6 completed, 1 recruiting, 1 suspended, 1 terminated. 9 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 9 | Completed 6, Recruiting 1, Suspended 1, Terminated 1 |
| Phase 2 | 3 | Completed 1, Recruiting 1, Suspended 1 |
Follow Mitral Valve Insufficiency: new trials by email Literature Review of Mitral Valve Insufficiency trials Research Report on Mitral Valve Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effects of VALsartan On atRIAl Mitral Regurgitation (VALORIA) - Pilot Valsartan, Placebo - Atrial Functional Mitral Regurgitation | Phase 2 / Phase 3 | Recruiting | Jonathan Beaudoin | 50 | 2026-07-13 | 2026-08-20 |
| Ertugliflozin for Functional Mitral Regurgitation Ertugliflozin, Placebo - Mitral Valve Insufficiency, Left Ventricular Systolic Dysfunction | Phase 3 | Completed | Asan Medical Center | 128 | 2020-11-04 | 2025-01-06 |
| Influence of Anesthetics on Clinical Outcome in Mitral and Aortic Valve Replacement in Adults Propofol, Isoflurane, Sevoflurane - Mitral Valve Insufficiency, Aortic Valve Insufficiency | Phase 3 | Completed | Astana Medical University | 75 | 2020-01-03 | 2023-01-25 |
| Comparison of Sternal Wound Infiltration With Liposomal Bupivacaine v. Bupivacaine Hydrochloride Exparel Injectable Product, Bupivacaine Hydrochloride - Coronary Artery Disease, Coronary Artery Stenoses | Phase 3 | Completed | Kathirvel Subramaniam | 60 | 2018-11-15 | 2021-09-05 |
| Safety and Efficacy Study of the PTMA Device to Reduce Mitral Valve Regurgitation in Patients With Heart Failure Percutaneous transvenous mitral annuloplasty - Mitral Regurgitation, Heart Failure | Phase 2 / Phase 3 | Suspended | Viacor | 20 | 2009-02-01 | 2011-02-14 |
| Effectiveness of Surgical Mitral Valve Repair Versus Medical Treatment for People With Significant Mitral Regurgitation and Non-ischemic Congestive Heart Failure Surgical mitral valvuloplasty with placement of annular ring (SMVR), Optimal medical therapy (OMT) - Mitral Valve Insufficiency, Heart Failure | Phase 3 | Terminated | Duke University | 2 | 2008-03-01 | 2018-04-04 |
| Safety and Efficacy Study of the Sorin 3D Annuloplasty Ring For Mitral Repair Implantation of the MEMO 3D Annuloplasty Ring - Mitral Valve Regurgitation | Phase 3 | Completed | Sorin Group USA, Inc. | 278 | 2007-08-01 | 2015-01-26 |
| Molecular Mechanisms of Volume Overload-Aim 1(SCCOR in Cardiac Dysfunction and Disease) metoprolol succinate (Toprol XL), Placebo - Mitral Regurgitation | Phase 2 / Phase 3 | Completed | University of Alabama at Birmingham | 38 | 2004-08-01 | 2012-11-22 |
| Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitral Valve Surgery Patients inhaled milrinone, intravenous milrinone - Pulmonary Hypertension, Mitral Regurgitation | Phase 3 | Completed | Konkuk University Medical Center | 20 | 2003-01-01 | 2012-06-19 |
Heart Failure (2) · Ventricular Dysfunction, Left (2) · Aortic Valve Insufficiency (1) · Cardiomyopathy, Dilated (1) · Coronary Artery Disease (1) · Coronary Stenosis (1) · Edema (1) · Hypertension, Pulmonary (1) · Pain, Postoperative (1) · Tricuspid Valve Insufficiency (1)
Cardiovascular Diseases (9) · Heart Diseases (9) · Heart Valve Diseases (9) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Vascular Diseases (2) · Ventricular Dysfunction (2) · Aortic Valve Disease (1) · Arterial Occlusive Diseases (1) · Arteriosclerosis (1) · Cardiomegaly (1) · Cardiomyopathies (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1) · Coronary Disease (1) · Genetic Diseases, Inborn (1)
Anesthesia (1) · Bupivacaine (1) · Isoflurane (1) · Metoprolol (1) · Milrinone (1) · Mitral Valve Annuloplasty (1) · Propofol (1) · Sevoflurane (1) · Valsartan (1) · ertugliflozin (1)
Asan Medical Center (1) · Astana Medical University (1) · Duke University (1) · Jonathan Beaudoin (1) · Kathirvel Subramaniam (1) · Konkuk University Medical Center (1) · Sorin Group USA, Inc. (1) · University of Alabama at Birmingham (1) · Viacor (1)
Canada (4) · United States (4) · South Korea (2) · Kazakhstan (1)
Alibek Kh Mustafin, Professor (1) · Clark Hargrove, M.D. (1) · Eugene Braunwald, MD (1) · Kathirvel Subramaniam, MD, MPH (1) · Kerry L. Lee, PhD (1) · Louis . J. Dell'Italia, M.D (1) · Luc Bilodeau, MD (1) · Tae-Yop Kim, MD PhD (1)
U01HL084904 (1)