62 completed, 33 recruiting, 26 unknown, 14 not yet recruiting. 77 Not applicable, 7 Phase 4, 3 Phase 3, 2 Phase 1, 2 Phase 2.
Follow Aortic Valve Insufficiency: new trials by email Literature Review of Aortic Valve Insufficiency trials Research Report on Aortic Valve Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| SYMmetric Valve fraME Expansion To Reduce hYpoattenuated Leaflet Thickening After Balloon-expandable TAVI: the SYMMETRY Trial Double-TAP post-dilatation - Aortic Valve Stenosis and/or Insufficiency, Hypoattenuated Leaflet Thickening | Not applicable | Not yet recruiting | Erasmus Medical Center | 422 | 2026-11-01 | 2026-10-16 |
| Prospective Multicenter Study Evaluating Myval TAVR Safety and Effectiveness in High-risk Severe AR Myval THV series - Aortic Regurgitation, Aortic Disease | Not applicable | Not yet recruiting | Ceric Sàrl | 164 | 2026-10-30 | 2026-08-07 |
| Active Post-Market Surveillance of Innovative Devices for Valvular Heart Disease Transcatheter Aortic Valve Replacement, Transcatheter Edge-to-Edge Repair, Transcatheter Tricuspid Valve Annuloplasty - Aortic Stenosis, Aortic Regurgitation | Not yet recruiting | Beijing Anzhen Hospital | 5500 | 2026-05-10 | 2026-05-26 | |
| DELINEATE-Prospective Valve Disease, Aortic, Mitral Regurgitation (MR) | Recruiting | Columbia University | 50 | 2026-04-15 | 2026-04-16 | |
| JOURNEY LVAD: JOURNEY Left Ventricular Assist Device J-Valve Transfemoral System - Aortic Valve Regurgitation, Aortic Valve Disease Mixed | Not applicable | Not yet recruiting | JC Medical, Inc., an affiliate of Edwards Lifesciences LLC | 50 | 2026-04-01 | 2026-03-05 |
| TAVR for Aortic Regurgitation Under TTE Guidance TTE guided TAVR - Aortic Regurgitation, Transcatheter Aortic Valve Replacement (TAVR) | Not applicable | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 30 | 2026-03-10 | 2026-03-09 |
| ART Trial: Transcatheter J-VALVE Versus Surgery for Aortic Regurgitation Therapy J-VALVE Transfemoral Aortic Valve system, Commercially available surgical biological aortic valve replacement device - Aortic Regurgitation, Aortic Valve Insufficiency | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 1250 | 2026-03-05 | 2026-08-12 |
| TAVR for Aortic Regurgitation Under TEE Guidance TEE guided TAVR - Aortic Regurgitation, Transcatheter Aortic Valve Replacement | Not applicable | Not yet recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 30 | 2026-03-01 | 2026-03-06 |
| Comparison of Early Postoperative Outcomes Between Minimally Invasive Valve Surgery Via Right Thoracotomy and Conventional Valve Surgery Via Sternotomy. Minimally Invasive Valve Surgery, Conventional Valve Surgery - Heart Valve Diseases or Prosthesis, Aortic Valve Stenosis | Not applicable | Not yet recruiting | Chaudhry Pervaiz Elahi Institute of Cardiology | 32 | 2025-12-15 | 2025-11-26 |
| Artificial Intelligence in Aortic Regurgitation AI-Assisted Group, Manual measurement group - Aortic Regurgitation Disease | Not applicable | Recruiting | Chinese University of Hong Kong | 540 | 2025-12-01 | 2026-03-20 |
| Clinical Investigation for the PoliaValve Aortic Heart Valve- India PoliaValve (Aortic) - AORTIC VALVE DISEASES, Aortic Valve Stenosis | Not applicable | Not yet recruiting | Suzhou Hearthill Medical Technology Co.,LTD | 50 | 2025-11-15 | 2025-08-14 |
| Evaluation of Safety and Effectiveness of the EMBLOK EPS Compared With No Cerebral Embolic Protection During TAVR EMBLOK™ Embolic Protection System ("EMBLOK EPS") - AORTIC VALVE DISEASES, Aortic Valve Stenosis and/or Insufficiency | Not applicable | Not yet recruiting | Emblok, Inc. | 560 | 2025-10-21 | 2025-08-19 |
| Prospective, Long-term Evaluation of the SAPIEN 3 Ultra RESILIA Valve Transcatheter aortic valve (S3UR) replacement (TAVR) - Transcatheter Aortic Valve Replacement (TAVR), Aortic-Stenosis | Recruiting | Institut für Pharmakologie und Präventive Medizin | 500 | 2025-09-15 | 2026-07-30 | |
| The ARTEMIS Data Collection Study Aortic Regurgitation Disease | Recruiting | IRCCS Policlinico S. Donato | 75 | 2025-08-10 | 2025-12-24 | |
| Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice Heart Valve Diseases, Aortic Valve Stenosis | Not yet recruiting | Yonsei University | 30000 | 2025-08-01 | 2025-07-16 | |
| Mild and Moderate Aortic Regurgitation: Risk Factors for Progress and Outcome Aortic Regurgitation | Not yet recruiting | Uppsala University | 35000 | 2025-08-01 | 2025-08-05 | |
| 3-Dimensional Simulation Guided Transcatheter Aortic Valve Replacement in Aortic Regurgitation(DIGITAL) 3D simulation technique - Aortic Regurgitation | Not applicable | Enrolling by invitation | Xijing Hospital | 354 | 2025-07-30 | 2026-02-10 |
| Effect of Losartan on the Neurohumoral Axis and Ventricular Remodeling of Patients With Severe Aortic Regurgitation Undergoing Valve Surgery. Losartan 50 mg, Placebo - Heart Valve Diseases, Left Ventricle Remodeling | Phase 4 | Recruiting | Vitor Emer Egypto Rosa | 60 | 2025-07-01 | 2025-08-01 |
| Prophylactic Suture Line Sealing With NE'X Glue R-eco in Cardiac and Vascular Surgery Surgical placement of a prosthetic or biologic graft (patch), or an allograft for cardiac and (cardio)vascular repair. - Aortic Aneurysm, Aortic Aneurysm Abdominal | Not applicable | Not yet recruiting | Grena Biomed Limited | 60 | 2025-06-30 | 2025-04-09 |
| Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve Polymer Prosthetic Heart Valve - AORTIC VALVE DISEASES, Mitral Valve Disease | Not applicable | Recruiting | Mitrassist Lifesciences Limited Co., Ltd. | 10 | 2025-06-27 | 2025-07-31 |
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Aortic Valve Stenosis (92) · Mitral Valve Insufficiency (31) · Aortic Valve Disease (29) · Heart Valve Diseases (25) · Tricuspid Valve Insufficiency (12) · Mitral Valve Stenosis (10) · Coronary Artery Disease (9) · Aortic Diseases (7) · Aortic Aneurysm (6) · Gastroesophageal Reflux (6) · Bicuspid Aortic Valve Disease (5) · Heart Diseases (5) · Heart Failure (5) · Aortic Root Aneurysm (3)
Cardiovascular Diseases (162) · Heart Diseases (160) · Heart Valve Diseases (140) · Aortic Valve Disease (136) · Ventricular Outflow Obstruction (91) · Vascular Diseases (25) · Aneurysm (11) · Pathological Conditions, Signs and Symptoms (10) · Arterial Occlusive Diseases (9) · Arteriosclerosis (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (9) · Coronary Disease (9) · Myocardial Ischemia (9) · Aortic Diseases (8) · Cardiovascular Abnormalities (8)
Transcatheter Aortic Valve Replacement (18) · Isoflurane (3) · Propofol (3) · Sevoflurane (3) · Aspirin (2) · Echocardiography (2) · Losartan (2) · Replantation (2) · amlodipine-losartan drug combination (2) · Amlodipine (1) · Anesthesia (1) · Antithrombin III (1) · Blood Specimen Collection (1) · Cardiopulmonary Bypass (1) · Contrast Media (1)
Abbott Medical Devices (7) · Edwards Lifesciences (7) · JenaValve Technology, Inc. (6) · The Cleveland Clinic (5) · Biostable Science & Engineering (4) · JC Medical, Inc., an affiliate of Edwards Lifesciences LLC (4) · Astana Medical University (3) · Chinese Academy of Medical Sciences, Fuwai Hospital (3) · Sorin Group USA, Inc. (3) · Suzhou Hearthill Medical Technology Co.,LTD (3) · Xijing Hospital (3) · Anteris Technologies Ltd. (2) · Assistance Publique - Hôpitaux de Paris (2) · Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec (2) · CryoLife, Inc. (2)
United States (39) · Germany (24) · China (19) · Italy (19) · Canada (14) · France (14) · Belgium (10) · Netherlands (10) · United Kingdom (9) · Russia (6) · South Korea (6) · Spain (6) · Switzerland (6) · Poland (5) · Austria (4)
Alibek Kh Mustafin, Professor (3) · Barathi Sethuraman (3) · Dean J Kereiakes, MD (2) · Dominico Mazzitelli, MD (2) · Hartzell Schaff, MD (2) · Hendrik Treede, MD (2) · Jim D Thomas, MD (2) · Martin B. Leon, MD (2) · Patrick W Serruys, MD, PhD (2) · Scott B Capps, MS (2) · Stephan Baldus, MD (2) · Torsten P. Vahl, MD (2) · Vinod H. Thourani, MD (2) · Vinod Thourani, MD (2)
PMID 29171730, PMID 34556282, PMID 37648345, PMID 41260228, PMID 10199882, PMID 10612754, PMID 10781763, PMID 11081028, PMID 11167098, PMID 12091180, PMID 12878961, PMID 13432835, PMID 14602258, PMID 15082276, PMID 15144988, PMID 15896604, PMID 16316968, PMID 16376439, PMID 16500110, PMID 16872961, PMID 18805263, PMID 19118260, PMID 19185153, PMID 19369085, PMID 19762251, PMID 19933939, PMID 20304137, PMID 20382029, PMID 20409726, PMID 20494035, PMID 20583388, PMID 20625143, PMID 21273254, PMID 21352983, PMID 21823153, PMID 22476605, PMID 22859310, PMID 22879371, PMID 22921819, PMID 23228404, PMID 23343835, PMID 23599348, PMID 23959743, PMID 24022003, PMID 24113022, PMID 24578598, PMID 24682026, PMID 24958752, PMID 25149108, PMID 25240525
2016 (1), 2023 (1), 2025 (1)