92 completed, 26 unknown, 17 terminated, 10 recruiting. 159 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 159 | Completed 92, Unknown 26, Terminated 17, Recruiting 10, Withdrawn 6, Not yet recruiting 4, Active not recruiting 3, Enrolling by invitation 1 |
Follow Epilepsy: new trials by email Literature Review of Epilepsy trials Research Report on Epilepsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex Epidiolex 100 mg/mL Oral Solution - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS) | Phase 4 | Not yet recruiting | Elizabeth Donner | 25 | 2027-01-01 | 2026-09-11 |
| A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGS Cannabidiol Oral Solution - Lennox-Gastaut Syndrome | Phase 4 | Not yet recruiting | Jazz Pharmaceuticals | 40 | 2026-11-18 | 2026-10-22 |
| Study of the Pharmacokinetics, Safety, and Tolerability of ZONISADE in Children 1 Month to 17 Years of Age With Partial-onset Seizures Zonisamide Oral Product - Seizures, Seizures, Focal | Phase 4 | Not yet recruiting | Azurity Pharmaceuticals | 40 | 2026-09-01 | 2026-09-15 |
| Outcomes After Planned Discontinuation of AntiSeizure Medication Discontinue antiseizure medications - Epilepsy | Phase 4 | Recruiting | University of Michigan | 40 | 2026-08-01 | 2026-08-06 |
| Medication Treatment of ADHD in Pediatric Epilepsy methylphenidate hydrochloride (Jornay PM) - ADHD - Attention Deficit Disorder With Hyperactivity | Phase 4 | Recruiting | Hugo W. Moser Research Institute at Kennedy Krieger, Inc. | 25 | 2026-05-29 | 2026-07-29 |
| The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome Project Fenfluramine treatment (Fintepla), Hypercapnia Challenge using the device (RespirAct) - Dravet Syndrome | Phase 4 | Recruiting | The University of Texas Health Science Center, Houston | 25 | 2026-04-27 | 2026-07-15 |
| Efficacy and Safety of Perampanel in the Treatment of Refractory Status Epilepticus Perampanel - Refractory Status Epilepticus | Phase 4 | Terminated | Wayne State University | 1 | 2025-10-10 | 2025-10-14 |
| Butylphthalide for Cognitive Impairment in Elderly Patients With Focal Epilepsy Butylphthalide, Placebo - Focal Epilepsy, Cognitive Impairment | Phase 4 | Recruiting | First Affiliated Hospital of Wenzhou Medical University | 220 | 2025-09-01 | 2025-09-25 |
| Early Post-Traumatic Seizures Prevention Trial (E-PTS Trial) Phenytoin, Levetiracetam, Placebo - Seizures, Traumatic Brain Injuries | Phase 4 | Recruiting | All India Institute of Medical Sciences, Jodhpur | 1260 | 2025-07-23 | 2026-10-29 |
| Clinical Trial on 7-day Followed by Maintenance Therapy for 10 Weeks vs. 14-day and no Maintenance Course of Prednisolone for the Treatment of Infantile Epileptic Spasms Syndrome (IESS) Short-Duration Oral Prednisolone with Extended Tapering, Standard Oral Prednisolone Regimen with Tapering - Spasms, Infantile, Prednisolone | Phase 4 | Active not recruiting | University of Colombo | 182 | 2025-01-01 | 2025-02-24 |
| Pro-Epileptic Effects of IV Ketamine Ketamine, Midazolam, Propofol - Epilepsy, Seizure | Phase 4 | Completed | Haseki Training and Research Hospital | 300 | 2024-12-01 | 2025-12-15 |
| Assessment of Safety of the Use of Fenfluramine in Children With Dravet Syndrome Under 24 Months of Age fenfluramine - Dravet Syndrome (DS), Children Under 2 Years | Phase 4 | Recruiting | University of Colorado, Denver | 5 | 2024-10-22 | 2026-05-15 |
| A Clinical Study on the Efficacy and Safety of Zonisamide as a First Add-On Treatment in Epileptic Seizures Oral Zonisamide Therapy - Epilepsies, Partial, Epilepsy, Tonic-Clonic | Phase 4 | Recruiting | Affiliated Hospital of Nantong University | 30 | 2024-08-01 | 2025-05-13 |
| Effect of Adding Lamotrigine to Sodium Valproate in Childhood Epilepsy: Clinicolabratory Study Sodium Valproate 500 Mg Prolonged-Release Oral Tablet, Lamotrigine, E.E.G - Epilepsy, Lamotrigine | Phase 4 | Unknown | Assiut University | 50 | 2024-07-29 | 2024-07-30 |
| Assessment of Combined Praziquantel and Albendazole vs Albendazole Alone to Treat Active Parenchymal Neurocysticercosis albendazole and praziquantel, Albendazole - Neurocysticercosis | Phase 4 | Not yet recruiting | R-Evolution Worldwide S.r.l. Impresa Sociale | 300 | 2024-06-01 | 2024-04-23 |
| Seizure Rescue Medication (RM) as Part of a Comprehensive Epilepsy Self-management Package of Care SMART RM, Valtoco Nasal Product - Epilepsy | Phase 4 | Active not recruiting | University Hospitals Cleveland Medical Center | 31 | 2024-03-05 | 2026-07-06 |
| Brain Regions and Functional Neuronal Network Characteristics of Dexmedetomidine Analgesia Dexmedetomidine Injectable Solution, Sodium Chloride 0.9% Inj - Epilepsy, Radiofrequency Ablation | Phase 4 | Completed | China International Neuroscience Institution | 28 | 2024-01-15 | 2026-09-10 |
| Evaluation of Levetiracetam's Effectiveness and Tolerability for Treating Epilepsy in Older Adults Oral levetiracetam - Epilepsy, Elderly | Phase 4 | Completed | Nasim Tabrizi | 137 | 2023-09-13 | 2026-02-19 |
| Methylphenidate for the Treatment of Epilepsy-related Cognitive Deficits Methylphenidate, Placebo - Epilepsy | Phase 4 | Recruiting | VA Office of Research and Development | 226 | 2023-08-14 | 2026-04-20 |
| Bioequivalence Study of Sodium Valproate and Valproic Acid Tablets Sodium valproate and valproic acid extended release tablet - Epilepsy | Phase 4 | Unknown | Kathmandu University | 16 | 2023-08-06 | 2023-10-11 |
Showing 20 of 159. Sign in to see all of them.
Seizures (32) · Epilepsies, Partial (29) · Drug Resistant Epilepsy (8) · Lennox Gastaut Syndrome (6) · Nervous System Diseases (6) · Anxiety Disorders (5) · Epilepsies, Myoclonic (5) · Epilepsy, Rolandic (5) · Attention Deficit Disorder with Hyperactivity (3) · Brain Neoplasms (3) · Cognitive Dysfunction (3) · Depression (3) · Depressive Disorder, Major (3) · Epilepsy, Temporal Lobe (3)
Central Nervous System Diseases (158) · Brain Diseases (157) · Nervous System Diseases (153) · Pathological Conditions, Signs and Symptoms (44) · Signs and Symptoms (38) · Neurologic Manifestations (37) · Mental Disorders (22) · Epileptic Syndromes (20) · Epilepsy, Generalized (11) · Epilepsies, Partial (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (8) · Genetic Diseases, Inborn (7) · Pathologic Processes (7) · Neurodevelopmental Disorders (6)
Levetiracetam (25) · Lamotrigine (16) · Carbamazepine (13) · Valproic Acid (12) · Zonisamide (11) · Topiramate (10) · perampanel (9) · Pregabalin (8) · Lacosamide (7) · Phenytoin (7) · Oxcarbazepine (6) · Cannabidiol (5) · Clobazam (5) · Anticonvulsants (4) · Diet, Ketogenic (4)
UCB Pharma (9) · Eisai Korea Inc. (6) · GlaxoSmithKline (5) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (5) · Assiut University (3) · Cyberonics, Inc. (3) · Eisai Limited (3) · Hugo W. Moser Research Institute at Kennedy Krieger, Inc. (3) · Jazz Pharmaceuticals (3) · University of Cincinnati (3) · Eisai Inc. (2) · Institute of Child Health (2) · Kimford Jay Meador (2) · Lundbeck LLC (2) · Nasim Tabrizi (2)
United States (62) · South Korea (14) · Germany (9) · United Kingdom (9) · China (7) · Italy (7) · France (6) · Canada (5) · Austria (4) · India (4) · Spain (4) · Greece (3) · Iran (3) · Mexico (3) · Netherlands (3)
Jihee Mun (4) · Kimford Meador, MD (3) · Heidi Munger Clary, MD (2) · Jay Salpekar, MD (2) · Michel J Berg, MD (2) · Aashit Shah, MD (1) · Abeer Salamah, Lecturer (1) · Albert P Aldenkamp, PhD (1) · Alex Bekker, MD, PhD (1) · Andre M. Kanner, MD (1)
PMID 10208286, PMID 11117539, PMID 11137386, PMID 11976067, PMID 15069466, PMID 15145300, PMID 15199078, PMID 15521903, PMID 15652736, PMID 15767218, PMID 15794175, PMID 16344515, PMID 16406488, PMID 16524783, PMID 16674605, PMID 17300358, PMID 17472600, PMID 17681453, PMID 17826314, PMID 17851135, PMID 17888078, PMID 18456557, PMID 1947597, PMID 19682955, PMID 19920901, PMID 20331461, PMID 20462804, PMID 20685215, PMID 21352847, PMID 21454134, PMID 21909835, PMID 22378657, PMID 22658946, PMID 23435277, PMID 24314750, PMID 24403284, PMID 24655096, PMID 24754318, PMID 25616485, PMID 25663221, PMID 25684224, PMID 25948717, PMID 26216692, PMID 26425001, PMID 26514204, PMID 26875743, PMID 27199889, PMID 27315132, PMID 27513702, PMID 27521437
2005 (2), 2009 (2), 5UL1TR001420-03 (2), 2014 (1), 2018 (1), K23AG081463 (1), K23MH066835 (1), M01RR000069 (1), R49CE721682 (1)