8 unknown, 6 completed, 2 recruiting, 1 enrolling by invitation. 18 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 18 | Unknown 8, Completed 6, Recruiting 2, Enrolling by invitation 1, Terminated 1 |
Follow Mitral Valve Insufficiency: new trials by email Literature Review of Mitral Valve Insufficiency trials Research Report on Mitral Valve Insufficiency
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients Without an Indication for Oral Anticoagulant Experimental: Aspirin monotherapy, Active Comparator: Aspirin+Clopidogrel - Mitral Regurgitation | Phase 4 | Recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 1032 | 2025-07-31 | 2026-03-09 |
| STrategies for Antithrombotic tReatment Following Transcatheter Edge-to-Edge Repair in Patients With an Indication for Oral Anticoagulant Experimental: Rivaroxaban monotherapy, Active Comparator: Rivaroxaban+Clopidogrel - Mitral Regurgitation | Phase 4 | Recruiting | Chinese Academy of Medical Sciences, Fuwai Hospital | 880 | 2025-06-13 | 2026-03-09 |
| Optimal PeriproCeduraL AnticOagulation in Structural Transseptal Interventions early anticoagulation, late anticoagulation - Mitral Regurgitation, Atrial Fibrillation | Phase 4 | Enrolling by invitation | National Institute of Cardiology, Warsaw, Poland | 410 | 2022-03-13 | 2026-09-17 |
| The Prognostic Impact of Using High-dose Hydralazine in Severe Systolic Heart Failure With Hemodynamically Significant Mitral Regurgitation evidence-based medications vs. high-dose hydralazine + evidence-based medications - Systolic Heart Failure Stage D (Disorder), Mitral Regurgitation | Phase 4 | Unknown | Kaohsiung Veterans General Hospital. | 400 | 2017-01-01 | 2022-01-06 |
| Dabigatran in Patients With Atrial Fibrillation and Mitral Biological Prostheses Dabigatran Etexilate, Warfarin - Mitral Valve Stenosis and Insufficiency, Atrial Fibrillation | Phase 4 | Unknown | Research Institute for Complex Problems of Cardiovascular Diseases, Russia | 40 | 2016-06-29 | 2017-06-12 |
| Pharmacological Reduction of Functional, Ischemic Mitral REgurgitation LCZ696, Valsartan - Mitral Valve Insufficiency, Left Ventricular Dysfunction | Phase 4 | Completed | Asan Medical Center | 118 | 2016-03-01 | 2018-01-09 |
| (MitraClip in Non-Responders to Cardiac Resynchronization Therapy) MITRACLIP - MITRAL REGURGITATION | Phase 4 | Unknown | Hospital Clinic of Barcelona | 30 | 2015-09-01 | 2017-02-23 |
| High and Intermediate Risk Degenerative Mitral Regurgitation Treatment: A Trial Comparing MitraClip® to Surgical Therapy MitraClip®, Mitral valve Surgery - Mitral Valve Insufficiency | Phase 4 | Terminated | University of Zurich | 294 | 2015-04-01 | 2016-09-09 |
| Effect of Ranolazine on Valvular Disease in Patients With Pacemakers Ranolazine (Active drug), Placebo - Ischemic Mitral Regurgitation | Phase 4 | Unknown | University Cardiology | 50 | 2013-11-01 | 2013-11-08 |
| The Use of Paravertebral Block for Cardiac Surgery Paravertebral Block, Placebo Comparator - Mitral Valve Insufficiency | Phase 4 | Completed | NYU Langone Health | 60 | 2013-01-01 | 2016-03-15 |
| Abrogation of Mitral Regurgitation Using the MitraClip System in High-Risk Patients Unsuitable for Surgery percutaneous treatment by implanting a Mitra Clip device - Mitral Regurgitation | Phase 4 | Unknown | Deutsches Herzzentrum Muenchen | 100 | 2011-09-01 | 2011-09-09 |
| Surgical Treatment of Ischemic Mitral Regurgitation CABG, CABG combined with MV repair with remodeling annuloplasty rigid ring, CABG combined with MV repair with remodeling annuloplasty rigid ring and endoventricularplasty of subvalvular apparatus - Mitral Valve Insufficiency | Phase 4 | Unknown | Meshalkin Research Institute of Pathology of Circulation | 420 | 2011-05-01 | 2015-09-23 |
| Beating Versus Arrested Heart for Mitral Valve Replacement Mitral valve replacement, mitral valve replacement - Mitral Stenosis, Mitral Insufficiency | Phase 4 | Completed | Federal University of Bahia | 34 | 2010-04-01 | 2012-07-18 |
| Pilot Study of Lovaza (Omega 3 Fatty Acids) to Improve Cardiac Antioxidant/Anti-inflammatory Profile Before Cardiac Surgery Lovaza group - Mitral Valve Regurgitation, Left Atrium Dilatation and Hypertrophy | Phase 4 | Unknown | East Carolina University | 24 | 2010-01-01 | 2013-09-10 |
| Study of Administration Of Antithrombin in Patients With Low Plasmatic Levels of Antithrombin After Cardiac Surgery antithrombin III - Aortic Valve Insufficiency, Aortic Valve Stenosis | Phase 4 | Unknown | University of Bari | 90 | 2009-09-01 | 2010-09-15 |
| CG Future® Annuloplasty Ring/Band Clinical Trial CG Future Annuloplasty Ring/Band - Mitral Valve Insufficiency | Phase 4 | Completed | Medtronic Cardiac Rhythm and Heart Failure | 77 | 2009-06-01 | 2015-10-29 |
| Effect of Etomidate on Hemodynamics and Adrenocortical Function After Cardiac Surgery Etomidate, Propofol, Hydrocortisone - Coronary Artery Disease, Mitral Valve Regurgitation | Phase 4 | Completed | Insel Gruppe AG, University Hospital Bern | 130 | 2006-11-01 | 2010-03-04 |
| Angiotensin-II Blockade in Mitral Regurgitation Candesartan, atacand, Placebo - Mitral Regurgitation | Phase 4 | Completed | Mayo Clinic | 60 | 1998-08-01 | 2010-10-15 |
Mitral Valve Stenosis (3) · Atrial Fibrillation (2) · Cardiovascular Diseases (2) · Embolism and Thrombosis (2) · Hemorrhage (2) · Myocardial Infarction (2) · Stroke (2) · Acute Coronary Syndrome (1) · Addison Disease (1) · Aortic Valve Insufficiency (1) · Aortic Valve Stenosis (1) · Coronary Artery Disease (1) · Heart Failure, Systolic (1) · Hypertrophy (1)
Heart Diseases (18) · Heart Valve Diseases (18) · Cardiovascular Diseases (16) · Pathological Conditions, Signs and Symptoms (6) · Pathologic Processes (5) · Myocardial Ischemia (4) · Vascular Diseases (4) · Arrhythmias, Cardiac (2) · Brain Diseases (2) · Central Nervous System Diseases (2) · Cerebrovascular Disorders (2) · Infarction (2) · Ischemia (2) · Necrosis (2) · Nervous System Diseases (2)
Antithrombin III (1) · Cosyntropin (1) · Dabigatran (1) · Etomidate (1) · Hydralazine (1) · Hydrocortisone (1) · Propofol (1) · Ranolazine (1) · Sodium Chloride (1) · Valsartan (1) · Warfarin (1) · candesartan (1) · candesartan cilexetil (1) · sacubitril and valsartan sodium hydrate drug combination (1)
Chinese Academy of Medical Sciences, Fuwai Hospital (2) · Asan Medical Center (1) · Deutsches Herzzentrum Muenchen (1) · East Carolina University (1) · Federal University of Bahia (1) · Hospital Clinic of Barcelona (1) · Insel Gruppe AG, University Hospital Bern (1) · Kaohsiung Veterans General Hospital. (1) · Mayo Clinic (1) · Medtronic Cardiac Rhythm and Heart Failure (1) · Meshalkin Research Institute of Pathology of Circulation (1) · NYU Langone Health (1) · National Institute of Cardiology, Warsaw, Poland (1) · Research Institute for Complex Problems of Cardiovascular Diseases, Russia (1) · University Cardiology (1)
United States (4) · Germany (3) · China (2) · Italy (2) · Poland (2) · Russia (2) · Switzerland (2) · Belgium (1) · Brazil (1) · Greece (1) · Norway (1) · South Korea (1) · Spain (1) · Taiwan (1)
Xiangbin Pan, MD,PhD (2) · Alexander Cherniavskiy, MD, PhD (1) · D C Iliopoulos, Prof (1) · Domenico Paparella, Investigator (1) · Duk-Hyun Kang, M.D. (1) · Ethan J Anderson, PhD (1) · F Riess, Dr. (1) · Francesco Maisano, Prof. (1) · G El Khoury, Dr (1) · Hasema Lesevic, MD (1) · Joerg Hausleiter, MD (1) · Juergen Pache, MD (1) · K Matschke, Dr. (1)
PMID 41616808, PMID 26914224, PMID 30586756, PMID 36124767, PMID 38401649