69 completed, 55 recruiting, 54 unknown, 22 not yet recruiting. 129 Not applicable, 38 Phase 2, 18 Phase 3, 14 Phase 1, 8 Early Phase 1.
Follow Drug Resistant Epilepsy: new trials by email Literature Review of Drug Resistant Epilepsy trials Research Report on Drug Resistant Epilepsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Characterisation of Laryngeal Evoked Potentials Induced by Vagus Nerve Stimulation in Refractory Epilepsy Patients Increasing VNS Intensities Induced with Magnet - Refractory Epilepsy, Epilepsy | Not applicable | Not yet recruiting | Université Catholique de Louvain | 110 | 2027-01-01 | 2026-10-29 |
| Electrophysiological Dose-Response to Anterior Thalamic Deep Brain Stimulation in Drug-Resistant Focal Epilepsy Anterior thalamic deep brain stimulation with a standardized amplitude schedule and acute stimulation challenges - Drug Resistant Epilepsy, Focal Epilepsy | Not applicable | Not yet recruiting | Yonsei University | 10 | 2026-11-01 | 2026-11-03 |
| Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy Textile-based wearable electrocardiography - Epilepsy, Temporal Lobe, Drug Resistant Epilepsy | Not yet recruiting | Acibadem University | 40 | 2026-10-15 | 2026-09-23 | |
| Overnight TI in TLE Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi - Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy | Not applicable | Recruiting | Duke University | 20 | 2026-10-15 | 2026-10-16 |
| Sleep Disruption Pattern - Epilepsy Monitoring Unit Alarm system - Epilepsy Intractable | Not applicable | Not yet recruiting | Duke University | 75 | 2026-10-01 | 2026-09-08 |
| Prospective Longitudinal Study of Sleep, Brain Activity, and Plasma Analyses in Patients Undergoing Epilepsy Surgery Epilepsy, Sleep | Not yet recruiting | Region Skane | 40 | 2026-09-21 | 2026-10-21 | |
| Post-Market Real-World Evidence Registry for the NeuroOne OneRF® Ablation System for Epilepsy Participants are not assigned an intervention as part of the study. - Drug Resistant Epilepsy, Refractory Epilepsy | Recruiting | NeuroOne Medical Technologies Corporation | 100 | 2026-09-18 | 2026-10-16 | |
| Temporal Interference Brain Stimulation for Adults With Drug-Resistant Epilepsy Undergoing Stereo-EEG Monitoring Temporal Interference Stimulation, Direct Electrical Stimulation - Drug-Resistant Focal Epilepsy | Not applicable | Recruiting | Duke University | 30 | 2026-09-16 | 2026-10-15 |
| Safety and Efficacy of AV078 in Participants With Tuberous Sclerosis Complex (TSC) Refractory Epilepsy (RESTOR-1) AV078, Placebo - Tuberous Sclerosis Complex, Epilepsy | Phase 2 | Not yet recruiting | Aeovian Pharmaceuticals, Inc. | 42 | 2026-09-01 | 2026-09-29 |
| Assessment of MRI-guided HIFU for Patients With Drug-resistant Focal Epilepsy MR-guided HIFU thermoablation, EEG, MRI - Epilepsy | Not applicable | Not yet recruiting | Assistance Publique - Hôpitaux de Paris | 13 | 2026-09-01 | 2026-05-15 |
| Fluorescence Guided Focal Cortical Dysplasia Surgery 5-ALA (Gliolan) - Drug Resistant Epilepsy | Phase 2 | Not yet recruiting | Hospices Civils de Lyon | 5 | 2026-09-01 | 2026-06-18 |
| Feasibility Study of the iVEAcare Neuromodulation System for the Treatment of Drug-Resistant Epilepsy iVEAcare Neuromodulation System - Drug Resistant Epilepsy | Not applicable | Recruiting | iVEAcare | 30 | 2026-07-29 | 2026-09-22 |
| CANnabinoids for Drug Resistant Epilepsy (DRE) in Adults and Children Placebo, CBD Isolate, CBD CHE - Drug Resistant Epilepsy | Phase 2 | Not yet recruiting | University of Manitoba | 90 | 2026-07-27 | 2026-06-11 |
| Pediatric Epilepsy Cedrus RB series response pad; Adtech Behnke-Fried micro-electrodes; Neuralynx or Blackrock electrophysiology system; Blackrock Cerestim or Natus Nicolet stimulator - Epilepsy Intractable | Not applicable | Recruiting | University of Texas Southwestern Medical Center | 200 | 2026-07-01 | 2026-10-06 |
| Retinal OCT Changes and Biomarkers in Drug-Resistant Epilepsy Epilepsy (Treatment Refractory), Epilepsy | Enrolling by invitation | Kemal Tutkavul | 250 | 2026-07-01 | 2026-07-21 | |
| Biomarkers of Response to SEEG Thermocoagulation Quality of life questionnaires (QOLIE, EFIQUACEE for children), psychiatric questionnaires (NDDIE, GAD-7, PCL-5) at Visit 1 (V1), V5, V6 and V7, Resting state SEEG recording 30min before and 30 min after RFTC, Blood sample at Visit 1 (V1), V2, V4 and V5 - Drug Resistant Epilepsy | Not applicable | Recruiting | Assistance Publique Hopitaux De Marseille | 45 | 2026-06-19 | 2026-06-26 |
| Developmental and Epileptic Encephalopathies Diagnosed Via Long-read Genome Sequencing Long-read Whole Genome Sequencing (lrWGS) - Developmental and Epileptic Encephalopathy, Epilepsy in Children | Not yet recruiting | University Hospital, Strasbourg, France | 20 | 2026-06-01 | 2026-02-09 | |
| A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome [18F]MPPF PET-MRI - Epilepsy, Dravet Syndrome | Not applicable | Recruiting | Hospices Civils de Lyon | 30 | 2026-05-04 | 2026-05-08 |
| Long-Term Epilepsy Outcomes in Children With a History of Perinatal Stroke Perinatal Stroke, Epilepsy | Recruiting | University Hospital, Strasbourg, France | 120 | 2026-04-28 | 2026-10-27 | |
| Neuronal Mechanisms of Learning and Utilizing Abstract Representations Cedrus RB-844 response pad; Adtech Behnke-Fried micro-electrodes; Neurolynx electrophysiology system; Blackrock Cerestim stimulator - Epilepsy Intractable | Not applicable | Enrolling by invitation | Cedars-Sinai Medical Center | 114 | 2026-03-30 | 2026-09-15 |
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Epilepsy (97) · Seizures (36) · Epilepsies, Partial (25) · Epilepsy, Temporal Lobe (7) · Central Nervous System Diseases (3) · Epilepsies, Myoclonic (3) · Epilepsy, Generalized (3) · Tuberous Sclerosis (3) · Alzheimer Disease (2) · Brain Diseases (2) · CDKL5 deficiency disorder (2) · Diffuse Cerebral Sclerosis of Schilder (2) · Epilepsy, Tonic-Clonic (2) · Focal Cortical Dysplasia (2)
Brain Diseases (248) · Nervous System Diseases (248) · Central Nervous System Diseases (247) · Epilepsy (153) · Pathological Conditions, Signs and Symptoms (48) · Neurologic Manifestations (42) · Signs and Symptoms (42) · Epileptic Syndromes (15) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (11) · Mental Disorders (11) · Pathologic Processes (9) · Epilepsy, Generalized (8) · Behavior (7) · Congenital Abnormalities (7) · Epilepsies, Partial (7)
Cannabidiol (8) · Diet, Ketogenic (8) · Transcranial Direct Current Stimulation (8) · Electroencephalography (4) · Anticonvulsants (3) · Surveys and Questionnaires (3) · Therapeutics (3) · Vagus Nerve Stimulation (3) · padsevonil (3) · perampanel (3) · Blood Specimen Collection (2) · Cholecalciferol (2) · Clobazam (2) · Hematologic Tests (2) · Ketamine (2)
Xuanwu Hospital, Beijing (14) · Duke University (5) · Hospices Civils de Lyon (5) · All India Institute of Medical Sciences (4) · Assistance Publique Hopitaux De Marseille (4) · Beijing Pins Medical Co., Ltd (4) · Biohaven Therapeutics Ltd. (4) · Cedars-Sinai Medical Center (4) · Cliniques universitaires Saint-Luc- Université Catholique de Louvain (4) · NaviFUS Corporation (4) · University Hospital, Grenoble (4) · Xijing Hospital (4) · Assiut University (3) · LivaNova (3) · Mayo Clinic (3)
United States (75) · France (34) · China (26) · Italy (21) · United Kingdom (20) · Belgium (17) · Poland (15) · Spain (15) · Canada (14) · Australia (13) · Germany (11) · India (11) · Portugal (9) · Turkey (Türkiye) (9) · Czechia (8)
Liankun Ren, MD (11) · Adam Mamelak, MD (4) · Ueli Rutishauser, PhD (4) · Birgit Frauscher, MD PD (3) · Liankun Ren (2) · Satinder Aneja, MD (2) · Sheffali Gulati, MD (2) · Vinay Penematsa, MD (2) · Zhuo Huang, PhD (2) · Aaron Boes, MD, PhD (1) · Abdelrahim A Sadek, MD, PhD (1) · Adam Williamson, PhD (1)
PMID 32588435, PMID 19889013, PMID 36176044, PMID 10332020, PMID 10356376, PMID 10660394, PMID 10742367, PMID 10870204, PMID 10996924, PMID 11188984, PMID 11254763, PMID 11299481, PMID 11971127, PMID 12436398, PMID 1418457, PMID 15816939, PMID 16158066, PMID 16189532, PMID 16499758, PMID 16499772, PMID 17444813, PMID 17641989, PMID 17642053, PMID 17880009, PMID 17903391, PMID 19450130, PMID 19694741, PMID 19914135, PMID 20064729, PMID 21167786, PMID 21464890, PMID 21561445, PMID 21747585, PMID 21885255, PMID 22278892, PMID 22368518, PMID 22399764, PMID 22709423, PMID 22853973, PMID 23223279, PMID 23365066, PMID 23530510, PMID 23646961, PMID 23646966, PMID 23996681, PMID 24370818, PMID 24791078, PMID 24828683, PMID 24886843, PMID 25149833
2023 (6), 2017 (2), 2025 (2), 2018 (1), K23NS126495 (1), R00NS126715 (1), R01MH133729 (1), R01MH134990 (1), R01NS106611 (1), R01NS119483 (1), R21MH120441 (1), R21MH124674 (1), R21MH126968 (1), R56NS148323 (1), R61DC022835 (1)