112 completed, 28 recruiting, 28 terminated, 20 unknown. 70 Phase 3, 51 Phase 2, 30 Not applicable, 23 Phase 1, 13 Phase 4.
Follow Epilepsy, Generalized: new trials by email Literature Review of Epilepsy, Generalized trials Research Report on Epilepsy, Generalized
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| High-Intensity Focused Ultrasonic Ablation of the Centromedian Thalamic Nucleus for Treatment of Medically Refractory Generalized Epilepsy in Patients Ages 18 Years to 89 Years Intervention 1, Intervention 2 - Idiopathic Generalized Epilepsy | Not applicable | Not yet recruiting | Oregon Health and Science University | 10 | 2027-02-01 | 2026-09-04 |
| A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex Epidiolex 100 mg/mL Oral Solution - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS) | Phase 4 | Not yet recruiting | Elizabeth Donner | 25 | 2027-01-01 | 2026-09-11 |
| A Fully Remote Feasibility Trial of Phenylbutyrate for SLC6A1-Related Disorders Glycerol Phenylbutyrate - SLC6A1 | Phase 2 | Recruiting | Scripps Translational Science Institute | 20 | 2026-10-01 | 2026-09-29 |
| A Study to Evaluate the Safety and Efficacy of JZP926 Capsule for the Treatment of Juvenile Myoclonic Epilepsy JZP926 capsule, Placebo - Juvenile Myoclonic Epilepsy | Phase 2 / Phase 3 | Recruiting | Jazz Pharmaceuticals | 260 | 2026-09-18 | 2026-10-06 |
| Biomarkers of Neurodegeneration, Synaptic Plasticity and Neuroinflammation in Dravet Syndrome Dravet Syndrome (DS) | Not yet recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 90 | 2026-09-15 | 2026-09-03 | |
| IBIS - Investigating Reliability of BIS and SEDLINE Monitoring in Children With Developmental and Epileptic Encephalopathies (DEE). Monitoring of patients using electroencephalogram, a Bispectral Index (BIS) and Sedline monitors. - Epileptic Encephalopathy, Early Infantile Epileptic Encephalopathy | Not yet recruiting | Telethon Kids Institute | 40 | 2026-09-03 | 2026-07-17 | |
| ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome ION337 - Dravet Syndrome | Phase 1 / Phase 2 | Recruiting | Ionis Pharmaceuticals, Inc. | 32 | 2026-05-21 | 2026-09-03 |
| A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome [18F]MPPF PET-MRI - Epilepsy, Dravet Syndrome | Not applicable | Recruiting | Hospices Civils de Lyon | 30 | 2026-05-04 | 2026-05-08 |
| The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome Project Fenfluramine treatment (Fintepla), Hypercapnia Challenge using the device (RespirAct) - Dravet Syndrome | Phase 4 | Recruiting | The University of Texas Health Science Center, Houston | 25 | 2026-04-27 | 2026-07-15 |
| Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titration for Dravet and LGS Byteflies Remote patient monitoring solution (with reduced EEG) - Dravet Syndrome (DS), Lennox Gastaut Syndrome (LGS) | Not applicable | Enrolling by invitation | Byteflies | 20 | 2026-04-20 | 2026-10-08 |
| LEvetiracetam to Prevent Seizures in Symptomatic Alzheimer's Disease in Adults With Down Syndrome Levetiracetam 500mg, Placebo - Down Syndrome, Down Syndrome (DS) | Phase 3 | Recruiting | Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau | 120 | 2025-12-22 | 2026-01-12 |
| A Study to Evaluate the Safety and Pharmacokinetics of RC001 in Children With Dravet Syndrome RC001 injection-Dose Escalation Cohort, RC001 injection-Fixed Dose Cohort - Dravet Syndrome (DS) | Early Phase 1 | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 8 | 2025-12-22 | 2026-06-30 |
| Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents Epilepsy, West Syndrome | Recruiting | Assistance Publique - Hôpitaux de Paris | 1000 | 2025-12-11 | 2026-02-24 | |
| Personalized Antisense Oligonucleotide for A Single Participant (nL62541) With ATN1 Gene Mutation nL-ATN1-001 - Dentatorubral-Pallidoluysian Atrophy | Phase 1 / Phase 2 | Active not recruiting | n-Lorem Foundation | 1 | 2025-11-06 | 2026-04-07 |
| Clinical Trial of Vormatrigine in Adult Patients With Epilepsy vormatrogine - Epilepsy, Tonic-Clonic, Focal Seizure | Phase 3 | Enrolling by invitation | Praxis Precision Medicines | 700 | 2025-10-27 | 2026-08-03 |
| Longitudinal Study of Phenotypic and Developmental Severity in Patients With Dravet Syndrome With SCN1A Gene Mutation Dravet Syndrome | Recruiting | Assistance Publique - Hôpitaux de Paris | 50 | 2025-09-15 | 2026-02-03 | |
| Ketogenic Diet for Prevention of Epileptic Spasms in Infantile Onset Genetic Epilepsies Ketogenic diet - Developmental and Epileptic Encephalopathies, Epileptic Spasms | Phase 1 | Terminated | Heather Olson | 1 | 2025-08-11 | 2026-10-14 |
| Non-Invasive Low Intensity Focused Ultrasound Stimulation for Drug-Resistant Epilepsy Target optimization using LIFU, Serial LIFU stimulation - Drug-Resistant Epilepsy, Epilepsy | Not applicable | Recruiting | University of California, San Francisco | 40 | 2025-07-09 | 2026-07-02 |
| A Double-blind Study Evaluating the Efficacy, Safety, and Tolerability of Zorevunersen in Patients With Dravet Syndrome zorevunersen, Sham Comparator - Dravet Syndrome | Phase 3 | Active not recruiting | Stoke Therapeutics, Inc | 170 | 2025-06-04 | 2026-10-20 |
| Bioavailability of Stiripentol After Single Oral Dose of Capsule vs Suspension in Healthy Subjects (STILIQ) Stiripentol capsule (Diacomit®), Stiripentol oral suspension (Diacomit®) - Dravet Syndrome, Epilepsy | Phase 1 | Completed | Biocodex | 24 | 2025-06-01 | 2025-09-16 |
Showing 20 of 236. Sign in to see all of them.
Epilepsies, Myoclonic (92) · Epilepsy (82) · Seizures (62) · Spasms, Infantile (47) · Lennox Gastaut Syndrome (30) · Epilepsy, Absence (24) · Epilepsy, Tonic-Clonic (23) · Epilepsies, Partial (13) · Drug Resistant Epilepsy (11) · Myoclonic Epilepsies, Progressive (11) · Epilepsy, Idiopathic Generalized (9) · Tuberous Sclerosis (8) · Brain Diseases (6) · CDKL5 deficiency disorder (6)
Central Nervous System Diseases (234) · Nervous System Diseases (234) · Brain Diseases (230) · Epileptic Syndromes (181) · Epilepsy (154) · Pathological Conditions, Signs and Symptoms (91) · Neurologic Manifestations (81) · Signs and Symptoms (81) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (53) · Genetic Diseases, Inborn (52) · Neurodegenerative Diseases (25) · Epilepsies, Myoclonic (24) · Heredodegenerative Disorders, Nervous System (22) · Pathologic Processes (21)
Cannabidiol (21) · Fenfluramine (14) · Levetiracetam (9) · Topiramate (7) · Vigabatrin (7) · Prednisolone (5) · brivaracetam (5) · stiripentol (5) · Clobazam (4) · Lamotrigine (4) · Valproic Acid (4) · soticlestat (4) · Adrenocorticotropic Hormone (3) · Diet, Ketogenic (3) · Pyridoxine (3)
Jazz Pharmaceuticals (10) · Takeda (7) · Johnson & Johnson Pharmaceutical Research & Development, L.L.C. (6) · University of Colorado, Denver (6) · Lady Hardinge Medical College (5) · Longboard Pharmaceuticals (5) · UCB Pharma (5) · Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc. (5) · Encoded Therapeutics (4) · Lundbeck LLC (4) · National Institute of Neurological Disorders and Stroke (NINDS) (4) · All India Institute of Medical Sciences (3) · Assistance Publique - Hôpitaux de Paris (3) · Fondazione Policlinico Universitario Agostino Gemelli IRCCS (3) · Gillette Children's Specialty Healthcare (3)
United States (133) · France (34) · Italy (31) · Spain (28) · Canada (25) · United Kingdom (23) · Australia (22) · Germany (22) · Poland (16) · Belgium (15) · India (14) · Netherlands (13) · Japan (11) · China (10) · Brazil (9)
Neha Parikh (3) · Salvador Rico, M.D., Ph.D (3) · Ahmed Elkashef, MD (2) · Alexander Rotenberg, MD, PhD (2) · Ann Dandurand, MD (2) · Beverly S Wical, MD (2) · Dennis J Dlugos, MD (2) · Domenica Immacolata Battaglia (2)
PMID 34768178, PMID 17283312, PMID 19327967, PMID 26666500, PMID 33461041, PMID 33540241, PMID 34265088, PMID 41780062, PMID 10208286, PMID 10227614, PMID 10368073, PMID 10561962, PMID 10565592, PMID 10768306, PMID 11117539, PMID 11673582, PMID 11976067, PMID 12403260, PMID 12690085, PMID 14734931, PMID 15069466, PMID 15145300, PMID 15159460, PMID 15509243, PMID 15521903, PMID 15541450, PMID 15794175, PMID 16344515, PMID 16406488, PMID 16524783, PMID 17625106, PMID 17826314, PMID 18077226, PMID 18285535, PMID 1947597, PMID 19682955, PMID 20200383, PMID 20608959, PMID 20685215, PMID 20937567, PMID 21070215, PMID 21352847, PMID 21454134, PMID 21920781, PMID 21956725, PMID 22050371, PMID 22378657, PMID 22658946, PMID 22689735, PMID 22859699
2023 (5), 2014 (4), 2015 (2), 2016 (2), 2018 (2), U54NS078059 (2), 2004 (1), 2017 (1), 2019 (1), K12TR004410 (1), R01HD102723 (1), R01NS037466 (1), R43NS129363 (1), RC3NS070658 (1), U01NS045803 (1)