18 completed, 9 unknown, 5 withdrawn, 3 terminated. 40 Phase 2, 20 Phase 1, 4 Phase 3.
Follow Intervertebral Disc Degeneration: new trials by email Literature Review of Intervertebral Disc Degeneration trials Research Report on Intervertebral Disc Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Intradiscal rhGDF-6 for the Treatment of Lumbar Disc Degeneration High Dose, Low Dose - Disc Degenerative Disease, Back Pain | Phase 1 / Phase 2 | Not yet recruiting | Cartago Biotech Pty Ltd | 60 | 2026-07-04 | 2026-06-25 |
| Effect of RECK in Posterior Spinal Fusion Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo - Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease | Phase 1 / Phase 2 | Withdrawn | University of Maryland, Baltimore | 2025-10-01 | 2025-07-31 | |
| EvaluatIon of Autologous Nucleus Pulposus Cells (aNPC) in Degenerative Disc Disease aNPC - Intervertebral Disc Degeneration | Phase 1 / Phase 2 | Recruiting | ASTEROGENE Biomedical Co. Ltd. | 12 | 2025-09-26 | 2026-04-03 |
| LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF) LDGraft, Allograft Bone - Degenerative Disc Disease, Lumbar Disc Disease | Phase 1 / Phase 2 | Recruiting | Locate Bio Pty Ltd | 40 | 2024-11-12 | 2026-08-26 |
| Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain CELZ-201-DDT, Placebo - Chronic Low-back Pain, Degenerative Disc Disease | Phase 1 / Phase 2 | Active not recruiting | Creative Medical Technology Holdings Inc | 45 | 2024-05-21 | 2026-08-21 |
| Erector Spinae Plane Block vs Local Infiltration Following Fusion Surgery Erector Spinae Block, Local infiltration with local anesthetic - Postoperative Delirium, Pain, Postoperative | Phase 2 | Completed | Rashmi Mueller | 29 | 2024-05-15 | 2026-02-13 |
| Efficacy of Intradiscal Injection of Autologous BM-MSC in Subjects With Chronic LBP Due to Multilevel Lumbar IDD Autologous BM-MSC, Sham - Intervertebral Disc Degeneration, Chronic Low-back Pain | Phase 2 | Unknown | Fondazione Policlinico Universitario Campus Bio-Medico | 52 | 2021-03-22 | 2025-05-25 |
| Effect of Abaloparatide on Lumbar Disc Degeneration Abaloparatide, Placebo - Degeneration Disc Intervertebral | Phase 2 | Withdrawn | Johns Hopkins University | 2021-03-01 | 2021-04-12 | |
| A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease AGA111, Placebo - Degenerative Disc Disease | Phase 1 / Phase 2 | Completed | Angitia Biopharmaceuticals | 60 | 2020-12-01 | 2022-10-10 |
| Analgesic Effects of Perioperative Propranolol Administration for Spine Surgery Propranolol Hcl 40mg Tab, Placebo oral tablet - Lumbar Disc Disease, Spinal Fusion | Phase 2 | Withdrawn | Duke University | 2020-12-01 | 2021-03-16 | |
| Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion ART352-L - Degenerative Spondylolisthesis | Phase 1 / Phase 2 | Unknown | Ankasa Regenerative Therapeutics, Inc. | 12 | 2020-09-30 | 2020-10-12 |
| Evaluation of Safety, Tolerability, and Efficacy of CordSTEM-DD in Patients With Chronic Low Back Pain CordSTEM-DD (0.7 x 10^7 cells), CordSTEM-DD (2.1 x 10^7 cells), Placebo - Chronic Low-back Pain, Disc Degeneration | Phase 1 / Phase 2 | Completed | CHABiotech CO., Ltd | 36 | 2020-09-21 | 2023-08-30 |
| KUR-113 Bone Graft Versus Local Autograft for the Treatment of Single-level Transforaminal Lumbar Interbody Fusion TGplPTH1-34 in fibrin, Autologous Bone Graft - Degenerative Disc Disease, Spinal Fusion | Phase 2 | Unknown | Kuros Biosurgery AG | 50 | 2020-08-27 | 2023-08-09 |
| TXA in Spinal Fusion Tranexamic Acid, Saline Solution, Visual Acuity Exam - Degenerative Disc Disease | Phase 2 | Completed | Catherine R. Olinger | 123 | 2020-08-01 | 2024-12-12 |
| Efficacy of Intradiscal Injection of Autologous BM-MSC in Worker Patients Affected by Chronic LBP Due to Multilevel IDD Autologous BM-MSC, Sham Procedure - Intervertebral Disc Degeneration, Chronic Low-back Pain | Phase 2 | Completed | Fondazione Policlinico Universitario Campus Bio-Medico | 48 | 2019-11-03 | 2025-05-25 |
| Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive Allogenic BM-MSCs Injection, Sham Procedure - Recurrent Low Back Pain, Degenerative Disc Disease (DDD) | Phase 2 / Phase 3 | Active not recruiting | University Hospital, Montpellier | 113 | 2019-02-18 | 2025-09-30 |
| Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs Bone Marrow Concentrate - Low Back Pain, Disc Disease | Phase 2 / Phase 3 | Unknown | Stem Cures | 80 | 2018-11-21 | 2020-09-22 |
| Fibrin for Chronic Multi-level Discogenic Low Back Pain Fibrin sealant - Low Back Pain, Disc Disease | Phase 2 / Phase 3 | Unknown | Pauza, Kevin, MD | 400 | 2018-06-11 | 2020-11-09 |
| Effectiveness and Safety of Mesenchymal Stem Cell (MSC) Implantation on Degenerative Discus Disease Patients Mesenchymal Stem Cell + NaCl 0,9% 2ml - Degenerative Disc Disease, Low Back Pain | Phase 2 | Unknown | Ahmad Jabir Rahyussalim | 10 | 2017-07-24 | 2020-08-06 |
| Comparison of Posterior Cellular Bonegraft Options for Single Level Lumbar Spinal Fusion Use iliac bone graft, use bone morphogenetic protein, use bone derived allograft MSCs - Disc Degenerative Disease, Spine Fusion for Degenerative Spine Disease | Phase 2 / Phase 3 | Completed | Midwest Spine & Brain Institute | 119 | 2015-10-13 | 2025-10-08 |
Showing 20 of 40. Sign in to see all of them.
Low Back Pain (13) · Back Pain (7) · Spondylolisthesis (6) · Spinal Stenosis (4) · Intervertebral disc disease (3) · Pain, Postoperative (2) · Radiculopathy (2) · Agnosia (1) · Delirium (1) · Emergence Delirium (1) · Intervertebral Disc Displacement (1) · Musculoskeletal Diseases (1) · Sciatica (1) · Spinal Diseases (1)
Bone Diseases (40) · Musculoskeletal Diseases (39) · Spinal Diseases (39) · Neurologic Manifestations (21) · Pathological Conditions, Signs and Symptoms (21) · Signs and Symptoms (21) · Pain (19) · Back Pain (10) · Spondylolysis (6) · Spondylosis (6) · Nervous System Diseases (5) · Neurobehavioral Manifestations (3) · Confusion (2) · Mental Disorders (2) · Neurocognitive Disorders (2)
Spinal Fusion (3) · Genes, mos (2) · Therapeutics (2) · Transplantation, Autologous (2) · salicylhydroxamic acid (2) · Anesthetics, Local (1) · Clonidine (1) · Contraceptives, Oral (1) · Epinephrine (1) · Fibrin (1) · Fibrin Tissue Adhesive (1) · Glucose (1) · Hyaluronic Acid (1) · Injections (1) · Lidocaine (1)
DePuy Spine (4) · Mesoblast, Ltd. (4) · BioSurface Engineering Technologies, Inc (2) · Fondazione Policlinico Universitario Campus Bio-Medico (2) · Red de Terapia Celular (2) · Yuhan Corporation (2) · ASTEROGENE Biomedical Co. Ltd. (1) · Ahmad Jabir Rahyussalim (1) · Angitia Biopharmaceuticals (1) · Ankasa Regenerative Therapeutics, Inc. (1) · Bioinova, s.r.o. (1) · Bone Therapeutics S.A (1) · CHABiotech CO., Ltd (1) · Cartago Biotech Pty Ltd (1) · Catherine R. Olinger (1)
United States (20) · Australia (4) · South Korea (4) · Italy (3) · France (2) · Germany (2) · Spain (2) · Austria (1) · Belgium (1) · Canada (1) · China (1) · Indonesia (1) · Taiwan (1)
Donna Skerrett, MD (2) · Roger Brown (2) · Ana Sanchez, MD, PhD (1) · Brent Atkinson, PhD (1) · Catherine Olinger, M.D. (1) · David C Noriega, MD, PhD (1) · David M Hooper, PhD (1) · Domagoj Coric, MD (1) · FRancisco Ardura, MD, PhD (1) · Hans-Joerg Meisel, Professor (1)
PMID 24716739, PMID 26920137, PMID 27661661, PMID 33945627, PMID 39393844, PMID 40276619
2019 (2), 2017 (1)