327 completed, 132 unknown, 64 recruiting, 37 terminated. 200 Phase 4, 159 Phase 3, 157 Not applicable, 99 Phase 2, 25 Phase 1.
Follow Tranexamic Acid: new trials by email Literature Review of Tranexamic Acid trials Research Report on Tranexamic Acid
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| HTO and Tranexamic Acid Study Tranexamic Acid, Routine medial opening wedge high tibial osteotomy - Osteoarthritis, Knee | Phase 3 | Not yet recruiting | Western University, Canada | 200 | 2027-01-01 | 2026-09-17 |
| Prospective Study: TXA, Anticoagulant, Orthopaedic Trauma Tranexamic Acid (TXA) - Patients Undergoing Operative Fixation of Long Bone Fractures Within the Community Medical Centers System | Phase 4 | Not yet recruiting | Arbi Nazarian, MD | 200 | 2027-01-01 | 2026-08-11 |
| Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction Tranexamic Acid, Placebo - Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture | Phase 3 | Not yet recruiting | Dave Bernholt | 100 | 2026-11-01 | 2026-10-26 |
| Baseline Dermoscopic Vascular Score and Response to Oral Tranexamic Acid in Facial Melasma Tranexamic acid, Standardised sunscreen and emollient - Melasma | Phase 4 | Not yet recruiting | Allied Hospital Faisalabad | 128 | 2026-11-01 | 2026-10-19 |
| Tranexamic Acid to Reduce Blood Loss After Varus Derotation Osteotomy Tranexamic Acid (IV), Placebo - Cerebral Palsy, Hip Surgery Corrective | Phase 3 | Not yet recruiting | Murdoch Childrens Research Institute | 52 | 2026-11-01 | 2026-10-14 |
| Microneedling-Assisted Metformin, Tranexamic Acid, and Modified Kligman's Formula for Melasma Metformin 30% Topical Lotion, Tranexamic Acid 0.5% Topical Solution, Modified Kligman's Formula - Melasma (Facial Melasma) | Phase 4 | Enrolling by invitation | Sameh Sarsik | 80 | 2026-10-25 | 2026-10-27 |
| New Treatment in Melasma Tranexamic Acid - topical, Microneedling with Topical Tranexamic acid, Modified Kligman's Formula - Female, With | Not applicable | Not yet recruiting | Sohag University | 75 | 2026-10-18 | 2026-10-21 |
| Intraosseous Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty Tranexamic Acid, Normal Saline - Knee Osteoarthritis | Phase 4 | Not yet recruiting | The Second Affiliated Hospital of Kunming Medical University | 70 | 2026-10-01 | 2026-10-09 |
| Traumatic Injury Clinical Trial Evaluating Tranexamic Acid in Children: An Efficacy Study Tranexamic acid injection - Brain Injuries, Traumatic, Wounds and Injury | Phase 3 | Not yet recruiting | Daniel Nishijima, MD, MAS | 2000 | 2026-10-01 | 2025-12-15 |
| Evaluating the Effectiveness and Safety of Microneedling With Topical Tranexamic Acid in Treatment of Striae Rubra Topical tranexamic acid, normal saline (0.9% NaCl) - Striae Rubra | Not applicable | Not yet recruiting | Sohag University | 50 | 2026-10-01 | 2026-09-10 |
| Oral Versus Intravenous Tranexamic Acid in Off-Pump Coronary Artery Bypass Surgery Oral tranexamic acid, Exacyl®, Intravenous placebo - Coronary Artery Disease, Perioperative Bleeding | Phase 4 | Not yet recruiting | Clinique Saint-Luc | 160 | 2026-10-01 | 2026-07-31 |
| The Safety of Simplified Tranexamic Acid Regimen Tranexamic Acid (TXA) - Trauma Coagulopathy, Hemorrhage | Phase 4 | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 60 | 2026-10-01 | 2026-10-09 |
| Comparison Between Efficacy of Inhaled VS Intravenous Tranexamic Acid for Hemoptysis Tranexamic Acid - Hemoptysis | Phase 4 | Enrolling by invitation | Dow University of Health Sciences | 154 | 2026-09-15 | 2026-09-29 |
| REDUCER Trial (TXA in Urethroplasty) Tranexamic Acid, Urethroplasty - Urethral Stricture, Urethral Diseases | Phase 4 | Not yet recruiting | Amjad Alwaal, MD, MSc, FRCSC, FACS | 40 | 2026-09-01 | 2026-08-13 |
| Tranexamic Acid for Anaemia Trial Tranexamic Acid 500 MG, Placebo - Anaemia | Phase 3 | Recruiting | London School of Hygiene and Tropical Medicine | 4000 | 2026-08-10 | 2026-08-17 |
| Postoperative Non-Opioid Pain Management Utilizing Local Anesthetics Coupled With Modulated Coagulation Bupivacaine, Lidocaine, Thrombin - Postoperative Pain | Phase 4 | Not yet recruiting | NYU Langone Health | 40 | 2026-08-01 | 2026-06-12 |
| Evaluation of the Therapeutic Effect of Local Application of Tranexamic Acid in Rotator Cuff Repair Tranexamic Acid, Normal Saline - Rotator Cuff Tear Repair | Not applicable | Not yet recruiting | Hua Luo | 60 | 2026-08-01 | 2026-07-20 |
| Perioperative Haemostasis, Procedure-Related Pain After Physiological or Pharmacological Modifications of Local Anaesthesia Around the Eyes Sodium Bicarbonate (NaHCO3), Warmed lignocaine, Hyaluronidase Injection - Dermatochalasis of Upper Eyelid, Blepharoplasty | Phase 3 | Not yet recruiting | Prince of Wales Hospital, Shatin, Hong Kong | 80 | 2026-08-01 | 2026-08-03 |
| Oral Tranexamic Acid Plus Triple Combination vs Triple Combination Alone in Melasma Oral tranexamic acid + triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin), Triple combination cream (fluocinolone acetonide + hydroquinone + tretinoin) alone - Melasma, Melasma (Facial Melasma) | Phase 4 | Not yet recruiting | Combined Military Hospital Abbottabad | 128 | 2026-07-15 | 2026-07-28 |
| Endoscopic Application of Hemostatic Drug Powder in Lower Gastrointestinal Bleeding: A Pilot Study Tranexamic acid and sucralfate powder spray, Standard endsocopic hemostasis - Bleeding After GI Endoscopy | Not applicable | Not yet recruiting | National Cheng-Kung University Hospital | 60 | 2026-07-01 | 2026-07-01 |
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Hemorrhage (147) · Postpartum Hemorrhage (51) · Blood Loss, Surgical (44) · Postoperative Hemorrhage (31) · Hip Fractures (23) · Melanosis (22) · Osteoarthritis, Knee (20) · Menorrhagia (19) · Osteoarthritis (17) · Anemia (11) · Wounds and Injuries (11) · Pain, Postoperative (10) · Placenta Previa (9) · Hemoptysis (8) · Brain Injuries, Traumatic (7)
Assiut University (18) · Cairo University (14) · Aswan University Hospital (12) · London School of Hygiene and Tropical Medicine (9) · NYU Langone Health (9) · Ain Shams University (7) · Chinese Academy of Medical Sciences, Fuwai Hospital (7) · St. Olavs Hospital (7) · Chang Gung Memorial Hospital (6) · Hospital for Special Surgery, New York (6) · Northwestern University (6) · Ferring Pharmaceuticals (5) · Henry Ford Health System (5) · Rush University Medical Center (5) · University of Alabama at Birmingham (5)
United States (174) · Egypt (64) · Canada (52) · China (39) · Pakistan (26) · France (23) · Turkey (Türkiye) (21) · Spain (15) · Israel (13) · South Korea (12) · India (11) · Thailand (11) · Denmark (10) · Taiwan (10) · Norway (9)
Haleema Shakur-Still (4) · Jun-Wen Wang, MD (4) · Ian Roberts (3) · Jia Shi, MD (3) · Andre Lamy, MD (2) · Anton Bermont, MD (2) · Arthur Hertling, MD (2) · Birger Henning Endreseth, MD PhD (2) · Daniel K Nishijima, MD, MAS (2) · David Chiu, MD (2) · Jean Wong, MD, FRCPC (2) · Lihuan Li, M.D (2) · Lihuan Li, MD (2)
PMID 20554319, PMID 37870112, PMID 19926634, PMID 28456509, PMID 39162220, PMID 21043553, PMID 21439633, PMID 21936146, PMID 22012809, PMID 23371895, PMID 23477634, PMID 26559015, PMID 29107495, PMID 30908754, PMID 31271691, PMID 31299040, PMID 31623894, PMID 32278572, PMID 32492040, PMID 35977357, PMID 39226704, PMID 40735345, PMID 10400410, PMID 11413430, PMID 12697586, PMID 12825966, PMID 15273542, PMID 1598671, PMID 1623693, PMID 16438759, PMID 16531440, PMID 16568327, PMID 16810012, PMID 17005947, PMID 17073887, PMID 17218108, PMID 17403800, PMID 17538089, PMID 17943760, PMID 18042876, PMID 18440953, PMID 18480196, PMID 18931201, PMID 19011538, PMID 19638912, PMID 19770617, PMID 19832693, PMID 20063079, PMID 20236640, PMID 20370916
2015 (4), 2023 (3), 2014 (2), 2016 (2), 2018 (2), 2004 (1), 2008 (1), 2009 (1), 2017 (1), D43TW009343 (1), K23HL141640 (1), KL2TR001877 (1), R01HD110109 (1), R21HD091337 (1), U01HL077863 (1)