13 completed, 4 unknown, 3 recruiting, 3 terminated. 30 Phase 1, 20 Phase 2.
Follow Intervertebral Disc Degeneration: new trials by email Literature Review of Intervertebral Disc Degeneration trials Research Report on Intervertebral Disc Degeneration
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Determine the Safety and Tolerability of TG-C in Subjects With Back Pain Due to Degenerative Disc Disease TG-C High Dose, TG-C Mid Dose, TG-C Low Dose - Degenerative Disc Disease | Phase 1 | Not yet recruiting | Kolon TissueGene, Inc. | 24 | 2027-01-19 | 2026-08-20 |
| SCLife®-LDD hUC-MSCs Injection Therapy for Patients With Lumbar Intervertebral Disc Degeneration human umbilical cord mesenchymal stem cell suspension, total endoscopic extraction of lumbar nucleus pulposus - Lumbar Disc Degeneration | Phase 1 | Suspended | Sclnow Biotechnology Co., Ltd. | 20 | 2026-12-31 | 2026-04-27 |
| Intradiscal rhGDF-6 for the Treatment of Lumbar Disc Degeneration High Dose, Low Dose - Disc Degenerative Disease, Back Pain | Phase 1 / Phase 2 | Not yet recruiting | Cartago Biotech Pty Ltd | 60 | 2026-07-04 | 2026-06-25 |
| Novel Soluble Epoxide Hydrolase Inhibitor for Neuropathic Pain in Patients With Spinal Cord Injury EC5026 oral tablet, Placebo oral tablet - Spinal Cord Injuries, Neuropathic Pain | Phase 1 | Recruiting | EicOsis Human Health Inc. | 36 | 2026-05-01 | 2026-07-10 |
| Effect of RECK in Posterior Spinal Fusion Ropivacaine, Epinephrine, Clonidine, and Ketorolac Injection Cocktail, Placebo - Degenerative Lumbar Spinal Stenosis, Degenerative Disc Disease | Phase 1 / Phase 2 | Withdrawn | University of Maryland, Baltimore | 2025-10-01 | 2025-07-31 | |
| EvaluatIon of Autologous Nucleus Pulposus Cells (aNPC) in Degenerative Disc Disease aNPC - Intervertebral Disc Degeneration | Phase 1 / Phase 2 | Recruiting | ASTEROGENE Biomedical Co. Ltd. | 12 | 2025-09-26 | 2026-04-03 |
| LDGraft in Single Level Anterior Lumbar Interbody Fusion (ALIF) LDGraft, Allograft Bone - Degenerative Disc Disease, Lumbar Disc Disease | Phase 1 / Phase 2 | Recruiting | Locate Bio Pty Ltd | 40 | 2024-11-12 | 2026-08-26 |
| Safety, Tolerability, and Effectiveness of Intramuscular Injection of CELZ-201-DDT for the Treatment of Chronic Lower Back Pain CELZ-201-DDT, Placebo - Chronic Low-back Pain, Degenerative Disc Disease | Phase 1 / Phase 2 | Active not recruiting | Creative Medical Technology Holdings Inc | 45 | 2024-05-21 | 2026-08-21 |
| Intra-discal Injection of Platelet-rich Plasma (PRP) Enriched With Exosomes in Chronic Low Back Pain Platelet rich plasma (PRP) with exosomes, Normal Saline - Chronic Low Back Pain, Degenerative Disc Disease | Phase 1 | Completed | Dr. Himanshu Bansal Foundation | 30 | 2021-09-10 | 2022-08-02 |
| A Phase I/II Study of AGA111 for Lumbar Interbody Fusion in Patients With Degenerative Disc Disease AGA111, Placebo - Degenerative Disc Disease | Phase 1 / Phase 2 | Completed | Angitia Biopharmaceuticals | 60 | 2020-12-01 | 2022-10-10 |
| Safety Evaluation of ART352-L in Subjects Undergoing Posterolateral Spinal Fusion ART352-L - Degenerative Spondylolisthesis | Phase 1 / Phase 2 | Unknown | Ankasa Regenerative Therapeutics, Inc. | 12 | 2020-09-30 | 2020-10-12 |
| Evaluation of Safety, Tolerability, and Efficacy of CordSTEM-DD in Patients With Chronic Low Back Pain CordSTEM-DD (0.7 x 10^7 cells), CordSTEM-DD (2.1 x 10^7 cells), Placebo - Chronic Low-back Pain, Disc Degeneration | Phase 1 / Phase 2 | Completed | CHABiotech CO., Ltd | 36 | 2020-09-21 | 2023-08-30 |
| Clinical Effectiveness of Pre-operative Methadone in Single Level Lateral Transpsoas Interbody Fusions Methadone Hydrochloride, Oxycodone-Acetaminophen - Degenerative Disc Disease, Spondylolisthesis, Lumbar Region | Phase 1 | Unknown | The Methodist Hospital Research Institute | 150 | 2020-02-11 | 2020-01-29 |
| Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Disc Degeneration IDCT, Sham - Degenerative Disc Disease | Phase 1 | Completed | DiscGenics, Inc. | 38 | 2019-05-23 | 2025-11-20 |
| Autologous, Culture-Expanded Mesenchymal Stromal Cells for Degenerative Disc Disease Autologous Adipose-Derived Mesenchymal Stromal Cells - Degenerative Disc Disease | Phase 1 | Terminated | Mayo Clinic | 1 | 2018-10-17 | 2022-01-25 |
| AMG0103 in Subjects With Chronic Discogenic Lumbar Back Pain Placebo, AMG0103 - Degenerative Disc Disease | Phase 1 | Completed | AnGes, Inc. | 25 | 2018-02-26 | 2021-10-12 |
| Study to Evaluate the Safety and Preliminary Efficacy of IDCT, a Treatment for Symptomatic Lumbar Intervertebral Disc Degeneration IDCT, Saline Solution, Sodium Hyaluronate - Degenerative Disc Disease | Phase 1 | Completed | DiscGenics, Inc. | 60 | 2018-02-26 | 2023-01-25 |
| A Study of the Safety, Tolerability, and Pharmacokinetics of SM04690 Injectable Suspension Following Single Intradiscal Injection in Subjects With Degenerative Disc Disease SM04690 - Degenerative Disc Disease | Phase 1 | Terminated | Biosplice Therapeutics, Inc. | 6 | 2017-07-26 | 2019-04-23 |
| Utilization of Autologous Mesenchymal Cells in Posterolateral Spinal Fusion in Degenerative Spine Disease Suspension of human autologous MSC 3P in 1.5 ml - Degenerative Disc Disease | Phase 1 / Phase 2 | Terminated | Bioinova, s.r.o. | 10 | 2013-08-27 | 2020-01-18 |
| Treatment of Degenerative Disc Disease With Allogenic Mesenchymal Stem Cells (MSV) Allogenic Mesenchymal Stromal Cells, Mepivacaine - Degenerative Disc Disease, Intervertebral Disc Disease | Phase 1 / Phase 2 | Completed | Red de Terapia Celular | 24 | 2013-06-21 | 2024-04-29 |
Showing 20 of 30. Sign in to see all of them.
Spondylolisthesis (6) · Low Back Pain (4) · Back Pain (3) · Spinal Stenosis (3) · Intervertebral disc disease (2) · Musculoskeletal Diseases (2) · Agnosia (1) · Intervertebral Disc Displacement (1) · Neuralgia (1) · Spinal Cord Injuries (1) · Spinal Diseases (1) · Spondylosis (1)
Bone Diseases (30) · Spinal Diseases (29) · Musculoskeletal Diseases (28) · Neurologic Manifestations (9) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (9) · Pain (8) · Spondylolysis (6) · Spondylosis (6) · Back Pain (4) · Nervous System Diseases (2) · Central Nervous System Diseases (1) · Hernia (1) · Neurobehavioral Manifestations (1) · Neuromuscular Diseases (1)
Genes, mos (2) · Saline Solution (2) · Spinal Fusion (2) · Clonidine (1) · Contraceptives, Oral (1) · EC5026 (1) · Epinephrine (1) · Hyaluronic Acid (1) · Mepivacaine (1) · Methadone (1) · Ropivacaine (1) · Sodium Chloride (1) · Transplantation, Autologous (1) · lorecivivint (1) · oxycodone-acetaminophen (1)
DePuy Spine (3) · BioSurface Engineering Technologies, Inc (2) · DiscGenics, Inc. (2) · Mesoblast, Ltd. (2) · Red de Terapia Celular (2) · ASTEROGENE Biomedical Co. Ltd. (1) · AnGes, Inc. (1) · Angitia Biopharmaceuticals (1) · Ankasa Regenerative Therapeutics, Inc. (1) · Bioinova, s.r.o. (1) · Biosplice Therapeutics, Inc. (1) · CHABiotech CO., Ltd (1) · Cartago Biotech Pty Ltd (1) · Creative Medical Technology Holdings Inc (1) · Dr. Himanshu Bansal Foundation (1)
United States (13) · Australia (3) · South Korea (3) · China (2) · Austria (1) · Canada (1) · Germany (1) · India (1) · Japan (1) · Spain (1) · Taiwan (1)
Donna Skerrett, MD (2) · Ana Sanchez, MD, PhD (1) · Brent Atkinson, PhD (1) · David C Noriega, MD, PhD (1) · David M Hooper, PhD (1) · FRancisco Ardura, MD, PhD (1) · Hans-Joerg Meisel, Professor (1) · In-Bo Han (1) · James Rathmell, MD (1)
PMID 31442616, PMID 26920137, PMID 27661661, PMID 33945627, PMID 34284523, PMID 38925869