54 completed, 11 unknown, 10 terminated, 4 withdrawn. 28 Phase 3, 18 Phase 2, 15 Not applicable, 11 Phase 4, 5 Phase 1.
Follow Fibrin Tissue Adhesive: new trials by email Literature Review of Fibrin Tissue Adhesive trials Research Report on Fibrin Tissue Adhesive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 2a Multi-Center Prospective, Randomized Trial to Evaluate the Safety & Efficacy of Topical PEP-TISSEEL for Diabetic Foot Ulcers (DFU) PEP (Purified Exosome Product) / TISSEEL - Diabetic Foot Ulcer | Phase 2 | Completed | Rion Inc. | 59 | 2024-02-27 | 2026-07-20 |
| A Trial of Intraoperative Fibrin Sealant on Postoperative Recovery After Total Knee Replacement fibrin sealant, Tranexamic Acid (TXA) - Osteo Arthritis of the Knee | Phase 4 | Completed | Singapore General Hospital | 78 | 2024-01-01 | 2026-03-06 |
| Sensory Recovery of Digital Nerves After Microsurgical Epineural Neurorrhaphy Alone or in Combination With Tisseel - RET Tisseel® - Digital Nerve Injuries | Not applicable | Unknown | Insel Gruppe AG, University Hospital Bern | 74 | 2023-03-01 | 2023-03-03 |
| Fibrin Sealant in Eyelid Surgery Tisseel - Blepharoptosis, Ecchymosis; Eyelid | Phase 2 / Phase 3 | Unknown | University of Calgary | 30 | 2022-05-01 | 2022-05-03 |
| Fibrin Glue Versus Titanium Platelet-rich Fibrin in Lateral Sinus Lifting Fibrin Glue, T-PRF, Negative control - Sinus Floor Augmentation, Graftless Sinus Elevation | Not applicable | Completed | Hams Hamed Abdelrahman | 30 | 2022-02-01 | 2023-04-26 |
| Stromal Vascular Fraction (SVF) Cells for Non-Operative Treatment of Small Rotator Cuff Tears Tisseel Injectable Product, Stromal Vascular Fraction Cells - Rotator Cuff Tears | Phase 2 | Withdrawn | AdventHealth | 2022-01-09 | 2023-02-15 | |
| Efficacy of Fibrin Sealant in Hypospadias Surgery fibrin sealant in hypospadias - Hypospadias | Not applicable | Unknown | Al-Azhar University | 200 | 2022-01-01 | 2024-02-13 |
| PEP on a Skin Graft Donor Site Wound 10% PEP, TISSEEL, 20% PEP - Skin Graft | Phase 1 | Unknown | Rion Inc. | 8 | 2021-03-16 | 2023-09-08 |
| Tisseel® as a Reinforcement of Esophagojejunal Anastomoses Tisseel, No Tisseel - Gastric Cancer, Anastomotic Leak | Phase 4 | Unknown | Germans Trias i Pujol Hospital | 146 | 2020-07-21 | 2020-07-23 |
| The Use of Fibrin Sealant to Reduce Post Operative Pain in Cleft Palate Surgery Tisseel - Cleft Palate | Phase 4 | Withdrawn | University of Alberta | 2019-09-01 | 2022-05-20 | |
| A Comparison Between Surgical Techniques for Securing Conjunctival Autografting in Primary Pterygium Surgery conjunctival autograft with fibrin glue, sutured conjunctival autograft, sutureless and glue-free conjunctival autograft - Pterygium | Not applicable | Unknown | Assiut University | 60 | 2019-02-24 | 2019-01-09 |
| Efficacy of Buccal Pad of Fat, Advanced Platelet Rich Fibrin, Fibrin Glue and Oxidized Cellulose Plug in Management of Oro-Antral Communication, Comparative Clinical Study Buccal Pad of Fat, A-PRF, fibrin glue - Healthy Volunteers Only | Not applicable | Completed | October 6 University | 24 | 2019-01-01 | 2024-01-24 |
| A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery Fibrin Sealant, Silver Microparticles - Hernia, Ventral Hernia | Phase 1 | Withdrawn | Hobart Harris | 2019-01-01 | 2020-02-06 | |
| Fibrin for Chronic Multi-level Discogenic Low Back Pain Fibrin sealant - Low Back Pain, Disc Disease | Phase 2 / Phase 3 | Unknown | Pauza, Kevin, MD | 400 | 2018-06-11 | 2020-11-09 |
| Cauterization Versus fibrin Glue for Conjunctival Autografting in Primary Pterygium Surgery Cauterization, Fibrin glue - Pterygium of Conjunctiva and Cornea | Not applicable | Recruiting | University of Split, School of Medicine | 164 | 2018-05-08 | 2022-11-02 |
| The EVARREST® Pediatric Mild or Moderate Liver and Soft Tissue Bleeding Study EVARREST® Fibrin Sealant Patch - Controlling Mild to Moderate Bleeding During Surgery | Phase 3 | Completed | Ethicon, Inc. | 35 | 2018-03-20 | 2026-04-08 |
| Treatment of Intractable Common Extensor Tendon Injury Using Mesenchymal Stem Cells (Allo-ASC) High concentration of Allo-ASC, Low concentration of Allo-ASC, Fibrin glue - Lateral Epicondylitis | Phase 2 | Completed | Seoul National University Hospital | 30 | 2018-03-15 | 2025-04-06 |
| A Randomized Trial of CT Fluoroscopy-guided Targeted Autologous Blood and Fibrin Glue Patching for Treatment TISSEEL - Cerebrospinal Fluid Leaks | Phase 2 | Completed | Duke University | 15 | 2017-12-18 | 2021-06-18 |
| Reducing Blood Loss Using Tisseel in TKA Tisseel, Tranexamic Acid - Total Blood Loss | Phase 4 | Unknown | Chang Gung Memorial Hospital | 100 | 2017-11-01 | 2017-10-16 |
| Persistent Pleural Effusion Treatment Following Cardiothoracic Surgery by Platelet-Fibrin Glue Platelet-Rich Plasma and Fibrin Glue - Pleural Effusion | Phase 2 | Completed | Daryoush Hamidi Alamdari, PhD | 19 | 2017-05-01 | 2024-06-07 |
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Hemorrhage (11) · Seroma (5) · Pterygium (4) · Cerebrospinal Fluid Leak (3) · Hernia, Inguinal (3) · Melanoma (3) · Rectal Fistula (3) · Recurrence (3) · Anastomotic Leak (2) · Breast Neoplasms (2) · Burns (2) · Cerebrospinal Fluid Otorrhea (2) · Intervertebral Disc Degeneration (2) · Pain (2) · Pain, Postoperative (2)
Baxter Healthcare Corporation (9) · Ethicon, Inc. (9) · Mallinckrodt (4) · Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau (3) · M.D. Anderson Cancer Center (2) · Rion Inc. (2) · Tigenix S.A.U. (2) · AdventHealth (1) · Al-Azhar University (1) · Alejandro Gonzalez-Ojeda (1) · Asociación para Evitar la Ceguera en México (1) · Assiut University (1) · CLOTILDE FUENTES OROZCO (1) · Cardiochirurgia E.H. (1) · Careggi Hospital (1)
United States (29) · Spain (9) · United Kingdom (8) · Germany (7) · Belgium (6) · Canada (5) · Egypt (4) · Denmark (3) · Italy (3) · Mexico (3) · South Korea (3) · Switzerland (3) · Australia (2) · Austria (2) · France (2)
Richard Kocharian, MD, PhD (3) · Richard Kocharian, MD (2) · Acacio AS Lima Filho, MD (1) · Aguilera Roig, Xavier (1) · Alejandro Gonzalez-Ojeda, PhD (1) · Andreas Q Fenger, Researcher (1) · Arnold Luterman, MD (1) · Azmi Rahman (1) · Bruce H Matt, MD,MSc (1) · Christian Skovgaard Nielsen, M.D (1) · Clotilde Fuentes-Orozco, PhD (1) · Damian Garcia Olmo, Dr (1)
PMID 15933795, PMID 22706128, PMID 38695613, PMID 12297693, PMID 12756590, PMID 15307986, PMID 15792759, PMID 18053915, PMID 18354285, PMID 18482765, PMID 18564433, PMID 18694359, PMID 19273960, PMID 19702708, PMID 19907303, PMID 20178792, PMID 20308876, PMID 20636801, PMID 20730858, PMID 21456091, PMID 22065114, PMID 22748849, PMID 23053677, PMID 23355162, PMID 23515377, PMID 25458801, PMID 25714528, PMID 26254451, PMID 26888731, PMID 29950464, PMID 30080735, PMID 34129409, PMID 35727196, PMID 36045358, PMID 38727726, PMID 40246197
2014 (2), 2009 (1), 2015 (1)