19 completed, 12 not yet recruiting, 11 recruiting, 9 unknown. 33 Phase 4, 13 Not applicable, 4 Phase 2, 4 Phase 3, 3 Early Phase 1.
Follow Esketamine: new trials by email Literature Review of Esketamine trials Research Report on Esketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery Dex-Esk, Placebo, Active tDCS - Older Patients, Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 1996 | 2026-10-01 | 2026-10-13 |
| Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After Surgery Dex-Esk, Placebo, Active tDCS - Older Patients, Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 1996 | 2026-10-01 | 2026-10-13 |
| Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral Reconstruction Combined dexmedetomidine-esketamine administration, Placebo administration - Ureteral Stricture, Dexmedetomidine | Phase 4 | Not yet recruiting | Peking University First Hospital | 658 | 2026-08-01 | 2026-08-14 |
| Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy Fentanyl and Propofol, Esketamine and remimazolam - Adverse Respiratory Events, Hypoxemia | Phase 4 | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 120 | 2026-08-01 | 2026-08-06 |
| Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment Dexmedetomidine-esketamine combination, Placebo - Older Adults, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking University First Hospital | 60 | 2026-06-01 | 2026-06-01 |
| Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression Esketamine-dexmedetomidine combination, Placebo - Parturients, Depressive Symptoms | Phase 4 | Not yet recruiting | Peking University First Hospital | 164 | 2026-06-01 | 2026-06-15 |
| Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients Intranasal dexmedetomidine-esketamine, Intranasal placebo (normal saline) - Adenotonsillectomy, Children | Phase 4 | Recruiting | Peking University First Hospital | 160 | 2026-04-07 | 2026-04-09 |
| Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients Esketamine 1, Esketamine 2, Esketamine 3 - Elderly, Noncardiac Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 120 | 2026-04-01 | 2026-04-14 |
| Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-16 |
| Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-14 |
| Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery Dexmedetomidine, Esketamine, Dexmedetomidine-esketamine - General Anesthesia, Surgery | Phase 4 | Recruiting | Peking University First Hospital | 316 | 2026-01-05 | 2026-04-13 |
| Subanesthetic Esketamine in Modified ECT for Severe Depression in Adolescents: Clinical and Mechanistic Study Esketamine injection group (0.25 mg/kg), Saline injection group (Consistent with esketamine injection volume) - Esketamine, ECT | Early Phase 1 | Recruiting | Min Su | 220 | 2025-11-25 | 2026-01-07 |
| Dexmedetomidine-Esketamine Combination for Sedation and Analgesia in ICU Patients Dexmedetomidine-Esketamine Combination, Dexmedetomidine - Aged, Intensive Care Units | Not applicable | Not yet recruiting | Peking University First Hospital | 1508 | 2025-11-01 | 2025-07-31 |
| Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients Dexmedetomidine, Dexmedetomidine-esketamine combination - Older Patients, Postoperative Care | Phase 4 | Completed | Peking University First Hospital | 100 | 2025-10-21 | 2026-06-30 |
| The Efficacy and Safety of Short Term S-ketamine Infusion as an Adjunctive Therapy in Patients With Fibromyalgia Pregabalin and venlafaxine concomitant therapy, Esketamine plus pregabalin and venlafaxine concomitant therapy - Fibromyalgia, Pregabalin | Not applicable | Recruiting | Beijing Tiantan Hospital | 92 | 2025-09-15 | 2026-05-07 |
| Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia sufentanil-ropivacaine combination, dexmedetomidine-esketamine-ropivacaine combination 1, dexmedetomidine-esketamine-ropivacaine combination 2 - Epidural Analgesia, Labor Pain | Phase 4 | Completed | Peking University First Hospital | 300 | 2025-09-05 | 2026-04-13 |
| Etomidate and Esketamine on Postoperative Pain After Tonsillectomy Undergoing Children Etomidate and fentanyl group, Etomidate and esketamine group - Etomidate, Esketamine | Not applicable | Not yet recruiting | Anqing Municipal Hospital | 64 | 2025-07-10 | 2025-07-14 |
| Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation remimazolam group, dexmedetomidine group, esketamine group - Remimazolam, Dexmedetomidine | Not applicable | Recruiting | Maternal and Child Health Hospital of Hubei Province | 150 | 2025-04-01 | 2025-07-10 |
| Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery Dexmedetomidine-esketamine combination, Placebo - Adults, Major Noncardiac Surgery | Phase 4 | Recruiting | Peking University First Hospital | 476 | 2025-03-18 | 2025-03-19 |
| Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia dexmedetomidine, Esketamine - Preoperative Anxiety, Preoperative Sedation | Phase 4 | Recruiting | Second Affiliated Hospital of Wenzhou Medical University | 80 | 2025-03-01 | 2025-12-02 |
Showing 20 of 54. Sign in to see all of them.
Pain, Postoperative (8) · Depression (7) · Delirium (4) · Sleep Initiation and Maintenance Disorders (4) · Anxiety Disorders (3) · Emergence Delirium (3) · Pain (3) · Agnosia (2) · Cognitive Dysfunction (2) · Depression, Postpartum (2) · Acute Pain (1) · Autism Spectrum Disorder (1) · Breast Neoplasms (1) · Consciousness Disorders (1) · Crohn Disease (1)
Pathological Conditions, Signs and Symptoms (22) · Signs and Symptoms (21) · Neurologic Manifestations (20) · Nervous System Diseases (19) · Mental Disorders (18) · Pathologic Processes (11) · Pain (10) · Postoperative Complications (10) · Neurobehavioral Manifestations (8) · Neurocognitive Disorders (8) · Behavior (7) · Behavioral Symptoms (7) · Confusion (6) · Sleep Wake Disorders (6) · Dyssomnias (5)
Esketamine (34) · Saline Solution (22) · Dexmedetomidine (15) · Pregabalin (3) · Sodium Chloride (3) · Fentanyl (2) · Ketamine (2) · remimazolam (2) · Analgesia (1) · Butorphanol (1) · Control Groups (1) · Etomidate (1) · Oxycodone (1) · Propofol (1) · Remifentanil (1)
Peking University First Hospital (25) · Beijing Tiantan Hospital (7) · Maternal and Child Health Hospital of Hubei Province (2) · Second Affiliated Hospital of Wenzhou Medical University (2) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1) · Ailin Luo (1) · Anqing Municipal Hospital (1) · Chinese PLA General Hospital (1) · First Affiliated Hospital of Chongqing Medical University (1) · Jinling Hospital, China (1) · Jinqiao Qian (1) · Min Su (1) · Nanfang Hospital, Southern Medical University (1) · Nanjing First Hospital, Nanjing Medical University (1) · Qian Wu (1)
China (49) · Netherlands (1)
Dong-Xin Wang, MD, PhD (16) · Dong-Xin Wang, MD,PhD (4) · Dong-Xin Wang (3) · Ruquan Han, M.D., Ph D. (2) · Dong-Xin Wang, M.D. (1) · Dong-Xin Wang, M.D., PhD. (1) · Gang Y Hao (1) · Huacheng Liu (1) · Huacheng Liu, Ph.D. (1) · Ji Qing (1) · Junbao Zhang, MD (1) · Ke-Xuan Liu, MD (1) · Linli Yue, MD (1) · Markus W Hollmann, Prof. dr. dr. (1)
PMID 37302963, PMID 11936706, PMID 14982564, PMID 16192522, PMID 16415311, PMID 16531445, PMID 17563882, PMID 18653496, PMID 21277735, PMID 21818162, PMID 23893490, PMID 23982301, PMID 24650832, PMID 24785989, PMID 25038833, PMID 25335575, PMID 25587641, PMID 26142712, PMID 26739975, PMID 26832926, PMID 27607187, PMID 29361458, PMID 29656663, PMID 29736744, PMID 30041987, PMID 30570761, PMID 30603826, PMID 31362907, PMID 32733363, PMID 33011083, PMID 33022440, PMID 33078536, PMID 33165407, PMID 33189715, PMID 33368991, PMID 33387333, PMID 33533982, PMID 33774474, PMID 33841692, PMID 34254003, PMID 34903279, PMID 34967355, PMID 34970147, PMID 34992482, PMID 35218404, PMID 35473735, PMID 35833034, PMID 35870990, PMID 36454569, PMID 36474581