103 completed, 30 active not recruiting, 23 recruiting, 21 unknown. 109 Not applicable, 3 Phase 2, 3 Phase 4, 1 Phase 1, 1 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| INSPIRIS RESILIA Aortic Valve, Valve-in-Valve Surveillance Study Subjects previously implanted with INSPIRIS RESILIA Model 11500A and are undergoing planned valve-in-valve treatment. - Aortic Valve Replacement | Suspended | Edwards Lifesciences | 50 | 2028-06-01 | 2026-08-04 | |
| ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral SAPIEN X4 THV - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Edwards Lifesciences | 125 | 2027-01-01 | 2025-12-22 |
| Continuous Assessment of Brain Blood Perfusion in Subarachnoid Hemorrhage Patients Using Near-Infrared Spectroscopy (NIRS) - Non-Invasive Near-infrared Spectroscopy (NIRS) device (HEM1 with Foresight Elite Sensor) - Subarachnoid Hemorrhage, Aneurysmal | Not yet recruiting | University of Alabama at Birmingham | 120 | 2026-11-30 | 2026-10-22 | |
| SYMmetric Valve fraME Expansion To Reduce hYpoattenuated Leaflet Thickening After Balloon-expandable TAVI: the SYMMETRY Trial Double-TAP post-dilatation - Aortic Valve Stenosis and/or Insufficiency, Hypoattenuated Leaflet Thickening | Not applicable | Not yet recruiting | Erasmus Medical Center | 422 | 2026-11-01 | 2026-10-16 |
| The CLASP III TR CED Study PASCAL Precision system Treated, Medicare Eligible Untreated Patients - Tricuspid Regurgitation, Heart Valve Diseases | Not yet recruiting | Edwards Lifesciences | 2350 | 2026-10-15 | 2026-10-06 | |
| Early Feasibility Study of the Edwards APTURE Transcatheter Shunt System Edwards APTURE transcatheter shunt system - Heart Failure | Not applicable | Recruiting | Edwards Lifesciences | 15 | 2026-10-01 | 2026-10-05 |
| CLAARITY is a Prospective, Observational, Single-arm, Multi-center, Post-market US Study Designed to Evaluate the Safety and Performance of the ECLIPTIS Left Atrial Appendage Exclusion System for Exclusion of the Left Atrial Appendage (LAA) During Concomitant Open-heart Cardiac Surgery. Edwards ECLIPTIS Left Atrial Appendage Exclusion System - Atrial Appendage | Not yet recruiting | Edwards Lifesciences | 168 | 2026-09-30 | 2026-08-03 | |
| TRIFORMIS RESILIA Real-world Study Assessing Safety and Performance (TRIBLAZE Study) Edwards TRIFORMIS RESILIA heart valve - Heart Valve Diseases, Heart Diseases | Recruiting | Edwards Lifesciences | 75 | 2026-09-22 | 2026-10-21 | |
| Capitalizing on AI to CapTure Undiagnosed Structural Heart Disease EHR Alert - Structural Heart Abnormality, Valve Heart Disease | Not applicable | Recruiting | Pierre Elias | 4000 | 2026-09-16 | 2026-09-25 |
| Autus Valve Continued Access Study (CAS) Pulmonary Valve Replacement Surgery - Congenital Heart Disease | Not applicable | Active not recruiting | Edwards Lifesciences | 4 | 2026-07-27 | 2026-10-20 |
| KONECT RESILIA Aortic Valved Conduit (AVC) Real-world Study Assessing Safety and Performance Edwards KONECT RESILIA AVC - Aortic Valve Disease | Recruiting | Edwards Lifesciences | 250 | 2026-06-25 | 2026-10-02 | |
| Dilation Optimisation for Uniform Bioprosthetic Leaflet Expansion 'Double tap' balloon post-dilation - Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation) | Not applicable | Not yet recruiting | The Alfred | 250 | 2026-04-01 | 2026-02-24 |
| Real World Data Collection on the INSPIRIS RESILIA Aortic Valve Edwards INSPIRIS RESILIA Aortic Valve - Aortic Valve Disease | Recruiting | Edwards Lifesciences | 500 | 2025-07-30 | 2026-10-02 | |
| MITRIS China Post Market Clinical Follow-up (PMCF) Study MITRIS RESILIA Mitral Valve - Mitral Valve Replacement | Recruiting | Edwards Lifesciences | 250 | 2025-07-08 | 2025-12-30 | |
| Circle Method Observational Project - Non-interventional, Retrospective, Multicenter Data Collection Aortic Stenosis With Bicuspid Valve | Completed | Institut für Pharmakologie und Präventive Medizin | 140 | 2025-06-06 | 2026-08-03 | |
| A Study of Transcatheter Aortic Valve Replacement Case Selection and Valve Sizing Using the ABC Bicuspid Sizing Algorithm The ABC Bicuspid Sizing Algorithm - Aortic Stenosis | Recruiting | World Health Research Inc. | 290 | 2025-05-13 | 2026-07-21 | |
| TTVR STRONG Under Coverage With Evidence Development (CED) Study EVOQUE - Tricuspid Regurgitation | Recruiting | Edwards Lifesciences | 2044 | 2025-03-19 | 2026-09-29 | |
| The Asia-Pacific Mitral & Tricuspid Valve-in-Valve/Valve-in-Ring Registry (AP ViV Registry) Valve Disease, Heart | Recruiting | National Heart Centre Singapore | 150 | 2025-03-17 | 2025-07-10 | |
| Clinical Outcomes of Edwards Lifesciences MITRIS RESLILA Mitral Valve in the Asian Population Mitral Valve Insufficiency | Recruiting | Asan Medical Center | 200 | 2024-12-20 | 2025-01-03 | |
| Double Transseptal Guide Sheath to Prevent Dock Drop During SAPIEN M3 Transcatheter Mitral Valve Replacement Mitral Regurgitation | Completed | Medical University of Vienna | 77 | 2024-12-18 | 2026-10-21 |
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Aortic Valve Stenosis (67) · Mitral Valve Insufficiency (37) · Cardiovascular Diseases (29) · Heart Valve Diseases (28) · Heart Diseases (21) · Tricuspid Valve Insufficiency (18) · Aortic Valve Disease (17) · Heart Failure (15) · Gastroesophageal Reflux (9) · Aortic Valve Insufficiency (8) · Pulmonary Valve Insufficiency (8) · Heart Defects, Congenital (6) · Hypotension (6) · Aortic Valve, Calcification of (5) · Coronary Artery Disease (5)
Transcatheter Aortic Valve Replacement (13) · Mitral Valve Annuloplasty (2) · Spectroscopy, Near-Infrared (2) · Aspirin (1) · Biosensing Techniques (1) · Clopidogrel (1) · Health Records, Personal (1) · Hemodynamic Monitoring (1) · Magnetic Resonance Imaging (1) · Microscopy, Atomic Force (1) · Models, Biological (1) · Standard of Care (1) · Tomography, X-Ray Computed (1) · carbetocin (1)
United States (77) · Germany (63) · Canada (42) · Italy (33) · United Kingdom (30) · Netherlands (29) · Switzerland (29) · France (28) · Austria (21) · Spain (19) · Australia (11) · Denmark (11) · Poland (10) · China (9) · Belgium (7)
John Webb, MD (5) · Martin B Leon, MD (5) · Vinod Thourani, MD (4) · Craig Smith, MD (3) · Mayra Guerrero, MD (3) · Michael Sander, Prof. (3) · Susheel Kodali, MD (3) · Tina Abdelnour, MS, BSN (3) · Alan Zajarias, MD (2) · Boguslaw Kapelak, MD, PhD (2) · Davinder Ramsingh, MD (2) · Derk Frank, Prof. (2) · Georg Nickenig, MD (2) · Gorav Ailawadi, MD (2)
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R01HL177055 (1)