | Not applicable | Not yet recruiting | Sunnybrook Health Sciences Centre | 1000 | 2026-12-01 | 2026-11-12 |
| NHLBI SESAME (SEptal Scoring Along Midline Endocardium) Multi-Center Prospective Study Using Improvised Off-Label Devices SESAME Procedure - Hypertrophic Cardiomyopathy, Left Ventricular Outflow Obstruction | Not applicable | Not yet recruiting | National Heart, Lung, and Blood Institute (NHLBI) | 200 | 2026-11-17 | 2026-11-12 |
| Exercise and Diet Supplements for Older Patients Undergoing TAVI: the IRON-TAVI Trial Personalized Multidomain Exercise Program, Oral Protein and Iron Nutritional Supplementation, Usual Care - Aortic Stenosis Disease, Aortic Stenosis Symptomatic | Not applicable | Recruiting | University Hospital of Ferrara | 450 | 2026-11-04 | 2026-11-05 |
| Safety and Clinical Performance of the Next-Generation SAFESYNC Transcatheter Heart Valve in Patients With Severe Aortic Stenosis INOVARE® SAFESYNC Next-Generation Bioprosthetic Heart Valve - Aortic Stenosis Senile, Aortic Stenosis Symptomatic | Not applicable | Not yet recruiting | Braile Biomedica Ind. Com. e Repr. Ltda. | 40 | 2026-11-01 | 2026-09-08 |
| Balloon- Versus Self-Expanding Intraannular TAVI in Small Aortic Annuli Meril Octapro+ THV System, Abbott Navitor/Navitor Vision THV system - Aortic Valve Stenosis | Not applicable | Not yet recruiting | Universitätsklinikum Hamburg-Eppendorf | 510 | 2026-10-26 | 2026-08-31 |
| SYMmetric Valve fraME Expansion To Reduce hYpoattenuated Leaflet Thickening After Balloon-expandable TAVI: the SYMMETRY Trial Double-TAP post-dilatation - Aortic Valve Stenosis and/or Insufficiency, Hypoattenuated Leaflet Thickening | Not applicable | Recruiting | Erasmus Medical Center | 422 | 2026-10-26 | 2026-10-30 |
| Systematic Ambulatory ECG Monitoring Following TAVI Ambulatory ECG monitoring - Aortic Stenosis, Conduction Disturbances | Not applicable | Recruiting | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | 754 | 2026-10-23 | 2026-11-04 |
| RVOT Stenting Versus Surgical RV-PA Conduit in Cyanotic Adults Cyanotic Congenital Heart Disease, Right Ventricular Outflow Tract Obstruction | Not yet recruiting | Assiut University | 30 | 2026-10-10 | 2026-10-08 | |
| The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial Beta-lactam antibiotic with spectrum for Enterococcus faecalis, Cephalosporin - Aortic Valve Stenosis | Not applicable | Recruiting | Copenhagen University Hospital, Rigshospitalet | 1986 | 2026-10-01 | 2026-10-05 |
| PULSTA TPV Observational Study Heart Disease | Not yet recruiting | Taewoong Medical Co., Ltd. | 200 | 2026-10-01 | 2026-08-10 | |
| Comparing Suture vs. Combined Closure Strategies for Large Blood Vessel Access in Patients Undergoing Transcatheter Aortic Valve Implantation (TAVI) Single Suture-Based Vascular Closure Device, Extravascular Collagen Plug-Based Closure Device - Aortic Valve Stenosis, Postoperative Complications | Not applicable | Not yet recruiting | University Hospital, Basel, Switzerland | 705 | 2026-10-01 | 2026-08-04 |
| Molecular Imaging to Identify Predictors of Aortic Valve Disease Activity AORTIC VALVE DISEASES, Calcification; Heart | Not yet recruiting | Massachusetts General Hospital | 100 | 2026-09-30 | 2026-09-16 | |
| Coronary Access After Evolut FX Plus TAVI: Impact of Commissural Alignment and the Large-Cell Frame Design: ACCESS-FX+ Registry Severe Aortic Stenosis | Not yet recruiting | Yonsei University | 122 | 2026-09-29 | 2026-09-10 |
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Aortic Valve Stenosis (991) · Aortic Valve Insufficiency (93) · Heart Valve Diseases (89) · Aortic Valve Disease (77) · Cardiovascular Diseases (54) · Coronary Artery Disease (47) · Mitral Valve Insufficiency (38) · Heart Failure (36) · Heart Diseases (35) · Aortic Valve, Calcification of (32) · Pulmonary Valve Stenosis (23) · Tricuspid Valve Insufficiency (17) · Hypertrophy, Left Ventricular (16) · Stroke (16) · Cardiomyopathy, Hypertrophic (15)
Heart Diseases (998) · Cardiovascular Diseases (979) · Heart Valve Diseases (943) · Aortic Valve Disease (937) · Pathological Conditions, Signs and Symptoms (149) · Vascular Diseases (127) · Pathologic Processes (100) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (58) · Myocardial Ischemia (58) · Coronary Disease (49) · Arterial Occlusive Diseases (48) · Arteriosclerosis (47) · Nervous System Diseases (47) · Congenital Abnormalities (42)
Transcatheter Aortic Valve Replacement (130) · Echocardiography (15) · Aspirin (10) · Clopidogrel (9) · Hematologic Tests (7) · Saline Solution (7) · Exercise (6) · Standard of Care (6) · Anesthesia, Local (5) · Electrocardiography, Ambulatory (5) · Replantation (5) · Ticagrelor (5) · Anesthesia, General (4) · Blood Specimen Collection (4) · MYK-461 (4)
Edwards Lifesciences (45) · Abbott Medical Devices (23) · Medtronic Cardiovascular (17) · Boston Scientific Corporation (16) · Institut für Pharmakologie und Präventive Medizin (16) · National Heart, Lung, and Blood Institute (NHLBI) (13) · University Hospital, Montpellier (12) · Insel Gruppe AG, University Hospital Bern (11) · Medtronic Cardiac Rhythm and Heart Failure (11) · Erasmus Medical Center (10) · Oslo University Hospital (10) · The Cleveland Clinic (9) · University of Edinburgh (9) · Assistance Publique - Hôpitaux de Paris (8) · Copenhagen University Hospital, Rigshospitalet (8)
United States (208) · Germany (184) · France (125) · Italy (115) · Netherlands (108) · United Kingdom (105) · Canada (86) · Spain (79) · Denmark (73) · China (66) · Switzerland (65) · Belgium (47) · Austria (43) · Sweden (35) · Australia (32)
Hendrik Treede, MD (6) · Martin B Leon, MD (6) · Robert J Lederman, M.D. (5) · John Webb, MD (4) · Seung-jung Park, MD (4) · Axel Linke, MD (3) · Barathi Sethuraman (3) · Craig Smith, MD (3) · David A Wood, MD (3) · David Messika-Zeitoun, MD (3) · Francis Duhay, MD (3) · Helene Eltchaninoff, Pr (3) · Manfred Boehm, M.D. (3) · Michael Reardon, MD (3)
PMID 20961243, PMID 33962483, PMID 29555836, PMID 31690104, PMID 21639811, PMID 31883339, PMID 35041482, PMID 38710669, PMID 12831818, PMID 31525069, PMID 32774184, PMID 34581194, PMID 35321859, PMID 35595203, PMID 35656983, PMID 36515976, PMID 16980116, PMID 22424519, PMID 22443479, PMID 23349346, PMID 24657695, PMID 24678937, PMID 25655063, PMID 25788234, PMID 26139739, PMID 26384204, PMID 26436963, PMID 26491110, PMID 26896466, PMID 27040324, PMID 27601429, PMID 28279376, PMID 28321003, PMID 29912142, PMID 29914867, PMID 30341970, PMID 30621974, PMID 30883058, PMID 31141105, PMID 31362540, PMID 31505615, PMID 31665959, PMID 33059828, PMID 33334422, PMID 33574022, PMID 33754803, PMID 34130476, PMID 34387097, PMID 34529944, PMID 35699482
2023 (4), 2015 (2), 2019 (2), R01AG089981 (2), 2009 (1), 2016 (1), 2018 (1), 5UL1TR002240-05 (1), P30AG031679 (1), P30AG048785 (1), R01AG073633 (1), R01HL039052 (1), R01HL072771 (1), R61HL169336 (1), U01HL088942 (1)