13 completed, 10 not yet recruiting, 6 recruiting, 2 unknown. 33 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 33 | Completed 13, Not yet recruiting 10, Recruiting 6, Unknown 2, Active not recruiting 1, Terminated 1 |
Follow Esketamine: new trials by email Literature Review of Esketamine trials Research Report on Esketamine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Long-term Follow-up of Dexmedetomidine-esketamine and tDCS for Neurocognitive Complications After Surgery Dex-Esk, Placebo, Active tDCS - Older Patients, Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 1996 | 2026-10-01 | 2026-10-13 |
| Dexmedetomidine-esketamine and tDCS for Prevention of Neurocognitive Complications After Surgery Dex-Esk, Placebo, Active tDCS - Older Patients, Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 1996 | 2026-10-01 | 2026-10-13 |
| Dexmedetomidine-Esketamine Combination on Depression and Anxiety After Laparoscopic Ureteral Reconstruction Combined dexmedetomidine-esketamine administration, Placebo administration - Ureteral Stricture, Dexmedetomidine | Phase 4 | Not yet recruiting | Peking University First Hospital | 658 | 2026-08-01 | 2026-08-14 |
| Comparing Esketamine and Remazolam With Propofol for Breathing Safety in Pediatric Gastroscopy Fentanyl and Propofol, Esketamine and remimazolam - Adverse Respiratory Events, Hypoxemia | Phase 4 | Not yet recruiting | Second Affiliated Hospital of Wenzhou Medical University | 120 | 2026-08-01 | 2026-08-06 |
| Intranasal Dexmedetomidine-esketamine on Sleep and Cognition in Older Adults With Mild-to-moderate Cognitive Impairment Dexmedetomidine-esketamine combination, Placebo - Older Adults, Cognitive Impairment | Phase 4 | Not yet recruiting | Peking University First Hospital | 60 | 2026-06-01 | 2026-06-01 |
| Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression Esketamine-dexmedetomidine combination, Placebo - Parturients, Depressive Symptoms | Phase 4 | Not yet recruiting | Peking University First Hospital | 164 | 2026-06-01 | 2026-06-15 |
| Intranasal Dexmedetomidine-esketamine Administration and Postoperative Pain in Pediatric Patients Intranasal dexmedetomidine-esketamine, Intranasal placebo (normal saline) - Adenotonsillectomy, Children | Phase 4 | Recruiting | Peking University First Hospital | 160 | 2026-04-07 | 2026-04-09 |
| Impact of Esketamine on Delayed Neurocognitive Recovery in Older Patients Esketamine 1, Esketamine 2, Esketamine 3 - Elderly, Noncardiac Surgery | Phase 4 | Not yet recruiting | Peking University First Hospital | 120 | 2026-04-01 | 2026-04-14 |
| Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-16 |
| Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery Combined dexmedetomidine-esketamine administration, Placebo administration - Spinal Surgery, Pain Intensity | Phase 4 | Not yet recruiting | Peking University First Hospital | 274 | 2026-04-01 | 2026-04-14 |
| Impact of Perioperative Dexmedetomidine and Esketamine on Postoperative Quality of Recovery Dexmedetomidine, Esketamine, Dexmedetomidine-esketamine - General Anesthesia, Surgery | Phase 4 | Recruiting | Peking University First Hospital | 316 | 2026-01-05 | 2026-04-13 |
| Sedation With Dexmedetomidine-esketamine Combination and Delirium in ICU Patients Dexmedetomidine, Dexmedetomidine-esketamine combination - Older Patients, Postoperative Care | Phase 4 | Completed | Peking University First Hospital | 100 | 2025-10-21 | 2026-06-30 |
| Dexmedetomidine-esketamine-ropivacaine Versus Sufentanil-ropivacaine for Epidural Labor Analgesia sufentanil-ropivacaine combination, dexmedetomidine-esketamine-ropivacaine combination 1, dexmedetomidine-esketamine-ropivacaine combination 2 - Epidural Analgesia, Labor Pain | Phase 4 | Completed | Peking University First Hospital | 300 | 2025-09-05 | 2026-04-13 |
| Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery Dexmedetomidine-esketamine combination, Placebo - Adults, Major Noncardiac Surgery | Phase 4 | Recruiting | Peking University First Hospital | 476 | 2025-03-18 | 2025-03-19 |
| Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia dexmedetomidine, Esketamine - Preoperative Anxiety, Preoperative Sedation | Phase 4 | Recruiting | Second Affiliated Hospital of Wenzhou Medical University | 80 | 2025-03-01 | 2025-12-02 |
| Effects of Esketamine on Oxygenation and Quality of Recovery in Patients Undergoing Thoracoscopic Surgery Esketamine, Dexmedetomidine, Normal Saline - Esketamine, One-lung Ventilation | Phase 4 | Not yet recruiting | Jinqiao Qian | 126 | 2025-03-01 | 2025-02-12 |
| Different Doses of Dexmedetomidine Combined With Esketamine in Women Undergoing Cesarean Delivery Esketamine 0.2 mg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.1 µg/kg, Esketamine 0.2 mg/kg + dexmedetomidine 0.15 µg/kg - Cesarean Delivery, Esketamine | Phase 4 | Completed | Peking University First Hospital | 120 | 2024-10-08 | 2024-12-30 |
| Mini-dose Dexmedetomidine-Esketamine Supplemented Analgesia in Patients at High-risk of OSA Dexmedetomidine-esketamine combination, Placebo - Obstructive Sleep Apnea, Surgery | Phase 4 | Completed | Peking University First Hospital | 100 | 2024-09-11 | 2026-09-04 |
| Dexmedetomidine-esketamine Combined Nasal Administration and Emergence Delirium Dexmedetomidine, Esketamine, Normal saline - Older Patients, Nasal Administration | Phase 4 | Completed | Peking University First Hospital | 340 | 2024-09-02 | 2025-07-31 |
| Effect of Dexmedetomidine and Esketamine on Catheter-related Bladder Discomfort Normal saline, Dexmedetomidine, Esketamine - Urinary Catheter, Catheter-related Bladder Discomfort | Phase 4 | Recruiting | Peking University First Hospital | 1740 | 2024-06-06 | 2025-07-31 |
Showing 20 of 33. Sign in to see all of them.
Pain, Postoperative (5) · Depression (4) · Pain (3) · Sleep Initiation and Maintenance Disorders (3) · Anxiety Disorders (2) · Delirium (2) · Emergence Delirium (2) · Acute Pain (1) · Agnosia (1) · Breast Neoplasms (1) · Cognitive Dysfunction (1) · Crohn Disease (1) · Depression, Postpartum (1) · Hyperalgesia (1) · Hypoxia (1)
Pathological Conditions, Signs and Symptoms (16) · Signs and Symptoms (15) · Neurologic Manifestations (14) · Mental Disorders (10) · Nervous System Diseases (10) · Pathologic Processes (8) · Pain (7) · Postoperative Complications (7) · Neurocognitive Disorders (5) · Behavior (4) · Behavioral Symptoms (4) · Confusion (4) · Dyssomnias (4) · Neurobehavioral Manifestations (4) · Sleep Disorders, Intrinsic (4)
Esketamine (19) · Saline Solution (13) · Dexmedetomidine (12) · Ketamine (2) · Analgesia (1) · Butorphanol (1) · Fentanyl (1) · Propofol (1) · Sodium Chloride (1) · Sufentanil (1) · remimazolam (1)
Peking University First Hospital (23) · Second Affiliated Hospital of Wenzhou Medical University (2) · Chinese PLA General Hospital (1) · Jinling Hospital, China (1) · Jinqiao Qian (1) · Qian Wu (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Second People's Hospital of Hefei City (1) · The Second Affiliated Hospital of Chongqing Medical University (1) · Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (1)
China (33)
Dong-Xin Wang, MD, PhD (14) · Dong-Xin Wang, MD,PhD (4) · Dong-Xin Wang (3) · Dong-Xin Wang, M.D. (1) · Dong-Xin Wang, M.D., PhD. (1) · Gang Y Hao (1) · Huacheng Liu (1) · Huacheng Liu, Ph.D. (1) · Ji Qing (1) · Junbao Zhang, MD (1) · Min Yan, Doctor (1) · Shiying Yuan, PhD, MD (1) · Weidong Mi, MD (1) · Wensheng He, MD (1) · Xianwen Hu, PhD (1)
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