8 completed, 4 unknown, 3 active not recruiting, 3 recruiting. 23 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 23 | Completed 8, Unknown 4, Active not recruiting 3, Recruiting 3, Terminated 2, Withdrawn 2, Enrolling by invitation 1 |
| Phase 2 | 4 | Unknown 2, Active not recruiting 1, Completed 1 |
Follow Intervertebral Disc Degeneration: new trials by email Literature Review of Intervertebral Disc Degeneration trials Research Report on Intervertebral Disc Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Efficacy and Safety of Novosis Putty in Transforaminal Lumbar Interbody Fusion for Patients With Lumbar Degenerative Disc Disease Novosis Putty, Standard of Care - Degenerative Disc Disease | Phase 3 | Recruiting | CGBio Inc. | 316 | 2026-06-11 | 2026-08-26 |
| MDT-0123 Japan Study MDT-0123, ICBG - Disc Degeneration, Spinal Deformity | Phase 3 | Recruiting | Medtronic Spinal and Biologics | 140 | 2026-04-24 | 2026-09-09 |
| A Study to Evaluate the Effectiveness of IDCT (Intradiscal Cell Therapy) in Subjects With One Level, Symptomatic Mild to Moderate Lumbar Degenerative Disc Disease IDCT (rebonuputemcel), Sham (No Treatment) - Degenerative Disc Disease | Phase 3 | Recruiting | DiscGenics, Inc. | 162 | 2025-12-23 | 2026-10-15 |
| Efficacy and Safety of Rexlemestrocel-L Combined With HA* in Participants With Moderate to Severe Chronic Low Back Pain Rexlemestrocel-L + HA mixture, Saline - Degenerative Disc Disease | Phase 3 | Active not recruiting | Mesoblast, Ltd. | 300 | 2024-07-03 | 2026-06-17 |
| A Phase 3 Study of AGA111 in Patients With Degenerative Disc Disease Undergoing Lumbar Interbody Fusion AGA111, Placebo - Degenerative Disc Disease | Phase 3 | Terminated | Angitia Biopharmaceuticals | 412 | 2023-12-08 | 2026-06-29 |
| Moderate - Severe Degenerative Disc Disease Evaluation of the Lumbar Spine SB-01 For Injection, Sham Needle - Lumbar Degenerative Disc Disease | Phase 3 | Active not recruiting | Spine BioPharma, Inc | 417 | 2022-08-19 | 2025-06-10 |
| Intradiscal and Intra-articular Injection of Autologous Platelet-Rich-Plasma (PRP) in Patients With Lumbar Degenerative Disc Disease and Facet Joint Syndrome Autologous PRP - Degenerative Disc Disease, Facet Joint Syndrome | Phase 3 | Unknown | Stylianos Kapetanakis | 50 | 2022-04-01 | 2022-03-23 |
| GA + ESP vs. SA + ESP in Lumbar Decompression Surgeries General anesthetic, SA + ESP - Lumbar Disc Herniation, Lumbar Disc Disease | Phase 3 | Enrolling by invitation | Hospital for Special Surgery, New York | 142 | 2022-03-22 | 2026-04-28 |
| Efficacy of Intradiscal Injection of BM-MSC in Subjects With Chronic Low Back Pain (LBP) Due to Lumbar Degenerative Disc Disease (DDD) Unresponsive Allogenic BM-MSCs Injection, Sham Procedure - Recurrent Low Back Pain, Degenerative Disc Disease (DDD) | Phase 2 / Phase 3 | Active not recruiting | University Hospital, Montpellier | 113 | 2019-02-18 | 2025-09-30 |
| Bone Marrow Concentrate (BMC) Injection in Intervertebral Discs Bone Marrow Concentrate - Low Back Pain, Disc Disease | Phase 2 / Phase 3 | Unknown | Stem Cures | 80 | 2018-11-21 | 2020-09-22 |
| Fibrin for Chronic Multi-level Discogenic Low Back Pain Fibrin sealant - Low Back Pain, Disc Disease | Phase 2 / Phase 3 | Unknown | Pauza, Kevin, MD | 400 | 2018-06-11 | 2020-11-09 |
| Peri-Incisional Drug Injection in Lumbar Spine Surgery Morphine, Epinephrine, naropin - Lumbar Disc Herniation, Degenerative Disc Disease | Phase 3 | Withdrawn | University of Minnesota | 2018-06-01 | 2022-08-19 | |
| Impact of Local Steroid Application in Extreme Lateral Lumbar Interbody Fusion Methylprednisolone, Saline - Stenosis, Herniated Nucleus Pulposus | Phase 3 | Withdrawn | Rush University Medical Center | 2018-05-22 | 2020-11-20 | |
| Comparison of Posterior Cellular Bonegraft Options for Single Level Lumbar Spinal Fusion Use iliac bone graft, use bone morphogenetic protein, use bone derived allograft MSCs - Disc Degenerative Disease, Spine Fusion for Degenerative Spine Disease | Phase 2 / Phase 3 | Completed | Midwest Spine & Brain Institute | 119 | 2015-10-13 | 2025-10-08 |
| Placebo-controlled Study to Evaluate Rexlemestrocel-L Alone or Combined With Hyaluronic Acid in Participants With Chronic Low Back Pain Rexlemestrocel-L, Rexlemestrocel-L + HA Mixture, Placebo - Degenerative Disc Disease | Phase 3 | Completed | Mesoblast, Ltd. | 404 | 2015-03-06 | 2022-10-19 |
| Treatment of Symptomatic Lumbar Internal Disc Disruption (IDD) With the Biostat® System BIOSTAT BIOLOGX, Saline - Back Pain, Chronic Low Back Pain | Phase 3 | Terminated | Spinal Restoration, Inc. | 220 | 2010-03-01 | 2014-05-16 |
| XL TDR® eXtreme Lateral Total Disc Replacement for the Treatment of Lumbar Degenerative Disc Disease (DDD) XL TDR, Lumbar fusion surgery - Degenerative Disc Disease | Phase 3 | Completed | NuVasive | 246 | 2009-07-01 | 2015-07-30 |
| Wallis Stabilization System for Low Back Pain Interspinous process and dynamic stabilization (Wallis System), Total Disc Replacement - Low Back Pain | Phase 3 | Unknown | Zimmer Spine | 340 | 2007-01-01 | 2011-10-04 |
| Safety and Efficacy Study of Healos as a Bone Replacement to Treat Degenerative Disc Disease HEALOS and Leopard Cage, Leopard Cage and Autograft - Degenerative Disc Disease | Phase 3 | Completed | Advanced Technologies and Regenerative Medicine, LLC (ATRM) | 138 | 2006-04-01 | 2011-03-03 |
| rhBMP-2/CRM/CD HORIZON® Spinal System Pivotal Study rhBMP-2/CRM/CD HORIZON® Spinal System, Autograft/CD HORIZON® Spinal System - Degenerative Disc Disease | Phase 3 | Completed | Medtronic Spinal and Biologics | 463 | 2002-03-01 | 2023-05-10 |
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Low Back Pain (6) · Radiculopathy (4) · Intervertebral Disc Displacement (3) · Back Pain (2) · Intervertebral disc disease (2) · Bone Diseases (1) · Constriction, Pathologic (1) · Musculoskeletal Diseases (1) · Nervous System Diseases (1) · Neurologic Manifestations (1) · Pain (1) · Sciatica (1) · Spinal Cord Diseases (1) · Spinal Diseases (1)
Bone Diseases (22) · Musculoskeletal Diseases (22) · Spinal Diseases (22) · Pathological Conditions, Signs and Symptoms (11) · Signs and Symptoms (7) · Neurologic Manifestations (6) · Pain (6) · Back Pain (5) · Nervous System Diseases (4) · Neuromuscular Diseases (4) · Pathological Conditions, Anatomical (4) · Peripheral Nervous System Diseases (4) · Hernia (3) · Central Nervous System Diseases (1) · Mononeuropathies (1)
Sodium Chloride (3) · Fibrin Tissue Adhesive (2) · Total Disc Replacement (2) · Transplantation, Autologous (2) · Anesthetics, General (1) · Epinephrine (1) · Injections (1) · Lidocaine (1) · Methylprednisolone (1) · Morphine (1) · Parapsychology (1) · Pedicle Screws (1) · Ropivacaine (1) · Standard of Care (1) · salicylhydroxamic acid (1)
DePuy Spine (2) · Medtronic Spinal and Biologics (2) · Mesoblast, Ltd. (2) · Advanced Technologies and Regenerative Medicine, LLC (ATRM) (1) · Angitia Biopharmaceuticals (1) · CGBio Inc. (1) · DiscGenics, Inc. (1) · Hospital for Special Surgery, New York (1) · Midwest Spine & Brain Institute (1) · NuVasive (1) · Pauza, Kevin, MD (1) · Rush University Medical Center (1) · Spinal Restoration, Inc. (1) · Spine BioPharma, Inc (1) · Stem Cures (1)
United States (17) · Australia (1) · China (1) · France (1) · Germany (1) · Italy (1) · Japan (1) · Spain (1)
Aristeidis Kritis, Associate Professor (1) · Christopher Bergin, MD (1) · Christopher Gilligan, MD, MBA (1) · John Dimar, MD (1) · John J. Regan, MD (1) · Kenneth Burkus, MD (1) · Kern Singh, MD (1) · Kevin J Pauza, MD (1) · Kevin Pauza, MD (1) · Lisa Flood (1) · Nikolaos Gkantsinikoudis, PhD Candidate (1) · Roger Brown (1)
PMID 15346999, PMID 16025024, PMID 16025025, PMID 39393844
2017 (1)