90 completed, 39 unknown, 32 terminated, 20 recruiting. 108 Not applicable, 14 Phase 4, 11 Phase 2, 8 Phase 1, 8 Phase 3.
Follow Spondylolysis: new trials by email Literature Review of Spondylolysis trials Research Report on Spondylolysis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Study of ProteiOS in Lumbar Interbody Fusion (TLIF) Allograft-derived growth factor (ProteiOS®), Standard of Care (SOC) - Degenerative Disc Disease, Spinal Stenosis Lumbar | Not applicable | Not yet recruiting | Isto Biologics | 280 | 2026-12-01 | 2026-08-20 |
| Kore Fiber PLF Study Kore Fiber, Autologous bone graft - Degenerative Lumbar Spine Diseases, Lumbar Degenerative Disc Disease | Not applicable | Not yet recruiting | Kolosis Bio, LLC | 75 | 2026-11-01 | 2026-10-22 |
| The Impact of Artificial Intelligence-Assisted X-ray Interpretation on Radiologists' Diagnostic Performance Pneumothorax, Intestinal Obstruction | Not yet recruiting | The Third Affiliated Hospital of Southern Medical University | 500 | 2026-10-01 | 2026-10-15 | |
| Evaluation of an Online Peri-operative Health Education Platform for Patients Undergoing Spine Surgery: Ready Set Recover Ready Set Recover - Medium-/Long-segment Spinal Fusion Patients, Spine Surgeons | Early Phase 1 | Not yet recruiting | National University of Natural Medicine | 60 | 2026-09-30 | 2026-08-17 |
| A Pilot Study on the Safety of Active Conservative Management of Low Grade Lumbar Stress Reactions in Adolescent Soccer Players Active rehabilitation protocol - Spondylolysis Lumbar | Not applicable | Not yet recruiting | Western Norway University of Applied Sciences | 40 | 2026-05-01 | 2026-05-06 |
| PMCF Study on the Effectiveness and Safety of METROSAN Spinal Systems and BONEGRAFT Filling Materials Titania® Cervical Interbody Fusion Cage (Titanium), Titania® Cervical Interbody Fusion Cage (PEEK), Titania® Posterior Cervical Stabilization System - Degenerative Disc Disease (DDD), Spinal Stenosis | Recruiting | Metrosan End. ve Elk. Mek. Cihazlar ve Tibbi Malz. San. Tic. Ltd. Co. | 561 | 2026-04-27 | 2026-05-29 | |
| Effect of Hip Extension Mobilization on Functional Disability in Patients With Spondylolisthesis hip extension mobilization, conventional treatment - Spondylolisthesis | Not applicable | Not yet recruiting | Cairo University | 32 | 2026-04-25 | 2026-04-23 |
| Comparative Analysis of Two Transforaminal Lumbar Interbody Fusion (TLIF) Procedures in the Treatment of Single-Level Lumbar Spinal Stenosis (LSS): A Single-Center, Prospective, Randomized Controlled Trial LUSE-TLIF, MIS-TLIF - Lumbar Spinal Stenosis | Not applicable | Recruiting | The Third Affiliated Hospital of Southern Medical University | 276 | 2026-03-18 | 2026-05-14 |
| PMCF Study Fortilink-TS Ti Posterior lumbar interbody fusion surgery - Degenerative Disc Disease Lumbar, Spondylolisthesis, Grade 1 | Recruiting | BAAT Medical Products B.V. | 50 | 2026-01-01 | 2026-09-22 | |
| PMCF Study Fortilink-TC Ti Transforaminal lumbar interbody fusion surgery - Degenerative Disc Disease Lumbar, Spondylolisthesis, Grade 1 | Recruiting | BAAT Medical Products B.V. | 50 | 2026-01-01 | 2026-09-22 | |
| Bone Stimulator for Spondylolysis Bone Stimulator, Standard of Care Spondylolysis Treatment - Spondylolysis, Symptomatic Spondylolysis | Not applicable | Recruiting | The Methodist Hospital Research Institute | 48 | 2025-12-03 | 2026-03-25 |
| Evaluation of Balance Using the Biodex Balance System Among Different Subcategories of Low Back Pain Assessment of balance will be measured by The Biodex Balance System (BBS) which computes Postural Stability key indices: the medial-lateral stability index (MLSI), anterior-posterior stability index - Low Back Pain, Spondylolisthesis | Not applicable | Completed | Cairo University | 104 | 2025-12-01 | 2026-10-21 |
| Rate of Bone Union After Surgery With Stand-alone Fibergraft Questionnaires, Computer Tomography - Spine Degeneration, Spine Disorder | Not yet recruiting | AO Innovation Translation Center | 80 | 2025-10-31 | 2025-09-30 | |
| Effects of Orthosis & Exercise on Spondylolisthesis Stabilitation Exercise, Conventional Exercise, Orthosis - Spondylolisthesis, Orthosis | Not applicable | Recruiting | Medipol University | 48 | 2025-07-26 | 2026-08-03 |
| A Study on the Clinical Use of a New Expandable OLIF Cage With Posterior Bone Grafting in Lumbar Spine Surgery Expandable OLIF cage with posterior bone grafting, Conventional OLIF cage - Lumbar Spondylolisthesis, Degenerative Lumbar Scoliosis | Not applicable | Not yet recruiting | The Affiliated Hospital of Qingdao University | 340 | 2025-06-10 | 2025-06-19 |
| Facet Tropism in Low Back Pain Patients Low Back Pain, Spondylolisthesis | Completed | Istanbul Physical Medicine Rehabilitation Training and Research Hospital | 92 | 2025-06-01 | 2025-07-09 | |
| Perioperative Nutrition Management in Patients Undergoing Open Posterior Lumbar Surgery Oral nutritional supplements (ONS), Carbohydrate loading (OCL), 'Probiotics (Bifidobacterium and Lactobacillus triple live capsules)' - Lumbar Degenerative Disease, Lumbar Spondylolisthesis | Not applicable | Completed | First Affiliated Hospital of Kunming Medical University | 90 | 2025-05-22 | 2026-10-30 |
| Effects of a Single Session of Physiotherapy on Patients Operated for Lumbar Spondylolisthesis Education, Usual Care - Spondylolisthesis | Not applicable | Not yet recruiting | Istituto Clinico Humanitas | 50 | 2025-03-01 | 2025-01-29 |
| Adult Patient Outcomes After Spine Surgery With Fibergraft BG Putty/Viper Prime Use of Viper Prime/Expedium system with Fibergraft BG Putty - Spondylolisthesis, Lumbar Region, Spinal Trauma With Neurological Deficit | Recruiting | Nitin Agarwal | 100 | 2024-12-20 | 2026-01-22 | |
| Screening and Prospective Cohort Study of Risk Factors for Enhanced Recovery After Spinal Fusion Surgery in Advanced Age Patient This is an observational study - Lumbar Disk Herniation, Lumbar Spinal Stenosis | Enrolling by invitation | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 500 | 2024-09-03 | 2024-09-19 |
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Spondylolisthesis (205) · Spinal Stenosis (83) · Intervertebral Disc Degeneration (77) · Intervertebral Disc Displacement (24) · Spondylosis (24) · Low Back Pain (21) · Constriction, Pathologic (11) · Scoliosis (11) · Spinal Diseases (9) · Lymphoma, Follicular (8) · Radiculopathy (8) · Intervertebral disc disease (7) · Pain, Postoperative (7) · Pseudarthrosis (6)
Bone Diseases (212) · Musculoskeletal Diseases (212) · Spinal Diseases (204) · Spondylosis (189) · Pathological Conditions, Signs and Symptoms (67) · Signs and Symptoms (41) · Neurologic Manifestations (40) · Pathological Conditions, Anatomical (36) · Pain (35) · Hernia (24) · Back Pain (22) · Nervous System Diseases (21) · Neoplasms (15) · Wounds and Injuries (13)
Transplantation, Autologous (5) · Spinal Fusion (4) · Laminectomy (3) · Ropivacaine (3) · Sodium Chloride (3) · Surgical Procedures, Operative (3) · Analgesia, Patient-Controlled (2) · Educational Status (2) · Grafton demineralized bone matrix gel (2) · Physical Therapy Modalities (2) · Saline Solution (2) · Standard of Care (2) · Acceptance and Commitment Therapy (1) · Acupuncture Therapy (1) · Adrenergic alpha-2 Receptor Agonists (1)
Zimmer Biomet (7) · Ohio State University (5) · Aesculap AG (4) · Baxano Surgical, Inc. (4) · NuVasive (4) · Assiut University (3) · K2M, Inc. (3) · Medtronic Spinal and Biologics (3) · Mesoblast, Ltd. (3) · Nova Scotia Health Authority (3) · Pioneer Surgical Technology, Inc. (3) · Seoul National University Hospital (3) · Advanced Scanners Inc. (2) · BAAT Medical Products B.V. (2) · BioSurface Engineering Technologies, Inc (2)
United States (102) · Germany (13) · France (10) · Netherlands (10) · China (9) · Italy (8) · South Korea (7) · Canada (6) · Spain (6) · Switzerland (6) · United Kingdom (4) · Belgium (3) · Egypt (3) · Finland (3) · Hungary (3)
Kyle Malone, MS (3) · Aaron Bernstein, PhD (2) · Donna Skerrett, MD (2) · Jan Siewe, Dr. (2) · Joel Batts (2) · Mitchell Selhorst, DPT (2) · Zoher Ghogawala, MD (2) · Adam M Pearson, MD (1) · Ahmed Shawky Abdelgawaad, Professor (1) · Alessandro Vergari (1) · Amir Fayyazi, MD (1) · Anthony Perruccio, PhD (1)
PMID 11723406, PMID 13287061, PMID 17538085, PMID 19125304, PMID 19342933, PMID 19487505, PMID 19752698, PMID 19755935, PMID 20121352, PMID 20375829, PMID 21372654, PMID 22008088, PMID 22048651, PMID 22817607, PMID 23373567, PMID 23442780, PMID 23783372, PMID 23948848, PMID 24568365, PMID 24809838, PMID 24945292, PMID 25189113, PMID 25238480, PMID 25769789, PMID 25844282, PMID 26335675, PMID 26501698, PMID 26895529, PMID 27074066, PMID 27074067, PMID 27400960, PMID 27548582, PMID 27565009, PMID 27825292, PMID 28400657, PMID 28622187, PMID 29253630, PMID 29424677, PMID 29452283, PMID 29546538, PMID 29548343, PMID 29704223, PMID 29742708, PMID 29794943, PMID 30680635, PMID 31042664, PMID 31451936, PMID 31501123, PMID 31542473, PMID 31651299
2015 (1), 2016 (1), K23AR077088 (1), K24AR080786 (1), U01AR045444 (1)