66 completed, 26 recruiting, 24 unknown, 14 terminated. 86 Not applicable, 10 Phase 4, 8 Phase 2, 8 Phase 3, 4 Phase 1.
Follow Tibial Fractures: new trials by email Literature Review of Tibial Fractures trials Research Report on Tibial Fractures
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Outpatient Floor Pedal Bike Utilization Floor Pedal Bike with Guided Instructions for Home - Femur Fracture, Tibia Fracture | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 20 | 2027-01-01 | 2026-10-26 |
| Low-cost Negative Pressure Wound Therapy vs Standard Dressings for Gustilo IIIb Tibial Fractures (Bukavu Pilot RCT) intervention2: standard wound dressing, Intervention1: Low-cost NPWT - Open Tibia Fracture | Not applicable | Not yet recruiting | Université Catholique de Bukavu | 66 | 2027-01-01 | 2026-08-27 |
| Personalized Weight-Bearing With Smart Crutch Tips After Surgery for Tibial Plateau Fractures Crutch Tip Biofeedback System, Individualized FEA-Guided Postoperative Weight-Bearing, Usual-Care Postoperative Weight-Bearing - Tibial Plateau Fracture | Not applicable | Not yet recruiting | Comeback Mobility Inc | 86 | 2026-11-15 | 2026-10-27 |
| Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. Nitroglycerin Ointment 2% - Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia | Phase 1 | Not yet recruiting | Johns Hopkins University | 15 | 2026-11-01 | 2026-03-31 |
| Magnesium Alloy Scaffold With Controlled Degradation for Periarticular Bone Defects Magnesium Alloy Scaffold, Calcium Sulfate Bone Graft Substitute - Periarticular Bone Defect, Proximal Humerus Fracture | Not applicable | Not yet recruiting | Peking University Third Hospital | 120 | 2026-11-01 | 2026-10-30 |
| Criteria-Based Rehabilitation After Tibial Fracture Fixation: A Randomized Controlled Trial Criteria-Based Progressive Loading and Functional Rehabilitation Program - Tibial Fracture | Not applicable | Recruiting | Al-Azhar University | 120 | 2026-09-18 | 2026-09-21 |
| Assessment of the Verus Frame in Tibial Intramedullary Nailing Verus frame to stabilize tibia - Tibial Fracture | Not applicable | Recruiting | Hemitec Finland Oy | 25 | 2026-09-02 | 2026-09-18 |
| MY01 Pressure Monitoring in Adolescent Tibia Fractures Continuous Compartmental Pressure Monitor - Proximal Tibia Fracture, Tibial Shaft Fracture | Not applicable | Recruiting | Boston Children's Hospital | 50 | 2026-08-17 | 2026-10-23 |
| Comparison of Functional Outcome Between Locking Plate Technique Versus Hybrid Ilizarov Technique in Patients With Schatzker Type V and VI Tibial Plateau Fractures Hybrid Ilizarov Fixation, Locking Plate Fixation - Tibial Plateau Fracture | Not applicable | Recruiting | Prof. Sajjad Hussain Goraya | 78 | 2026-08-16 | 2026-08-19 |
| Elastic Nailing With Kirschner Wires Versus Plate Fixation for Distal Tibial Fractures in Adolescents Elastic Stable Intramedullary Nailing Supplemented by Kirschner Wires, Plate fixation - Distal Tibial Fracture, Tibial Fracture | Not applicable | Recruiting | Sohag University | 60 | 2026-07-01 | 2026-08-26 |
| Robot-Assisted Closed Reduction and Internal Fixation for Extra-Articular Distal Tibial Fractures Robot-assisted closed reduction, Traditional surgeon-led reduction - Distal Tibial Fracture, Tibial Fractures | Not applicable | Recruiting | Beijing Jishuitan Hospital | 60 | 2026-07-01 | 2026-07-29 |
| Multiregion BHA in Open Tibia Fractures BHA - Tibial Fractures | Phase 2 | Withdrawn | Carmell Therapeutics Corporation | 2026-07-01 | 2024-02-08 | |
| Magnesium-Titanium Hybrid Intramedullary Nail System For Long Bone Fractures Magnesium-Titanium Hybrid Intramedullary Nail System, Commercially Locked Metallic Intramedullary Nail - Tibial Fracture, Femoral Fracture | Not applicable | Not yet recruiting | HuaMg Perfection Med Tech (Suzhou) Co., Ltd. | 160 | 2026-05-01 | 2026-05-06 |
| Blood Flow Restriction Therapy Improves Tibial Plateau Fracture Recovery Blood Flow Restriction Cuff, Physical Therapy - Tibial Plateau Fractures | Not applicable | Withdrawn | Medical College of Wisconsin | 2025-12-01 | 2025-11-10 | |
| Smart Crutch Tips for Guided Weight-Bearing in Patients Recovering From Tibial Shaft Fractures Smart Crutch Tips™, Finite Element Analysis (FEA), Iterative walking - Fracture Healing, Tibial Fractures | Not applicable | Recruiting | Comeback Mobility Inc | 30 | 2025-10-28 | 2026-04-14 |
| Oral Supplementation With a Formulation Based on Cetylated Fatty Acids for Post-fracture Long Bone Healing CFA-based food supplement, Placebo - Fracture Femur, Fracture Tibia | Not applicable | Recruiting | Pharmanutra S.p.a. | 100 | 2025-10-01 | 2025-12-23 |
| Assessment of the Feasibility of Using a Preoperative Surgical Fracture Analysis Tool 3D Fracture Analysis Tool - Tibia Fractures, Trauma (Including Fractures) | Not applicable | Recruiting | Brigham and Women's Hospital | 40 | 2025-09-10 | 2025-09-26 |
| Blood Flow Restriction Therapy to Optimize Muscle Size and Strength in Recovery From Lower Limb Fractures Blood Flow Restriction Therapy - Tibial Fracture | Not applicable | Not yet recruiting | University of British Columbia | 20 | 2025-09-01 | 2025-08-05 |
| Tibial IMN Vs. Tibial Micromotion IMN Intramedullary tibial Nail, Intermedullary nail - Tibial Fracture | Not applicable | Recruiting | University of Chicago | 372 | 2025-07-01 | 2026-07-09 |
| Saphenous Nerve Block After Tibial Plateau ORIF Saphenous Nerve Block with Ropivacaine Treatment, Saphenous Nerve Block with Saline Control - Tibial Plateau Fracture, Pain, Postoperative | Not applicable | Withdrawn | Stanford University | 2025-05-01 | 2026-07-01 |
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Tibial Plateau Fractures (30) · Femoral Fractures (20) · Fractures, Bone (17) · Fractures, Open (7) · Ankle Fractures (6) · Pain (6) · Pain, Postoperative (6) · Agnosia (4) · Fractures, Ununited (4) · Humeral Fractures (4) · Wound Infection (3) · Wounds and Injuries (3) · Femoral Fractures, Distal (2) · Fractures, Closed (2)
Leg Injuries (156) · Wounds and Injuries (155) · Fractures, Bone (141) · Knee Injuries (31) · Knee Fractures (30) · Pathological Conditions, Signs and Symptoms (22) · Neurologic Manifestations (14) · Pathologic Processes (14) · Signs and Symptoms (14) · Postoperative Complications (10) · Arm Injuries (7) · Ankle Injuries (6) · Musculoskeletal Diseases (6) · Pain (5)
Fracture Fixation, Intramedullary (7) · Fracture Fixation, Internal (5) · Bupivacaine (4) · Open Fracture Reduction (3) · Sodium Chloride (3) · Standard of Care (3) · Butylated Hydroxyanisole (2) · Cholecalciferol (2) · External Fixators (2) · Ibuprofen (2) · Morphine (2) · Physical Therapy Modalities (2) · Saline Solution (2) · Surgical Procedures, Operative (2) · Therapeutics (2)
AO Clinical Investigation and Publishing Documentation (7) · Major Extremity Trauma Research Consortium (5) · University of Utah (5) · Assiut University (4) · Wake Forest University Health Sciences (4) · AO Innovation Translation Center (2) · Ain Shams University (2) · Boston Medical Center (2) · Carmell Therapeutics Corporation (2) · Comeback Mobility Inc (2) · Denver Health and Hospital Authority (2) · Florida Orthopaedic Institute (2) · Hadassah Medical Organization (2) · Kathmandu University School of Medical Sciences (2) · Second Affiliated Hospital of Soochow University (2)
United States (60) · Germany (14) · Canada (11) · China (10) · Egypt (10) · Spain (8) · United Kingdom (8) · Finland (7) · Switzerland (7) · Australia (6) · Austria (6) · Belgium (6) · France (6) · Netherlands (6) · India (4)
Alan Johnstone, Professor (2) · Dankward Hoentzsch, MD (2) · Erik Kubiak (2) · Harm Hoekstra, Prof. MD (2) · Janet M Vargo, PhD (2) · Joseph Hsu, MD (2) · Justin Haller, MD (2) · Afshin Farhadi, MD (1) · Aleksi Reito, Assoc prof (1) · Ali F Abdelrahem, lecturer (1) · Aly M Mohamed, Prof (1) · Andrew Carrothers, FRCS (Tr & Orth) (1) · Anthony Christiano, MD (1) · Ariana Nelson, MD (1) · Aziz Ahmadi, MD (1)
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R01AR048529 (1), R21AR081008 (1)