66 completed, 14 terminated, 13 unknown, 9 recruiting. 112 Phase 3, 19 Phase 2.
Follow Leg Injuries: new trials by email Literature Review of Leg Injuries trials Research Report on Leg Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Extended Post-Operative Oral Tranexamic Acid Dosing After ACL Reconstruction Tranexamic Acid, Placebo - Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture | Phase 3 | Not yet recruiting | Dave Bernholt | 100 | 2026-11-01 | 2026-10-26 |
| Intrathecal Dexmedetomidine and Postoperative Delirium in Elderly Hip Fracture Surgery Dexmedetomidine, Hyperbaric Bupivacaine with Normal Saline - Postoperative Delirium, Hip Fractures | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 130 | 2026-10-01 | 2026-09-09 |
| Topical Diclofenac vs.Oral Ibuprofen for MSK Pain in Children Voltaren Topical Gel, Ibuprofen Oral Suspension 100 mg/5mL, ORA-Blend Oral Suspension - Musculoskeletal Injury, Pediatrics | Phase 3 | Recruiting | University of Calgary | 60 | 2026-04-02 | 2026-04-13 |
| Counterpain PXM Versus Diclofenac Versus Piroxicam Piroxicam plus Counterirritant (brand name Counterpain® PXM)., Diclofenac Sodium 10 mg (Brand Name Hotin® DCL), Piroxicam 0.5% (Brand name Pirofel® gel) - Ankle Sprain, Back Pain | Phase 3 | Completed | Taisho Pharmaceutical Indonesia | 180 | 2025-11-04 | 2026-03-16 |
| Remimazolam vs. Midazolam for Sedation and Cognitive Outcomes in Orthopedic Surgery Midazolam, REMIMAZOLAM BESYLATE 2.5 Mg in 1 mL INTRAVENOUS INJECTION, POWDER, LYOPHILIZED, for SOLUTION [BYFAVO] - Postoperative Cognitive Dysfunction, Orthopedic Procedures | Phase 3 | Recruiting | Romanian Society for Enteral and Parenteral Nutrition | 120 | 2025-10-01 | 2025-10-01 |
| Phase III Trial to Evaluate the Efficacy and Safety in Patients With Ankle Sprains. Esflurbiprofen Topical System (EFTS), Placebo Patch - Ankle Sprains | Phase 3 | Completed | Teikoku Seiyaku Co., Ltd. | 69 | 2025-03-31 | 2025-11-26 |
| Incisional Negative Pressure Wound Therapy to Reduce Infection and Complications in High-Risk Fractures Incisional Negative Pressure Wound Therapy (NPWT) - Fracture of Tibia, Wound Heal | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 352 | 2025-01-01 | 2026-05-12 |
| Thromboprophylaxis in Lower Limb Immobilisation Rivaroxaban, Apixaban, Enoxaparin Injectable Solution - Thrombosis, Injury Leg | Phase 3 | Recruiting | Queen Mary University of London | 10044 | 2024-11-12 | 2026-07-02 |
| Reduce Opiate Exposure With ACL Surgery Opiate Sparing, Opiate Based - Anterior Cruciate Ligament Injuries | Phase 3 | Enrolling by invitation | Campbell Clinic | 56 | 2024-09-01 | 2026-09-15 |
| Comparison of EOSP Between Usg Guided S-FICB vs USG Guided PENG Block in Pts Undergoing Femur Fracture Surgery USG GUIDED SUPRA-INGUINAL FASCIA ILIACA BLOCK, PERICAPSULAR NERVE BLOCK - Post Operative Pain, Bradycardia | Phase 2 / Phase 3 | Recruiting | Sahiwal medical college sahiwal | 70 | 2024-07-10 | 2025-10-23 |
| Intramedullary Calcium Sulfate Antibiotic Depot Vancomycin Hydrochloride, Gentamicin, Standard Intramedullary Nail - Open tíbia Fracture, Osteomyelitis Tibia | Phase 3 | Recruiting | Wake Forest University Health Sciences | 242 | 2024-04-08 | 2026-10-14 |
| Effect of Adding Magnesium Sulphate in Pericapsular Nerve Group Block Pericapsular nerve group block using bupivicaine and magnesium sulphate - Hip Fractures | Phase 2 / Phase 3 | Unknown | Assiut University | 62 | 2024-01-01 | 2023-12-22 |
| Effectiveness Comparison Between Continuous Cryotherapy and Ice Pack Therapy After Anterior Cruciate Ligament Reconstruction Surgery Continuous compression cryotherapy, Conventional ice treatment - Postoperative Pain, Acute, Anterior Cruciate Ligament Injuries | Phase 2 / Phase 3 | Completed | University Medical Center Ho Chi Minh City (UMC) | 72 | 2023-06-01 | 2024-10-08 |
| PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics - Infections, Infected Wound | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 250 | 2023-05-30 | 2026-09-11 |
| Dronabinol After Arthroscopic Surgery Dronabinol, Placebo - Knee Osteoarthritis, Knee Injuries | Phase 3 | Active not recruiting | Northwestern University | 30 | 2022-06-28 | 2026-09-25 |
| PRP in ACLR to Prevent PTOA platelet rich plasma (PRP) injection, placebo saline injection - Anterior Cruciate Ligament Injuries, Post-traumatic Osteoarthritis | Phase 3 | Recruiting | Hospital for Special Surgery, New York | 56 | 2022-06-27 | 2026-02-13 |
| Efficacy of Nasal Oxygen Therapy to Reduce Postoperative Complications in Ankle Trauma Surgery in At-risk Patients: a Randomized Pilot Study. Oxygen, no oxygen therapy - Ankle Fractures | Phase 3 | Active not recruiting | Nantes University Hospital | 200 | 2022-04-09 | 2026-01-14 |
| Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture antibiotic loaded bone cement (gentamicin+clindamycin) COPAL G+C (Heraeus)., antibiotic loaded bone cement (gentamicin) Paladins R+G (Heraeus) or Refobacin (Biomet). - Femoral Neck Fractures, Prosthetic Infection | Phase 3 | Active not recruiting | Umeå University | 7000 | 2022-01-01 | 2026-03-10 |
| Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures Ibuprofen - Tibia Fracture | Phase 3 | Unknown | Major Extremity Trauma Research Consortium | 1000 | 2021-09-14 | 2021-10-06 |
| Effect of NSAIDs on Union, Opioid Utilization and Pain Management for Tibia Fractures: A Pragmatic, Randomized Controlled Trial 600 mg Ibuprofen - Tibial Fractures, Pain | Phase 3 | Recruiting | Major Extremity Trauma Research Consortium | 1000 | 2021-05-26 | 2025-06-05 |
Showing 20 of 112. Sign in to see all of them.
Hip Fractures (36) · Ankle Injuries (20) · Anterior Cruciate Ligament Injuries (14) · Knee Injuries (13) · Pain (11) · Femoral Neck Fractures (8) · Pain, Postoperative (7) · Tibial Fractures (7) · Ankle Fractures (5) · Fractures, Bone (5) · Soft Tissue Injuries (5) · Osteoporosis (4) · Wounds and Injuries (4) · Femoral Fractures (3)
Wounds and Injuries (108) · Fractures, Bone (55) · Hip Injuries (44) · Femoral Fractures (43) · Pathological Conditions, Signs and Symptoms (31) · Neurologic Manifestations (23) · Signs and Symptoms (23) · Pathologic Processes (20) · Knee Injuries (16) · Musculoskeletal Diseases (12) · Postoperative Complications (9) · Hip Fractures (8) · Cardiovascular Diseases (7) · Joint Diseases (7)
Tranexamic Acid (7) · Bupivacaine (5) · Dexmedetomidine (4) · Diclofenac (4) · Acetaminophen (3) · Ketorolac (3) · Ropivacaine (3) · Saline Solution (3) · oxycodone-acetaminophen (3) · Alendronate (2) · Celecoxib (2) · Cimetidine (2) · Dietary Supplements (2) · Enoxaparin (2) · Gabapentin (2)
Major Extremity Trauma Research Consortium (4) · Assistance Publique - Hôpitaux de Paris (3) · Assiut University (3) · Novartis (3) · Prince of Songkla University (3) · RTI Surgical (3) · Biologische Heilmittel Heel GmbH (2) · Cartiva, Inc. (2) · Cerimon Pharmaceuticals (2) · Chinese University of Hong Kong (2) · Eli Lilly and Company (2) · Henry Ford Health System (2) · Hisamitsu Pharmaceutical Co., Inc. (2) · Lancaster General Hospital (2) · Medical University of Graz (2)
United States (51) · Canada (14) · France (7) · Germany (7) · Spain (5) · Sweden (5) · United Kingdom (5) · China (4) · India (4) · Israel (4) · Netherlands (4) · Australia (3) · Austria (3) · Egypt (3) · Romania (3)
Boonsin Tangtrakulwanich, MD.,Ph.D (2) · Michael Karns, MD (2) · Renan Castillo, PhD (2) · Scott Houston (2) · Adeel Riaz, MD (1) · Ahmed A Khater, MD (1) · Akbar Nawab, MD (1) · Alaa M Attia, Professor (1) · Alexander G. Turpie (1) · Ana Maria Dumitriu, MD, PhD (1) · Andreas Platz, MD (1) · Anis Aribogan, Prof., MD (1) · Anne C Voss, PhD (1)
PMID 15329580, PMID 16835255, PMID 17113683, PMID 17878149, PMID 17904460, PMID 18567675, PMID 18767928, PMID 19926634, PMID 20458090, PMID 20973952, PMID 21037195, PMID 21249332, PMID 21467282, PMID 22152181, PMID 22353604, PMID 22429800, PMID 22631877, PMID 22705148, PMID 23812596, PMID 23889885, PMID 24330470, PMID 24839241, PMID 25043629, PMID 26323728, PMID 26631990, PMID 27195774, PMID 27779431, PMID 28279428, PMID 28711636, PMID 28974464, PMID 29377866, PMID 30941485, PMID 31161044, PMID 33238043, PMID 34388107, PMID 34766330, PMID 35277406, PMID 35803549, PMID 36045358, PMID 36070134, PMID 36194219, PMID 36476466, PMID 36566202, PMID 36794826, PMID 38085188, PMID 38772577, PMID 40340976, PMID 40372752, PMID 40468690, PMID 40540943
2008 (1), 2009 (1), 2016 (1)