80 completed, 47 unknown, 22 recruiting, 8 withdrawn. 120 Not applicable, 12 Phase 4, 5 Phase 2, 5 Phase 3, 4 Early Phase 1.
Follow Ankle Fractures: new trials by email Literature Review of Ankle Fractures trials Research Report on Ankle Fractures
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. Nitroglycerin Ointment 2% - Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia | Phase 1 | Not yet recruiting | Johns Hopkins University | 15 | 2026-11-01 | 2026-03-31 |
| Dynamic Fixation for Complex Ankle Fractures With Syndesmotic Diastasis. the dynamic fixation, the screw fixation - Ankle Fractures, Syndesmotic Injury of the Ankle | Not applicable | Not yet recruiting | Fuzhou University Affiliated Provincial Hospital | 100 | 2026-10-01 | 2026-09-23 |
| Early Ambulation Safely in Unstable Ankle Fractures (EASY-Ankle) Postoperative Weight-Bearing Rehabilitation Protocol - Trimalleolar Ankle Fracture, Unstable Trimalleolar Ankle Fracture | Not applicable | Not yet recruiting | Ottawa Hospital Research Institute | 50 | 2026-09-08 | 2026-09-10 |
| Biodegradable Magnesium Screws for Unstable Ankle Fracture Surgery RemeOs Magnesium-Based Biodegradable Screw - Ankle Fractures, Syndesmotic Injury | Not applicable | Not yet recruiting | Massachusetts General Hospital | 28 | 2026-08-01 | 2026-07-27 |
| Turkish Version of the Ankle Fracture Outcome of Rehabilitation Measure (A-FORM-TR): A Multi-Centre Validation Study Ankle Fractures, Ankle Injuries | Active not recruiting | Utku Gürhan | 150 | 2026-07-24 | 2026-10-16 | |
| Early Virtual Ankle Rehabilitation (EVAR): Acceptability EVAR, EMADE - Ankle Fracture | Not applicable | Not yet recruiting | University of Nottingham | 30 | 2026-07-22 | 2026-08-07 |
| Physical Recovery During Bracing After Ankle Fracture (Re-BAF) Ankle stirrup, Foot-ankle brace - Ankle Fracture, Recovery | Not applicable | Recruiting | Odense University Hospital | 280 | 2026-06-01 | 2026-10-16 |
| Performance and Safety Follow-up of Bioabsorbable Headless Inion CompressOnTM Screws in the Fixation of Bone Fractures in Ankle, Knee and Elbow of Pediatric and Adolescent Patients Fracture fixation operation - Ankle Fractures, Knee Fractures | Not applicable | Recruiting | Inion Oy | 80 | 2026-05-29 | 2026-06-03 |
| Bracing After Ankle Fracture ankel stirrup, Foot-ankel brace (walker) - Ankle Fracture, Rehabilitation | Not applicable | Recruiting | Odense University Hospital | 1400 | 2026-04-23 | 2026-04-29 |
| Double Compression Screw Fixation for Symptomatic Non-union of Lateral Malleolar Ankle Fractures Double Compression Screw Fixation for Symptomatic Non-union of Lateral Malleolar Ankle Fractures - Lateral Malleolus Fractures | Not applicable | Recruiting | Sohag University | 10 | 2026-02-01 | 2026-04-20 |
| Auricular Acupuncture as Part of Multimodal Analgesia After Lower Leg Fracture Auricular acupuncture - Pain, Postoperative, Fracture, Ankle | Not applicable | Withdrawn | Baylor College of Medicine | 2025-12-11 | 2026-03-03 | |
| Efficacy and Clinical Feasibility of the Ankle Muscle Power (AMP) Program for Return to Duty After an Ankle Fracture Ankle Muscle Power (AMP) program, Standard of Care - Ankle Fractures | Not applicable | Recruiting | Brian W. Noehren | 60 | 2025-11-13 | 2025-12-02 |
| Stability of Distal Tibiofibular Syndesmosis With or Without Fixation of Posterior Fragments in Bimalleolar Fractures Surgical management of bimalleolar ankle fractures with osteosynthesis of the posterior fragments., Surgical management of bimalleolar ankle fractures without osteosynthesis of the posterior fragments - Ankle Fractures, Osteoarthritis, Ankle | Not applicable | Active not recruiting | Groupe Hospitalier Diaconesses Croix Saint-Simon | 150 | 2025-09-22 | 2026-08-26 |
| Waterproof Casting Versus Standard Casting for Short Leg Walking Casts Waterproof padding, Non-waterproof padding - Ankle Fractures, Foot Fracture | Not applicable | Withdrawn | West Virginia University | 2025-09-01 | 2025-09-08 | |
| Neuromuscular Electrical Stimulation in Foot and Ankle Surgery VPOD Wireless Tens Unit, Physical Therapy, Biodex - Ankle Fractures | Not applicable | Recruiting | NYU Langone Health | 20 | 2025-06-19 | 2026-02-27 |
| Fibula Plating vs Intramedullary K-Wire in Bimalleolar Ankle Fractures Fibula Plating Intervention Arm - Bimalleolar Ankle Fracture | Not applicable | Completed | Shaikh Zayed Hospital, Lahore | 200 | 2025-05-07 | 2026-04-06 |
| Buprenorphine as a Post-operative Analgesic in Opioid-Naive Patients After Ankle Fracture Surgery Buprenorphine Transdermal System, Placebo Patch - Pain, Postoperative, Ankle Fracture Surgery | Phase 4 | Recruiting | Jenna-Leigh Wilson | 100 | 2025-04-21 | 2026-04-06 |
| The Efficacy and Safety of Venostan in Promoting Postoperative Swelling Reduction in Patients With Ankle Fractures Venostasin (horse chestnut seed extract tablets), standard treatment - Swelling/ Edema | Not applicable | Recruiting | Beijing Jishuitan Hospital | 290 | 2025-04-16 | 2025-07-16 |
| Compression Therapy for Swelling Management Following Ankle Injury Compression sleeve - Ankle Fracture, Ankle Arthrodesis | Phase 4 | Not yet recruiting | Nova Scotia Health Authority | 50 | 2025-04-01 | 2025-01-24 |
| Telerehabilitation in Patients With Ankle Fracture Tele-rehabilitation, Hospital rehabilitation - Ankle Fracture | Not applicable | Completed | Instituto Mexicano del Seguro Social | 200 | 2025-02-18 | 2026-10-27 |
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Ankle Injuries (24) · Fractures, Bone (12) · Pain, Postoperative (9) · Wrist Fractures (8) · Arthritis (6) · Hip Fractures (5) · Tibial Fractures (5) · Shoulder Fractures (4) · Wounds and Injuries (4) · Disease (3) · Motor Activity (3) · Sprains and Strains (3) · Surgical Wound Infection (3) · Edema (2)
Leg Injuries (180) · Wounds and Injuries (176) · Fractures, Bone (168) · Ankle Injuries (156) · Pathological Conditions, Signs and Symptoms (26) · Pathologic Processes (19) · Signs and Symptoms (17) · Musculoskeletal Diseases (15) · Neurologic Manifestations (15) · Postoperative Complications (13) · Pain (11) · Arm Injuries (10) · Joint Diseases (10) · Wrist Injuries (8) · Hip Injuries (5)
Surgical Procedures, Operative (7) · Fracture Fixation, Internal (6) · Bupivacaine (4) · Open Fracture Reduction (4) · Standard of Care (4) · Conservative Treatment (3) · Epinephrine (3) · Ketorolac (3) · Ketorolac Tromethamine (3) · Physical Therapy Modalities (3) · Ropivacaine (3) · Control Groups (2) · Morphine (2) · Sodium Chloride (2) · Telerehabilitation (2)
Ostfold Hospital Trust (5) · Oslo University Hospital (4) · Assiut University (3) · BioMimetic Therapeutics (3) · Inion Oy (3) · Ludwig-Maximilians - University of Munich (3) · NYU Langone Health (3) · Ottawa Hospital Research Institute (3) · University of Iowa (3) · AO Clinical Investigation and Publishing Documentation (2) · Corewell Health West (2) · Instituto Mexicano del Seguro Social (2) · Johns Hopkins University (2) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (2) · Mayo Clinic (2)
United States (55) · Canada (13) · Norway (11) · Denmark (10) · Switzerland (7) · Turkey (Türkiye) (7) · United Kingdom (7) · Finland (6) · Egypt (5) · Germany (5) · Italy (5) · Netherlands (5) · Brazil (4) · China (4) · France (3)
Harri J Pakarinen, MD, PhD (2) · Jason M Wilken, PT, PhD (2) · Alan Giachino (1) · Alan Johnstone, MBChB FRCS (1) · Alex Demers, MD (1) · Ali Jarragh, MD (1) · Amr A Abdelgawad, MD PhD MBA (1) · Anders Holsgaard-Larsen, PhD (1) · Angus Wallace (1) · Anna Ng-Pellegrino (1) · Ashley Suttmiller, PhD (1) · Babar Shafi, MD, MSPT (1) · Ben A Marson, FRCS, PhD (1)
PMID 12143985, PMID 12776983, PMID 15563389, PMID 15566705, PMID 16596889, PMID 17054878, PMID 17545357, PMID 18594108, PMID 19119395, PMID 19267907, PMID 20185615, PMID 20309522, PMID 20567742, PMID 20886654, PMID 21075372, PMID 21959254, PMID 22222143, PMID 22357084, PMID 22461750, PMID 22610971, PMID 22901424, PMID 23051785, PMID 23152232, PMID 23850371, PMID 24700526, PMID 24939377, PMID 25059747, PMID 25260059, PMID 25373046, PMID 25948694, PMID 26503187, PMID 27175917, PMID 27798674, PMID 27915053, PMID 28231779, PMID 28279428, PMID 28292290, PMID 28348185, PMID 28574942, PMID 28708777, PMID 28738797, PMID 29267955, PMID 29409288, PMID 29413771, PMID 29443762, PMID 29685558, PMID 29929022, PMID 30191190, PMID 30411313, PMID 30545314
2017 (2), 2018 (2), 2015 (1), 2023 (1)