Epileptic Syndromes: Clinical Trials

133 completed, 43 recruiting, 40 terminated, 36 unknown. 76 Phase 3, 59 Not applicable, 56 Phase 2, 28 Phase 1, 20 Phase 4.

By phase and status

Phase	Trials	Status
Phase 3	76	Completed 33, Terminated 18, Unknown 7, Withdrawn 6, Active not recruiting 5, Recruiting 5, Enrolling by invitation 1, Suspended 1
Not applicable	59	Completed 23, Recruiting 11, Unknown 10, Terminated 5, Not yet recruiting 3, Withdrawn 3, Active not recruiting 2, Enrolling by invitation 2
Phase 2	56	Completed 15, Terminated 15, Recruiting 11, Active not recruiting 7, Unknown 6, Not yet recruiting 1, Withdrawn 1
Phase 1	28	Completed 13, Active not recruiting 5, Recruiting 5, Terminated 2, Unknown 2, Not yet recruiting 1
Phase 4	20	Completed 6, Unknown 3, Withdrawn 3, Active not recruiting 2, Not yet recruiting 2, Recruiting 2, Terminated 2
Early Phase 1	3	Recruiting 2, Unknown 1

Follow Epileptic Syndromes: new trials by email Literature Review of Epileptic Syndromes trials Research Report on Epileptic Syndromes

Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Sleep-Driven Adaptive Neuromodulation in Lennox-Gastaut Syndrome Personalized Adaptive Deep Brain Stimulation Therapy, Conventional Non-Personalized Deep Brain Stimulation Therapy - Lennox Gastaut Syndrome (LGS), Epilepsy	Not applicable	Not yet recruiting	University of Minnesota	4	2027-01-01	2026-10-07
A Study to Investigate the Transition of Children From 'Artisanal" Cannabidiol (CBD) to Epidiolex Epidiolex 100 mg/mL Oral Solution - Dravet Syndrome (DS), Lennox-Gastaut Syndrome (LGS)	Phase 4	Not yet recruiting	Elizabeth Donner	25	2027-01-01	2026-09-11
Accelerated iTBS for Depression and Suicidality Accelerated Intermittent Theta Burst (aiTBS), Electroconvulsive therapy (ECT) - Major Depressive Disorder, Suicide	Not applicable	Not yet recruiting	University of Iowa	50	2026-12-01	2025-05-20
A Study to Investigate the Effect of Gradual Titration to Optimize Cannabidiol Treatment in Adults With LGS Cannabidiol Oral Solution - Lennox-Gastaut Syndrome	Phase 4	Not yet recruiting	Jazz Pharmaceuticals	40	2026-11-18	2026-10-22
Peri-procedural Weighted Blanket Use for ECT Weighted blanket, Usual Care Group - Post-ect Agitation, Post-ictal Agitation	Not applicable	Not yet recruiting	Mayo Clinic	200	2026-11-01	2026-10-28
Studying Heart Rhythms With a Wearable Sensor to Detect and Predict Seizures in People With Epilepsy Textile-based wearable electrocardiography - Epilepsy, Temporal Lobe, Drug Resistant Epilepsy		Not yet recruiting	Acibadem University	40	2026-10-15	2026-09-23
Overnight TI in TLE Non-invasive Temporal Interference (TI) Stimulation Targeting Bilateral Hippocampi - Temporal Lobe Epilepsy (TLE), Drug Resistant Epilepsy	Not applicable	Recruiting	Duke University	20	2026-10-15	2026-10-16
A Fully Remote Feasibility Trial of Phenylbutyrate for SLC6A1-Related Disorders Glycerol Phenylbutyrate - SLC6A1	Phase 2	Recruiting	Scripps Translational Science Institute	20	2026-10-01	2026-09-29
A Study to Evaluate the Safety and Efficacy of JZP926 Capsule for the Treatment of Juvenile Myoclonic Epilepsy JZP926 capsule, Placebo - Juvenile Myoclonic Epilepsy	Phase 2 / Phase 3	Recruiting	Jazz Pharmaceuticals	260	2026-09-18	2026-11-12
Biomarkers of Neurodegeneration, Synaptic Plasticity and Neuroinflammation in Dravet Syndrome Dravet Syndrome (DS)		Not yet recruiting	Fondazione Policlinico Universitario Agostino Gemelli IRCCS	90	2026-09-15	2026-09-03
IBIS - Investigating Reliability of BIS and SEDLINE Monitoring in Children With Developmental and Epileptic Encephalopathies (DEE). Monitoring of patients using electroencephalogram, a Bispectral Index (BIS) and Sedline monitors. - Epileptic Encephalopathy, Early Infantile Epileptic Encephalopathy		Not yet recruiting	Telethon Kids Institute	40	2026-09-03	2026-07-17
ASCEND: Safety and Tolerability of ION337 for the Treatment of Dravet Syndrome ION337 - Dravet Syndrome	Phase 1 / Phase 2	Recruiting	Ionis Pharmaceuticals, Inc.	32	2026-05-21	2026-11-02
A PET-MRI Study of Serotoninergic Brainstem Pathway in Patients With Dravet Syndrome [18F]MPPF PET-MRI - Epilepsy, Dravet Syndrome	Not applicable	Recruiting	Hospices Civils de Lyon	30	2026-05-04	2026-05-08
EEG Dynamics in Lennox-Gastaut Syndrome Patients Undergoing Fenfluramine Treatment fenfluramine HCl - Lennox Gastaut Syndrome (LGS)		Enrolling by invitation	University of Chicago	20	2026-05-01	2026-08-06
The FINTEPLA as an Anti-SUDEP Therapy in Dravet Syndrome Project Fenfluramine treatment (Fintepla), Hypercapnia Challenge using the device (RespirAct) - Dravet Syndrome	Phase 4	Recruiting	The University of Texas Health Science Center, Houston	25	2026-04-27	2026-07-15
Clinical Utility of Reduced EEG Home Monitoring in Fenfluramine Titration for Dravet and LGS Byteflies Remote patient monitoring solution (with reduced EEG) - Dravet Syndrome (DS), Lennox Gastaut Syndrome (LGS)	Not applicable	Enrolling by invitation	Byteflies	20	2026-04-20	2026-10-08
MRI Volumetry and Diffusion Tensor Imaging in Temporal Lobe Epilepsy MRI - Temporal Lobe Epilepsy (TLE)		Not yet recruiting	Assiut University	78	2026-04-01	2026-02-03
The Children's Adaptive Deep Brain Stimulation for Epilepsy Trial Deep Brain Stimulation - Lennox Gastaut Syndrome (LGS)	Not applicable	Recruiting	University College, London	22	2026-03-24	2026-04-07
A Study to Evaluate the Safety and Pharmacokinetics of RC001 in Children With Dravet Syndrome RC001 injection-Dose Escalation Cohort, RC001 injection-Fixed Dose Cohort - Dravet Syndrome (DS)	Early Phase 1	Recruiting	Second Affiliated Hospital of Guangzhou Medical University	8	2025-12-22	2026-06-30
Multicentre Real-life Follow-up Study of Rare Epileptic Syndromes in Children and Adolescents Epilepsy, West Syndrome		Recruiting	Assistance Publique - Hôpitaux de Paris	1000	2025-12-11	2026-02-24

Showing 20 of 315. Sign in to see all of them.

Narrower conditions

Epilepsy (109)  ·  Epilepsies, Myoclonic (92)  ·  Lennox Gastaut Syndrome (68)  ·  Seizures (63)  ·  Epilepsy, Temporal Lobe (62)  ·  Spasms, Infantile (47)  ·  Epilepsy, Absence (24)  ·  Epilepsy, Rolandic (23)  ·  Drug Resistant Epilepsy (15)  ·  Epilepsies, Partial (13)  ·  Myoclonic Epilepsies, Progressive (11)  ·  Brain Diseases (10)  ·  Depression (9)  ·  Tuberous Sclerosis (8)

Broader conditions

Central Nervous System Diseases (311)  ·  Nervous System Diseases (311)  ·  Brain Diseases (305)  ·  Epilepsy (206)  ·  Epilepsy, Generalized (177)  ·  Pathological Conditions, Signs and Symptoms (97)  ·  Congenital, Hereditary, and Neonatal Diseases and Abnormalities (93)  ·  Genetic Diseases, Inborn (89)  ·  Neurologic Manifestations (88)  ·  Signs and Symptoms (88)  ·  Epilepsies, Partial (80)  ·  Mental Disorders (26)  ·  Neurodegenerative Diseases (25)  ·  Epilepsies, Myoclonic (24)

Interventions

Cannabidiol (26)  ·  Fenfluramine (16)  ·  Vigabatrin (7)  ·  Prednisolone (6)  ·  Topiramate (6)  ·  Levetiracetam (5)  ·  brivaracetam (5)  ·  rufinamide (5)  ·  soticlestat (5)  ·  stiripentol (5)  ·  Clobazam (4)  ·  Diet, Ketogenic (4)  ·  S-2-O-carbamoyl-1-o-chlorophenyl-ethanol (4)  ·  Valproic Acid (4)  ·  Adrenocorticotropic Hormone (3)

Sponsors

National Institute of Neurological Disorders and Stroke (NINDS) (15)  ·  Jazz Pharmaceuticals (14)  ·  Takeda (8)  ·  Hospices Civils de Lyon (7)  ·  Eisai Inc. (6)  ·  Longboard Pharmaceuticals (6)  ·  University of Colorado, Denver (6)  ·  Zogenix International Limited, Inc., a subsidiary of Zogenix, Inc. (6)  ·  Lady Hardinge Medical College (5)  ·  Assistance Publique - Hôpitaux de Paris (4)  ·  Encoded Therapeutics (4)  ·  INSYS Therapeutics Inc (4)  ·  King's College London (4)  ·  Lundbeck LLC (4)  ·  SK Life Science, Inc. (4)

Countries

United States (172)  ·  France (50)  ·  Italy (39)  ·  Spain (34)  ·  Canada (32)  ·  United Kingdom (31)  ·  Australia (30)  ·  Germany (27)  ·  China (23)  ·  Poland (22)  ·  Belgium (20)  ·  Netherlands (18)  ·  Japan (17)  ·  India (14)  ·  Denmark (11)

Top investigators

Neha Parikh (4)  ·  William H Theodore, M.D. (4)  ·  Marc Kamin, MD (3)  ·  Salvador Rico, M.D., Ph.D (3)  ·  Ahmed Elkashef, MD (2)  ·  Alexander Rotenberg, MD, PhD (2)  ·  Amit Ray, MD (2)  ·  Ann Dandurand, MD (2)  ·  Beverly S Wical, MD (2)  ·  Dennis J Dlugos, MD (2)  ·  Domenica Immacolata Battaglia (2)

Results publications

PMID 33825230, PMID 34768178, PMID 26666500, PMID 27683846, PMID 29768152, PMID 33461041, PMID 33540241, PMID 33797076, PMID 34265088, PMID 37052803, PMID 40775196, PMID 41780062, PMID 10368073, PMID 10371538, PMID 10561962, PMID 10565592, PMID 11673582, PMID 12403260, PMID 14734931, PMID 15159460, PMID 15509243, PMID 15541450, PMID 18077226, PMID 20200383, PMID 20331461, PMID 20608959, PMID 21070215, PMID 21391767, PMID 21920781, PMID 21956725, PMID 22396514, PMID 22689735, PMID 22859699, PMID 23141144, PMID 24657009, PMID 25048310, PMID 25564232, PMID 25663221, PMID 26143305, PMID 26216500, PMID 26280806, PMID 26302697, PMID 26805435, PMID 27012680, PMID 27199889, PMID 27350662, PMID 27354526, PMID 27838190, PMID 28538134, PMID 28916534

NIH funding

2014 (7), 2023 (5), 2018 (3), 2015 (2), 2016 (2), 2017 (2), U54NS078059 (2), 1UG3NS112826-01 (1), 2005 (1), 2019 (1), DP1MH116506 (1), K12TR004410 (1), K23NS116110 (1), R01NS037466 (1), R01NS047530 (1)