Gastroesophageal Reflux: Clinical Trials

738 completed, 179 unknown, 109 recruiting, 82 terminated. 477 Not applicable, 129 Phase 3, 127 Phase 4, 87 Phase 2, 82 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	477	Completed 238, Unknown 72, Recruiting 57, Terminated 32, Not yet recruiting 31, Withdrawn 25, Active not recruiting 13, Enrolling by invitation 7, Suspended 2
Phase 3	129	Completed 99, Unknown 13, Terminated 6, Withdrawn 6, Not yet recruiting 2, Recruiting 2, Active not recruiting 1
Phase 4	127	Completed 76, Unknown 19, Withdrawn 10, Terminated 9, Recruiting 8, Not yet recruiting 4, Active not recruiting 1
Phase 2	87	Completed 58, Unknown 11, Terminated 10, Withdrawn 4, Recruiting 3, Not yet recruiting 1
Phase 1	82	Completed 64, Unknown 8, Withdrawn 4, Terminated 3, Recruiting 2, Not yet recruiting 1
Early Phase 1	8	Completed 3, Unknown 3, Recruiting 1, Terminated 1

Follow Gastroesophageal Reflux: new trials by email Literature Review of Gastroesophageal Reflux trials Research Report on Gastroesophageal Reflux

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Oral Fosamprenavir for GERD Fosamprenavir Calcium 700 MG Oral Tablet, Placebo - Refractory Gastroesophageal Reflux Disease, Gastroesophageal Reflux Disease	Phase 2	Not yet recruiting	Medical College of Wisconsin	60	2027-10-01	2026-09-10
Endoscopic Band Ligation for Treating Reflux Disease Band Ligation - GERD	Not applicable	Not yet recruiting	El Katib Hospital	10	2027-01-01	2026-09-10
Pilot Study of Salivary Bile Acids and Pepsin as Predictive Biomarkers of Reflux Disease After Sleeve Gastrectomy Reflux Disease, Gastro-Esophageal, Sleeve Gastrectomy		Not yet recruiting	Hospital de Mataró	60	2026-12-01	2026-05-26
PROPER-GERD: A Prospective Crossover Study to Evaluate Probe Placement Optimization for Reflux Testing in Women and Lower-BMI Patients Bravo pH monitoring sessions - GERD	Not applicable	Not yet recruiting	University of Chicago	80	2026-12-01	2026-10-13
Symptom Severity, Posture, Pain, and Physical Activity in Gastroesophageal Reflux Disease Gastroesophageal Reflux Disease (GERD), Symptom		Recruiting	Karabuk University	51	2026-11-12	2026-11-09
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (AU) Transcatheter mitral valve repair - Mitral Valve (MV) Regurgitation	Not applicable	Not yet recruiting	Polares Medical SA	15	2026-11-01	2026-08-11
Gastroesophageal Reflux and Respiratory Function in Patients Undergoing Abdominoplasty Assessment of anthropometric and sociodemographic data and clinical history, Assessment of Symptoms, Quality of Life, and Physical Activity, Spirometric assessment - Abdominoplasty, Diaphragm		Not yet recruiting	Universidade Federal de Pernambuco	30	2026-11-01	2026-10-16
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (FR) Transcatheter mitral valve repair (MRace Implant and Delivery System) - Mitral Valve (MV) Regurgitation	Not applicable	Not yet recruiting	Polares Medical SA	20	2026-11-01	2026-08-11
A Prospective, Multicenter, Single-Arm Study to Support the Clinical Evidence Base for MRace as a Treatment Option for FMR Patients With Complex M-TEER Anatomies (DE) Transcatheter mitral valve repair (MRace Implant and Delivery System) - Mitral Valve (MV) Regurgitation	Not applicable	Not yet recruiting	Polares Medical SA	20	2026-11-01	2026-08-11
Effects of Tirzepatide on Esophagogastric Junction Mechanics, Reflux Burden, and Gastric Physiology in Adults With Obesity Placebo, Tirzepatide - Obese Adults	Phase 4	Not yet recruiting	Mayo Clinic	30	2026-10-26	2026-10-26
De Novo Gastroesophageal Reflux Disease After Sleeve Gastrectomy With and Without Omentopexy Sleeve Gastrectomy With Omentopexy, Sleeve Gastrectomy Without Omentopexy - Omentopexy, Sleeve Gastrectomy	Not applicable	Not yet recruiting	China-Japan Friendship Hospital	140	2026-10-15	2026-10-15
Fosamprenavir for Laryngopharyngeal Upper Airway Tissue Treatment and Enzyme Reduction Fosamprenavir Calcium, Placebo - Laryngopharyngeal Reflux	Phase 2	Recruiting	Medical College of Wisconsin	104	2026-10-01	2026-09-10
Antireflux Surgery Without Preoperative Esophageal Manometry Preoperative workup without high-resolution esophageal manometry, Standard preoperative workup with high-resolution esophageal manometry - GERD, Hiatal Hernia	Not applicable	Not yet recruiting	McMaster University	96	2026-10-01	2026-08-10
A Study to Evaluate the Efficacy and Safety of Vonoprazan 10 mg Compared to Placebo for Relief of Episodic Heartburn in Participants With Symptomatic Non-Erosive Gastroesophageal Reflux Disease Through 24 Weeks Vonoprazan, Placebo - Symptomatic Non-erosive Gastroesophageal Reflux Disease	Phase 3	Recruiting	Phathom Pharmaceuticals, Inc.	500	2026-09-25	2026-10-07
Effect of Omeprazole on Gut Microbiota in Adults With Obesity and GERD Omeprazole, Standard Non-pharmacological Recommendations for GERD - Obesity & Overweight, Gastroesophageal Reflux Disease	Phase 4	Not yet recruiting	Federal State Budgetary Scientific Institution	26	2026-09-25	2026-10-01
Preoperative Predictors of Symptom Improvement After Laparoscopic Fundoplication Laparoscopic Nissen fundoplication, Laparoscopic Toupet fundoplication - Gastroesophageal Reflux Disease, Hiatal Hernia		Recruiting	Minia University	470	2026-09-20	2026-09-22
POEM Versus Laparoscopic Heller Myotomy With Dor Fundoplication for Esophageal Achalasia Peroral endoscopic myotomy, Laparoscopic Heller myotomy with Dor fundoplication - Esophageal Achalasia, Esophageal Motility Disorders	Not applicable	Recruiting	Minia University	220	2026-09-20	2026-09-22
A Study to Evaluate Tegoprazan as a Diagnostic Tool for GERD Tegoprazan 50 mg, Placebo - GERD (Gastroesophageal Reflux Disease)	Phase 4	Not yet recruiting	HK inno.N Corporation	100	2026-09-01	2026-09-17
Catheter Ablation for AF in Patients With Severe Mitral Regurgitation After Successful Transcatheter Mitral-Valve Repair Usual Care, Pulmonary Vein Isolation - Atrial Fibrillation (AF), Mitral Valve (MV) Regurgitation	Not applicable	Not yet recruiting	Atrial Fibrillation Network	956	2026-09-01	2026-09-10
A Comparison of Cosmos Rx Medication Adherence Platform vs. Pharmacy Fill Adherence Measures Fortiskap - GERD (Gastroesophageal Reflux Disease)	Not applicable	Not yet recruiting	Cosmos Rx, Inc	50	2026-09-01	2026-07-17

Showing 20 of 1257. Sign in to see all of them.

Narrower conditions

Heartburn (93)  ·  Barrett Esophagus (69)  ·  Laryngopharyngeal Reflux (53)  ·  Obesity (49)  ·  Non-Erosive Reflux Disease (46)  ·  Dyspepsia (37)  ·  Hernia, Hiatal (37)  ·  Esophagitis (33)  ·  Esophagitis, Peptic (29)  ·  Deglutition Disorders (25)  ·  Obesity, Morbid (22)  ·  Respiratory Aspiration of Gastric Contents (21)  ·  Cough (20)  ·  Asthma (19)

Broader conditions

Digestive System Diseases (1254)  ·  Esophageal Motility Disorders (1250)  ·  Esophageal Diseases (1245)  ·  Gastrointestinal Diseases (1243)  ·  Deglutition Disorders (1232)  ·  Pathological Conditions, Signs and Symptoms (361)  ·  Signs and Symptoms (275)  ·  Respiratory Tract Diseases (162)  ·  Signs and Symptoms, Digestive (145)  ·  Neoplasms (85)  ·  Gastroenteritis (84)  ·  Nutritional and Metabolic Diseases (83)  ·  Respiration Disorders (75)  ·  Body Weight (74)

Interventions

Esomeprazole (106)  ·  Rabeprazole (53)  ·  Lansoprazole (52)  ·  Omeprazole (46)  ·  Pantoprazole (41)  ·  Dexlansoprazole (27)  ·  Fundoplication (19)  ·  Proton Pump Inhibitors (18)  ·  Endoscopy, Digestive System (15)  ·  1-(5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl)-N-methylmethanamine (14)  ·  Endoscopy (14)  ·  Domperidone (12)  ·  lesogaberan (10)  ·  Biopsy (8)  ·  BID protein, human (7)

Sponsors

AstraZeneca (91)  ·  Mayo Clinic (31)  ·  Takeda (31)  ·  Asian Institute of Gastroenterology, India (14)  ·  Chinese University of Hong Kong (14)  ·  Johns Hopkins University (11)  ·  Midwest Biomedical Research (11)  ·  Universitaire Ziekenhuizen KU Leuven (11)  ·  Assiut University (10)  ·  Chong Kun Dang Pharmaceutical (10)  ·  Seoul National University Hospital (9)  ·  Edwards Lifesciences (8)  ·  Eisai Inc. (8)  ·  Medical College of Wisconsin (8)  ·  National Taiwan University Hospital (8)

Countries

United States (433)  ·  Italy (75)  ·  South Korea (73)  ·  Germany (69)  ·  China (63)  ·  France (62)  ·  Belgium (54)  ·  United Kingdom (52)  ·  Canada (45)  ·  Netherlands (35)  ·  Poland (34)  ·  Switzerland (31)  ·  Taiwan (29)  ·  Brazil (27)  ·  Austria (25)

Top investigators

Prateek Sharma, MD (12)  ·  Ronnie Fass, MD (10)  ·  Paula Fernstrom (7)  ·  Michael Vaezi, MD, PhD (6)  ·  Nicholas Shaheen, MD, MPH (6)  ·  Marie Sundin (5)  ·  Stuart J Spechler, MD (5)  ·  Sergey Morozov, MD, PhD (4)

Results publications

PMID 19735233, PMID 22146488, PMID 1451966, PMID 18590344, PMID 18590345, PMID 19737151, PMID 20010088, PMID 21114792, PMID 21129076, PMID 21586712, PMID 21740077, PMID 23689261, PMID 23853213, PMID 25304129, PMID 25330784, PMID 25478944, PMID 25858519, PMID 28487349, PMID 29408585, PMID 30711626, PMID 35432994, PMID 35579516, PMID 36270615, PMID 8784314, PMID 10875990, PMID 11190378, PMID 11275880, PMID 11677201, PMID 11709516, PMID 11725167, PMID 11736981, PMID 11804862, PMID 12010876, PMID 12050578, PMID 12110413, PMID 12119661, PMID 12141885, PMID 12150380, PMID 12161727, PMID 12184547, PMID 12200646, PMID 12374519, PMID 12540773, PMID 12556808, PMID 12558356, PMID 12797675, PMID 12860585, PMID 12872107, PMID 14499769, PMID 14557228

NIH funding

2008 (6), 2015 (3), 2025 (3), 2023 (2), K23AT009218 (2), 1UM1HL119089 (1), 2009 (1), 2014 (1), 2019 (1), K23DK066165 (1), K23DK068149 (1), K23DK115827 (1), K23DK125266 (1), K24DK083268 (1), P30CA014520 (1)