56 completed, 13 unknown, 10 terminated, 8 recruiting. 99 Phase 2, 19 Phase 3, 15 Phase 1.
Follow Leg Injuries: new trials by email Literature Review of Leg Injuries trials Research Report on Leg Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline - Postoperative Delirium, Hip Fractures | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 130 | 2026-10-01 | 2026-09-09 |
| Multiregion BHA in Open Tibia Fractures BHA - Tibial Fractures | Phase 2 | Withdrawn | Carmell Therapeutics Corporation | 2026-07-01 | 2024-02-08 | |
| CITADEL: Effectiveness of CITicoline in Preventing Cognitive Decline After DELirium Citicoline - Cognitive Decline, Delirium | Phase 2 | Recruiting | University of Milano Bicocca | 122 | 2026-06-03 | 2026-09-09 |
| Losartan to Improve Outcomes After Multi-ligament Knee Injury losartan 25 mg, Placebo capsule - Multi-ligament Knee Injury | Phase 2 | Recruiting | Brigham and Women's Hospital | 90 | 2025-10-01 | 2026-01-20 |
| Non-Narcotic Pain Control After ACL Reconstruction dispense of study drug, Ketorolac - ACL - Anterior Cruciate Ligament Rupture, ACL Injuries | Phase 2 | Active not recruiting | The Cleveland Clinic | 30 | 2025-07-15 | 2026-08-24 |
| Safety and Efficacy of Isomyosamine in Reducing Inflammation and Treating Muscle Loss in Older Adults After Hip or Thigh Bone Fractures Isomyosamine 250mg, Placebo 250 mg - Sarcopenia in Elderly, Frailty | Phase 2 | Not yet recruiting | TNF Pharmaceuticals, Inc. | 60 | 2025-05-01 | 2025-04-24 |
| Vitamin D to Improve Quadricep Muscle Strength Vitamin D3, Placebo - Anterior Cruciate Ligament Injuries, Quadriceps Muscle Atrophy | Phase 2 | Recruiting | Chinese University of Hong Kong | 60 | 2025-03-17 | 2025-03-18 |
| Assessment of Medrol Dosepak to Reduce Opioid Consumption in Foot and Ankle Surgical Patients medrol dosepak, HYDROcodone Oral Tablet - Foot Injuries and Disorders, Ankle Injuries and Disorders | Phase 2 | Recruiting | Emory University | 180 | 2025-01-27 | 2026-03-09 |
| BDSF Vs DHS With Anterotational Screw in Vertical FNF Dynamic Hip Screw with Anterotation Screw Fixation, Biplane Double-Supported Screw Fixation - Evaluation of BDSF in FNF | Phase 2 | Active not recruiting | Ain Shams University | 30 | 2024-09-01 | 2026-10-26 |
| Comparison of EOSP Between Usg Guided S-FICB vs USG Guided PENG Block in Pts Undergoing Femur Fracture Surgery USG GUIDED SUPRA-INGUINAL FASCIA ILIACA BLOCK, PERICAPSULAR NERVE BLOCK - Post Operative Pain, Bradycardia | Phase 2 / Phase 3 | Recruiting | Sahiwal medical college sahiwal | 70 | 2024-07-10 | 2025-10-23 |
| Essential Amino Acid Supplementation for Femoral Fragility Fractures Essential Amino Acid Supplementation - Femoral Fracture, Fragility Fracture | Phase 2 | Recruiting | Michael C Willey | 60 | 2024-06-17 | 2026-10-07 |
| HIP Fracture Oral thromboPROphylaxis (Hip PRO Pilot) Rivaroxaban 10mg, acetylsalicylic acid (ASA) 81mg Oral Tablet - Hip Fractures | Phase 2 | Recruiting | University of Calgary | 250 | 2024-05-21 | 2026-10-09 |
| Preventing Injured Knees From osteoArthritis: Severity Outcomes Metformin, Placebo - Osteoarthritis, Knee, Post-traumatic Osteoarthritis | Phase 2 | Recruiting | Brigham and Women's Hospital | 512 | 2024-05-06 | 2026-10-15 |
| Effect of Adding Magnesium Sulphate in Pericapsular Nerve Group Block Pericapsular nerve group block using bupivicaine and magnesium sulphate - Hip Fractures | Phase 2 / Phase 3 | Unknown | Assiut University | 62 | 2024-01-01 | 2023-12-22 |
| Platelet-Rich Plasma and the Effects of NSAIDs on Pain and Functional Scores in Knee Osteoarthritis Ibuprofen and PRP, Acetaminophen and PRP, Placebo and PRP - Osteoarthritis of the Knee, Degenerative Osteoarthritis | Phase 1 / Phase 2 | Withdrawn | QC Kinetix LLC | 2023-11-01 | 2024-10-09 | |
| Effectiveness Comparison Between Continuous Cryotherapy and Ice Pack Therapy After Anterior Cruciate Ligament Reconstruction Surgery Continuous compression cryotherapy, Conventional ice treatment - Postoperative Pain, Acute, Anterior Cruciate Ligament Injuries | Phase 2 / Phase 3 | Completed | University Medical Center Ho Chi Minh City (UMC) | 72 | 2023-06-01 | 2024-10-08 |
| Effect of Palmitoylethanolamide on Reducing Opioid Consumption for Below Knee Fracture Fixation Palmitoylethanolamide, Placebo - Tibial Fractures, Fibula Fracture | Phase 2 | Withdrawn | University of California, Irvine | 2023-05-01 | 2023-05-09 | |
| PFNA vs Dual Mobility in Treatment of Unstable Trochanteric Fractures Proximal Femoral Nail, Dual Mobility Arthroplasty - Trochanteric Fractures | Phase 2 | Unknown | Cairo University | 40 | 2023-01-01 | 2023-01-11 |
| Synovial Tissue and Fat Pad Stromal Vascular Fraction Bioengineering in Patients With Knee Articular Cartilage Injury Synovial Tissue and Fat Pad Stromal Vascular Fraction - Cell- and Tissue-Based Therapy, Cartilage Injury | Phase 1 / Phase 2 | Unknown | University of Sao Paulo General Hospital | 10 | 2022-04-01 | 2021-11-15 |
| Clinical Efficacy of Exosome in Degenerative Meniscal Injury SF-MSC-EX, SF-MSC - Knee; Injury, Meniscus (Lateral) (Medial), Meniscus Tear | Phase 2 | Unknown | Eskisehir Osmangazi University | 30 | 2022-03-01 | 2022-03-04 |
Showing 20 of 99. Sign in to see all of them.
Hip Fractures (34) · Anterior Cruciate Ligament Injuries (21) · Knee Injuries (13) · Ankle Injuries (10) · Tibial Fractures (8) · Ankle Fractures (5) · Fractures, Bone (5) · Wounds and Injuries (5) · Disease (4) · Femoral Fractures (4) · Femoral Neck Fractures (4) · Muscular Atrophy (4) · Osteoarthritis (4) · Osteoarthritis, Knee (4) · Pain, Postoperative (4)
Wounds and Injuries (94) · Fractures, Bone (50) · Hip Injuries (38) · Femoral Fractures (37) · Pathological Conditions, Signs and Symptoms (25) · Knee Injuries (22) · Signs and Symptoms (19) · Neurologic Manifestations (18) · Musculoskeletal Diseases (15) · Pathologic Processes (15) · Nervous System Diseases (12) · Joint Diseases (8) · Neuromuscular Manifestations (7) · Arthritis (6)
Saline Solution (5) · Sodium Chloride (5) · Acetaminophen (3) · Anterior Cruciate Ligament Reconstruction (2) · Betamethasone (2) · Bupivacaine (2) · Dexmedetomidine (2) · Gabapentin (2) · Interleukin 1 Receptor Antagonist Protein (2) · Ketorolac (2) · Ketorolac Tromethamine (2) · Ropivacaine (2) · Teriparatide (2) · Tranexamic Acid (2) · betamethasone sodium phosphate (2)
Assiut University (3) · Hadassah Medical Organization (3) · Hospital for Special Surgery, New York (3) · Ain Shams University (2) · Banc de Sang i Teixits (2) · Brigham and Women's Hospital (2) · Chinese University of Hong Kong (2) · Duke University (2) · Isfahan University of Medical Sciences (2) · Washington University School of Medicine (2) · Air Liquide Santé International (1) · AlgoRx Pharmaceuticals (1) · Amgen (1) · Andrews Research & Education Foundation (1) · Arcadia University (1)
United States (43) · Australia (6) · Germany (6) · Israel (6) · Spain (6) · Canada (5) · Denmark (5) · Hungary (5) · Sweden (5) · United Kingdom (5) · Belgium (4) · Czechia (4) · Egypt (4) · Italy (4) · Netherlands (4)
Jeri W Nieves, PhD (2) · Adam W Anz, MD (1) · Adeel Riaz, MD (1) · Adi Fridman, Dr. (1) · Afshin Farhadi, MD (1) · Ahmed A Khater, MD (1) · Alaa M Attia, Professor (1) · Amal Khoury, M.D (1) · Andri MT Lubis, MD, PhD (1) · Anne R Bass, MD (1) · Ariana Nelson, MD (1) · Arny Ferrando, PhD (1) · Austin Stone, MD (1) · Austin Stone, MD, PhD (1)
PMID 11090729, PMID 12492792, PMID 15329580, PMID 16835255, PMID 17244900, PMID 17904460, PMID 18088349, PMID 18567675, PMID 19460169, PMID 21067829, PMID 21194441, PMID 22091574, PMID 22273632, PMID 22631877, PMID 22863663, PMID 23016882, PMID 24330470, PMID 25769789, PMID 26049805, PMID 26787787, PMID 27140500, PMID 27266885, PMID 27687059, PMID 28173788, PMID 28265448, PMID 28271084, PMID 28279428, PMID 28768528, PMID 29397119, PMID 29398998, PMID 29511256, PMID 30807886, PMID 31195095, PMID 31870451, PMID 32452208, PMID 32641270, PMID 33026537, PMID 33238043, PMID 34016037, PMID 34383100, PMID 34460897, PMID 34766330, PMID 36070134, PMID 36098133, PMID 38605374, PMID 39032093, PMID 39867299, PMID 40052182, PMID 40234828, PMID 40540943
2017 (1), 2025 (1), R01AR052293 (1), R01AR056630 (1), R03HD041944 (1), R21AG027549 (1), UL1TR000457-06 (1)