2 completed, 1 terminated, 1 unknown. 4 Phase 3, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 2, Terminated 1, Unknown 1 |
| Phase 2 | 3 | Completed 2, Unknown 1 |
Follow Esketamine: new trials by email Literature Review of Esketamine trials Research Report on Esketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Fentanyl OR Esketamine for Traumatic PAIN (FORE-PAIN) Trial Fentanyl Citrate, Esketamine - Acute Pain Due to Trauma, Analgesia | Phase 3 | Terminated | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | 235 | 2024-01-11 | 2026-09-15 |
| Esketamine Combined With Pregabalin on CPSP in Spinal Patients. S-ketamine and pregabalin, Normal saline and placebo capsule - Esketamine, Pregabaline | Phase 2 / Phase 3 | Unknown | Beijing Tiantan Hospital | 150 | 2023-11-10 | 2023-11-07 |
| Esketamine Combined With Pregabalin on Acute Postoperative Pain in Patients Undergoing Resection of Spinal Neoplasms. S-ketamine and pregabalin, Normal saline and placebo capsule - Esketamine, Pregabalin | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 90 | 2021-12-01 | 2023-07-06 |
| Esketamine and Perioperative Depressive Symptoms Esketamine, Normal saline - Depressive Symptoms, Esketamine | Phase 2 / Phase 3 | Completed | Beijing Tiantan Hospital | 435 | 2021-02-19 | 2025-08-01 |
Pain, Postoperative (2) · Agnosia (1) · Depression (1) · Drug-Related Side Effects and Adverse Reactions (1) · Spinal Cord Neoplasms (1)
Neurologic Manifestations (3) · Pathological Conditions, Signs and Symptoms (3) · Signs and Symptoms (3) · Nervous System Diseases (2) · Pain (2) · Pathologic Processes (2) · Postoperative Complications (2) · Behavior (1) · Behavioral Symptoms (1) · Central Nervous System Diseases (1) · Central Nervous System Neoplasms (1) · Chemically-Induced Disorders (1) · Neoplasms (1) · Neoplasms by Site (1) · Nervous System Neoplasms (1)
Esketamine (4) · Saline Solution (3) · Pregabalin (2) · Fentanyl (1)
Beijing Tiantan Hospital (3) · Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) (1)
China (3) · Netherlands (1)
Ruquan Han, M.D., Ph D. (2) · Markus W Hollmann, Prof. dr. dr. (1) · Ruquan Han, M.D., Ph D (1)
PMID 35473735, PMID 36841794, PMID 38501980, PMID 40420189, PMID 42119799