49 completed, 10 terminated, 5 withdrawn, 4 unknown. 21 Phase 3, 17 Phase 4, 15 Phase 2, 10 Phase 1, 6 Not applicable.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Real-world Study of Efficacy and Safety of Zonisamide in add-on Therapy for Patients With Focal Epilepsy Zonisamide - Epilepsies, Partial | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 400 | 2024-04-01 | 2024-04-19 | |
| Zonisamide Versus Topiramate in Migraine Zonisamide 50 MG, Topiramate 50 MG - Migraine | Phase 3 | Completed | Kafrelsheikh University | 600 | 2024-04-01 | 2026-05-27 |
| Zonisamide Versus Propranolol in Migraine Zonisamide 50 MG, Propranolol - Migraine | Phase 3 | Unknown | Kafrelsheikh University | 600 | 2024-03-29 | 2024-04-23 |
| The Zonisamide and Reinforcement for Reducing Alcohol Use (ZARRA) Study Zonisamide, Placebo - Alcohol Use Disorder (AUD) | Phase 2 | Active not recruiting | Washington State University | 205 | 2022-01-07 | 2026-07-06 |
| The Effects of Combination Zonisamide and Bupropion on Switching to an Electronic Cigarette Bupropion, Zonisamide, Placebo bupropion - Smoking Cessation | Phase 3 | Completed | Rose Research Center, LLC | 180 | 2021-12-14 | 2026-02-06 |
| Noise-Induced Hearing Loss-Acute Exposure Treatment (UA) Zonisamide 100Mg Cap, Placebo - Hearing Loss, Noise-Induced | Phase 2 | Terminated | Washington University School of Medicine | 3 | 2021-11-10 | 2026-02-13 |
| Noise-Induced Hearing Loss-Acute Exposure Treatment Zonisamide 100Mg Cap, Placebo - Hearing Loss, Noise-Induced | Phase 2 | Terminated | Washington University School of Medicine | 24 | 2021-10-04 | 2025-01-15 |
| Modification of Epilepsy Screen Questionnaire and Treatment Feasibility Evaluation Zonisamide 100mg, Levetiracetam 500mg, LamoTRIgine 50mg - Epilepsy | Not applicable | Unknown | National Taiwan University Hospital | 40 | 2021-07-01 | 2021-06-25 |
| Low vs. Standard Daily Doses of Antiepileptic Drugs in Newly Diagnosed, Previously Untreated Epilepsy(STANDLOW) Low dose carbamazepine, Standard dose carbamazepine, Low dose levetiracetam - Epilepsies, Partial | Phase 4 | Completed | Mario Negri Institute for Pharmacological Research | 58 | 2021-05-10 | 2025-07-08 |
| Zonisamide/Bupropion Effects on Switching to Electronic Cigarettes Zonisamide, Bupropion, Halo G6 e-cigarette - Smoking Cessation | Phase 3 | Completed | Rose Research Center, LLC | 26 | 2020-05-27 | 2022-04-13 |
| Role of Zonisamide in Advanced Parkinson's Disease (PD) in Egyptian Population: Pilot Study Zonisamide Capsules - Parkinson Disease | Not applicable | Completed | Ain Shams University | 69 | 2020-04-01 | 2023-02-16 |
| Zonisamide Outpatient Study Zonisamide, Placebo Comparator - Post Traumatic Stress Disorder, Alcohol Use Disorder | Phase 2 | Withdrawn | Pharmacotherapies for Alcohol and Substance Use Disorders Alliance | 2019-03-01 | 2021-03-09 | |
| Prevention of Noise-induced Hearing Loss Zonisamide, Methylprednisolone - Noise-induced Hearing Loss | Phase 1 / Phase 2 | Withdrawn | Washington University School of Medicine | 2017-10-31 | 2017-11-06 | |
| Interdisciplinary Study of A Novel Anticonvulsant in Alcoholism Zonisamide, Take Control, Placebo (for Zonisamide) - Alcohol Dependence | Phase 3 | Completed | Boston University Charles River Campus | 81 | 2017-09-21 | 2023-06-18 |
| Population Pharmacokinetics of Antiepileptic in Pediatrics Valproic acid, carbamazepine, phenobarbital - Epilepsy | Completed | Assistance Publique - Hôpitaux de Paris | 753 | 2017-06-19 | 2025-11-20 | |
| Characterization of Epilepsy Patients BEEP 2b Oxcarbazepine (brand name vs generic drugs), Divalproex Sodium (brand name vs generic drugs), Carbamazepine (brand name vs generic drugs) - Epilepsy | Phase 1 | Completed | Food and Drug Administration (FDA) | 21 | 2017-06-08 | 2020-03-27 |
| Zonisamide Treatment of Alcohol Use Disorder: an Evaluation of Efficacy and Mechanism of Action Zonisamide, Placebo - Alcohol Use Disorder | Phase 3 | Completed | Virginia Commonwealth University | 156 | 2016-10-01 | 2022-10-13 |
| An Open-Label Tolerability and Exploratory Efficacy Study of Zonisamide for Dyskinesias in Parkinson's Disease Zonegran - Parkinson Disease, Parkinsonism | Phase 4 | Suspended | The Cooper Health System | 20 | 2016-04-08 | 2021-11-23 |
| Effectiveness of Zonisamide in Alcohol Dependent Veterans Zonisamide, Placebo - Alcohol Use Disorder | Phase 3 | Terminated | VA Office of Research and Development | 92 | 2015-03-01 | 2020-12-07 |
| Ketogenic Diet in Infants With Epilepsy (KIWE) Ketogenic diet, Antiepileptic drug therapy - Epilepsy | Phase 4 | Unknown | University College, London | 160 | 2015-01-01 | 2017-05-04 |
Showing 20 of 70. Sign in to see all of them.
Epilepsy (23) · Alcoholism (11) · Seizures (6) · Migraine Disorders (5) · Alcoholic Intoxication (3) · Bipolar Disorder (3) · Epilepsies, Partial (3) · Hearing Loss, Noise-Induced (3) · Obesity (3) · Parkinson Disease (3) · Smoking Cessation (3) · Drinking Behavior (2) · Essential Tremor (2) · Psychotic Disorders (2) · Stress Disorders, Post-Traumatic (2)
Eisai Inc. (10) · Eisai Limited (5) · Eisai Korea Inc. (4) · Washington University School of Medicine (3) · Assistance Publique - Hôpitaux de Paris (2) · Boston University (2) · Dr. Reddy's Laboratories Limited (2) · Elan Pharmaceuticals (2) · Johns Hopkins University (2) · Kafrelsheikh University (2) · Lindner Center of HOPE (2) · Mutual Pharmaceutical Company, Inc. (2) · Mylan Pharmaceuticals Inc (2) · Rose Research Center, LLC (2) · Yale University (2)
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Jihee Mun (4) · Albert J Arias, MD (2) · Annie Umbricht, M.D. (2) · Antonio R Pizarro, M.D (2) · Craig A Buchman, MD, FACS (2) · Dorian Williams, M.D. (2) · Adrian Handforth, M.D. (1) · Albert Arias, MD (1) · Albert J. Arias, MD (1) · Ali Shalash, PhD (1) · Amitabh Dash (1) · Andrew Yeates (1) · Christian Elger (1) · Clifford Knapp, PhD (1)
PMID 11914403, PMID 12807523, PMID 8984084, PMID 17194267, PMID 20840778, PMID 21672497, PMID 22367654, PMID 22683226, PMID 25123600, PMID 25427171, PMID 26476459, PMID 28446244, PMID 37230961, PMID 38376645, PMID 39306870
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