44 completed, 14 terminated, 8 unknown, 5 recruiting. 27 Phase 1, 17 Phase 4, 12 Phase 2, 10 Not applicable, 8 Phase 3.
Follow Phenytoin: new trials by email Literature Review of Phenytoin trials Research Report on Phenytoin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Drug-drug Interaction Study to Assess the Effect of Phenytoin and Itraconazole on the Pharmacokinetics of Pelabresib in Healthy Participants Pelabresib, Phenytoin, Itraconazole - Healthy Participants | Phase 1 | Recruiting | Novartis Pharmaceuticals | 30 | 2026-09-02 | 2026-09-22 |
| A Study to Investigate the Effect of the CYP3A Inducer Phenytoin and the CYP3A Inhibitor Itraconazole on the Pharmacokinetics of BGB-58067 in Healthy Participants BGB-58067, Phenytoin, Itraconazole - Healthy Volunteers | Phase 1 | Recruiting | BeOne Medicines | 30 | 2026-06-04 | 2026-10-09 |
| Compairing Micro Needling With Phenytoin Versus Microneedling Alone on Striae Alba Phenytoin, Micro needling - Treatment of Striae Alba | Not applicable | Completed | Al-Azhar University | 30 | 2025-12-15 | 2026-09-25 |
| Early Post-Traumatic Seizures Prevention Trial (E-PTS Trial) Phenytoin, Levetiracetam, Placebo - Seizures, Traumatic Brain Injuries | Phase 4 | Recruiting | All India Institute of Medical Sciences, Jodhpur | 1260 | 2025-07-23 | 2025-08-06 |
| A Study to Evaluate VH4524184 Tablet Absorption, Effects of Food, and Interactions With Other Drugs in Healthy Adults VH4524184, Itraconazole, Rifabutin - HIV Infections | Phase 1 | Completed | ViiV Healthcare | 126 | 2025-07-07 | 2026-03-09 |
| Phenytoin in Treatment of Atrophic Post Acne Scars. Topical nano preparation of Phenytoin, Fractional CO2 laser - Atrophic Acne Scar | Phase 4 | Not yet recruiting | Assiut University | 30 | 2025-07-01 | 2025-04-24 |
| Drug-Drug Interaction Study of Casdatifan in Healthy Adult Participants (ARC-29) Casdatifan, Itraconazole, Phenytoin - Healthy Participants | Phase 1 | Completed | Arcus Biosciences, Inc. | 14 | 2025-05-02 | 2025-11-13 |
| Effect of Phenytoin or Itraconazole on How BGB-16673 is Absorbed and Removed From the Body in Healthy Participants BGB-16673, Itraconazole, Phenytoin - Healthy Volunteers | Phase 1 | Completed | BeiGene | 37 | 2025-04-03 | 2026-08-24 |
| A Clinical Study of Belzutifan (MK-6482) Alone or With Phenytoin in Healthy Participants (CA46602/MK-6482-035) Belzutifan, Phenytoin - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 14 | 2025-03-28 | 2025-06-13 |
| Drug-drug Interaction Study of Clemizole (EPX-100) in Healthy Participants EPX-100, Itraconazole, Phenytoin - Drug Drug Interaction | Phase 1 | Completed | Epygenix | 54 | 2025-01-15 | 2026-09-17 |
| A Study to Evaluate the Effects of Phenytoin and Itraconazole on Sonrotoclax (BGB-11417) in Healthy Volunteers Phenytoin, Itraconazole, sonrotoclax - Not Determined | Phase 1 | Completed | BeiGene | 30 | 2024-08-19 | 2024-11-27 |
| A Study to Learn How Different Forms of The Study Medicine Called Phenytoin Are Taken up Into the Blood in Healthy Adults Phenytoin (Ascoli), Phenytoin (Vega Baja) - Healthy | Phase 1 | Completed | Pfizer | 35 | 2024-07-03 | 2024-10-08 |
| A Study of the Effect of Itraconazole and Phenytoin on Calderasib (MK-1084) in Healthy Adults (MK-1084-008) Calderasib, Itraconazole, Phenytoin - Healthy | Phase 1 | Completed | Merck Sharp & Dohme LLC | 28 | 2024-05-20 | 2026-02-11 |
| Drug-Drug Interaction (DDI) Study of Leramistat in Healthy Adult Subjects leramistat 40mg, Itraconazole 200 mg, Phenytoin 100 Mg Oral Capsule - Pharmacokinetics | Phase 1 | Unknown | Modern Biosciences Ltd | 48 | 2024-04-08 | 2024-08-09 |
| A Study of the Interaction of TAK-279 With Substances That Have an Impact on Metabolism in Healthy Adults TAK-279, Erythromycin, Phenytoin - Healthy Volunteers | Phase 1 | Completed | Takeda | 172 | 2023-08-11 | 2024-02-06 |
| A Study to Assess the Effect of Phenytoin on the Drug Levels of Afimetoran and the Effect of Afimetoran on the Drug Levels of Midazolam Afimetoran, Phenytoin, Midazolam - Healthy Participants | Phase 1 | Completed | Bristol-Myers Squibb | 65 | 2023-06-14 | 2024-08-07 |
| The Benefit and Safety of Older Generation Anti-Epileptic Drugs (AEDs) in Drug-Resistant Epilepsy Children Valproic acid, Carbamazepin, Phenytoin - Drug Resistant Epilepsy | Phase 4 | Unknown | Dr Cipto Mangunkusumo General Hospital | 100 | 2023-03-01 | 2023-01-26 |
| Clinical Study Evaluating Safety of Pentoxifylline and Celecoxib in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy Phenytoin, Pentoxifylline 400 MG, Celecoxib 200mg - Epilepsy | Phase 2 | Recruiting | Mostafa Bahaa | 90 | 2022-12-20 | 2024-07-18 |
| Efficacy of Phenytoin vs Levetiracetam in Status Epilepticus at Institute of Child Health,Faisalabad Levetiracetam, Phenytoin - Status Epilepticus | Not applicable | Completed | Shaheed Zulfiqar Ali Bhutto Medical University | 70 | 2022-08-01 | 2023-10-04 |
| Dual Anti-glutamate Therapy in Super-refractory Status Epilepticus After Cardiac Arrest Ketamine, Any anti-epileptic and anesthetic therapy, excluding Ketamine and Perampanel - Status Epilepticus, Cardiac Arrest | Completed | University of Milano Bicocca | 84 | 2022-01-15 | 2026-07-14 |
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Epilepsy (15) · Seizures (12) · Brain Injuries, Traumatic (5) · Status Epilepticus (4) · Cognitive Dysfunction (2) · Depression (2) · Epilepsy, Post-Traumatic (2) · Leukemia (2) · Lymphoma (2) · Mental Disorders (2) · Neurologic Manifestations (2) · Optic Neuritis (2) · Rare Diseases (2) · Subarachnoid Hemorrhage (2) · Acquired Immunodeficiency Syndrome (1)
Hadassah Medical Organization (3) · BeiGene (2) · Bial - Portela C S.A. (2) · Bristol-Myers Squibb (2) · Mansoura University (2) · Merck Sharp & Dohme LLC (2) · Pfizer's Upjohn has merged with Mylan to form Viatris Inc. (2) · University College, London (2) · University of Texas Southwestern Medical Center (2) · Al-Azhar University (1) · All India Institute of Medical Sciences, Jodhpur (1) · Arcus Biosciences, Inc. (1) · Assistance Publique - Hôpitaux de Paris (1) · Assiut University (1) · Baylor College of Medicine (1)
United States (31) · Egypt (5) · Israel (5) · United Kingdom (4) · Spain (2) · Australia (1) · Cambodia (1) · Canada (1) · France (1) · Georgia (1) · Germany (1) · India (1) · Indonesia (1) · Iran (1) · Italy (1)
Yoseph Caraco, MD (3) · Amira Darwish, MD (1) · Amit Ray, MD, MBA, FAES, FAAN (1) · Bassel F Shneker, MD (1) · Debra Houry, MD (1) · Dorothy Hatsukami, Ph.D. (1) · Dr Apinderpreet Singh Additional Professor, MCh Neurosugery (1) · Dr Kamlesh Bhaisora Additional Professor, MCh Neurosugery (1) · E. Sherwood Brown, MD, PhD (1) · Elton Kisanga, PharmD, PhD (1) · Erik K St. Louis, M.D. (1)
PMID 20633037, PMID 22342434, PMID 23864647, PMID 24287594, PMID 26822749, PMID 27878474, PMID 28446244, PMID 31156538, PMID 34930487, PMID 35499204, PMID 37609651, PMID 40739381, PMID 40997284, PMID 42837646
K23NS058669 (1), P30CA016058 (1), R49CE721682 (1)