267 completed, 93 unknown, 50 recruiting, 21 not yet recruiting. 315 Not applicable, 25 Phase 3, 25 Phase 4, 14 Phase 2, 5 Early Phase 1.
Follow Ankle Injuries: new trials by email Literature Review of Ankle Injuries trials Research Report on Ankle Injuries
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of the AxisBoard Single-Leg Balance Board in Adults With Lateral Ankle Sprain AxisBoard Single-Leg Balance Board - Ankle Sprains, Lateral Ankle Sprain | Not applicable | Not yet recruiting | DITU Inc. | 80 | 2027-01-04 | 2026-10-06 |
| Outpatient Floor Pedal Bike Utilization Floor Pedal Bike with Guided Instructions for Home - Femur Fracture, Tibia Fracture | Not applicable | Not yet recruiting | Wake Forest University Health Sciences | 20 | 2027-01-01 | 2026-10-26 |
| Enhancing Wound Perfusion in High-Risk Lower Extremity Orthopaedic Surgery: A Study on Nitropaste Using Intraoperative SPY Imaging. Nitroglycerin Ointment 2% - Achilles Tendon Repairs/Reconstructions, Pilon Fracture of Tibia | Phase 1 | Not yet recruiting | Johns Hopkins University | 15 | 2026-11-01 | 2026-03-31 |
| Enovis High Ankle Sprain Brace Testing Ankle tape, Standard lace-up ankle brace, Standard high ankle-sprain (HAS) brace - Athletes in Cutting Sports | Not applicable | Suspended | University of Wisconsin, Madison | 30 | 2026-10-01 | 2026-08-14 |
| Dynamic Fixation for Complex Ankle Fractures With Syndesmotic Diastasis. the dynamic fixation, the screw fixation - Ankle Fractures, Syndesmotic Injury of the Ankle | Not applicable | Not yet recruiting | Fuzhou University Affiliated Provincial Hospital | 100 | 2026-10-01 | 2026-09-23 |
| Effects Of Criteria Versus Time-Based Rehabilitation On Return To Play In Football Players Experimental: Criteria based, Active comparator: Time based rehabilitation - Hamstring Muscle Strain | Not applicable | Recruiting | Riphah International University | 52 | 2026-09-25 | 2026-09-29 |
| Early Ambulation Safely in Unstable Ankle Fractures (EASY-Ankle) Postoperative Weight-Bearing Rehabilitation Protocol - Trimalleolar Ankle Fracture, Unstable Trimalleolar Ankle Fracture | Not applicable | Not yet recruiting | Ottawa Hospital Research Institute | 50 | 2026-09-08 | 2026-09-10 |
| Collagen Scaffold Bioaugmentation for ATFL Repair in Chronic Ankle Instability Arthroscopic Anterior Talofibular Ligament Repair, Internal Brace Augmentation, REGENETEN Bioinductive Collagen Scaffold - Chronic Ankle Instability, Ankle Sprain | Not applicable | Not yet recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 84 | 2026-09-01 | 2026-10-16 |
| Biodegradable Magnesium Screws for Unstable Ankle Fracture Surgery RemeOs Magnesium-Based Biodegradable Screw - Ankle Fractures, Syndesmotic Injury | Not applicable | Not yet recruiting | Massachusetts General Hospital | 28 | 2026-08-01 | 2026-07-27 |
| The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Amateur Athletes With Chronic Ankle Instability Postural Stabilization Training, Vestibulo-Ocular Reflex Exercise in addition to Postural Stabilization Training - Ankle Sprain, Ankle Sprain Strain | Not applicable | Recruiting | Bahçeşehir University | 56 | 2026-07-25 | 2026-08-17 |
| Turkish Version of the Ankle Fracture Outcome of Rehabilitation Measure (A-FORM-TR): A Multi-Centre Validation Study Ankle Fractures, Ankle Injuries | Active not recruiting | Utku Gürhan | 150 | 2026-07-24 | 2026-10-16 | |
| Early Virtual Ankle Rehabilitation (EVAR): Acceptability EVAR, EMADE - Ankle Fracture | Not applicable | Not yet recruiting | University of Nottingham | 30 | 2026-07-22 | 2026-08-07 |
| The Effects of Vestibulo-Ocular Reflex Exercises Added to Postural Stabilization Training in Chronic Ankle Instability Postural Stabilization Training, Vestibulo-Ocular Reflex Exercise in addition to Postural Stabilization Training - Ankle Sprains, Ankle Sprain Strain | Not applicable | Recruiting | Bahçeşehir University | 50 | 2026-07-22 | 2026-10-23 |
| Dynamic Neuromuscular Stability Exercises With and Without Rhythmic Auditory Stimulation in Lateral Ankle Sprain Dynamic Neuromuscular Stabilization with Rhythmic Auditory Stimulation, Dynamic Neuromuscular Stabilization Alone - Ankle Sprain, Lateral Ankle Sprain | Not applicable | Recruiting | Riphah International University | 44 | 2026-07-14 | 2026-08-12 |
| Physical Recovery During Bracing After Ankle Fracture (Re-BAF) Ankle stirrup, Foot-ankle brace - Ankle Fracture, Recovery | Not applicable | Recruiting | Odense University Hospital | 280 | 2026-06-01 | 2026-10-16 |
| Performance and Safety Follow-up of Bioabsorbable Headless Inion CompressOnTM Screws in the Fixation of Bone Fractures in Ankle, Knee and Elbow of Pediatric and Adolescent Patients Fracture fixation operation - Ankle Fractures, Knee Fractures | Not applicable | Recruiting | Inion Oy | 80 | 2026-05-29 | 2026-06-03 |
| Pelvic Parameters in Males With and Without Ankle Instability Chronic Ankle Instability | Not yet recruiting | Ahmed Korany Abdallah Ahmed | 38 | 2026-05-07 | 2026-05-18 | |
| Bracing After Ankle Fracture ankel stirrup, Foot-ankel brace (walker) - Ankle Fracture, Rehabilitation | Not applicable | Recruiting | Odense University Hospital | 1400 | 2026-04-23 | 2026-04-29 |
| Resurfacing of Foot and Distal Leg Soft Tissue Defects Using Reversed Pedicled Peroneal Artery Flaps Augmented by Superficial Sural Artery Reversed Pedicled Peroneal Artery Flap - Soft Tissue Injuries, Leg Injuries | Not applicable | Not yet recruiting | Assiut University | 30 | 2026-04-01 | 2026-03-05 |
| Distinct Directional Postural Stability Deficits Across Lower Limb Musculoskeletal Disorders diagnosis of APSI, MLSI, OASI - Ankle Sprains, Patellofemoral Pain Syndrome | Not yet recruiting | Cairo University | 90 | 2026-03-30 | 2026-04-09 |
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Ankle Fractures (180) · Disease (24) · Foot Injuries (22) · Sprains and Strains (19) · Joint Instability (18) · Pain (15) · Fractures, Bone (14) · Wounds and Injuries (14) · Knee Injuries (13) · Emergencies (9) · Motor Activity (9) · Pain, Postoperative (9) · Athletic Injuries (8) · Wrist Fractures (8)
Leg Injuries (476) · Wounds and Injuries (469) · Fractures, Bone (172) · Pathological Conditions, Signs and Symptoms (83) · Pathologic Processes (53) · Musculoskeletal Diseases (48) · Signs and Symptoms (46) · Neurologic Manifestations (41) · Joint Diseases (37) · Pain (22) · Arm Injuries (13) · Behavior (13) · Postoperative Complications (13) · Disease Attributes (10)
Diclofenac (7) · Fracture Fixation, Internal (7) · Standard of Care (7) · Surgical Procedures, Operative (7) · Bupivacaine (6) · Control Groups (6) · Exercise (6) · Physical Therapy Modalities (6) · Sodium Chloride (6) · Acetaminophen (4) · Dexamethasone (4) · Open Fracture Reduction (4) · Surveys and Questionnaires (4) · Athletic Tape (3) · Braces (3)
Riphah International University (10) · University of Virginia (7) · Cairo University (6) · London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's (6) · Assiut University (5) · Bahçeşehir University (5) · Hacettepe University (5) · Novartis (5) · Ostfold Hospital Trust (5) · Oslo University Hospital (4) · Peking University Third Hospital (4) · Second Affiliated Hospital, Zhejiang University, School of Medicine (4) · University of Utah (4) · Yeditepe University (4) · Acibadem University (3)
United States (127) · Turkey (Türkiye) (42) · France (25) · Canada (23) · China (20) · Pakistan (18) · Egypt (16) · Spain (16) · Brazil (15) · Denmark (15) · Germany (12) · Norway (11) · Switzerland (10) · Italy (9) · Finland (8)
Jacy Legue (3) · Dong Jiang, MD (2) · Eamonn Delahunt, PhD (2) · Guobin Liu, Master (2) · Harri J Pakarinen, MD, PhD (2) · Janet Knechtel, BA (2) · Jason M Wilken, PT, PhD (2) · Jay Hertel, PhD (2) · Jeremy T Smith, MD (2) · Kristian Thorborg, PhD (2) · Mustafa Serinken, MD (2) · Nell Blake, DPM (2)
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