12 completed, 1 active not recruiting, 1 not yet recruiting, 1 withdrawn. 11 Phase 2, 6 Phase 1, 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 11 | Completed 10, Withdrawn 1 |
| Phase 1 | 6 | Completed 5, Withdrawn 1 |
| Phase 3 | 4 | Completed 2, Active not recruiting 1, Not yet recruiting 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase III Trial of Remestemcel-L-rknd Added to Ruxolitinib for Grade III-IV Steroid-Refractory Acute Graft-Versus-Host Disease Remestemcel-L-rknd, Placebo - GVHD - Graft-Versus-Host Disease | Phase 3 | Not yet recruiting | Mesoblast, Ltd. | 180 | 2026-08-31 | 2026-05-05 |
| Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain Rexlemestrocel-L + HA mixture, Saline - Degenerative Disc Disease | Phase 3 | Active not recruiting | Mesoblast, Ltd. | 300 | 2024-07-03 | 2026-06-17 |
| Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture, Placebo - Degenerative Disc Disease | Phase 3 | Completed | Mesoblast, Ltd. | 404 | 2015-03-06 | 2022-10-19 |
| P3 Study of Umbilical Cord Blood Cells Expanded With MPCs for Transplantation in Patients With Hematologic Malignancies Infusion of one MPC expanded cord unit and one unexpanded cord unit, Infusion of two unexpanded cord blood units. - Acute Myelogenous Leukemia, Acute Lymphoblastic Leukemia | Phase 3 | Completed | Mesoblast, Ltd. | 49 | 2013-08-01 | 2020-06-26 |
| A Multi-center Study a Single IV Infusion of Allogeneic MPCs in Patients With Rheumatoid Arthritis and Incomplete Response to at Least One TNFα Inhibitor Allogeneic Mesenchymal Precursor Cells, Normal Saline - Rheumatoid Arthritis | Phase 2 | Completed | Mesoblast, Ltd. | 48 | 2013-07-01 | 2020-06-26 |
| Safety and Efficacy of Mesenchymal Precursor Cells in Diabetic Nephropathy Mesenchymal Precursor Cells (MPCs) - Diabetic Nephropathy, Type 2 Diabetes | Phase 1 / Phase 2 | Completed | Mesoblast, Ltd. | 30 | 2013-07-01 | 2016-10-14 |
| Safety Study of Mesenchymal Precursor Cells in Type 2 Diabetes Mesenchymal Precursor Cells (MPCs) - Type 2 Diabetes | Phase 1 / Phase 2 | Completed | Mesoblast, Ltd. | 61 | 2012-04-01 | 2020-06-02 |
| Safety and Preliminary Efficacy Study of Mesenchymal Precursor Cells (MPCs) in Subjects With Lumbar Back Pain Single Dose MPCs Injection, Single injection of saline solution, Single injection of hyaluronic acid - Degenerative Disc Disease | Phase 2 | Completed | Mesoblast, Ltd. | 100 | 2011-08-01 | 2020-06-26 |
| Safety and Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy and Fusion NeoFuse, MasterGraft Granules - Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis | Phase 1 / Phase 2 | Completed | Mesoblast, Ltd. | 12 | 2010-06-01 | 2020-06-29 |
| Safety and Preliminary Efficacy Study of NeoFuse in Subjects Undergoing Multi-Level Anterior Cervical Discectomy NeoFuse, Allograft - Cervical Degenerative Disc Disease, Degenerative Spondylolisthesis | Phase 2 | Completed | Mesoblast, Ltd. | 24 | 2010-06-01 | 2019-08-16 |
| Safety and Preliminary Efficacy Study of NeoFuse in Subjects Requiring Lumbar Interbody Fusion Lumbar Interbody Fusion with Autograft, Lumbar Interbody Fusion with NeoFuse - Degenerative Disc Disease, Degenerative Spondylolisthesis | Phase 2 | Completed | Mesoblast, Ltd. | 24 | 2009-09-01 | 2020-06-29 |
| Safety and Efficacy Study of MSB-CAR001 in Subjects 6 Weeks Post an Anterior Cruciate Ligament Reconstruction MSB-CAR001 Combined With Hyaluronan, Hyaluronan - Anterior Cruciate Ligament Injury, Osteoarthritis | Phase 1 / Phase 2 | Completed | Mesoblast, Ltd. | 17 | 2009-03-01 | 2018-08-15 |
| Safety and Efficacy Study of NeoFuse in Subjects Requiring Posterolateral Lumbar Fusion PLF with autograft, PLF with NeoFuse - Degenerative Disc Disease, Degenerative Spondylolisthesis | Phase 1 / Phase 2 | Withdrawn | Mesoblast, Ltd. | 2008-11-01 | 2020-06-02 | |
| A Phase II Dose-escalation Study to Assess the Feasibility and Safety of Transendocardial Delivery of Three Different Doses of Allogeneic Mesenchymal Precursor Cells (MPCs)in Subjects With Heart Failure Mesenchymal Precursor Cells (MPCs), standard-of-care treatment with mock mapping and injection procedures. - Heart Failure | Phase 2 | Completed | Mesoblast, Ltd. | 60 | 2008-08-01 | 2020-03-11 |
| Study of 3 Doses of NeoFuse Combined With MasterGraft Granules in Subjects Requiring Posterolateral Lumbar Fusion (PLF) NeoFuse, posterolateral spinal fusion with instrumentation - Degenerative Disc Disease, Spondylolisthesis | Phase 1 / Phase 2 | Completed | Mesoblast, Ltd. | 6 | 2007-10-01 | 2020-06-29 |
Intervertebral Disc Degeneration (6) · Spinal Stenosis (5) · Spondylolisthesis (3) · Back Pain (2) · Diabetes Mellitus, Type 2 (2) · Low Back Pain (2) · Anterior Cruciate Ligament Injuries (1) · Arthritis, Rheumatoid (1) · Bone Diseases (1) · Diabetic Nephropathies (1) · Graft vs Host Disease (1) · Heart Failure (1) · Hodgkin Disease (1) · Leukemia (1) · Leukemia, Myeloid, Acute (1)
Spinal Fusion (3) · Gene Fusion (2) · Hyaluronic Acid (2) · Sodium Chloride (2) · Transplantation, Autologous (2) · Anterior Cruciate Ligament Reconstruction (1) · Injections (1) · Saline Solution (1) · Transplantation, Homologous (1)
United States (11) · Australia (6)
Roger Brown (5) · Donna Skerrett, MD (3) · Donna Skerrett, MD, MS (2) · K Segal, PhD (2) · Elizabeth J. Shpall, MD (1) · Emerson Perin, MD (1) · Roger D Brown (1)