Spinal Stenosis: Clinical Trials

197 completed, 70 unknown, 52 recruiting, 34 terminated. 203 Not applicable, 37 Phase 4, 15 Phase 3, 14 Phase 2, 7 Phase 1.

By phase and status

Phase	Trials	Status
Not applicable	203	Completed 96, Unknown 39, Recruiting 21, Terminated 15, Not yet recruiting 12, Withdrawn 12, Active not recruiting 6, Enrolling by invitation 1, Suspended 1
Phase 4	37	Completed 24, Terminated 5, Withdrawn 3, Recruiting 2, Unknown 2, Suspended 1
Phase 3	15	Unknown 5, Completed 4, Recruiting 3, Terminated 3
Phase 2	14	Completed 9, Unknown 3, Enrolling by invitation 1, Withdrawn 1
Phase 1	7	Completed 4, Recruiting 1, Terminated 1, Withdrawn 1
Early Phase 1	4	Completed 2, Recruiting 2

Follow Spinal Stenosis: new trials by email Literature Review of Spinal Stenosis trials Research Report on Spinal Stenosis

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Prospective Study of ProteiOS in Lumbar Interbody Fusion (TLIF) Allograft-derived growth factor (ProteiOS®), Standard of Care (SOC) - Degenerative Disc Disease, Spinal Stenosis Lumbar	Not applicable	Not yet recruiting	Isto Biologics	280	2026-12-01	2026-08-20
Continuous Erector Spinae Block for Analgesia Following Lumbar Decompression Continuous erector spinae plane block - Lumbar Spinal Stenosis, Lumbar Radiculopathy	Not applicable	Not yet recruiting	Nova Scotia Health Authority	100	2026-12-01	2026-02-17
Kore Fiber PLF Study Kore Fiber, Autologous bone graft - Degenerative Lumbar Spine Diseases, Lumbar Degenerative Disc Disease	Not applicable	Not yet recruiting	Kolosis Bio, LLC	75	2026-11-01	2026-10-22
Combined Analysis of Retrospective and Prospective Data From Patients Who Underwent Facet Arthroplasty With the TOPS™ System or the TOPS + Versalink™ Fixation System at a Single Center. Questionnaire - Spinal Stenosis, Bilateral Lumbar Arthrodesis		Not yet recruiting	GCS Ramsay Santé pour l'Enseignement et la Recherche	200	2026-10-30	2026-09-28
Surgical Treatment of Adjacent Segment Stenosis Microsurgical Decompression with Extension of Fusion, Microsurgical Decompression Alone - Adjacent Segment Disease, Lumbar Spinal Stenosis	Not applicable	Recruiting	Charite University, Berlin, Germany	338	2026-10-27	2026-10-28
Activity Post Spinal Surgery Engagement Trial Wrist based activity tracker wear, Basic Study Activities, Telephonic Active Coaching (Motivational Interviewing) + Financial Incentives - Spinal Surgery for Lumbar Spinal Stenosis (LSS)	Not applicable	Recruiting	Brigham and Women's Hospital	75	2026-10-19	2026-10-22
Sarcopenia and Interlaminar Epidural Steroid Injection Outcomes in Lumbar Spinal Stenosis Spinal Stenosis Lumbar, Sarcopenia		Recruiting	Marmara University	70	2026-10-02	2026-10-07
Neuropathic Pain Severity and Its Association With Radiological Findings in Lumbar Spinal Stenosis Spinal Stenosis Lumbar, Neuropathic Pain		Recruiting	Marmara University	100	2026-10-02	2026-10-07
CGM-Based Glycemic Analysis After ESI Epidural Steroid Injection, Continuous Glucose Monitoring - Type 2 Diabetes (T2DM), Hyperglycemia		Not yet recruiting	Korea University Anam Hospital	36	2026-08-05	2026-08-12
CLE-PAD : Prevalence of PAD in Patients With Surgically Lumbar Spinal Stenosis contrast-enhanced CT scan - PAD - Peripheral Arterial Disease, Lumbar Spinal Stenosis	Not applicable	Recruiting	Rennes University Hospital	49	2026-08-01	2026-08-12
Role of Intraoperative Computed Tomography in Assessment of Spine Instability in Lumbar Degenerative Disease Intraoperative Computed Tomography (O-arm) - Degenerative Lumbar Spine Diseases, Lumbar Spinal Instability		Not yet recruiting	4th Military Clinical Hospital with Polyclinic, Poland	100	2026-08-01	2026-06-12
The Lumbar Adjacent Segment Stenosis Trial Decompression alone, Decompression with extended fusion - Lumbar Adjacent Spinal Stenosis, Chronic Low Back and Leg Pain	Not applicable	Not yet recruiting	Oslo University Hospital	192	2026-08-01	2026-06-26
Hybrid vs Fluoroscopy-Guided Interlaminar Epidural Injection in Lumbar Spinal Stenosis Ultrasound-guided lumbar interlaminar epidural steroid injection with fluoroscopic confirmation, Fluoroscopy-guided lumbar interlaminar epidural steroid injection - Lumbar Spinal Stenosis	Not applicable	Not yet recruiting	Marmara University	44	2026-07-01	2026-05-29
Effect of Obesity Phenotype on Intraabdominal Pressure and Bleeding in Major Lumbar Spinal Surgery Intraabdominal Pressure Measurement via Urinary Bladder Catheter, Total Intravenous Anesthesia (TIVA) - Lumbar Spinal Stenosis, Lumbar Degenerative Disease		Not yet recruiting	Marmara University Pendik Training and Research Hospital	90	2026-06-15	2026-07-07
Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury EC5026 oral tablet, Placebo oral tablet - Spinal Cord Injuries, Neuropathic Pain	Phase 1	Recruiting	EicOsis Human Health Inc.	36	2026-05-01	2026-07-10
PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System - Degenerative Disc Disease (DDD), Spinal Stenosis		Recruiting	Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co.	561	2026-04-27	2026-05-29
Proprio Spine Measurement Tool Intraoperative spinal measurement system - Intervertebral Disc Degeneration, Intervertebral Disc Displacement	Not applicable	Withdrawn	Duke University		2026-04-20	2026-04-23
Clinical and MRI Findings in Lumbar Disc Disease Lumbar Disc Disease, Low Back Pain		Not yet recruiting	Assiut University	96	2026-04-01	2026-04-08
Full-Endoscopic Decompression vs. Endoscopic Lumbar Fusion for Middle-Aged and Older Adults With Spinal Stenosis Full-Endoscopic Decompression, Endoscopic Lumbar Interbody Fusion - Spinal Stenosis Lumbar	Not applicable	Not yet recruiting	The First Affiliated Hospital with Nanjing Medical University	176	2026-04-01	2026-03-27
Comparative Analysis of Two Transforaminal Lumbar Interbody Fusion (TLIF) Procedures in the Treatment of Single-Level Lumbar Spinal Stenosis (LSS): A Single-Center, Prospective, Randomized Controlled Trial LUSE-TLIF, MIS-TLIF - Lumbar Spinal Stenosis	Not applicable	Recruiting	The Third Affiliated Hospital of Southern Medical University	276	2026-03-18	2026-05-14

Showing 20 of 417. Sign in to see all of them.

Narrower conditions

Spondylolisthesis (83)  ·  Intervertebral Disc Degeneration (63)  ·  Intervertebral Disc Displacement (61)  ·  Low Back Pain (40)  ·  Radiculopathy (29)  ·  Spondylosis (21)  ·  Spinal Diseases (19)  ·  Intervertebral disc disease (12)  ·  Back Pain (11)  ·  Pain, Postoperative (10)  ·  Motor Activity (9)  ·  Scoliosis (8)  ·  Spinal Fractures (8)  ·  Spinal Cord Neoplasms (7)

Broader conditions

Bone Diseases (416)  ·  Musculoskeletal Diseases (414)  ·  Spinal Diseases (398)  ·  Pathological Conditions, Signs and Symptoms (134)  ·  Signs and Symptoms (86)  ·  Spondylolysis (82)  ·  Neurologic Manifestations (79)  ·  Spondylosis (71)  ·  Pain (69)  ·  Pathological Conditions, Anatomical (67)  ·  Hernia (61)  ·  Nervous System Diseases (61)  ·  Back Pain (44)  ·  Neuromuscular Diseases (43)  ·  Peripheral Nervous System Diseases (40)

Interventions

Laminectomy (13)  ·  Decompression (10)  ·  Gene Fusion (9)  ·  Surgical Procedures, Operative (9)  ·  Acetaminophen (6)  ·  Acupuncture Therapy (6)  ·  Dexamethasone (6)  ·  Physical Therapy Modalities (6)  ·  Exercise (5)  ·  Transplantation, Autologous (5)  ·  Control Groups (4)  ·  Gabapentin (4)  ·  Injections (4)  ·  Saline Solution (4)  ·  Spinal Fusion (4)

Sponsors

Peking University Third Hospital (9)  ·  Marmara University (8)  ·  Seoul National University Hospital (8)  ·  Yonsei University (7)  ·  Vertos Medical, Inc. (6)  ·  Assiut University (5)  ·  Baxano Surgical, Inc. (5)  ·  Dartmouth-Hitchcock Medical Center (5)  ·  Mesoblast, Ltd. (5)  ·  Ohio State University (5)  ·  University Hospital, Basel, Switzerland (5)  ·  Boston Scientific Corporation (4)  ·  Medtronic Spinal and Biologics (4)  ·  Université du Québec à Trois-Rivières (4)  ·  Allina Health System (3)

Countries

United States (146)  ·  Turkey (Türkiye) (29)  ·  China (27)  ·  South Korea (26)  ·  Canada (20)  ·  France (15)  ·  Germany (14)  ·  Denmark (13)  ·  Switzerland (12)  ·  Netherlands (11)  ·  Spain (9)  ·  Italy (7)  ·  Sweden (7)  ·  United Kingdom (7)  ·  Norway (6)

Top investigators

James N. Weinstein, DO, MS (3)  ·  Natalie Bloom Lyons (3)  ·  Roger Brown (3)  ·  Bohdan W Chopko, MD (2)  ·  Christelle Nguyen, MD, PhD (2)  ·  Cordula Netzer, PD Dr. med. (2)  ·  Debra K. Weiner, MD (2)  ·  Donna Skerrett, MD (2)  ·  Eeric Truumees, MD (2)  ·  Nicolai Maldaner, MD (2)  ·  Oliver B Zielinski, MD (2)  ·  Steven Passmore, DC, PhD (2)

Results publications

PMID 22048651, PMID 27074067, PMID 29372860, PMID 39313282, PMID 10976589, PMID 12447088, PMID 15995108, PMID 16231283, PMID 16858467, PMID 17119140, PMID 17119141, PMID 17538085, PMID 18287602, PMID 18777603, PMID 19018250, PMID 19075203, PMID 19219713, PMID 19487505, PMID 19730217, PMID 19755935, PMID 20047458, PMID 20084410, PMID 20309389, PMID 20375829, PMID 20453723, PMID 20648206, PMID 20664045, PMID 21102963, PMID 21267039, PMID 21286714, PMID 21309472, PMID 21311402, PMID 21358354, PMID 21372654, PMID 21429671, PMID 21728727, PMID 21802441, PMID 21859765, PMID 21971123, PMID 22215593, PMID 22272730, PMID 22791040, PMID 22824921, PMID 22828681, PMID 22885827, PMID 22922544, PMID 23373567, PMID 23575742, PMID 23725394, PMID 23992774

NIH funding

U01AR045444 (3), 2019 (1), K23AR077088 (1), K23HL070058 (1), R01AG081582 (1), R01AR045622 (1), R01AT012534 (1)