68 recruiting, 51 completed, 31 unknown, 23 active not recruiting. 112 Not applicable, 5 Phase 3, 3 Phase 4, 1 Phase 1, 1 Phase 2.
Follow Tricuspid Valve Insufficiency: new trials by email Literature Review of Tricuspid Valve Insufficiency trials Research Report on Tricuspid Valve Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Categorizing Patient Risk for Tricuspid Regurgitation (TR) Intervention With Admittance Pulmonary Artery Catheter System (APACS) Right Heart Catheterization - Tricuspid Regurgitation (TR) | Not yet recruiting | Feldman Cardiology, PLLC | 8 | 2027-07-10 | 2026-03-30 | |
| Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study Tricuspid Regurgitation, Heart Failure | Enrolling by invitation | Columbia University | 140 | 2027-01-01 | 2026-02-12 | |
| Early Feasibility Study of 3930M Defibrillation Lead Implantation Via the Middle Cardiac Vein in Patients With Tricuspid Valve Regurgitation Defibrillator - Defibrillator, Tricuspid Valve Regurgitation | Not applicable | Not yet recruiting | Minneapolis Heart Institute Foundation | 5 | 2026-11-01 | 2026-09-10 |
| The CLASP III TR CED Study PASCAL Precision system Treated, Medicare Eligible Untreated Patients - Tricuspid Regurgitation, Heart Valve Diseases | Not yet recruiting | Edwards Lifesciences | 2350 | 2026-10-15 | 2026-10-06 | |
| A Prospective, Randomized Multicenter Clinical Trial of the TricValve® Transcatheter Bicaval Valve System in Subjects With Severe Tricuspid Regurgitation. TricValve System, Optimal medical therapy - Tricuspid Valve Disease, Heart Valve Diseases | Not applicable | Not yet recruiting | P+F Products + Features USA Inc. | 780 | 2026-10-01 | 2026-10-09 |
| Transcatheter Tricuspid Valve Replacement With the Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System in Severe Tricuspid Regurgitation Medtronic Intrepid™ Transcatheter Tricuspid Valve Replacement (TTVR) System, Edwards EVOQUE Tricuspid Valve Replacement (TTVR) System - Severe Tricuspid Regurgitation | Not applicable | Recruiting | Medtronic Cardiovascular | 1186 | 2026-09-11 | 2026-09-25 |
| Tricuspid Regurgitation Treatment With LAPLACE Transcatheter Tricuspid Valve Replacement System Transcatheter Tricuspid Valve Replacement (TTVR) with Laplace TTVR System, Transcatheter Tricuspid Valve Replacement (TTVR) with Edwards EVOQUE TTVR System - Severe Tricuspid Valve Regurgitation, Tricuspid Valve Regurgitation | Not applicable | Not yet recruiting | Laplace Interventional, Inc | 700 | 2026-09-01 | 2026-07-22 |
| Comparing the Effects of Newer Pacemakers and Their Effects on the Heart and Valve Function in the Short-term. Temporary left bundle branch area pacing, Temporary leadless right ventricular pacing - Pacemaker-Induced Cardiomyopathy, Tricuspid Regurgitation | Recruiting | Guy's and St Thomas' NHS Foundation Trust | 20 | 2026-08-18 | 2026-08-21 | |
| PASCAL Precision-GDMT Registry Tricuspid Insufficiency, Tricuspid Regurgitation (TR) | Not yet recruiting | Ceric Sàrl | 50 | 2026-08-01 | 2026-05-13 | |
| TRicuspid Uk STudy transcatheter edge to edge repair, Placebo - Tricuspid Regurgitation | Not applicable | Not yet recruiting | Barts & The London NHS Trust | 150 | 2026-07-31 | 2026-02-27 |
| VDyne Transcatheter Tricuspid Valve Replacement Study to Evaluate Safety and Clinical Efficacy in Patients With Symptomatic Severe Tricuspid Valve Regurgitation (TRIVITA Pivotal Trial) Transcatheter Tricuspid Valve Replacement (TTVR) with VDyne System, Transcatheter Tricuspid Valve Replacement (TTVR) with Edwards EVOQUE System - Tricuspid Valve Regurgitation, Tricuspid Valve Disease | Not applicable | Recruiting | VDyne, Inc. | 730 | 2026-07-28 | 2026-08-17 |
| Pivotal Trial to Evaluate TraNsvenous TrIcuspid Valve ReplacemenT With LuX-Valve Plus System (The TRINITY Pivotal Trial) TTVI with LuX-Valve Plus System, TTVI with EVOQUE - Tricuspid Regurgitation (TR) | Not applicable | Recruiting | Jenscare Innovation Inc. | 680 | 2026-07-15 | 2026-08-28 |
| The TRICURE US IDE Pivotal Study TRiCares Topaz TTVR System, Edwards EVOQUE TTVR System - Tricuspid Regurgitation (TR) | Not applicable | Recruiting | TRiCares | 831 | 2026-07-08 | 2026-10-22 |
| A Post-Market Assessment of the Safety and Performance of the TriClip™ System Tricuspid Transcatheter Edge-to-Edge Repair (TEER) - Tricuspid Regurgitation (TR) | Recruiting | Abbott Medical Devices | 1000 | 2026-07-02 | 2026-10-06 | |
| Efficacy of Verciguat in TR and RV Failure Vericiguat - HFrEF, Tricuspid Regurgitation (TR) | Phase 4 | Not yet recruiting | Daejeon St. Mary's hospital | 100 | 2026-07-01 | 2026-06-25 |
| Evaluation of a Management Algorithm for TAVI Patients With Concomitant Mitral or Tricuspid Regurgitation Aortic Stenosis, Mitral Regurgitation | Not yet recruiting | Josep Rodes-Cabau | 300 | 2026-06-05 | 2026-06-03 | |
| Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease Transcatheter Aortic Valve Replacement, Transcatheter Edge-to-Edge Repair, Transcatheter Tricuspid Valve Annuloplasty - Aortic Stenosis, Aortic Regurgitation | Not yet recruiting | Beijing Anzhen Hospital | 5500 | 2026-05-10 | 2026-05-26 | |
| Natural History of Atrial Fibrillation-Induced Tricuspid Valve Remodeling in the Absence of Significant Tricuspid Regurgitation: A Three-Dimensional Echocardiographic Study Atrial Fibrillation (AF), Tricuspid Regurgitation (TR) | Recruiting | Centro Cardiologico Monzino | 66 | 2026-05-04 | 2026-06-01 | |
| First-in-man Trial to Assess the Safety, Performance and Clinical Benefit of the TRICENTO G2 Transcatheter Valve System for Tricuspid Regurgitation TRICENTOG2 Transcatheter Valve System for Tricuspid Regurgitation (TRICENTOG2 TVSTR) - Symptomatic Tricuspid Regurgitation (TR) Graded as Severe or Greater | Not applicable | Not yet recruiting | Medira GmbH | 10 | 2026-05-01 | 2026-04-17 |
| DELINEATE-Prospective Valve Disease, Aortic, Mitral Regurgitation (MR) | Recruiting | Columbia University | 50 | 2026-04-15 | 2026-04-16 |
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Heart Valve Diseases (39) · Mitral Valve Insufficiency (29) · Heart Failure (26) · Aortic Valve Stenosis (17) · Cardiovascular Diseases (17) · Aortic Valve Insufficiency (12) · Mitral Valve Stenosis (7) · Heart Diseases (6) · Aortic Valve Disease (4) · Atrial Fibrillation (4) · Gastroesophageal Reflux (4) · Aneurysm, Ascending Aorta (2) · Coronary Artery Disease (2) · Mitral Valve Prolapse (2)
Heart Diseases (206) · Cardiovascular Diseases (195) · Heart Valve Diseases (173) · Ventricular Outflow Obstruction (17) · Aortic Valve Disease (14) · Pathological Conditions, Signs and Symptoms (10) · Pathologic Processes (9) · Vascular Diseases (6) · Arrhythmias, Cardiac (5) · Deglutition Disorders (4) · Digestive System Diseases (4) · Esophageal Diseases (4) · Esophageal Motility Disorders (4) · Gastrointestinal Diseases (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3)
Drug Delivery Systems (3) · Hydroxyethyl Starch Derivatives (3) · Echocardiography (2) · Replantation (2) · Blood Specimen Collection (1) · Bupivacaine (1) · Carvedilol (1) · Catheter Ablation (1) · Caves (1) · Defibrillators (1) · Echocardiography, Stress (1) · Electrocardiography (1) · Enavogliflozin (1) · Exercise Test (1) · Mitral Valve Annuloplasty (1)
Edwards Lifesciences (14) · Abbott Medical Devices (7) · LMU Klinikum (7) · Mayo Clinic (5) · Charite University, Berlin, Germany (4) · TRiCares (4) · Universitaire Ziekenhuizen KU Leuven (4) · 4Tech Cardio Ltd. (3) · Asan Medical Center (3) · Cardiovalve Ltd. (3) · Hangzhou Valgen Medtech Co., Ltd (3) · Heart and Diabetes Center North-Rhine Westfalia (3) · Konkuk University Medical Center (3) · Laplace Interventional, Inc (3) · Medtronic Cardiovascular (3)
United States (58) · Germany (49) · Italy (29) · China (24) · France (17) · Belgium (13) · South Korea (13) · Spain (13) · Canada (12) · Netherlands (11) · Switzerland (11) · Austria (7) · Israel (7) · United Kingdom (7) · Denmark (5)
Susheel Kodali, MD (3) · Alexander Lauten, Prof.Dr.med. (2) · Azeem Latib, MD (2) · Daniel Braun, MD (2) · Firas Zahr, MD (2) · Georg Nickenig, MD (2) · Gorav Ailawadi, MD (2) · Maria Salomone, MD (2) · Meghan Griffin (2) · Neil Fam, MD (2) · Rebecca Hahn, MD (2) · Robert J Lederman, M.D. (2) · Adam Rdzanek, MD PhD (1) · Aldo Rinaldi, MD (1)
PMID 38069986, PMID 12835667, PMID 23487435, PMID 24698557, PMID 24780907, PMID 25387993, PMID 28385308, PMID 30255476, PMID 30452076, PMID 30999993, PMID 31708188, PMID 32912460, PMID 33046437, PMID 33413863, PMID 33478646, PMID 33478647, PMID 33509390, PMID 33541097, PMID 33559474, PMID 33722059, PMID 33744150, PMID 34112461, PMID 34191132, PMID 34294396, PMID 34767705, PMID 34887055, PMID 35272771, PMID 35576863, PMID 36445158, PMID 36445668, PMID 36517335, PMID 36639288, PMID 36669972, PMID 36876753, PMID 37137586, PMID 37207923, PMID 37208936, PMID 37278243, PMID 37582170, PMID 38437953, PMID 38759905, PMID 38818766, PMID 38938712, PMID 39026154, PMID 39134125, PMID 39222896, PMID 39243264, PMID 39313112, PMID 39322365, PMID 39466215
2014 (1), 2016 (1), 2023 (1), R01AG073633 (1), U01HL088942 (1)