20 completed, 12 unknown, 8 recruiting, 3 active not recruiting. 17 Not applicable, 3 Phase 1, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 17 | Completed 10, Active not recruiting 3, Unknown 3, Terminated 1 |
| Phase 1 | 3 | Completed 2, Unknown 1 |
| Phase 2 | 2 | Completed 1, Terminated 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Mitral Valve Prolapse: new trials by email Literature Review of Mitral Valve Prolapse trials Research Report on Mitral Valve Prolapse
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mitral Valve Prolapse Arrhythmic Risk Risk prediction model - Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest | Recruiting | Oslo University Hospital | 500 | 2026-08-07 | 2026-09-29 | |
| The Role of cardIac magNeTic rEsonance in surGical Decision Making in Patients With Severe pRimAry miTral rEgurgitation mitral valve surgery, Clinical Follow up - Mitral Valve Prolapse, Mitral Regurgitation | Not applicable | Active not recruiting | Centro Cardiologico Monzino | 260 | 2025-12-01 | 2026-06-10 |
| Korea VHD Echo Study: Surveillance of Aortic, Mitral & Tricuspid Patients - Insights From Real-world Practice Heart Valve Diseases, Aortic Valve Stenosis | Not yet recruiting | Yonsei University | 30000 | 2025-08-01 | 2025-07-16 | |
| AI-Based Shape and Function Analysis of Mitral Valve Prolapse Using 3D Ultrasound Mitral Valve Prolapse, Myxomatous Mitral Valve Degeneration | Recruiting | IRCCS Policlinico S. Donato | 150 | 2025-05-26 | 2026-02-03 | |
| A Study of Mitral Annular Disjunction in Mitral Valve Prolapse Patients and Arrhythmia Risk Mitral Valve Prolapse, Mitral Valve Insufficiency | Not yet recruiting | Assiut University | 30 | 2025-02-14 | 2024-12-19 | |
| Mitro-annular Disjunction in Cardiac Magnetic Resonance Mitral Valve Prolapse Syndrome, Arrhythmogenic Bileaflet Mitral Prolapse | Completed | IRCCS San Raffaele | 4000 | 2024-05-15 | 2026-01-15 | |
| Arrhythmic Mitral Valve Prolapse Detection Using Long-term Ambulatory Rhythm Monitoring 14-day rhythm monitoring - Mitral Valve Prolapse, Ventricular Arrythmia | Not applicable | Completed | Universitaire Ziekenhuizen KU Leuven | 60 | 2024-05-01 | 2026-07-21 |
| Ventricular Arrhythmias in Patients Undergoing Mitral Valve Surgery Mitral valve surgery - Mitral Regurgitation, Mitral Valve Prolapse | Recruiting | Karolinska Institutet | 90 | 2024-02-21 | 2025-09-11 | |
| PRIMARY Ancillary Substudy Cardiac Magnetic Resonance Imaging, ZioPatch Monitoring, Myocardial Tissue Biopsy - Mitral Valve Prolapse, Left Ventricular Fibrosis | Not applicable | Active not recruiting | Annetine Gelijns | 250 | 2023-10-16 | 2026-09-08 |
| Patient-Centered Approach for Treatment Decisions in Mitral Valve Prolapse Focus Groups/Quantitative Survey for Patients, Focus Group/Quantitative Survey for HCPs, Qualitative Focus Group - Mitral Valve Prolapse | Recruiting | Northwell Health | 150 | 2023-09-01 | 2024-12-17 | |
| Multiparametric SCores for Prediction of Myocardial fIbrosis in Patients With MITral vAlve pRolapse Mitral Valve Prolapse | Recruiting | Centro Cardiologico Monzino | 300 | 2023-06-19 | 2026-09-21 | |
| Effect and Safety of Flecainide and Metoprolol Versus Metoprolol Alone to Suppress Ventricular Arrhythmias in Arrhythmic Mitral Valve Prolapse Flecainide, Metoprolol - Mitral Valve Prolapse, Ventricular Arrhythmias and Cardiac Arrest | Phase 3 | Recruiting | Oslo University Hospital | 50 | 2023-01-04 | 2025-07-30 |
| European FIH Study - NeoChord Transcatheter Mitral Repair System for Symptomatic Mitral Regurgitation NeoChord Transcatheter Mitral Repair System (or "NeoChord System") - Mitral Valve Insufficiency, Mitral Valve Prolapse | Not applicable | Unknown | NeoChord | 30 | 2022-08-01 | 2022-06-21 |
| STretch and Myocardial Characterization in Arrythmogenic Mitral Valve Prolapse-2 Cardiac MRI, Blood collection, Prolongation of the MRI examination - Mitral Valve Prolapse | Not applicable | Active not recruiting | Central Hospital, Nancy, France | 280 | 2021-08-30 | 2026-06-18 |
| Erector Spinae Plane Block for Minimally Invasive Mitral Valve Surgery Erector spinae plane catheter with 0.5% Ropivacaine, Erector spinae plane catheter with saline - Mitral Regurgitation, Mitral Valve Insufficiency | Not applicable | Unknown | University of California, San Francisco | 50 | 2021-04-01 | 2021-03-03 |
| Mitral Valve Prolapse, Arrhythmias and Mitral Valve Surgery Mitral Valve Prolapse, Cardiac Arrhythmia | Unknown | Ospedale San Raffaele | 200 | 2021-02-10 | 2022-10-04 | |
| Neochordae Technique in Mitral Valve Repair adjustable neochordae Technique - Mitral Valve Prolapse, Mitral Regurgitation | Phase 1 | Unknown | National Heart Institute, Egypt | 30 | 2020-03-02 | 2020-03-09 |
| Multicenter Post-Market Observational Registry of the NeoChord Artificial Chordae Delivery System NeoChord Artificial Chordae Delivery System, Model DS1000 - Mitral Regurgitation, Mitral Valve Disease | Recruiting | NeoChord | 500 | 2020-02-09 | 2020-07-10 | |
| Patient Specific Mitral Valve Modeling for Surgical Planning and Training Mitral Valve Model - Mitral Valve Prolapse, Mitral Regurgitation | Unknown | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 65 | 2018-07-01 | 2018-08-01 | |
| Operative Mitral Valve Reconstruction in Functional mv Insufficiency With Reduced Systolic Ventricle Function mitral valve repair - Mitral Valve Insufficiency, Left Ventricular Systolic Dysfunction | Completed | Institut für Pharmakologie und Präventive Medizin | 105 | 2018-06-05 | 2023-09-28 |
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Mitral Valve Insufficiency (24) · Heart Failure (5) · Heart Valve Diseases (5) · Coronary Artery Disease (4) · Myocardial Infarction (4) · Cardiovascular Diseases (3) · Heart Diseases (3) · Death, Sudden, Cardiac (2) · Heart Arrest (2) · Heart Murmurs (2) · Systolic Murmurs (2) · Tricuspid Valve Insufficiency (2) · Ventricular Premature Complexes (2) · Aortic Diseases (1)
Heart Valve Prolapse (47) · Cardiovascular Diseases (44) · Heart Diseases (44) · Heart Valve Diseases (42) · Pathological Conditions, Signs and Symptoms (12) · Pathologic Processes (8) · Vascular Diseases (5) · Arterial Occlusive Diseases (4) · Arteriosclerosis (4) · Coronary Disease (4) · Infarction (4) · Ischemia (4) · Myocardial Ischemia (4) · Necrosis (4) · Cardiac Conduction System Disease (3)
Blood Specimen Collection (1) · Exercise Test (1) · Flecainide (1) · Focus Groups (1) · Magnetic Resonance Spectroscopy (1) · Metoprolol (1) · Mitral Valve Annuloplasty (1) · Ropivacaine (1) · Sodium Chloride (1) · Sternotomy (1) · salicylhydroxamic acid (1)
Abbott Medical Devices (5) · Edwards Lifesciences (5) · NeoChord (4) · CSD Labs GmbH (2) · Central Hospital, Nancy, France (2) · Centro Cardiologico Monzino (2) · Oslo University Hospital (2) · Ospedale San Raffaele (2) · Annetine Gelijns (1) · Assiut University (1) · Centre Hospitalier Universitaire, Amiens (1) · Eric Y. Yang, MD PhD (1) · French Cardiology Society (1) · IRCCS Policlinico S. Donato (1) · IRCCS San Raffaele (1)
United States (10) · Italy (9) · France (7) · Germany (5) · Canada (3) · Poland (3) · United Kingdom (3) · Belgium (2) · Egypt (2) · Lithuania (2) · Norway (2) · Switzerland (2) · Austria (1) · Denmark (1) · Greece (1)
Ted Feldman, M.D. (3) · Boguslaw Kapelak, MD, PhD (2) · Alexander Iribarne, MD, MS, FACC (1) · Alison Duncan, MD (1) · Amr Zaher, M.D. (1) · Andres Beiras Fernandez, MD PhD (1) · Anno Diegeler, MD (1) · Antonio Esposito, MD (1) · Donald D Glower Jr., MD (1) · Donald G Glower Jr., MD (1) · Donald G Glower Jr.,, M.D. (1) · Eivind W Aabel, MD PhD (1) · Evaldas Girdauskas, MD (1) · Gerhard Pichler, MD (1)
PMID 25593120, PMID 30586701, PMID 21422390, PMID 21492763, PMID 23633132, PMID 25011722, PMID 33038223, PMID 37204382, PMID 16305903, PMID 16325053, PMID 17080467, PMID 17570634, PMID 19679246, PMID 20598968, PMID 21463154, PMID 21741608, PMID 22222076, PMID 22422577, PMID 22423604, PMID 22464260, PMID 23608290, PMID 23665364, PMID 24014834, PMID 24076529, PMID 24184254, PMID 26309835, PMID 26718672, PMID 27436878, PMID 27777278, PMID 28566364, PMID 29102688, PMID 29535132, PMID 30077993, PMID 33017212, PMID 36581901, PMID 36750353, PMID 37376817, PMID 40783073
U01HL088942 (1)