9 completed, 2 recruiting, 2 suspended, 2 withdrawn. 17 Phase 2, 6 Phase 1, 3 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 17 | Completed 9, Recruiting 2, Suspended 2, Withdrawn 2, Terminated 1, Unknown 1 |
| Phase 1 | 6 | Completed 3, Withdrawn 2, Recruiting 1 |
| Phase 3 | 3 | Completed 1, Recruiting 1, Suspended 1 |
Follow Mitral Valve Insufficiency: new trials by email Literature Review of Mitral Valve Insufficiency trials Research Report on Mitral Valve Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of VALsartan On atRIAl Mitral Regurgitation (VALORIA) - Pilot Valsartan, Placebo - Atrial Functional Mitral Regurgitation | Phase 2 / Phase 3 | Recruiting | Jonathan Beaudoin | 50 | 2026-07-13 | 2026-08-20 |
| Comparison of Erector Spinae Block and Pecto-Intercostal Facial Block For Enhanced Recovery in Adult Cardiac Surgery Ultrasound guided Pecto-intercostal- fascial plane block, Ultrasound guided erector spinae plane block, Bupivacain - Cardiac Septal Defects With Coarctation of the Aorta, Mitral Regurgitation | Phase 2 | Completed | Alexandria University | 60 | 2022-05-25 | 2022-07-27 |
| Use of Phenylephrine for Assessment of Mitral Regurgitation Severity Mydfrin - Mitral Regurgitation | Phase 1 / Phase 2 | Recruiting | Montefiore Medical Center | 35 | 2020-12-01 | 2025-07-20 |
| Atrial Functional Mitral Regurgitation Response In Mitral Loop Cerclage Annuloplasty (AFRICA Study) Mitral Loop Cerclage Annuloplasty - Atrial Functional Mitral Regurgitation, Heart Failure | Phase 1 / Phase 2 | Completed | Tau-MEDICAL Co., Ltd. | 1 | 2018-04-02 | 2021-04-26 |
| CardiAQ-Edwards™ Transcatheter Mitral Valve Replacement (TMVR) Study Transcatheter Mitral Valve Re-placement (TMVR) with the CardiAQ-Edwards™ Transcatheter Mitral Valve - Mitral Valve Regurgitation | Phase 1 / Phase 2 | Withdrawn | Edwards Lifesciences | 2016-11-01 | 2018-01-09 | |
| Medical Versus Surgical Management of Moderate Mitral Regurgitation Following Percutaneous Coronary Intervention surgical mitral valve repair w/ mitral valve annuloplasty - Myocardial Infarction, Mitral Regurgitation | Phase 1 / Phase 2 | Withdrawn | Southern Illinois University | 2010-07-01 | 2014-06-16 | |
| Surgical Ablation Versus No Surgical Ablation for Patients With Atrial Fibrillation Undergoing Mitral Valve Surgery MVS, Ablation - Atrial Fibrillation, Mitral Valve Insufficiency | Phase 2 | Completed | Annetine Gelijns | 260 | 2010-01-01 | 2017-02-06 |
| Safety and Efficacy Study of the PTMA Device to Reduce Mitral Valve Regurgitation in Patients With Heart Failure Percutaneous transvenous mitral annuloplasty - Mitral Regurgitation, Heart Failure | Phase 2 / Phase 3 | Suspended | Viacor | 20 | 2009-02-01 | 2011-02-14 |
| Dynamic Annuloplasty System With Activation for the Treatment of Mitral Regurgitation Dynamic Annuloplasty Ring (with option to adjust off-pump) - Mitral Valve Regurgitation | Phase 2 | Unknown | MiCardia Corporation | 130 | 2008-12-01 | 2009-01-30 |
| Comparing the Effectiveness of Repairing Versus Replacing the Heart's Mitral Valve in People With Severe Chronic Ischemic Mitral Regurgitation Mitral Valve Repair with Annuloplasty, Mitral Valve Replacement - Mitral Valve Insufficiency, Coronary Artery Disease | Phase 2 | Completed | Icahn School of Medicine at Mount Sinai | 251 | 2008-12-01 | 2019-03-15 |
| Study of Safety and Efficacy of the Percutaneous Reduction of Mitral Valve Regurgitation in Heart Failure Patients PTMA (Percutaneous Transvenous Mitral Annuloplasty) Implant - Heart Failure, Mitral Regurgitation | Phase 2 | Suspended | Viacor | 30 | 2008-10-01 | 2011-02-14 |
| Aachen Safety and Efficacy of the Percutaneous Transvenous Mitral Annuloplasty Device to Reduce Mitral Regurgitation PTMA Implant - Heart Failure, Mitral Regurgitation | Phase 1 / Phase 2 | Completed | Viacor | 4 | 2007-02-01 | 2008-11-06 |
| Mitral Valve Reconstruction in Chronic Heart Failure (CHF): Identification of Predictors for a Successful Therapy mitral valve repair - Chronic Heart Failure, Mitral Insufficiency | Phase 2 | Terminated | University of Leipzig | 5 | 2006-06-01 | 2016-10-27 |
| Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) metoprolol succinate (Toprol XL), Placebo - Mitral Regurgitation | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 38 | 2004-08-01 | 2012-11-22 |
| RESTOR-MV: Randomized Evaluation of a Surgical Treatment for Off-Pump Repair of the Mitral Valve Less invasive mitral valve repair - Mitral Valve Regurgitation, Left Ventricular Dysfunction | Phase 2 | Completed | Myocor | 250 | 2004-06-01 | 2009-05-07 |
| Safety and Efficacy of TP10, a Complement Inhibitor, in Adult Women Undergoing Cardiopulmonary Bypass Surgery TP10 - Myocardial Ischemia, Coronary Arteriosclerosis | Phase 2 | Completed | Avant Immunotherapeutics | 300 | 2004-04-01 | 2007-07-20 |
| Feasibility Study of a Percutaneous Mitral Valve Repair System. Percutaneous mitral valve repair (MitraClip Implant) - Mitral Valve Insufficiency, Mitral Valve Regurgitation | Phase 1 / Phase 2 | Completed | Abbott Medical Devices | 55 | 2003-07-01 | 2018-11-07 |
Heart Failure (6) · Coronary Artery Disease (3) · Atrial Fibrillation (2) · Myocardial Infarction (2) · Ventricular Dysfunction, Left (2) · Aortic Valve Insufficiency (1) · Cardiac Septal Defects with Coarctation of the Aorta (1) · Edema (1) · Gastroesophageal Reflux (1) · Lymphoma, Follicular (1) · Mitral Valve Prolapse (1) · Mitral Valve Stenosis (1) · Myocardial Ischemia (1) · Neoplasm Metastasis (1)
Cardiovascular Diseases (17) · Heart Diseases (17) · Heart Valve Diseases (17) · Pathological Conditions, Signs and Symptoms (6) · Pathologic Processes (5) · Vascular Diseases (4) · Arterial Occlusive Diseases (3) · Arteriosclerosis (3) · Coronary Disease (3) · Myocardial Ischemia (3) · Arrhythmias, Cardiac (2) · Infarction (2) · Ischemia (2) · Necrosis (2) · Ventricular Dysfunction (2)
Mitral Valve Annuloplasty (4) · Bupivacaine (1) · Metoprolol (1) · Mutagenesis, Insertional (1) · Oxymetazoline (1) · Phenylephrine (1) · Valsartan (1)
Viacor (3) · Abbott Medical Devices (1) · Alexandria University (1) · Annetine Gelijns (1) · Avant Immunotherapeutics (1) · Edwards Lifesciences (1) · Icahn School of Medicine at Mount Sinai (1) · Jonathan Beaudoin (1) · MiCardia Corporation (1) · Montefiore Medical Center (1) · Myocor (1) · Southern Illinois University (1) · Tau-MEDICAL Co., Ltd. (1) · University of Alabama at Birmingham (1) · University of Leipzig (1)
United States (8) · Canada (6) · Germany (5) · Netherlands (3) · Switzerland (2) · Belgium (1) · Czechia (1) · Denmark (1) · Egypt (1) · France (1) · Italy (1) · South Korea (1)
Annetine C. Gelijns, Ph.D. (2) · Patrick O'Gara, MD (2) · Rainer Hoffmann, MD (2) · Timothy Gardner, MD (2) · Christina Vassileva, M.D. (1) · Gerhard Schuler, Prof. (1) · Lars Sondergaard (1) · Louis . J. Dell'Italia, M.D (1) · Luc Bilodeau, MD (1) · Mario Garcia, MD (1) · Stefan Sack, Md, PhD (1) · Ted Feldman, M.D. (1) · Yong-Hyun Park, MD, PhD (1)
PMID 19679246, PMID 21126639, PMID 21168015, PMID 21422390, PMID 21492763, PMID 22818065, PMID 23633132, PMID 24245543, PMID 25500293, PMID 25853744, PMID 26550689, PMID 27777294, PMID 30785252, PMID 31097163, PMID 31146872, PMID 33573741
U01HL088942 (2), 595 (1)