21 completed, 17 unknown, 12 recruiting, 4 active not recruiting. 22 Not applicable, 6 Phase 4, 4 Phase 3, 3 Phase 2, 1 Phase 1.
Follow Mitral Valve Stenosis: new trials by email Literature Review of Mitral Valve Stenosis trials Research Report on Mitral Valve Stenosis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ALLIANCE Mitral: Safety and Effectiveness of SAPIEN X4 Transcatheter Heart Valve - Mitral SAPIEN X4 THV - Mitral Regurgitation, Mitral Valve Disease | Not applicable | Not yet recruiting | Edwards Lifesciences | 125 | 2027-01-01 | 2025-12-22 |
| The Feasibility Study of Polymer Artificial Heart Valve for the Treatment the Mitral Valve Disease. mitral valve replacement - Severe Mitral Valve Regurgitation, Severe Mitral Valve Stenosis | Not applicable | Recruiting | Shanghai HeartEpoch Medical Technology Co., Ltd | 10 | 2025-11-19 | 2026-07-06 |
| Abbott Cephea Mitral Valve Disease Registry Mitral Regurgitation, Mitral Stenosis | Recruiting | Abbott Medical Devices | 1000 | 2025-08-13 | 2026-09-10 | |
| Early Feasibility Study of Surgical Implantation of a Polymer Prosthetic Mitral and Aortic Valve Polymer Prosthetic Heart Valve - AORTIC VALVE DISEASES, Mitral Valve Disease | Not applicable | Recruiting | Mitrassist Lifesciences Limited Co., Ltd. | 10 | 2025-06-27 | 2025-07-31 |
| Cephea South America Feasibility Study Cephea Mitral Valve System - Mitral Regurgitation, Mitral Stenosis | Not applicable | Active not recruiting | Abbott Medical Devices | 20 | 2025-06-17 | 2026-09-11 |
| Cohort Observing Mechanisms, Progression and Sequelae of Valvular Heart Disease Heart Valve Disease, Mitral Valve (MV) Regurgitation | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 10000 | 2025-06-01 | 2025-12-05 | |
| Prospective Multicenter Registry of Patients With Mitral Stenosis Undergoing Percutaneous Mitral Balloon Commissurotomy Mitral Stenosis | Recruiting | Asan Medical Center | 400 | 2025-05-01 | 2025-09-16 | |
| Treating Severe Mitral Valve Annular or Valvular Calcification Using Shockwave Balloon SMARTWAVE SmartWave Lithotripsy balloon - Mitral Annulus Calcification, Rheumatic Heart Disease | Not applicable | Recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 10 | 2025-03-08 | 2026-09-16 |
| Assessment of Exercise Capacity, Muscle Oxygenation and Aortic Stiffness in Patients With Mitral Stenosis Mitral Stenosis | Recruiting | Gazi University | 40 | 2025-01-13 | 2026-08-04 | |
| Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery Acute normovolemic hemodilution (ANH), hydroxyethyl starch (HES 130/0.6) - Mitral Regurgitation, Mitral Stenosis | Not applicable | Not yet recruiting | Konkuk University Medical Center | 70 | 2024-10-28 | 2024-10-31 |
| Impact of Percutaneous Transvenous Mitral Commissurotomy on The Left Atrial Appendage Function in Patients With Mitral Stenosis. Transesophageal echocardiography - Mitral Stenosis | Not applicable | Not yet recruiting | Assiut University | 25 | 2024-07-01 | 2024-04-02 |
| Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients Ultrasound examination of the lungs - Ischemic Heart Disease, Aortic Stenosis, Severe | Not applicable | Recruiting | Saint Petersburg State University, Russia | 186 | 2024-05-15 | 2024-12-09 |
| European Association of Cardiovascular Imaging Multiple and Mixed Valvular Disease Study Intervention not provided - Heart Valve Diseases, Multiple Valve Disease, Unspecified | Recruiting | Assistance Publique - Hôpitaux de Paris | 1500 | 2024-02-07 | 2024-06-03 | |
| Ventricular-arterial Coupling of the Heart Among Patients With Mitral Stenosis Undergoing Percutaneous Trans-luminal Mitral Commissurotomy. Cardiac Magnetic Resonance Study Mitral Valve Stenosis | Unknown | Assiut University | 46 | 2023-12-01 | 2023-11-22 | |
| Assessment of Right Ventricular Function in Patients With Severe Mitral Stenosis Before and After Balloon Mitral Valvuloplasty Mitral Stenosis | Unknown | Assiut University | 30 | 2023-10-01 | 2023-10-05 | |
| The China Mviv Registry Transseptal Transcatheter Mitral valve-in-valve Replacement - Bioprosthesis Failure, Mitral Stenosis With Insufficiency | Not applicable | Unknown | Xiamen Cardiovascular Hospital, Xiamen University | 50 | 2023-07-11 | 2023-06-29 |
| Rate Control Efficacy in Atrial Fibrillation With Rheumatic Mitral Stenosis: Lenient vs Strict Rate Control Strategies Rate control - Atrial Fibrillation, Rheumatic Mitral Stenosis | Not applicable | Unknown | University of Brawijaya | 100 | 2023-03-01 | 2024-05-10 |
| Clinical Investigation for the Foldax Tria Mitral Valve- India Mitral Valve Replacement - Mitral Valve Disease, Mitral Regurgitation | Not applicable | Unknown | Foldax, Inc | 70 | 2023-03-01 | 2024-01-05 |
| Role of Ivabradine on Heart Rate and Quality of Life in Patients With Mitral Stenosis in Sinus Rhythm Ivabradine, Beta blocker - Mitral Stenosis | Phase 4 | Completed | Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh | 42 | 2023-02-01 | 2024-04-17 |
| Real-world Clinical Outcomes of the MITRIS RESILIA Mitral Valve MITRIS RESILIA Mitral Valve, Model 11400M - Mitral Stenosis, Mitral Valve Insufficiency | Active not recruiting | Edwards Lifesciences | 504 | 2023-01-11 | 2026-05-22 |
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Mitral Valve Insufficiency (30) · Aortic Valve Stenosis (13) · Aortic Valve Insufficiency (10) · Atrial Fibrillation (8) · Rheumatic Heart Disease (7) · Tricuspid Valve Insufficiency (7) · Heart Failure (6) · Aortic Valve Disease (3) · Heart Valve Diseases (3) · Coronary Artery Disease (2) · Gastroesophageal Reflux (2) · Heart Diseases (2) · Rheumatic Fever (2) · Acute Coronary Syndrome (1)
Cardiovascular Diseases (59) · Heart Diseases (58) · Heart Valve Diseases (57) · Ventricular Outflow Obstruction (13) · Aortic Valve Disease (11) · Pathologic Processes (11) · Pathological Conditions, Signs and Symptoms (11) · Vascular Diseases (8) · Arrhythmias, Cardiac (7) · Bacterial Infections (7) · Bacterial Infections and Mycoses (7) · Gram-Positive Bacterial Infections (7) · Infections (7) · Streptococcal Infections (6) · Myocardial Ischemia (5)
Warfarin (6) · Hydroxyethyl Starch Derivatives (3) · Dabigatran (2) · Ivabradine (2) · Rivaroxaban (2) · Adrenergic beta-Antagonists (1) · Antithrombin III (1) · Atenolol (1) · Blood Pressure Monitors (1) · Bosentan (1) · Cardiac Surgical Procedures (1) · Control Groups (1) · Echocardiography, Transesophageal (1) · Heart Rate (1) · Metoprolol (1)
Assiut University (4) · Abbott Medical Devices (3) · Edwards Lifesciences (3) · Konkuk University Medical Center (3) · National Heart, Lung, and Blood Institute (NHLBI) (3) · Asan Medical Center (2) · Foldax, Inc (2) · French Cardiology Society (2) · Aalborg University (1) · Annetine Gelijns (1) · Assistance Publique - Hôpitaux de Paris (1) · Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh (1) · Baylor Research Institute (1) · Baystate Medical Center (1) · Braile Biomedica Ind. Com. e Repr. Ltda. (1)
United States (10) · South Korea (6) · China (4) · Brazil (3) · Canada (3) · France (3) · Indonesia (3) · Poland (3) · Germany (2) · Greece (2) · Hong Kong (2) · India (2) · Iran (2) · Pakistan (2) · Russia (2)
Ade Meidian Ambari, MD,FIHA (1) · Adrian VS Hill, DPhil DM (1) · Amar Krishnaswamy, MD (1) · An Aldia Asrial, MD (1) · Andrew C Steer, FRACP PhD (1) · Annetine C. Gelijns, Ph.D. (1) · Ardian Rizal, MD, FIHA (1) · Barathi Sethuraman (1) · Birthe Dinesen, PhD (1) · Costanza Pellegrini, MD (1) · Domenico Paparella, Investigator (1) · Dr Neeraj Parakh, MD, DM (1) · Duk-Hyun Kang, MD, PhD (1)
PMID 25853744, PMID 26208006, PMID 26579590, PMID 26713491, PMID 27044310, PMID 28605428, PMID 29699609, PMID 30455168, PMID 30687584, PMID 31097163, PMID 31118146, PMID 31933658, PMID 32340804, PMID 32661631, PMID 32978200, PMID 34158575, PMID 34191132, PMID 34320949, PMID 34518254, PMID 34526318, PMID 35065065, PMID 35306032, PMID 37778503, PMID 37808026, PMID 38135262, PMID 39243268, PMID 39780838, PMID 39966045, PMID 40589299, PMID 40748697, PMID 41635678, PMID 41960126
2018 (1), R01HL072771 (1), U01HL088942 (1)