1041 completed, 512 unknown, 502 recruiting, 186 active not recruiting. 1106 Not applicable, 134 Phase 4, 124 Phase 2, 100 Phase 3, 50 Phase 1.
Follow Heart Valve Diseases: new trials by email Literature Review of Heart Valve Diseases trials Research Report on Heart Valve Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Categorizing Patient Risk for Tricuspid Regurgitation (TR) Intervention With Admittance Pulmonary Artery Catheter System (APACS) Right Heart Catheterization - Tricuspid Regurgitation (TR) | Not yet recruiting | Feldman Cardiology, PLLC | 8 | 2027-07-10 | 2026-03-30 | |
| Aficamten and Patient-Reported Outcomes in Real-World nHCM receiving aficamten - Hypertrophic Cardiomyopathy (HCM) | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 100 | 2027-06-01 | 2026-09-29 | |
| Understanding the Metabolic and Functional Derangement of Primary Mitral Regurgitation: a Feasibility Study Using Carbon 11(C-11) Acetate Cardiac Positron Emission Tomography Magnetic Resonance Imaging (PET-MRI) [11C] acetate - Mitral Valve Regurgitation | Early Phase 1 | Withdrawn | University of Alabama at Birmingham | 2027-06-01 | 2025-01-24 | |
| A Clinical Study of X-Clip Mitral Valve Clip System and Steerable Guide System for Transcatheter Mitral Valve Repair of Degenerative Mitral Regurgitation X-Clip Treatment for Degenerative Mitral Regurgitation - Transcatheter Mitral Valve Repair of Degenerative Mitral Regurgitation | Not applicable | Not yet recruiting | Shenzhen Lifevalve Medical Scientific Co., Ltd. | 15 | 2027-03-01 | 2026-06-22 |
| Improving Management and Secondary Prevention Through Azithromycin Comparative Trial in Rheumatic Heart Disease in Nigeria)- IMPACT-RHD Nigeria Benzathine Penicillin, Azithromycin (Azithro) - Rheumatic Fever, Valvular Heart Diseases | Not applicable | Not yet recruiting | Ladoke Akintola University of Technology, Ogbomoso, Nigeria | 474 | 2027-01-05 | 2026-06-04 |
| High Flow Nasal Oxygenation in Transcatheter Aortic Valve Replacement Procedures. TAVR-Highflow II Oxygen therapy during sedation provided via high nasal cannulae (60L/min at 60% FiO2), Oxygen therapy during sedation delivered via nasal cannulae at 5L/min - Aortic Stenosis Treated With TAVI, Sedation; Aged; Hemodynamics | Not applicable | Not yet recruiting | Hospital Clinic of Barcelona | 452 | 2027-01-01 | 2026-09-18 |
| Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study Tricuspid Regurgitation, Heart Failure | Enrolling by invitation | Columbia University | 140 | 2027-01-01 | 2026-02-12 | |
| ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral SAPIEN X4 THV - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Edwards Lifesciences | 125 | 2027-01-01 | 2025-12-22 |
| A Prospective, Multi-centre, Single Arm, Pivotal Clinical Study to Determine the Safety and Effectiveness of Crea Aortic Valve for Use as a Replacement Aortic Heart Valve Investigational Transcatheter Aortic Valve Replacement System - Aortic Valve Stenosis, Severe Aortic Stenosis | Not applicable | Not yet recruiting | Onecrea Medical Inc. | 30 | 2026-12-04 | 2026-07-29 |
| Gradual Tapering or Discontinuation of Beta-Blockers After Stabilization With Mavacamten Therapy Beta-Blocker Sequential Tapering and Discontinuation, Beta-Blocker Baseline Stable-Dose Maintenance - Obstructive Hypertrophic Cardiomyopathy (oHCM) | Not applicable | Not yet recruiting | First Affiliated Hospital of Wenzhou Medical University | 286 | 2026-12-01 | 2026-09-11 |
| Regression in Left Ventricular Hypertrophy and Fibrosis in Aortic Stenosis Dapagliflozin (DAPA), Spironolactone (drug), Spironolactone + Dapagliflozin - Aortic Stenosis | Phase 2 | Not yet recruiting | University College, London | 445 | 2026-12-01 | 2026-09-11 |
| Application of TAVI at Experienced Interventional Cardiac Centers Without On-site Cardiac Surgery (ATLAS Study) Transcatheter Aortic Valve Replacement (TAVR) with surgical oversight, Transcatheter Aortic Valve Replacement (TAVR) without surgical oversight - Aortic Stenosis, Severe Aortic Stenosis | Phase 4 | Not yet recruiting | University of Alberta | 600 | 2026-12-01 | 2026-10-27 |
| Exercise and Diet Supplements for Older Patients Undergoing TAVI: the IRON-TAVI Trial Personalized Multidomain Exercise Program, Oral Protein and Iron Nutritional Supplementation, Usual Care - Aortic Stenosis Disease, Aortic Stenosis Symptomatic | Not applicable | Not yet recruiting | University Hospital of Ferrara | 450 | 2026-11-04 | 2026-10-27 |
| Early Feasibility Study of 3930M Defibrillation Lead Implantation Via the Middle Cardiac Vein in Patients With Tricuspid Valve Regurgitation Defibrillator - Defibrillator, Tricuspid Valve Regurgitation | Not applicable | Not yet recruiting | Minneapolis Heart Institute Foundation | 5 | 2026-11-01 | 2026-09-10 |
| Multi-center Research Clinical Trial Protocol for Etiology-pathology and Repair Classification of Mitral and Tricuspid Valves Valve repair, Valve replacement - Heart Valvular Disease | Not applicable | Not yet recruiting | Keli Huang | 200 | 2026-11-01 | 2026-10-07 |
| Safety and Clinical Performance of the Next-Generation SAFESYNC Transcatheter Heart Valve in Patients With Severe Aortic Stenosis INOVARE® SAFESYNC Next-Generation Bioprosthetic Heart Valve - Aortic Stenosis Senile, Aortic Stenosis Symptomatic | Not applicable | Not yet recruiting | Braile Biomedica Ind. Com. e Repr. Ltda. | 40 | 2026-11-01 | 2026-09-08 |
| A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (AU) Transcatheter mitral valve repair - Mitral Valve (MV) Regurgitation | Not applicable | Not yet recruiting | Polares Medical SA | 15 | 2026-11-01 | 2026-08-11 |
| SYMmetric Valve fraME Expansion To Reduce hYpoattenuated Leaflet Thickening After Balloon-expandable TAVI: the SYMMETRY Trial Double-TAP post-dilatation - Aortic Valve Stenosis and/or Insufficiency, Hypoattenuated Leaflet Thickening | Not applicable | Not yet recruiting | Erasmus Medical Center | 422 | 2026-11-01 | 2026-10-16 |
| A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (FR) Transcatheter mitral valve repair (MRace Implant and Delivery System) - Mitral Valve (MV) Regurgitation | Not applicable | Not yet recruiting | Polares Medical SA | 20 | 2026-11-01 | 2026-08-11 |
| A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (DE) Transcatheter mitral valve repair (MRace Implant and Delivery System) - Mitral Valve (MV) Regurgitation | Not applicable | Not yet recruiting | Polares Medical SA | 20 | 2026-11-01 | 2026-08-11 |
Showing 20 of 2663. Sign in to see all of them.
Aortic Valve Stenosis (987) · Mitral Valve Insufficiency (429) · Cardiomyopathy, Hypertrophic (352) · Aortic Valve Disease (226) · Tricuspid Valve Insufficiency (212) · Heart Failure (181) · Coronary Artery Disease (167) · Aortic Valve Insufficiency (165) · Cardiovascular Diseases (127) · Heart Diseases (104) · Atrial Fibrillation (75) · Bicuspid Aortic Valve Disease (62) · Mitral Valve Stenosis (60) · Cardiomyopathies (48)
Heart Diseases (2559) · Cardiovascular Diseases (2536) · Aortic Valve Disease (1406) · Ventricular Outflow Obstruction (1021) · Pathological Conditions, Signs and Symptoms (429) · Vascular Diseases (398) · Aortic Valve Stenosis (385) · Aortic Stenosis, Subvalvular (353) · Cardiomyopathies (332) · Pathologic Processes (315) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (269) · Myocardial Ischemia (204) · Congenital Abnormalities (201) · Arterial Occlusive Diseases (177)
Transcatheter Aortic Valve Replacement (158) · MYK-461 (37) · Echocardiography (31) · Mitral Valve Annuloplasty (25) · Warfarin (20) · Blood Specimen Collection (17) · Aspirin (15) · Exercise (14) · Metoprolol (13) · Sodium Chloride (13) · Clopidogrel (12) · Saline Solution (12) · Propofol (11) · Magnetic Resonance Imaging (10) · Replantation (10)
Edwards Lifesciences (99) · Abbott Medical Devices (68) · National Heart, Lung, and Blood Institute (NHLBI) (43) · Medtronic Cardiovascular (31) · China National Center for Cardiovascular Diseases (27) · Bristol-Myers Squibb (25) · Xijing Hospital (25) · Assiut University (23) · Mayo Clinic (23) · Second Affiliated Hospital, Zhejiang University, School of Medicine (20) · Chinese Academy of Medical Sciences, Fuwai Hospital (19) · Yonsei University (19) · Institut für Pharmakologie und Präventive Medizin (18) · Assistance Publique - Hôpitaux de Paris (17) · Boston Scientific Corporation (17)
United States (609) · Germany (388) · China (278) · France (273) · Italy (272) · United Kingdom (228) · Canada (205) · Netherlands (182) · Spain (159) · Switzerland (128) · Denmark (121) · Belgium (99) · South Korea (89) · Poland (84) · Austria (80)
Vinod Thourani, MD (9) · Robert J Lederman, M.D. (8) · Hendrik Treede, MD (7) · Barathi Sethuraman (6) · John Webb, MD (6) · Martin B Leon, MD (6) · Susheel Kodali, MD (6) · Azeem Latib, MD (5) · Mayra Guerrero, MD (5) · Michael Reardon, MD (5) · Duk-Hyun Kang, M.D. (4) · Gorav Ailawadi, MD (4)
PMID 20961243, PMID 33962483, PMID 21639811, PMID 29555836, PMID 31690104, PMID 31883339, PMID 35041482, PMID 38710669, PMID 42636950, PMID 12831818, PMID 24678937, PMID 25593120, PMID 27040324, PMID 30586701, PMID 31525069, PMID 32774184, PMID 34581194, PMID 35321859, PMID 35595203, PMID 35656983, PMID 36515976, PMID 40392571, PMID 41251714, PMID 16980116, PMID 20096533, PMID 20188503, PMID 20566953, PMID 21273254, PMID 21422390, PMID 21492763, PMID 22424519, PMID 22443479, PMID 23349346, PMID 23633132, PMID 24621999, PMID 24657695, PMID 25011722, PMID 25500293, PMID 25533774, PMID 25655063, PMID 25788234, PMID 26139739, PMID 26384204, PMID 26436963, PMID 26491110, PMID 26896466, PMID 27601429, PMID 27609682, PMID 27777294, PMID 27815101
2023 (10), U01HL088942 (9), 2019 (7), 2018 (4), 2025 (4), 2015 (3), 2016 (2), 2017 (2), R01AG089981 (2), R21HL150373 (2), 1RC1LM010526 (1), 2009 (1), 2014 (1), 268201000048C-5-0-1 (1), 595 (1)